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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 11
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Animal Pharmacokinetics and Metabolism

Pharmacokinetics and metabolism of midazolam in chimeric mice with humanised livers

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Pages 1128-1137 | Received 15 Mar 2012, Accepted 26 Apr 2012, Published online: 30 May 2012

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Read on this site (3)

John R. Foster, Garry Lund, Svetlana Sapelnikova, D. Lorne Tyrrell & Norman M. Kneteman. (2014) Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies. Xenobiotica 44:2, pages 109-122.
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Chiaki Tanoue, Kazumi Sugihara, Naoto Uramaru, Yoshitaka Tayama, Yoko Watanabe, Toru Horie, Shigeru Ohta & Shigeyuki Kitamura. (2013) Prediction of human metabolism of the sedative-hypnotic zaleplon using chimeric mice transplanted with human hepatocytes. Xenobiotica 43:11, pages 956-962.
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Articles from other publishers (13)

Bo Feng, Rachel Pemberton, Wojciech Dworakowski, Zhengqi Ye, Craig Zetterberg, Guanyu Wang, Yoshio Morikawa & Sanjeev Kumar. (2021) Evaluation of the Utility of PXB Chimeric Mice for Predicting Human Liver Partitioning of Hepatic Organic Anion-Transporting Polypeptide Transporter Substrates. Drug Metabolism and Disposition 49:3, pages 254-264.
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Younah Kim, Jung Jae Jo, Piljoung Cho, Riya Shrestha, Kyu Min Kim, Sung Hwan Ki, Kyung‐Sik Song, Kwang‐Hyeon Liu, Im‐Sook Song, Ju‐Hyun Kim, Jae‐Mok Lee & Sangkyu Lee. (2020) Characterization of red ginseng–drug interaction by CYP3A activity increased in high dose administration in mice. Biopharmaceutics & Drug Disposition 41:7, pages 295-306.
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Karl-Dimiter Bissig, Weiguo Han, Mercedes Barzi, Nataliia Kovalchuk, Liang Ding, Xiaoyu Fan, Francis P. Pankowicz, Qing-Yu Zhang & Xinxin Ding. (2018) P450-Humanized and Human Liver Chimeric Mouse Models for Studying Xenobiotic Metabolism and Toxicity. Drug Metabolism and Disposition 46:11, pages 1734-1744.
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Ninad Varkhede, Nita Patel, William Chang, Kenneth Ruterbories & M. Laird Forrest. (2018) A Semi-Physiologically Based Pharmacokinetic Model Describing the Altered Metabolism of Midazolam Due to Inflammation in Mice. Pharmaceutical Research 35:8.
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Masashi Uchida, Yoriko Tajima, Masakazu Kakuni, Yutaka Kageyama, Taro Okada, Eri Sakurada, Chise Tateno & Ryoji Hayashi. (2018) Organic Anion–Transporting Polypeptide (OATP)–Mediated Drug-Drug Interaction Study between Rosuvastatin and Cyclosporine A in Chimeric Mice with Humanized Liver. Drug Metabolism and Disposition 46:1, pages 11-19.
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Miriam Lipiski, Margarete Arras, Paulin Jirkof & Nikola Cesarovic. (2017) Premedication with fentanyl-midazolam improves sevoflurane anesthesia for surgical intervention in laboratory mice. Experimental Biology and Medicine 242:12, pages 1287-1298.
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K. Samuelsson, N. Scheer, I. Wilson, C.R. Wolf & C.J. Henderson. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 130 149 .
Nico Scheer & Ian D. Wilson. (2016) A comparison between genetically humanized and chimeric liver humanized mouse models for studies in drug metabolism and toxicity. Drug Discovery Today 21:2, pages 250-263.
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XiaoMei Zhuang, XiaoYing Wang, Juan Wang, JingLai Li, AiPing Zheng, Chuang Lu & ZhenQing Zhang. (2015) Comparative pharmacokinetics and bioavailability of intranasal and rectal midazolam formulations relative to buccal administration in rabbits. RSC Advances 5:72, pages 58880-58888.
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Aidan Grimsley, Alison Foster, Richard Gallagher, Michael Hutchison, Anders Lundqvist, Kathryn Pickup, Ian D. Wilson & Kristin Samuelsson. (2014) A comparison of the metabolism of midazolam in C57BL/6J and hepatic reductase null (HRN) mice. Biochemical Pharmacology 92:4, pages 701-711.
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Richard Gallagher, Leonard Dillon, Aidan Grimsley, Jim Murphy, Kristin Samuelsson & David Douce. (2014) The application of a new microfluidic device for the simultaneous identification and quantitation of midazolam metabolites obtained from a single micro-litre of chimeric mice blood. Rapid Communications in Mass Spectrometry 28:11, pages 1293-1302.
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Seigo Sanoh & Shigeru Ohta. (2014) Chimeric mice transplanted with human hepatocytes as a model for prediction of human drug metabolism and pharmacokinetics. Biopharmaceutics & Drug Disposition 35:2, pages 71-86.
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Aidan Grimsley, Richard Gallagher, Michael Hutchison, Kathryn Pickup, Ian D. Wilson & Kristin Samuelsson. (2013) Drug–drug interactions and metabolism in cytochrome P450 2C knockout mice: Application to troleandomycin and midazolam. Biochemical Pharmacology 86:4, pages 529-538.
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