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Xenobiotica

the fate of foreign compounds in biological systems

Volume 42, 2012 - Issue 10

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General Xenobiochemistry

Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa

Roslyn S. Thelingwani

Kariema DhansayDepartment of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa

Peter SmithDepartment of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa

Kelly ChibaleDepartment of Chemistry, University of Cape Town, Cape Town, South Africa

Collen M. MasimirembwaCorrespondence[email protected] [email protected]

Pages 989-1000 | Received 08 Feb 2012, Accepted 27 Mar 2012, Published online: 25 Apr 2012

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https://doi.org/10.3109/00498254.2012.681077

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Misheck Mudyiwa, Manju Sharma, Samarendra Kumar Ray, Collen Masimirembwa & Roslyn Stella Thelingwani. (2023) Inhibitory effects of herbal medicines with claimed anticancer indications on cytochrome P450—An evaluation of drug-herb interactions risk. Scientific African 21, pages e01835.
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Qiu-yue Xiao, Tian-yuan Ye, Xiao-long Wang, Lu Han, Tong-xing Wang, Dong-mei Qi, Xiao-rui Cheng & Sheng-qi Wang. (2021) A network pharmacology-based study on key pharmacological pathways and targets of Qi Fu Yin acting on Alzheimer's disease. Experimental Gerontology 149, pages 111336.
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Ogochukwu Amaeze, Heather Eng, Lauren Horlbogen, Manthena V. S. Varma & Angela Slitt. (2021) Cytochrome P450 Enzyme Inhibition and Herb-Drug Interaction Potential of Medicinal Plant Extracts Used for Management of Diabetes in Nigeria. European Journal of Drug Metabolism and Pharmacokinetics 46:3, pages 437-450.
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Qiao Li, Chen Zhuang, Donghua Wang, Wei Zhang, Rongxuan Jia, Fengxia Sun, Yilin Zhang & Yunfei Du. (2019) Construction of trisubstituted chromone skeletons carrying electron-withdrawing groups via PhIO-mediated dehydrogenation and its application to the synthesis of frutinone A. Beilstein Journal of Organic Chemistry 15, pages 2958-2965.
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D. Oliver Sosa, Karla Almaraz & Manuel Amézquita-Valencia. (2019) Regioselective Synthesis of 4,5-Dihydro-6 H -oxepino[3,2- c ]chromene-2,6(3 H )-diones through Palladium-Catalyzed Intramolecular Alkoxycarbonylation of 3-Allyl-4-hydroxycoumarins . European Journal of Organic Chemistry 2019:29, pages 4682-4687.
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Paramita Das, Suman Ray, Piyali Bhanja, Asim Bhaumik & Chhanda Mukhopadhyay. (2018) Serendipitous Observation of Liquid-Phase Size Selectivity inside a Mesoporous Silica Nanoreactor in the Reaction of Chromene with Formic Acid. ChemCatChem 10:10, pages 2260-2270.
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Fernanda L. Moreira, Lucas M. M. Marques, Norberto P. Lopes & Anderson R. M. de Oliveira. (2016) In vitro metabolism studies of natural products are crucial in the early development of medicines. Phytochemistry Reviews 16:2, pages 355-373.
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Qian Dong, Hong C. Shen & Min Jiang. (2016) Efficient synthesis of functionalized chromones via a two-base mediated formal [3+3] cycloaddition. Tetrahedron Letters 57:19, pages 2116-2120.
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Yongje Shin, Changho Yoo, Youngtaek Moon, Yunho Lee & Sungwoo Hong. (2015) Efficient Synthesis of Frutinone A and Its Derivatives through Palladium-Catalyzed CH Activation/Carbonylation. Chemistry - An Asian Journal 10:4, pages 878-881.
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Daniel Hack, Pankaj Chauhan, Kristina Deckers, Gary N. Hermann, Lucas Mertens, Gerhard Raabe & Dieter Enders. (2014) Combining Silver Catalysis and Organocatalysis: A Sequential Michael Addition/Hydroalkoxylation One-Pot Approach to Annulated Coumarins. Organic Letters 16:19, pages 5188-5191.
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Masahito Yoshida, Koya Saito, Yuta Fujino & Takayuki Doi. (2014) A concise total synthesis of biologically active frutinones via tributylphosphine-catalyzed tandem acyl transfer-cyclization. Tetrahedron 70:21, pages 3452-3458.
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Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa

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Potent inhibition of CYP1A2 by Frutinone A, an active ingredient of the broad spectrum antimicrobial herbal extract from P. fruticosa

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