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Xenobiotica
the fate of foreign compounds in biological systems
Volume 43, 2013 - Issue 10
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Animal Pharmacokinetics and Metabolism

Simultaneous determination by LC-MS/MS of 25-methoxydammarane-3β,12β,20-triol epimers and active metabolites in rat plasma after intravenous administration

Cai-Hong ShiDepartment of Traditional Chinese Material Medica
,
Xiangrong ZhangDepartment of Traditional Chinese Material Medica
,
Hao SuoDepartment of Pharmaceutical Analysis, Shenyang Pharmaceutical University Shenyang 110016China
,
Tian YinDepartment of Traditional Chinese Material Medica
,
Haiyan XuDepartment of Pharmaceutical Analysis, Shenyang Pharmaceutical University Shenyang 110016China
,
Bo YuanDepartment of Pharmaceutical Analysis, Shenyang Pharmaceutical University Shenyang 110016China
&
Yuqing ZhaoDepartment of Traditional Chinese Material MedicaCorrespondence[email protected]
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Pages 868-874 | Received 12 Feb 2013, Accepted 20 Mar 2013, Published online: 30 Apr 2013

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Xiangrong Zhang, Yi Zhang, Shuang Guo, Feifei Bai, Tong Wu & Yuqing Zhao. (2016) Improved oral bioavailability of 20(R)-25-methoxyl-dammarane-3β, 12β, 20-triol using nanoemulsion based on phospholipid complex: design, characterization, and in vivo pharmacokinetics in rats. Drug Design, Development and Therapy 10, pages 3707-3716.
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Shuang Cai, Cai-Hong Shi, Xiangrong Zhang, Xiaojiao Tang, Hao Suo, Li Yang & Yuqing Zhao. (2014) Self-microemulsifying drug-delivery system for improved oral bioavailability of 20(S)-25-methoxyl-dammarane-3β, 12β, 20-triol: preparation and evaluation. International Journal of Nanomedicine 9, pages 913-920.
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Articles from other publishers (9)

Meng Ding, Lei Xu, Yumeng Zhang, Wei Li & Yuqing Zhao. (2021) Simultaneous quantification and ADME prediction of AD-1 and its eight metabolites in rat feces, and screening of PARP-1 inhibitors through molecular docking. Journal of Molecular Structure 1244, pages 131016.
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Dohyun Kim, Minwoo Park, Iqra Haleem, Younghong Lee, Jain Koo, Young Chae Na, Gidong Song & Jaehwi Lee. (2020) Natural Product Ginsenoside 20(S)-25-Methoxyl-Dammarane-3β, 12β, 20-Triol in Cancer Treatment: A Review of the Pharmacological Mechanisms and Pharmacokinetics. Frontiers in Pharmacology 11.
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Wei Li, Xiangrong Zhang, Meng Ding, Yanfei Xin, Yaoxian Xuan & Yuqing Zhao. (2019) Genotoxicity and subchronic toxicological study of a novel ginsenoside derivative 25-OCH3-PPD in beagle dogs. Journal of Ginseng Research 43:4, pages 562-571.
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Meng Ding, Xude Wang, Yumeng Zhang, Weihui Yuan, Huixing Zhang, Lei Xu, Ziyi Wang, Jincai Lu, Wei Li & Yuqing Zhao. (2019) New perspective on the metabolism of AD-1 in vivo: Characterization of a series of dammarane-type derivatives with novel metabolic sites and anticancer mechanisms of active oleanane-type metabolites. Bioorganic Chemistry 88, pages 102961.
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Nan Shao, Huan Jiang, Xiaotong Wang, Bo Yuan, Yi Jin, Mantong Song, Yuqing Zhao & Haiyan Xu. (2017) Stereoselective pharmacokinetics of 25-methoxyl-dammarane-3β,12β,20-triol and its active demethyl-metabolite epimers in rats after oral and intravenous administration. Fitoterapia 116, pages 139-145.
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Wei Li, Xiangrong Zhang, Yanfei Xin, Yaoxian Xuan, Jinping Liu, Pingya Li & Yuqing Zhao. (2016) Oral subchronic toxicity evaluation of a novel antitumor agent 25-methoxydammarane-3, 12, 20-triol from Panax notoginseng in Sprague–Dawley rats. Regulatory Toxicology and Pharmacology 77, pages 240-251.
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Meng Ding, Jingjing Lu, Chen Zhao, Sainan Zhang & Yuqing Zhao. (2016) Determination of 25-OCH3-PPD and the related substances by UPLC–MS/MS and their cytotoxic activity. Journal of Chromatography B 1022, pages 274-280.
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Ju-Hee Oh & Young-Joo Lee. (2014) Sample Preparation for Liquid Chromatographic Analysis of Phytochemicals in Biological Fluids. Phytochemical Analysis 25:4, pages 314-330.
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Xiangrong Zhang, Ji Zhang, Wei Li, Li Liu, Baoshan Sun, Zhenghong Guo, Caihong Shi & Yuqing Zhao. (2014) In Vitro Metabolism of 20(R)-25-Methoxyl-Dammarane-3, 12, 20-Triol from Panax notoginseng in Human, Monkey, Dog, Rat, and Mouse Liver Microsomes. PLoS ONE 9:4, pages e94962.
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