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Xenobiotica
the fate of foreign compounds in biological systems
Volume 42, 2012 - Issue 12
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General Xenobiochemistry

Mechanism-based inhibition of human Cytochrome P450-3A activity by grapefruit hybrids having low furanocoumarin content

David J. GreenblattSackler Program in Pharmacology and Experimental Therapeutics, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USACorrespondence[email protected]
,
Yanli ZhaoSackler Program in Pharmacology and Experimental Therapeutics, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA
,
Michael J. HanleySackler Program in Pharmacology and Experimental Therapeutics, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA
,
Chunxian ChenThe Citrus Research and Education Center, University of Florida, Lake Alfred, FL, USA
,
Jerold S. HarmatzSackler Program in Pharmacology and Experimental Therapeutics, Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine and Tufts Medical Center, Boston, MA, USA
,
Paul F. CancalonThe Florida Department of Citrus, Lake Alfred, FL, USA
&
Frederick G. Gmitter Jr.The Citrus Research and Education Center, University of Florida, Lake Alfred, FL, USA
 show all
Pages 1163-1169 | Received 26 Apr 2012, Accepted 01 Jun 2012, Published online: 18 Jul 2012

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Sidney J. Stohs, Howard Miller & Felice Romano. (2014) Absence of Furanocoumarins in Advantra Z® (Citrus aurantium, Bitter Orange) Extracts. Journal of Dietary Supplements 11:3, pages 288-293.
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Novera Alam, Mia G Angeli & David J Greenblatt. (2017) Mechanism of in-vitro inhibition of UGT1A1 by paritaprevir. Journal of Pharmacy and Pharmacology 69:12, pages 1794-1801.
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Sidney J. Stohs. (2017) Safety, Efficacy, and Mechanistic Studies Regarding Citrus aurantium (Bitter Orange) Extract and p -Synephrine . Phytotherapy Research 31:10, pages 1463-1474.
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Marina Kawaguchi-Suzuki, Negar Nasiri-Kenari, Jonathan Shuster, Fred G. Gmitter Jr., Paul Cancalon, Felipe de Oliveria, Jennifer Kight, Eileen M. Handberg, Carl J. Pepine, Reginald F. Frye & Rhonda M. Cooper-DeHoff. (2017) Effect of Low-Furanocoumarin Hybrid Grapefruit Juice Consumption on Midazolam Pharmacokinetics. The Journal of Clinical Pharmacology 57:3, pages 305-311.
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Yuan Wei, Chenxiao Tang, Vinayak Sant, Song Li, Samuel M. Poloyac & Wen Xie. (2016) A Molecular Aspect in the Regulation of Drug Metabolism: Does PXR-Induced Enzyme Expression Always Lead to Functional Changes in Drug Metabolism?. Current Pharmacology Reports 2:4, pages 187-192.
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Juan Xu, Lili Ma, Dong Jiang, Shiping Zhu, Fuhua Yan, Yunxia Xie, Zongzhou Xie, Wenwu Guo & Xiuxin Deng. (2015) Content evaluation of 4 furanocoumarin monomers in various citrus germplasms. Food Chemistry 187, pages 75-81.
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Chunxian ChenQibin YuXu WeiPaul F. CancalonFred G. Gmitter, Jr.. (2014) Identification of genes associated with low furanocoumarin content in grapefruit. Genome 57:10, pages 537-545.
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Christina S. Won, Tian Lan, Karen M. VanderMolen, Paul A. Dawson, Nicholas H. Oberlies, Wilbur W. Widmer, Yolanda V. Scarlett & Mary F. Paine. (2013) A Modified Grapefruit Juice Eliminates Two Compound Classes as Major Mediators of the Grapefruit Juice-Fexofenadine Interaction: An In Vitro-In Vivo “Connect”. The Journal of Clinical Pharmacology 53:9, pages 982-990.
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Michael J. Hanley, Gina Masse, Jerold S. Harmatz, Paul F. Cancalon, Gregory G. Dolnikowski, Michael H. Court & David J. Greenblatt. (2013) Effect of blueberry juice on clearance of buspirone and flurbiprofen in human volunteers. British Journal of Clinical Pharmacology 75:4, pages 1041-1052.
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