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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 10
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Research Article

Dissecting the relative contribution of OATP1B1-mediated uptake of xenobiotics into human hepatocytes using siRNA

B. WilliamsonDepartment of Molecular and Clinical Pharmacology, University of Liverpool LiverpoolUK
,
A. C. SoarsBioscience AstraZeneca, LeicsUK
,
A. OwenDepartment of Molecular and Clinical Pharmacology, University of Liverpool LiverpoolUKCorrespondence[email protected]
,
P. WhiteDiscovery DMPK, AstraZeneca, Loughborough LeicsUK
,
R. J. RileyDiscovery DMPK, AstraZeneca, Loughborough LeicsUK;New Opportunities iMED, AstraZeneca R&D Macclesfield, CheshireUK
&
M. G. SoarsDiscovery DMPK, AstraZeneca, Loughborough LeicsUK;Metabolism and Pharmacokinetics, Bristol-Myers Squibb Wallingford, CTUSA
Pages 920-931 | Received 09 Jan 2013, Accepted 11 Feb 2013, Published online: 06 Mar 2013

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Ravindra V. Alluri, Rui Li & Manthena V. S. Varma. (2020) Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?. Expert Opinion on Drug Metabolism & Toxicology 16:5, pages 387-401.
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Adam J. Lucas, Joanne L. Sproston, Patrick Barton & Robert J. Riley. (2019) Estimating human ADME properties, pharmacokinetic parameters and likely clinical dose in drug discovery. Expert Opinion on Drug Discovery 14:12, pages 1313-1327.
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Sumathy Mathialagan, Chester Costales, Laurie Tylaska, Emi Kimoto, Anna Vildhede, Jillian Johnson, Nathaniel Johnson, Takami Sarashina, Kenta Hashizume, Caleb D. Isringhausen, Lydia M. M. Vermeer, Andrea R. Wolff & A. David Rodrigues. (2018) In vitro studies with two human organic anion transporters: OAT2 and OAT7. Xenobiotica 48:10, pages 1037-1049.
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Beth Williamson & Robert J. Riley. (2017) Hepatic transporter drug-drug interactions: an evaluation of approaches and methodologies. Expert Opinion on Drug Metabolism & Toxicology 13:12, pages 1237-1250.
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M. Neary & A. Owen. (2017) Pharmacogenetic considerations for HIV treatment in different ethnicities: an update. Expert Opinion on Drug Metabolism & Toxicology 13:11, pages 1169-1181.
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R. J. Riley, S. A. Foley, P. Barton, M. G. Soars & B. Williamson. (2016) Hepatic drug transporters: the journey so far. Expert Opinion on Drug Metabolism & Toxicology 12:2, pages 201-216.
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Fen Chen, Xuejia Zhai, Chaoran Zhu & Yongning Lu. (2015) Effects of capsaicin on pharmacokinetics of pitavastatin in rats. Xenobiotica 45:2, pages 171-176.
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Articles from other publishers (21)

Kazuya Maeda & Yuichi Sugiyama. 2022. Drug Transporters. Drug Transporters 453 474 .
Daiki Mori, Emi Kimoto, Brian Rago, Yusuke Kondo, Amanda King‐Ahmad, Ragu Ramanathan, Linda S. Wood, Jillian G. Johnson, Vu H. Le, Manoli Vourvahis, A. David Rodrigues, Chieko Muto, Kenichi Furihata, Yuichi Sugiyama & Hiroyuki Kusuhara. (2020) Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs. Clinical Pharmacology & Therapeutics 107:4, pages 1004-1013.
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Emi Kimoto, R. Scott Obach & Manthena V.S. Varma. (2020) Identification and quantitation of enzyme and transporter contributions to hepatic clearance for the assessment of potential drug-drug interactions. Drug Metabolism and Pharmacokinetics 35:1, pages 18-29.
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Yoshitane Nozaki & Saki Izumi. (2020) Recent advances in preclinical in vitro approaches towards quantitative prediction of hepatic clearance and drug-drug interactions involving organic anion transporting polypeptide (OATP) 1B transporters. Drug Metabolism and Pharmacokinetics 35:1, pages 56-70.
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Rui Li. (2019) Estimating In Vivo Fractional Contribution of OATP1B1 to Human Hepatic Active Uptake by Mechanistically Modeling Pharmacogenetic Data. The AAPS Journal 21:4.
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Yi-an Bi, Chester Costales, Sumathy Mathialagan, Mark West, Soraya Eatemadpour, Sarah Lazzaro, Laurie Tylaska, Renato Scialis, Hui Zhang, John Umland, Emi Kimoto, David A. Tess, Bo Feng, Larry M. Tremaine, Manthena V. S. Varma & A. David Rodrigues. (2019) Quantitative Contribution of Six Major Transporters to the Hepatic Uptake of Drugs: “SLC-Phenotyping” Using Primary Human Hepatocytes. Journal of Pharmacology and Experimental Therapeutics 370:1, pages 72-83.
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Yueping Zhang, Erika Panfen, Marcus Fancher, Michael Sinz, Punit Marathe & Hong Shen. (2019) Dissecting the Contribution of OATP1B1 to Hepatic Uptake of Statins Using the OATP1B1 Selective Inhibitor Estropipate. Molecular Pharmaceutics 16:6, pages 2342-2353.
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Pallabi Mitra, Samantha Weinheimer, Meeghan Michalewicz & Mitchell E. Taub. (2018) Prediction and Quantification of Hepatic Transporter-Mediated Uptake of Pitavastatin Utilizing a Combination of the Relative Activity Factor Approach and Mechanistic Modeling. Drug Metabolism and Disposition 46:7, pages 953-963.
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Saki Izumi, Yoshitane Nozaki, Hiroyuki Kusuhara, Koichiro Hotta, Toshiki Mochizuki, Takafumi Komori, Kazuya Maeda & Yuichi Sugiyama. (2018) Relative Activity Factor (RAF)-Based Scaling of Uptake Clearance Mediated by Organic Anion Transporting Polypeptide (OATP) 1B1 and OATP1B3 in Human Hepatocytes. Molecular Pharmaceutics 15:6, pages 2277-2288.
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Houfu Liu & Jasminder Sahi. (2016) Role of Hepatic Drug Transporters in Drug Development. The Journal of Clinical Pharmacology 56, pages S11-S22.
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William Brian, Larry M Tremaine, Million Arefayene, Ruben de Kanter, Raymond Evers, Yingying Guo, James Kalabus, Wen Lin, Cho-Ming Loi & Guangqing Xiao. (2016) Assessment of drug metabolism enzyme and transporter pharmacogenetics in drug discovery and early development: perspectives of the I-PWG. Pharmacogenomics 17:6, pages 615-631.
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A. Vildhede, A. Mateus, E. K. Khan, Y. Lai, M. Karlgren, P. Artursson & M. C. Kjellsson. (2016) Mechanistic Modeling of Pitavastatin Disposition in Sandwich-Cultured Human Hepatocytes: A Proteomics-Informed Bottom-Up Approach. Drug Metabolism and Disposition 44:4, pages 505-516.
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Kyunghee Yang, Cen Guo, Jeffrey L. Woodhead, Robert L. St. ClaireIIIIII, Paul B. Watkins, Scott Q. Siler, Brett A. Howell & Kim L.R. Brouwer. (2016) Sandwich-Cultured Hepatocytes as a Tool to Study Drug Disposition and Drug-Induced Liver Injury. Journal of Pharmaceutical Sciences 105:2, pages 443-459.
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Magnus Ölander, Jacek R. Wiśniewski, Pär Matsson, Patrik Lundquist & Per Artursson. (2016) The Proteome of Filter-Grown Caco-2 Cells With a Focus on Proteins Involved in Drug Disposition. Journal of Pharmaceutical Sciences 105:2, pages 817-827.
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Stefanie Hennig, Suhashni Naiker, Tarylee Reddy, Deirdre Egan, Tracy Kellerman, Lubbe Wiesner, Andrew Owen, Helen McIlleron & Alexander Pym. (2016) Effect of SLCO1B1 Polymorphisms on Rifabutin Pharmacokinetics in African HIV-Infected Patients with Tuberculosis . Antimicrobial Agents and Chemotherapy 60:1, pages 617-620.
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Donald R.J. Singer & Zoulikha M. Zaïr. 2016. Personalized Medicine. Personalized Medicine 79 114 .
Annett Kunze, Jörg Huwyler, Gian Camenisch & Birk Poller. (2014) Prediction of Organic Anion-Transporting Polypeptide 1B1- and 1B3-Mediated Hepatic Uptake of Statins Based on Transporter Protein Expression and Activity Data. Drug Metabolism and Disposition 42:9, pages 1514-1521.
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Laurent Salphati, Xiaoyan Chu, Liangfu Chen, Bhagwat Prasad, Shannon Dallas, Raymond Evers, Donna Mamaril-Fishman, Ethan G. Geier, Jonathan Kehler, Jeevan Kunta, Mario Mezler, Loic Laplanche, Jodie Pang, Anja Rode, Matthew G. Soars, Jashvant D. Unadkat, Robert A. B. van Waterschoot, Jocelyn Yabut, Alfred H. Schinkel & Nico Scheer. (2014) Evaluation of Organic Anion Transporting Polypeptide 1B1 and 1B3 Humanized Mice as a Translational Model to Study the Pharmacokinetics of Statins. Drug Metabolism and Disposition 42:8, pages 1301-1313.
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Rui Li, Hugh A. Barton & Manthena V. Varma. (2014) Prediction of Pharmacokinetics and Drug–Drug Interactions When Hepatic Transporters are Involved. Clinical Pharmacokinetics 53:8, pages 659-678.
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Etienne P. A. Neve, Per Artursson, Magnus Ingelman-Sundberg & Maria Karlgren. (2013) An Integrated in Vitro Model for Simultaneous Assessment of Drug Uptake, Metabolism, and Efflux . Molecular Pharmaceutics 10:8, pages 3152-3163.
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Kazuya Maeda & Yuichi Sugiyama. 2013. Transporters in Drug Development. Transporters in Drug Development 121 153 .

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