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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 1
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Review Article

Evaluation of the intestinal toxicity and transport of xenobiotics utilizing precision-cut slices

Xiaoyu NiuDivision of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands
,
Inge A. M. de GraafDivision of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The Netherlands
&
Geny M. M. GroothuisDivision of Pharmacokinetics, Toxicology and Targeting, Department of Pharmacy, Groningen Research Institute for Pharmacy, University of Groningen, Groningen, The NetherlandsCorrespondence[email protected]
Pages 73-83 | Received 19 Aug 2012, Accepted 11 Sep 2012, Published online: 30 Oct 2012

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Ming Li, Inge A. M. de Graaf & Geny M. M. Groothuis. (2016) Precision-cut intestinal slices: alternative model for drug transport, metabolism, and toxicology research. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 175-190.
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Articles from other publishers (15)

Soumita Paul, Ujjal Ghosh & Mousumi Saha. 2023. Xenobiotics in Urban Ecosystems. Xenobiotics in Urban Ecosystems 69 85 .
C. Biel, O. Martinec, B. Sibering, K. van Summeren, A. M. A. Wessels, D. J. Touw, K. P. de Jong, V. E. de Meijer, K. N. Faber, J. P. ten Klooster, I. A. M. de Graaf & P. Olinga. (2022) Extending the viability of human precision-cut intestinal slice model for drug metabolism studies. Archives of Toxicology 96:6, pages 1815-1827.
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Carin Biel, Emilia Bigaeva, Melanie Hesse, Jordy J.M. Bomers, Kitty van Summeren, Marc A.T. Teunis, Stefan Vaessen, Jean Paul Ten Klooster & Peter Olinga. (2020) Survival and cellular heterogeneity of epithelium in cultured mouse and rat precision-cut intestinal slices. Toxicology in Vitro 69, pages 104974.
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Wei-wei Wang, Jing Wang, Hai-jun Zhang, Shu-geng Wu & Guang-hai Qi. (2019) Transcriptome analysis reveals mechanism underlying the differential intestinal functionality of laying hens in the late phase and peak phase of production. BMC Genomics 20:1.
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Emilia Bigaeva, Jordy J.M. Bomers, Carin Biel, Henricus A.M. Mutsaers, Inge A.M. de Graaf, Miriam Boersema & Peter Olinga. (2019) Growth factors of stem cell niche extend the life-span of precision-cut intestinal slices in culture: A proof-of-concept study. Toxicology in Vitro 59, pages 312-321.
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Edwin K. McDonaldIVIV, Heather Rasmussen, Christopher Forsyth & Ali Keshavarzian. 2018. Functional Foods and Beverages. Functional Foods and Beverages 15 51 .
Banya Yi, Kyu Young Shim, Sang Keun Ha, Jeonghun Han, Hong-Hoa Hoang, Inwook Choi, Sungsu Park & Jong Hwan Sung. (2017) Three-dimensional in vitro gut model on a villi-shaped collagen scaffold. BioChip Journal 11:3, pages 219-231.
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M. Li, I. A. M. de Graaf, S. Siissalo, M. H. de Jager, A. van Dam & G. M. M. Groothuis. (2016) The Consequence of Drug-Drug Interactions Influencing the Interplay between P-Glycoprotein and Cytochrome P450 3a: An Ex Vivo Study with Rat Precision-Cut Intestinal Slices. Drug Metabolism and Disposition 44:5, pages 683-691.
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Ming Li, Inge A.M. de Graaf, Marina H. de Jager & Geny M.M. Groothuis. (2015) Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo. Toxicology in Vitro 29:5, pages 1070-1078.
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Bao Tung Pham, Wouter Tobias van Haaften, Dorenda Oosterhuis, Judith Nieken, Inge Anne Maria de Graaf & Peter Olinga. (2015) Precision-cut rat, mouse, and human intestinal slices as novel models for the early-onset of intestinal fibrosis. Physiological Reports 3:4, pages e12323.
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. (2015) AbstractsIn Vitro Toxicology Society Annual Meeting10–11 November 2014AstraZeneca, Alderley ParkMacclesfield, United Kingdom. Applied In Vitro Toxicology 1:1, pages 83-89.
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G. M. M. Groothuis, A. Casini, H. Meurs & P. Olinga. 2014. Human-based Systems for Translational Research. Human-based Systems for Translational Research 38 65 .
Xiaoyu Niu, Inge A.M. de Graaf, Hendrik A. van der Bij & Geny M.M. Groothuis. (2014) Precision cut intestinal slices are an appropriate ex vivo model to study NSAID-induced intestinal toxicity in rats. Toxicology in Vitro 28:7, pages 1296-1305.
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Hans Lennernäs. (2013) Human in Vivo Regional Intestinal Permeability: Importance for Pharmaceutical Drug Development . Molecular Pharmaceutics 11:1, pages 12-23.
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József Lénárt, Erika Bujna, Béla Kovács, Eszter Békefi, Leonóra Száraz & Mihály Dernovics. (2013) Metabolomic Approach Assisted High Resolution LC–ESI-MS Based Identification of a Xenobiotic Derivative of Fenhexamid Produced by Lactobacillus casei . Journal of Agricultural and Food Chemistry 61:37, pages 8969-8975.
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