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Xenobiotica
the fate of foreign compounds in biological systems
Volume 45, 2015 - Issue 12
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Clinical Pharmacokinetics and Metabolism

Disposition, metabolism and mass balance of delafloxacin in healthy human volunteers following intravenous administration

Andrew McEwenDepartment of Metabolism, Quotient Bioresearch, Pegasus Way, Rushden, UK, Correspondence[email protected]
,
Laura LawrenceMelinta Therapeutics Inc., New Haven, CT, USA, and
,
Randy HooverMelinta Therapeutics Inc., New Haven, CT, USA, and
,
Lloyd StevensQuotient Clinical, Nottingham, UK
,
Stuart MairQuotient Clinical, Nottingham, UK
,
Gill FordDepartment of Metabolism, Quotient Bioresearch, Pegasus Way, Rushden, UK,
,
Dylan WilliamsDepartment of Metabolism, Quotient Bioresearch, Pegasus Way, Rushden, UK,
&
Stuart WoodDepartment of Metabolism, Quotient Bioresearch, Pegasus Way, Rushden, UK,
show all
Pages 1054-1062 | Received 24 Feb 2015, Accepted 16 Apr 2015, Published online: 19 May 2015

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Silvia Gómez-Zorrilla, Elena Sendra & Juan P. Horcajada. (2022) A profile of delafloxacin in the treatment of adults with community-acquired bacterial pneumonia. Expert Review of Clinical Pharmacology 15:6, pages 671-688.
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Matteo Bassetti, Monica Melchio & Daniele Roberto Giacobbe. (2022) Delafloxacin for the treatment of adult patients with community-acquired bacterial pneumonia. Expert Review of Anti-infective Therapy 20:5, pages 649-656.
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Georgios L. Voulgaris, Maria L. Voulgari & Matthew E. Falagas. (2019) Developments on antibiotics for multidrug resistant bacterial Gram-negative infections. Expert Review of Anti-infective Therapy 17:6, pages 387-401.
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Elda Righi, Alessia Carnelutti, Antonio Vena & Matteo Bassetti. (2018) Emerging treatment options for acute bacterial skin and skin structure infections: focus on intravenous delafloxacin. Infection and Drug Resistance 11, pages 479-488.
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Matteo Bassetti, Davide Pecori, Piergiorgio Cojutti, Elda Righi & Federico Pea. (2017) Clinical and pharmacokinetic drug evaluation of delafloxacin for the treatment of acute bacterial skin and skin structure infections. Expert Opinion on Drug Metabolism & Toxicology 13:11, pages 1193-1200.
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Articles from other publishers (14)

Adrien Turban, François Guérin, Aurélien Dinh & Vincent Cattoir. (2023) Updated Review on Clinically-Relevant Properties of Delafloxacin. Antibiotics 12:8, pages 1241.
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Simon G. Wong & Shuguang Ma. 2023. Overcoming Obstacles in Drug Discovery and Development. Overcoming Obstacles in Drug Discovery and Development 137 174 .
L. J. Scott. (2020) Delafloxacin: A Review in Acute Bacterial Skin and Skin Structure Infections. Drugs 80:12, pages 1247-1258.
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Jennifer Shiu, Grace Ting & Tony KL Kiang. (2018) Clinical Pharmacokinetics and Pharmacodynamics of Delafloxacin. European Journal of Drug Metabolism and Pharmacokinetics 44:3, pages 305-317.
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. 2019. Demystifying Drug Dosing in Renal Dysfunction. Demystifying Drug Dosing in Renal Dysfunction 15 86 .
Paul M Tulkens, Françoise Van Bambeke & Stephen H Zinner. (2019) Profile of a Novel Anionic Fluoroquinolone—Delafloxacin. Clinical Infectious Diseases 68:Supplement_3, pages S213-S222.
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忠秋 郭. (2019) Delafloxacin: A Novel Fluoroquinolones Broad-Spectrum Antibacterial. Pharmacy Information 08:01, pages 9-15.
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Matteo Bassetti, Elda Righi, Davide Pecori & Glenn Tillotson. (2018) Delafloxacin: an improved fluoroquinolone developed through advanced molecular engineering. Future Microbiology 13:10, pages 1081-1094.
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Randall Hoover, Harry AlcornJrJr, Laura Lawrence, Susan K. Paulson, Megan Quintas & Sue K. Cammarata. (2018) Pharmacokinetics of Intravenous Delafloxacin in Patients With End-Stage Renal Disease. The Journal of Clinical Pharmacology 58:7, pages 913-919.
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Bryan T Mogle, Jeffrey M Steele, Stephen J Thomas, KarenBeth H Bohan & Wesley D Kufel. (2018) Clinical review of delafloxacin: a novel anionic fluoroquinolone. Journal of Antimicrobial Chemotherapy 73:6, pages 1439-1451.
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Sarah C. J. Jorgensen, Nicholas J. Mercuro, Susan L. Davis & Michael J. Rybak. (2018) Delafloxacin: Place in Therapy and Review of Microbiologic, Clinical and Pharmacologic Properties. Infectious Diseases and Therapy 7:2, pages 197-217.
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Randall K. Hoover, Harry AlcornJr.Jr., Laura Lawrence, Susan K. Paulson, Megan Quintas & Sue K. Cammarata. (2017) Delafloxacin Pharmacokinetics in Subjects With Varying Degrees of Renal Function. The Journal of Clinical Pharmacology 58:4, pages 514-521.
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Randall Hoover, Thomas C. Marbury, Richard A. Preston, Megan Quintas, Laura E. Lawrence, Susan K. Paulson, David R. Luke & Sue K. Cammarata. (2017) Clinical Pharmacology of Delafloxacin in Patients With Hepatic Impairment. The Journal of Clinical Pharmacology 57:3, pages 328-335.
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Randall Hoover, Thomas Hunt, Michael Benedict, Susan K. Paulson, Laura Lawrence, Sue Cammarata & Eugene Sun. (2016) Safety, Tolerability, and Pharmacokinetic Properties of Intravenous Delafloxacin After Single and Multiple Doses in Healthy Volunteers. Clinical Therapeutics 38:1, pages 53-65.
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