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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 3
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General Xenobiochemistry

Mycophenolic acid glucuronide is transported by multidrug resistance-associated protein 2 and this transport is not inhibited by cyclosporine, tacrolimus or sirolimus

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Pages 229-235 | Received 07 Jun 2012, Accepted 27 Jun 2012, Published online: 30 Aug 2012

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Aishwarya Jala, Srikanth Ponneganti, Devi Swetha Vishnubhatla, Gayathri Bhuvanam, Prithvi Raju Mekala, Bincy Varghese, Pullapanthula Radhakrishnanand, Ramu Adela, Upadhyayula Suryanarayana Murty & Roshan M. Borkar. (2021) Transporter-mediated drug–drug interactions: advancement in models, analytical tools, and regulatory perspective. Drug Metabolism Reviews 53:3, pages 285-320.
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Joseph Berthier, Mehdi Benmameri, François-Ludovic Sauvage, Gabin Fabre, Benjamin Chantemargue, Hélène Arnion, Pierre Marquet, Patrick Trouillas, Nicolas Picard & Franck Saint-Marcoux. (2021) MRP4 is responsible for the efflux transport of mycophenolic acid β-d glucuronide (MPAG) from hepatocytes to blood. Xenobiotica 51:1, pages 105-114.
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Erkka Järvinen, Feng Deng, Wilma Kiander, Alli Sinokki, Heidi Kidron & Noora Sjöstedt. (2022) The Role of Uptake and Efflux Transporters in the Disposition of Glucuronide and Sulfate Conjugates. Frontiers in Pharmacology 12.
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Daniel Brazeau, Calvin J. Meaney, Joseph D. Consiglio, Gregory E. Wilding, Louise M. Cooper, Rocco C. Venuto & Kathleen M. Tornatore. (2021) Association of ABCC2 Haplotypes to Mycophenolic Acid Pharmacokinetics in Stable Kidney Transplant Recipients . The Journal of Clinical Pharmacology 61:12, pages 1592-1605.
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Quentin Faucher, Hugo Alarcan, Pierre Marquet & Chantal Barin-Le Guellec. (2020) Effects of Ischemia-Reperfusion on Tubular Cell Membrane Transporters and Consequences in Kidney Transplantation. Journal of Clinical Medicine 9:8, pages 2610.
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Juthipong Benjanuwattra, Dumnoensun Pruksakorn & Nut Koonrungsesomboon. (2019) Mycophenolic Acid and Its Pharmacokinetic Drug‐Drug Interactions in Humans: Review of the Evidence and Clinical Implications. The Journal of Clinical Pharmacology 60:3, pages 295-311.
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Mo'tasem M. Alsmadi, Mahdi Qasem Alfarah, Jawaher Albderat, Ghazi Alsalaita, Reham AlMardini, Salim Hamadi, Ahmad Al‐Ghazawi, Omar Abu‐Duhair & Nasir Idkaidek. (2019) The development of a population physiologically based pharmacokinetic model for mycophenolic mofetil and mycophenolic acid in humans using data from plasma, saliva, and kidney tissue. Biopharmaceutics & Drug Disposition 40:9, pages 325-340.
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Calvin J. Meaney, Patcharaporn Sudchada, Joseph D. Consiglio, Gregory E. Wilding, Louise M. Cooper, Rocco C. Venuto & Kathleen M. Tornatore. (2019) Influence of Calcineurin Inhibitor and Sex on Mycophenolic Acid Pharmacokinetics and Adverse Effects Post–Renal Transplant. The Journal of Clinical Pharmacology 59:10, pages 1351-1365.
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Ana Spasić, Aleksandra Catić-Đorđević, Radmila Veličković-Radovanović, Nikola Stefanović, Predrag Džodić & Tatjana Cvetković. (2019) Adverse effects of mycophenolic acid in renal transplant recipients: gender differences. International Journal of Clinical Pharmacy 41:3, pages 776-784.
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Izna Ali, Jason R. Slizgi, Josh D. Kaullen, Marija Ivanovic, Mikko Niemi, Paul W. Stewart, Alfred S. BarrittIVIV & Kim L.R. Brouwer. (2018) Transporter-Mediated Alterations in Patients With NASH Increase Systemic and Hepatic Exposure to an OATP and MRP2 Substrate. Clinical Pharmacology & Therapeutics 104:4, pages 749-756.
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Kazuaki Yoshimura, Ikuko Yano, Takashi Yamamoto, Tadakazu Kondo, Misaki Kawanishi, Yui Isomoto, Atsushi Yonezawa, Akifumi Takaori-Kondo & Kazuo Matsubara. (2018) Pharmacokinetic and Pharmacodynamic Markers of Mycophenolic Acid Associated with Effective Prophylaxis for Acute Graft-Versus-Host Disease and Neutrophil Engraftment in Cord Blood Transplant Patients. Biology of Blood and Marrow Transplantation 24:7, pages 1441-1448.
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K Yoshimura, I Yano, T Yamamoto, M Kawanishi, Y Isomoto, A Yonezawa, T Kondo, A Takaori-Kondo & K Matsubara. (2017) Population pharmacokinetics and pharmacodynamics of mycophenolic acid using the prospective data in patients undergoing hematopoietic stem cell transplantation. Bone Marrow Transplantation 53:1, pages 44-51.
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Anton Ivanyuk, Françoise Livio, Jérôme Biollaz & Thierry Buclin. (2017) Renal Drug Transporters and Drug Interactions. Clinical Pharmacokinetics 56:8, pages 825-892.
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Jeremiah D. Momper, Michael L. Misel & Dianne B. McKay. (2017) Sex differences in transplantation. Transplantation Reviews 31:3, pages 145-150.
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Ayman F. El‐Kattan. 2017. Oral Bioavailability Assessment. Oral Bioavailability Assessment 77 138 .
Ana C. Alvarez-Elías, Elisa C. Yoo, Ekaterina K. Todorova, Ram N. Singh & Guido Filler. (2017) A Retrospective Study on Mycophenolic Acid Drug Interactions: Effect of Prednisone, Sirolimus, and Tacrolimus With MPA. Therapeutic Drug Monitoring 39:3, pages 220-228.
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Shufan Ge, Yifan Tu & Ming Hu. (2016) Challenges and Opportunities with Predicting In Vivo Phase II Metabolism via Glucuronidation From In Vitro Data. Current Pharmacology Reports 2:6, pages 326-338.
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Mi Hye Kwon, Ji Na Yoon, Yu Jin Baek, Yu Chul Kim, Yong Yeon Cho & Hee Eun Kang. (2016) Effects of poloxamer 407-induced hyperlipidemia on hepatic multidrug resistance protein 2 (Mrp2/Abcc2) and the pharmacokinetics of mycophenolic acid in rats. Biopharmaceutics & Drug Disposition 37:6, pages 352-365.
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Lisa C. Martial, Bart A. W. Jacobs, Elisabeth A. M. Cornelissen, Anton F. J. de Haan, Birgit C. P. Koch, David M. Burger, Rob E. Aarnoutse, Michiel F. Schreuder & Roger J.M. Br?ggemann. (2016) Pharmacokinetics and target attainment of mycophenolate in pediatric renal transplant patients. Pediatric Transplantation 20:4, pages 492-499.
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Heike Bittersohl & Werner Steimer. 2016. Personalized Immunosuppression in Transplantation. Personalized Immunosuppression in Transplantation 199 226 .
Vladimir Trkulja, Zdenka Lalić, Sandra Nađ-Škegro, Ana Lebo, Paula Granić, Mila Lovrić, Josip Pasini & Nada Božina. (2014) Effect of Cyclosporine on Steady-State Pharmacokinetics of MPA in Renal Transplant Recipients Is Not Affected by the MPA Formulation. Therapeutic Drug Monitoring 36:4, pages 456-464.
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Azza A.K. El-Sheikh, Jan B. Koenderink, Alfons C. Wouterse, Petra H.H. van den Broek, Vivienne G.M. Verweij, Rosalinde Masereeuw & Frans G.M. Russel. (2014) Renal glucuronidation and multidrug resistance protein 2-/ multidrug resistance protein 4-mediated efflux of mycophenolic acid: interaction with cyclosporine and tacrolimus. Translational Research 164:1, pages 46-56.
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Christine E. Staatz & Susan E. Tett. (2014) Pharmacology and toxicology of mycophenolate in organ transplant recipients: an update. Archives of Toxicology 88:7, pages 1351-1389.
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Jean-Baptiste Woillard, Nicolas Picard, Antoine Thierry, Guy Touchard & Pierre Marquet. (2014) Associations between polymorphisms in target, metabolism, or transport proteins of mycophenolate sodium and therapeutic or adverse effects in kidney transplant patients. Pharmacogenetics and Genomics 24:5, pages 256-262.
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Maciej J. Zamek-Gliszczynski, Xiaoyan Chu, Joseph W. Polli, Mary F. Paine & Aleksandra Galetin. (2014) Understanding the Transport Properties of Metabolites: Case Studies and Considerations for Drug Development. Drug Metabolism and Disposition 42:4, pages 650-664.
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Norikazu Matsunaga, Sho Wada, Takeo Nakanishi, Miho Ikenaga, Mikio Ogawa & Ikumi Tamai. (2013) Mathematical Modeling of the in Vitro Hepatic Disposition of Mycophenolic Acid and Its Glucuronide in Sandwich-Cultured Human Hepatocytes . Molecular Pharmaceutics 11:2, pages 568-579.
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