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Li Guo, Li Zhang, Haiman Xu, Pei Yu, Zhigang Wang, Danyi Lu, Min Chen & Baojian Wu. (2021) Diurnal hepatic CYP3A11 contributes to chronotoxicity of the pyrrolizidine alkaloid retrorsine in mice. Xenobiotica 51:9, pages 1019-1028.
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Xiaobo He, Qingsu Xia, Qiang Shi & Peter P. Fu. (2020) Effects of glutathione and cysteine on pyrrolizidine alkaloid-induced hepatotoxicity and DNA adduct formation in rat primary hepatocytes. Journal of Environmental Science and Health, Part C 38:2, pages 109-123.
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Articles from other publishers (28)
Frances Widjaja, Liang Zheng, Sebastiaan Wesseling & Ivonne M. C. M. Rietjens. (2023) Physiologically based kinetic modeling of senecionine N-oxide in rats as a new approach methodology to define the effects of dose and endpoint used on relative potency values of pyrrolizidine alkaloid N-oxides. Frontiers in Pharmacology 14.
Crossref
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Martina Štampar, Helle Sedighi Frandsen, Adelina Rogowska-Wrzesinska, Krzysztof Wrzesinski, Metka Filipič & Bojana Žegura. (2021) Hepatocellular carcinoma (HepG2/C3A) cell-based 3D model for genotoxicity testing of chemicals. Science of The Total Environment 755, pages 143255.
Crossref
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Lukas Rutz, Lan Gao, Jan-Heiner Küpper & Dieter Schrenk. (2020) Structure-dependent genotoxic potencies of selected pyrrolizidine alkaloids in metabolically competent HepG2 cells. Archives of Toxicology 94:12, pages 4159-4172.
Crossref
Crossref
Ina Geburek, Angelika Preiss-Weigert, Monika Lahrssen-Wiederholt, Dieter Schrenk & Anja These. (2020) In vitro metabolism of pyrrolizidine alkaloids – Metabolic degradation and GSH conjugate formation of different structure types. Food and Chemical Toxicology 135, pages 110868.
Crossref
Crossref
Cathy Lester, John Troutman, Cindy Obringer, Kenneth Wehmeyer, Peter Stoffolano, Michael Karb, Yan Xu, Amy Roe, Greg Carr, Karen Blackburn & Catherine Mahony. (2019) Intrinsic relative potency of a series of pyrrolizidine alkaloids characterized by rate and extent of metabolism. Food and Chemical Toxicology 131, pages 110523.
Crossref
Crossref
Johanna Ebmeyer, Luise Franz, Ramonique Lim, Birgit Niemann, Hansruedi Glatt, Albert Braeuning, Alfonso Lampen & Stefanie Hessel‐Pras. (2019) Sensitization of Human Liver Cells Toward Fas‐Mediated Apoptosis by the Metabolically Activated Pyrrolizidine Alkaloid Lasiocarpine. Molecular Nutrition & Food Research 63:12, pages 1801206.
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Crossref
Jia Ning, Lu Chen, Marije Strikwold, Jochem Louisse, Sebastiaan Wesseling & Ivonne M. C. M. Rietjens. (2019) Use of an in vitro–in silico testing strategy to predict inter-species and inter-ethnic human differences in liver toxicity of the pyrrolizidine alkaloids lasiocarpine and riddelliine. Archives of Toxicology 93:3, pages 801-818.
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Johanna Ebmeyer, Jessica Behrend, Mario Lorenz, Georgia Günther, Raymond Reif, Jan G. Hengstler, Albert Braeuning, Alfonso Lampen & Stefanie Hessel-Pras. (2019) Pyrrolizidine alkaloid-induced alterations of prostanoid synthesis in human endothelial cells. Chemico-Biological Interactions 298, pages 104-111.
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Kelsey RettingDwayne CarterCandace Crogan-GrundyChirag KhatiwalaLeah NoronaElizabeth PaffenrothUmesh HanumegowdaAlice ChenLisa HazelwoodLois Lehman-McKeemanSharon Presnell. (2018) Modeling Liver Biology and the Tissue Response to Injury in Bioprinted Human Liver Tissues. Applied In Vitro Toxicology 4:3, pages 288-303.
Crossref
Crossref
Fashe Muluneh, Merja R. Häkkinen, Rami El-Dairi, Markku Pasanen & Risto O. Juvonen. (2018)
New glutathione conjugate of pyrrolizidine alkaloids produced by human cytosolic enzyme-dependent reactions
in vitro
. Rapid Communications in Mass Spectrometry 32:16, pages 1344-1352.
Crossref
Crossref
Yitong Liu. (2018) Incorporation of absorption and metabolism into liver toxicity prediction for phytochemicals: A tiered in silico QSAR approach. Food and Chemical Toxicology 118, pages 409-415.
Crossref
Crossref
Kristina Forsch, Verena Schöning, Lucia Disch, Beate Siewert, Matthias Unger & Jürgen Drewe. (2018) Development of an in vitro screening method of acute cytotoxicity of the pyrrolizidine alkaloid lasiocarpine in human and rodent hepatic cell lines by increasing susceptibility. Journal of Ethnopharmacology 217, pages 134-139.
Crossref
Crossref
Verena Schöning, Felix Hammann, Mark Peinl & Jürgen Drewe. (2017) Editor’s Highlight: Identification of Any Structure-Specific Hepatotoxic Potential of Different Pyrrolizidine Alkaloids Using Random Forests and Artificial Neural Networks. Toxicological Sciences 160:2, pages 361-370.
Crossref
Crossref
Xiaojing Yang, Weiwei Li, Ying Sun, Xiucai Guo, Wenlin Huang, Ying Peng & Jiang Zheng. (2017) Comparative Study of Hepatotoxicity of Pyrrolizidine Alkaloids Retrorsine and Monocrotaline. Chemical Research in Toxicology 30:2, pages 532-539.
Crossref
Crossref
Peter P. Fu. (2016) Pyrrolizidine Alkaloids: Metabolic Activation Pathways Leading to Liver Tumor Initiation. Chemical Research in Toxicology 30:1, pages 81-93.
Crossref
Crossref
Karl-Heinz Merz & Dieter Schrenk. (2016) Interim relative potency factors for the toxicological risk assessment of pyrrolizidine alkaloids in food and herbal medicines. Toxicology Letters 263, pages 44-57.
Crossref
Crossref
Meixia Chen, Liang Li, Dafang Zhong, Shuijie Shen, Jiang Zheng & Xiaoyan Chen. (2016)
9-Glutathionyl-6,7-dihydro-1-hydroxymethyl-5
H
-pyrrolizine Is the Major Pyrrolic Glutathione Conjugate of Retronecine-Type Pyrrolizidine Alkaloids in Liver Microsomes and in Rats
. Chemical Research in Toxicology 29:2, pages 180-189.
Crossref
Crossref
Muluneh M. Fashe, Risto O. Juvonen, Aleksanteri Petsalo, Juha Räsänen & Markku Pasanen. (2015)
Species-Specific Differences in the
in Vitro
Metabolism of Lasiocarpine
. Chemical Research in Toxicology 28:10, pages 2034-2044.
Crossref
Crossref
Liang Ma, Hengqiang Zhao, Qingsu Xia, Lining Cai & Peter P. Fu. (2015) Synthesis and phototoxicity of isomeric 7,9-diglutathione pyrrole adducts: Formation of reactive oxygen species and induction of lipid peroxidation. Journal of Food and Drug Analysis 23:3, pages 577-586.
Crossref
Crossref
Cheng-Hong Hsieh, Haw-Wen Chen, Chuan-Chen Lee, Bao-Jey He & Ya-Chen Yang. (2015) Hepatotoxic pyrrolizidine alkaloids in Emilia sonchifolia from Taiwan. Journal of Food Composition and Analysis 42, pages 1-7.
Crossref
Crossref
Muluneh M. Fashe, Risto O. Juvonen, Aleksanteri Petsalo, Jouko Vepsäläinen, Markku Pasanen & Minna Rahnasto-Rilla. (2015)
In Silico
Prediction of the Site of Oxidation by Cytochrome P450 3A4 That Leads to the Formation of the Toxic Metabolites of Pyrrolizidine Alkaloids
. Chemical Research in Toxicology 28:4, pages 702-710.
Crossref
Crossref
Qingsu Xia, Liang Ma, Xiaobo He, Lining Cai & Peter P. Fu. (2015) 7-Glutathione Pyrrole Adduct: A Potential DNA Reactive Metabolite of Pyrrolizidine Alkaloids. Chemical Research in Toxicology 28:4, pages 615-620.
Crossref
Crossref
Reuel A. Field, Bryan L. Stegelmeier, Steven M. Colegate, Ammon W. Brown & Benedict T. Green. (2015) An in vitro comparison of the cytotoxic potential of selected dehydropyrrolizidine alkaloids and some N-oxides. Toxicon 97, pages 36-45.
Crossref
Crossref
Muluneh M. Fashe, Risto O. Juvonen, Aleksanteri Petsalo, Minna Rahnasto-Rilla, Seppo Auriola, Pasi Soininen, Jouko Vepsäläinen & Markku Pasanen. (2014)
Identification of a New Reactive Metabolite of Pyrrolizidine Alkaloid Retrorsine: (3
H
-Pyrrolizin-7-yl)methanol
. Chemical Research in Toxicology 27:11, pages 1950-1957.
Crossref
Crossref
Meijuan Tu, Liping Li, Hongmei Lei, Zhiyuan Ma, Zhongjian Chen, Siyuan Sun, Siyun Xu, Hui Zhou, Su Zeng & Huidi Jiang. (2014) Involvement of organic cation transporter 1 and CYP3A4 in retrorsine-induced toxicity. Toxicology 322, pages 34-42.
Crossref
Crossref
Hong Gao, G.L. Prasad & Wolfgang Zacharias. (2014) Combusted but not smokeless tobacco products cause DNA damage in oral cavity cells. Environmental Toxicology and Pharmacology 37:3, pages 1079-1089.
Crossref
Crossref
Jeanne I. Rader & Rahul S. Pawar. (2013) Primary constituents of blue cohosh: quantification in dietary supplements and potential for toxicity. Analytical and Bioanalytical Chemistry 405:13, pages 4409-4417.
Crossref
Crossref
Rahul S. Pawar, Hemlata Tamta, Jun Ma, Alexander J. Krynitsky, Erich Grundel, Wayne G. Wamer & Jeanne I. Rader. (2013) Updates on chemical and biological research on botanical ingredients in dietary supplements. Analytical and Bioanalytical Chemistry 405:13, pages 4373-4384.
Crossref
Crossref