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Xenobiotica
the fate of foreign compounds in biological systems
Volume 1, 1971 - Issue 1
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Research Article

The Metabolism by Man of an Anticonvulsant Oxadiazole. An unusual Metabolic Route for Tertiary Amides

J. G. Allen Roche Products Limited, Broadwater Road, Welwyn Garden City, Herts, UK
,
M. J. Blackburn Roche Products Limited, Broadwater Road, Welwyn Garden City, Herts, UK
&
S. M. Caldwell Roche Products Limited, Broadwater Road, Welwyn Garden City, Herts, UK
Pages 3-12 | Received 09 Dec 1970, Published online: 15 Sep 2008

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Y. Fujimaki, T. Hosokami & K. Ono. (1995) Identification of urinary metabolites of ecabapide in rat. Xenobiotica 25:5, pages 501-510.
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F. S. Abbott, J. G. Slatter, R. Burton & Gun Il Kang. (1985) Methadone metabolism in the rat in vivo: identification of a novel formamide metabolite. Xenobiotica 15:2, pages 129-140.
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J. W. Gorrod & D. J. Temple. (1976) The Formation of an N-Hydroxymethyl Intermediate in the N-Demethylation of N-Methylcarbazole in vivo and in vitro. Xenobiotica 6:5, pages 265-274.
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Howard B. Hucker. (1974) Intermediates in Drug Metabolism Reactions. Drug Metabolism Reviews 2:1, pages 33-56.
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Articles from other publishers (8)

Taoufik Rohand, Youssef Ramli, Mukulesh Baruah, Jan Budka & Archana M. Das. (2019) Synthesis, Structure Elucidation and Antimicrobial Properties of New Bis-1,3,4-Oxadiazole Derivatives. Pharmaceutical Chemistry Journal 53:2, pages 150-154.
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Cheri M. Maciolek, Bennett Ma, Karsten Menzel, Sebastien Laliberte, Kevin Bateman, Paul Krolikowski & Christoper R. Gibson. (2011) Novel Cytochrome P450-Mediated Ring Opening of the 1,3,4-Oxadiazole in Setileuton, a 5-Lipoxygenase Inhibitor. Drug Metabolism and Disposition 39:5, pages 763-770.
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Walter Yu, Jeffrey M. Dener, Daniel A. Dickman, Paul Grothaus, Yun Ling, Liang Liu, Chris Havel, Kimberly Malesky, Tania Mahajan, Colin O’Brian, Emma J. Shelton, David Sperandio, Zhiwei Tong, Robert Yee & Joyce J. Mordenti. (2006) Identification of metabolites of the tryptase inhibitor CRA-9249: Observation of a metabolite derived from an unexpected hydroxylation pathway. Bioorganic & Medicinal Chemistry Letters 16:15, pages 4053-4058.
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Deepak K. Dalvie, Amit S. Kalgutkar, S. Cyrus Khojasteh-Bakht, R. Scott Obach & John P. O'Donnell. (2002) Biotransformation Reactions of Five-Membered Aromatic Heterocyclic Rings. Chemical Research in Toxicology 15:3, pages 269-299.
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J. Greg Slatter, Abdul E. Mutlib & Frank S. Abbott. (1989) Biotransformation of aliphatic formamides: Metabolites of (±)-N-methyl-N-(1-methyl-3,3-diphenylpropyl) formamide in rats. Biological Mass Spectrometry 18:9, pages 690-701.
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B. Ketterer, S.K.S. Srai, B. Waynforth, D.L. Tullis, F.E. Evans & F.F. Kadlubar. (1982) Formation of N-(glutathion-S-methylene)-4-aminoazobenzene following metabolic oxidation of the N-methyl group of the carcinogen, N-methyl-4-aminoazobenzene. Chemico-Biological Interactions 38:3, pages 287-302.
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J. J. P. Heykants, W. E. G. Meuldermans, A. G. Knaeps & L. J. M. Michiels. (1977) The excretion and netabolism of the antidiarrhoeal loperamide in the Wistar rat. European Journal of Drug Metabolism and Pharmacokinetics 2:2, pages 81-91.
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J.E. Tomaszewski, D.M. Jerina & J.W. Daly. 1974. Annual Reports in Medicinal Chemistry Volume 9. Annual Reports in Medicinal Chemistry Volume 9 290 299 .

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