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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 11
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Animal Pharmacokinetics and Metabolism

Isolation and identification of metabolites of osthole in rats

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Pages 1120-1127 | Received 23 Feb 2012, Accepted 26 Apr 2012, Published online: 26 May 2012

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Bing Liu, Ning Chen, Ying Xu, Jia-Wei Zhang, Yuan Sun, Li-Zhu Zhao & Yu-bin Ji. (2021) A new benzophenone with biological activities from metabolites of butyrolactone I in rat faeces . Natural Product Research 35:15, pages 2489-2497.
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Piljoung Cho, Su Min Choi, Younah Kim, Doo Hyun Lee, Yeeun Noh, Sujeong Kim, Ju-Hyun Kim, Taeho Lee & Sangkyu Lee. (2020) Characterization of osthenol metabolism in vivo and its pharmacokinetics. Xenobiotica 50:7, pages 839-846.
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Lin-peng Li, Xiao-juan Wang, Jin-Yu Zhang, Lu-lu Zhang, Yong-bing Cao, Li-qun Gu, Yi-qun Yu, Qi-lian Yang, Chun-ying Shen, Bing Han & Yuan-ying Jiang. (2018) Antifungal activity of osthol in vitro and enhancement in vivo through Eudragit S100 nanocarriers. Virulence 9:1, pages 555-562.
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Qi Zhao, Xin-Mei Li, Hong-Ning Liu, Frank J. Gonzalez & Fei Li. (2018) Metabolic map of osthole and its effect on lipids. Xenobiotica 48:3, pages 285-299.
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X. An, B.-M. Feng, G. Chen, S.-F. Chen, J. Bai, H.-M. Hua, H.-F. Wang & Y.-H. Pei. (2017) Isolation and identification of phase I metabolites of butyrolactone I in rats. Xenobiotica 47:3, pages 236-244.
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Xiu-Lan Xin, Pei Pei Dong, Gang Wang, Rong-Gang Xi, Dan Liu, Zhi-Ming Wu, Xian-Ce Sun, Rong Lan & Xiao-Bo Wang*. (2013) Biotransformation of osthole by Alternaria longipes . Journal of Asian Natural Products Research 15:7, pages 717-722.
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Articles from other publishers (16)

Jincai Chen, Xiaofei Liao & Juwen Gan. (2023) Review on the protective activity of osthole against the pathogenesis of osteoporosis. Frontiers in Pharmacology 14.
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Xin He, Min Nie, Mengyuan Wang, Shifei Wu, Xuemei Wei, Jiayuan Li, Changliang Yao, Chao Wang, Xiaochi Ma & De-an Guo. (2023) Microbial transformation of osthole by human intestinal fungi and anti-osteoporosis activities of its metabolites. Fitoterapia 167, pages 105510.
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Qi-Hang Zhou, Xia Lv, Zhen-Hao Tian, Moshe Finel, Lei Feng, Peng-Chao Huo, Ya-Di Zhu, Yin Lu, Jie Hou & Guang-Bo Ge. (2021) A fluorescence-based microplate assay for high-throughput screening and evaluation of human UGT inhibitors. Analytica Chimica Acta 1153, pages 338305.
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Sanjita Paudel, Younah Kim, Su Min Choi, Ju‐Hyun Kim, Jong‐Sup Bae, Taeho Lee & Sangkyu Lee. (2020) Identification of suberosin metabolites in human liver microsomes by high‐performance liquid chromatography combined with high‐resolution quadrupole–orbitrap mass spectrometer. Journal of Mass Spectrometry 56:4.
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Fatma Tosun, Feyyaz Mıhoğlugil, John A. Beutler, Esra Eroğlu Özkan & Mahmut Miski. (2020) Neopapillarine, an Unusual Coumarino-Alkaloid from the Root Extract of Neocryptodiscus papillaris with Cytotoxic Activity on Renal Cancer Cells. Molecules 25:13, pages 3040.
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Danmei Tian, Fangfang Wang, Menglong Duan, Lingyun Cao, Youwei Zhang, Xinsheng Yao & Jinshan Tang. (2019) Coumarin Analogues from the Citrus grandis (L.) Osbeck and Their Hepatoprotective Activity . Journal of Agricultural and Food Chemistry 67:7, pages 1937-1947.
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Pil Cho, Sanjita Paudel, Doohyun Lee, Yun Jin, GeunHyung Jo, Tae Jeong, Sangkyu Lee & Taeho Lee. (2018) Characterization of CYPs and UGTs Involved in Human Liver Microsomal Metabolism of Osthenol. Pharmaceutics 10:3, pages 141.
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Pil Joung Cho, WoongShik Nam, Doohyun Lee, Taeho Lee & Sangkyu Lee. (2018) Selective Inhibitory Effect of Osthenol on Human Cytochrome 2C8. Bulletin of the Korean Chemical Society 39:6, pages 801-805.
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Nani Wang, Xuping Wang, Yang Zhang, Qiaoyan Zhang, Pingcui Xu, Hailiang Xin, Renjie Wu, Dan Shou & Luping Qin. (2018) Comparative metabolites profiles of osthole in normal and osteoporosis rats using liquid chromatography quadrupole time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 154, pages 460-467.
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Lu Zhang, Yuanyuan Ge, Jin Li, Jia Hao, Hui Wang, Jun He, Xiu-mei Gao & Yan-xu Chang. (2018) Simultaneous determination of columbianetin-β- d -glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-β- d -glucopyranoside metabolites by ultra high-performance liquid chromatography coupled with quadrupole-time of flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 153, pages 221-231.
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Man Liao, Xinpeng Diao, Xiaoye Cheng, Yupeng Sun & Lantong Zhang. (2018) Nontargeted SWATH acquisition mode for metabolites identification of osthole in rats using ultra-high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. RSC Advances 8:27, pages 14925-14935.
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Dan-Dan Luo, Xiao-Ying Chen, Zhen-Biao Zhang, Chao-Yue Sun, Yi-Feng Zheng, Yu-Hong Liu, Xiu-Fen Wang, Qi Wang, Janis Ya-Xian Zhan & Zi-Ren Su. (2017) Different effects of (+)-borneol and (−)-borneol on the pharmacokinetics of osthole in rats following oral administration. Molecular Medicine Reports 15:6, pages 4239-4246.
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Xia Lv, Jie Hou, Yang-Liu Xia, Jing Ning, Gui-Yuan He, Ping Wang, Guang-Bo Ge, Zhi-Long Xiu & Ling Yang. (2015) Glucuronidation of bavachinin by human tissues and expressed UGT enzymes: Identification of UGT1A1 and UGT1A8 as the major contributing enzymes. Drug Metabolism and Pharmacokinetics 30:5, pages 358-365.
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Zhong-Rong Zhang, Wing Nang Leung, Ho Yee Cheung & Chun Wai Chan. (2015) Osthole: A Review on Its Bioactivities, Pharmacological Properties, and Potential as Alternative Medicine. Evidence-Based Complementary and Alternative Medicine 2015, pages 1-10.
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Yang-Liu Xia, Si-Cheng Liang, Liang-Liang Zhu, Guang-Bo Ge, Gui-Yuan He, Jing Ning, Xia Lv, Xiao-Chi Ma, Ling Yang & Sheng-Li Yang. (2014) Identification and Characterization of Human UDP-glucuronosyltransferases Responsible for the Glucuronidation of Fraxetin. Drug Metabolism and Pharmacokinetics 29:2, pages 135-140.
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Jie Li & Wan Chan. (2013) Investigation of the biotransformation of osthole by liquid chromatography/tandem mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 74, pages 156-161.
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