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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 10
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Research Article

Effects of 17α-ethynylestradiol-induced cholestasis on the pharmacokinetics of doxorubicin in rats: reduced biliary excretion and hepatic metabolism of doxorubicin

Young Hee Choi College of Pharmacy and Research Institute of Pharmaceutical Sciences, Dongguk University-Seoul, Goyang, South KoreaCorrespondence[email protected]
,
Yu Kyung Lee College of Pharmacy and Research Institute of Pharmaceutical Sciences, Dongguk University-Seoul, Goyang, South Korea
&
Myung Gull Lee College of Pharmacy, The Catholic University of Korea, Bucheon, South Korea
Pages 901-907 | Received 07 Jan 2013, Accepted 04 Mar 2013, Published online: 10 Apr 2013

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Xiaoyu Qu, Jinghui Zhai, Tingting Hu, Huan Gao, Lina Tao, Yueming Zhang, Yanqing Song & Sixi Zhang. (2019) Dioscorea bulbifera L. delays the excretion of doxorubicin and aggravates doxorubicin-induced cardiotoxicity and nephrotoxicity by inhibiting the expression of P-glycoprotein in mice liver and kidney. Xenobiotica 49:9, pages 1116-1125.
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Mark J Canet & Nathan J Cherrington. (2014) Drug disposition alterations in liver disease: extrahepatic effects in cholestasis and nonalcoholic steatohepatitis. Expert Opinion on Drug Metabolism & Toxicology 10:9, pages 1209-1219.
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Articles from other publishers (6)

Yue Zu, Yanan Liu, Lulu Lan, Chen Zhu, Chengliang Zhang & Dong Liu. (2023) Consecutive baicalin treatment relieves its accumulation in rats with intrahepatic cholestasis by increasing MRP2 expression. Heliyon 9:1, pages e12689.
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Young Hee Choi, Chao Zhang, Zhenzhen Liu, Mei-Juan Tu, Ai-Xi Yu & Ai-Ming Yu. (2021) A Novel Integrated Pharmacokinetic-Pharmacodynamic Model to Evaluate Combination Therapy and Determine In Vivo Synergism . Journal of Pharmacology and Experimental Therapeutics 377:3, pages 305-315.
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Ji Sang Lee & So Hee Kim. (2019) Dose-Dependent Pharmacokinetics of Tofacitinib in Rats: Influence of Hepatic and Intestinal First-Pass Metabolism. Pharmaceutics 11:7, pages 318.
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Cheng-liang Zhang, Yan-jiao Xu, Dong Xiang, Jin-yu Yang, Kai Lei & Dong Liu. (2018) Pharmacokinetic Characteristics of Baicalin in Rats with 17α-ethynyl-estradiol-induced Intrahepatic Cholestasis. Current Medical Science 38:1, pages 167-173.
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Nilay Thakkar, Jason R. Slizgi & Kim L.R. Brouwer. (2017) Effect of Liver Disease on Hepatic Transporter Expression and Function. Journal of Pharmaceutical Sciences 106:9, pages 2282-2294.
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Lucie Bořek-Dohalská, Petra Valášková, Věra Černá & Marie Stiborová. (2014) Role of rat cytochromes P450 in the oxidation of 17α-ethinylestradiol. Environmental Toxicology and Pharmacology 38:3, pages 852-860.
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