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Xenobiotica
the fate of foreign compounds in biological systems
Volume 44, 2014 - Issue 10
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General Xenobiochemistry

Modulatory effects of extracts of vinegar-baked Radix Bupleuri and saikosaponins on the activity of cytochrome P450 enzymes in vitro

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Pages 861-867 | Received 15 Feb 2014, Accepted 09 Apr 2014, Published online: 29 Apr 2014

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Hongfang Li, Yunyan Tang, Yang Wang, Weipeng Wei, Chengchen Yin & Fushang Tang. (2020) Effects of Saikosaponin D on CYP1A2 and CYP2D6 in HepaRG Cells. Drug Design, Development and Therapy 14, pages 5251-5258.
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Xinyue Yu, Zhuang Miao, Lizhen Zhang, Liqiao Zhu & Huagang Sheng. (2023) Extraction, purification, structure characteristics, biological activities and pharmaceutical application of Bupleuri Radix Polysaccharide: A review. International Journal of Biological Macromolecules 237, pages 124146.
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Ya Zhao, Jinqiu Wang, Lijuan Liu, Yayun Wu, Qiaohong Hu & Ruizhi Zhao. (2022) Vinegar-baked Radix Bupleuri enhances the liver-targeting effect of rhein on liver injury rats by regulating transporters. Journal of Pharmacy and Pharmacology 74:11, pages 1588-1597.
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Saneesh Kumar, Patrick J. Bouic & Bernd Rosenkranz. (2021) Investigation of CYP2B6, 3A4 and β-esterase interactions of Withania somnifera (L.) dunal in human liver microsomes and HepG2 cells. Journal of Ethnopharmacology 270, pages 113766.
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Carina Harkin. (2020) A review on plastic bioaccumulation, potential health effects and the potential to enhance biotransformation using herbal medicine and nutritional supplements. International Journal of Complementary and Alternative Medicine 13:1, pages 18-26.
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Ruijia Fu, Jingjing Liu, Yunwen Xue, Zunjian Zhang & Rui Song. (2019) Effects of Animal Strain, Dose, and Cotreatment with Saikosaponin b2 on the Pharmacokinetics of Saikosaponin a in Rats. European Journal of Drug Metabolism and Pharmacokinetics 44:6, pages 827-836.
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Haiyang Wu, Tongya Yu, Ye Tian, Yinjie Wang, Ruizhi Zhao & Shirui Mao. (2018) Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri. Phytomedicine 44, pages 1-8.
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Limin Feng, Lijuan Liu, Ya Zhao & Ruizhi Zhao. (2017) Saikosaponins A, C and D enhance liver-targeting effects of anticancer drugs by modulating drug transporters. Oncotarget 8:66, pages 110092-110102.
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Tianli Lei, Dandan Zhang, Kun Guo, Mingxiao Li, Chongning Lv, Jing Wang, Lingyun Jia & Jincai Lu. (2017) Validated UPLC-MS/MS method for simultaneous quantification of eight saikosaponins in rat plasma: Application to a comparative pharmacokinetic study in depression rats after oral administration of extracts of raw and vinegar-baked Bupleuri Radix. Journal of Chromatography B 1060, pages 231-239.
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Amrinder Singh & Kaicun Zhao. 2017. Neurobiology of Chinese Herb Medicine. Neurobiology of Chinese Herb Medicine 197 232 .
Ya Zhao, Yin-Jie Wang, Rui-Zhi Zhao & Fei-Jun Xiang. (2016) Vinegar amount in the process affected the components of vinegar-baked Radix Bupleuri and its hepatoprotective effect. BMC Complementary and Alternative Medicine 16:1.
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Dan-Dan Tian, Wei Wang, Hua-Ning Wang, Stephen Sze & Zhang-Jin Zhang. (2016) Pharmacokinetic Evaluation of Clozapine in Concomitant Use of Radix Rehmanniae, Fructus Schisandrae, Radix Bupleuri, or Fructus Gardeniae in Rats. Molecules 21:6, pages 696.
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Xinmin Wang, Yunru Peng, Xinyue Jing, Dawei Qian, Yuping Tang & Jin-ao Duan. (2014) In vitro and in vivo assessment of CYP2C9-mediated herb–herb interaction of Euphorbiae Pekinensis Radix and Glycyrrhizae Radix. Frontiers in Pharmacology 5.
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