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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 10
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General Xenobiochemistry

Method for predicting human intestinal first-pass metabolism of UGT substrate compounds

Takako FurukawaAnalysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, JapanCorrespondence[email protected]
,
Katsuhiro YamanoAnalysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan
,
Yoichi NaritomiAnalysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan
,
Kohichiro TanakaAnalysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan
,
Shigeyuki TerashitaAnalysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan
&
Toshio TeramuraAnalysis and Pharmacokinetics Research Laboratories, Astellas Pharma Inc., Ibaraki, Japan
Pages 980-988 | Received 03 Feb 2012, Accepted 26 Mar 2012, Published online: 27 Apr 2012

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Takako Furukawa, Yoichi Naritomi, Kazuhiro Tetsuka, Fumihiro Nakamori, Hiroyuki Moriguchi, Katsuhiro Yamano, Shigeyuki Terashita, Kenji Tabata & Toshio Teramura. (2014) Species differences in intestinal glucuronidation activities between humans, rats, dogs and monkeys. Xenobiotica 44:3, pages 205-216.
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Articles from other publishers (7)

Xiaomei I. Liu, John N. den Anker, Gilbert J. Burckart & André Dallmann. (2021) Evaluation of Physiologically Based Pharmacokinetic Models to Predict the Absorption of BCS Class I Drugs in Different Pediatric Age Groups. The Journal of Clinical Pharmacology 61:S1.
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John van den Anker, Michael D. Reed, Karel Allegaert & Gregory L. Kearns. (2018) Developmental Changes in Pharmacokinetics and Pharmacodynamics. The Journal of Clinical Pharmacology 58, pages S10-S25.
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Jean-Marie Nicolas, François Bouzom, Chanteux Hugues & Anna-Lena Ungell. (2017) Oral drug absorption in pediatrics: the intestinal wall, its developmental changes and current tools for predictions. Biopharmaceutics & Drug Disposition 38:3, pages 209-230.
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Sheila Annie Peters, Christopher R. Jones, Anna-Lena Ungell & Oliver J. D. Hatley. (2016) Predicting Drug Extraction in the Human Gut Wall: Assessing Contributions from Drug Metabolizing Enzymes and Transporter Proteins using Preclinical Models. Clinical Pharmacokinetics 55:6, pages 673-696.
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Christopher R. Jones, Oliver J. D. Hatley, Anna-Lena Ungell, Constanze Hilgendorf, Sheila Annie Peters & Amin Rostami-Hodjegan. (2016) Gut Wall Metabolism. Application of Pre-Clinical Models for the Prediction of Human Drug Absorption and First-Pass Elimination. The AAPS Journal 18:3, pages 589-604.
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Yoichi Naritomi, Fumihiro Nakamori, Takako Furukawa & Kenji Tabata. (2015) Prediction of hepatic and intestinal glucuronidation using in vitro–in vivo extrapolation. Drug Metabolism and Pharmacokinetics 30:1, pages 21-29.
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Laurent Grosse, Anne-Sophie Campeau, Sarah Caron, Frédéric-Alexandre Morin, Kim Meunier, Jocelyn Trottier, Patrick Caron, Mélanie Verreault & Olivier Barbier. (2013) Enantiomer Selective Glucuronidation of the Non-Steroidal Pure Anti-Androgen Bicalutamide by Human Liver and Kidney: Role of the Human UDP-Glucuronosyltransferase (UGT)1A9 Enzyme. Basic & Clinical Pharmacology & Toxicology 113:2, pages 92-102.
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