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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 11
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General Xenobiochemistry

Impact of nonlinear midazolam pharmacokinetics on the magnitude of the midazolam-ketoconazole interaction in rats

Ragini VuppugallaMetabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey, USACorrespondence[email protected]
,
Yueping ZhangMetabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey, USA
,
Shu ChangMetabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Pennington, New Jersey, USA
,
A. David RodriguesMetabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Princeton, New Jersey, USA
&
Punit H. MaratheMetabolism and Pharmacokinetics, Department of Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Co., Pennington, New Jersey, USA
Pages 1058-1068 | Received 09 Feb 2012, Accepted 06 Apr 2012, Published online: 11 May 2012

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Run Li, Qingqing Wang, Zihou Liu, Like Xie, Zhipeng Diao, Ying Peng, Guangji Wang & Jianguo Sun. (2023) Dose-dependent pharmacokinetics of midazolam in rats: influence of hepatic first-pass metabolism. Xenobiotica 53:3, pages 184-192.
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Articles from other publishers (9)

Hong-can Ren, Yang Sai, Tao Chen, Chun Zhang, Lily Tang & Cheng-guang Yang. (2021) Predicting the Drug–Drug Interaction Mediated by CYP3A4 Inhibition: Method Development and Performance Evaluation. The AAPS Journal 24:1.
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Sara Batista Nascimento, Mariana Lima Nascimento, Joaquim Maurício Duarte‐Almeida, Flávio Martins Oliveira, Maria Carmo Vieira, João Máximo Siqueira, Frank Pereira Andrade, Isabela Costa César & Whocely Victor Castro. (2020) Validation of a HPLC method for quantification of midazolam in rat plasma: Application during a Maytenus ilicifolia –drug interaction study . Biomedical Chromatography 35:3.
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Aarti Sawant-Basak, R. Scott Obach, Angela Doran, Peter Lockwood, Klaas Schildknegt, Hongying Gao, Jessica Mancuso, Susanna Tse & Thomas A. Comery. (2018) Metabolism of a 5HT 6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction . Drug Metabolism and Disposition 46:7, pages 934-942.
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Loai Basheer, Keren Schultz, Merav Fichman & Zohar Kerem. (2015) Use of In Vitro and Predictive In Silico Models to Study the Inhibition of Cytochrome P4503A by Stilbenes. PLOS ONE 10:10, pages e0141061.
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Katsuhito Nagai, Sho Suzuki, Ayumi Yamamura & Hiroki Konishi. (2015) Change in pharmacokinetic behavior of intravenously administered midazolam due to increased CYP3A2 expression in rats treated with menthol. Biopharmaceutics & Drug Disposition 36:3, pages 174-182.
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Rowan A. Stringer, Eckhard Weber, Bruno Tigani, Paul Lavan, Stephen Medhurst & Bindi Sohal. (2014) 1-Aminobenzotriazole Modulates Oral Drug Pharmacokinetics through Cytochrome P450 Inhibition and Delay of Gastric Emptying in Rats. Drug Metabolism and Disposition 42:7, pages 1117-1124.
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Shinya Uchida, Shimako Tanaka & Noriyuki Namiki. (2014) Simultaneous and comprehensive in vivo analysis of cytochrome P450 activity by using a cocktail approach in rats . Biopharmaceutics & Drug Disposition 35:4, pages 228-236.
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Nathalie Rioux, Edith Bellavance, Serge Bourg, Michel Garneau, Maria D. Ribadeneira & Jianmin Duan. (2013) Assessment of CYP3A‐mediated drug–drug interaction potential for victim drugs using an in vivo rat model . Biopharmaceutics & Drug Disposition 34:7, pages 396-401.
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Xin Tian, Zhen-Yu Cheng, Han Jin, Jie Gao & Hai-Ling Qiao. (2013) Inhibitory Effects of Baicalin on the Expression and Activity of CYP3A Induce the Pharmacokinetic Changes of Midazolam in Rats. Evidence-Based Complementary and Alternative Medicine 2013, pages 1-10.
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