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Peter Hlavica. (1994) Regulatory Mechanisms in the Activation of Nitrogenous Compounds by Mammalian Cytochrome P-450 Isozymes. Drug Metabolism Reviews 26:1-2, pages 325-348.
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A. M. Hackett, I. C. Shaw & L. A. Griffiths. (1984) The metabolism and excretion of [14C]imipramine in an experimental hepatitis. Xenobiotica 14:6, pages 491-499.
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Christer von Bahr. (1972) Binding and Oxidation of Amitriptyline and a Series of its Oxidized Metabolites in Liver Microsomes from Untreated and Phenobarbital-treated Rats. Xenobiotica 2:3, pages 293-306.
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Harri Vainio & Osmo Hänninen. (1972) Enhancement of Aniline p-Hydroxylation by Acetone in Rat Liver Microsomes. Xenobiotica 2:3, pages 259-267.
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Christer von Bahr, John B. Schenkman & Sten Orrenius. (1972) Effect of Phenobarbital and 3,4-Benzpyrene Treatment of Rats on the Microsomal Binding and Hydroxylation of Nortriptyline and Desmethyl-imipramine: Evidence for Qualitative Changes in Cytochrome P-450-Ligand Interaction following Phenobarbital Pretreatment. Xenobiotica 2:1, pages 89-99.
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D. J. Temple. (1971) Binding of Nitrogen Containing Compounds to Microsomal Cytochromes. Xenobiotica 1:4-5, pages 507-520.
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Christer von Bahr & Leif Bertilsson. (1971) Hydroxylation and Subsequent Glucuronide Conjugation of Desmethylimipramine in Rat Liver Microsomes. Xenobiotica 1:3, pages 205-212.
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Articles from other publishers (30)
Peter Hlavica. (2006) Functional interaction of nitrogenous organic bases with cytochrome P450: A critical assessment and update of substrate features and predicted key active-site elements steering the access, binding, and orientation of amines. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 1764:4, pages 645-670.
Crossref
Crossref
Jin‐Ding Huang & Ching‐Yi Hsieh. (2004)
Stereoselective inhibition of diphenylhydantoin metabolism by
p
‐hydroxyphenyl‐phenylhydantoin enantiomers in rats
. Chirality 3:6, pages 454-459.
Crossref
Crossref
Masato Chiba, Shoichi Fujita & Tokuji Suzuki. (1988) Parallel Pathway Interactions in Imipramine Metabolism in Rats. Journal of Pharmaceutical Sciences 77:11, pages 944-947.
Crossref
Crossref
Kenji Kawahara, Toshikazu Awaji, Kazumasa Uda & Yasuo Sakai. (1987) Determination of four metabolites of dothiepin in urine by high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 5:2, pages 183-189.
Crossref
Crossref
Eric C. Kok, Beverley J. Wilson & Ben Potgieter. (1986) Influence of estrogen levels on anticholinergic activity of tricyclic antidepressives. Progress in Neuro-Psychopharmacology and Biological Psychiatry 10:1, pages 49-55.
Crossref
Crossref
Alison E.M. Vickers, I.Glenn Sipes & Klaus Brendel. (1986) Metabolism-related spectral characterization and subcellular distribution of polychlorinated biphenyl congeners in isolated rat hepatocytes. Biochemical Pharmacology 35:2, pages 297-306.
Crossref
Crossref
K. Kawahara, T. Awaji, K. Uda, Y. Sakai & Y. Hashimoto. (1986) Urinary excretion of conjugates of dothiepin and northiaden (mono- N-demethyl-dothiepin) after an oral dose of dothiepin to humans. European Journal of Drug Metabolism and Pharmacokinetics 11:1, pages 29-32.
Crossref
Crossref
Ryozo Ishida, Takashi Usui, Yoshiko Fukushima, Shoichi Fujita & Tokuji Suzuki. (1985) Effect of Vitamin K3 on the First-Pass Elimination of Propranolol in the Rat. Journal of Pharmaceutical Sciences 74:5, pages 578-581.
Crossref
Crossref
E. Maria Savenije-Chapel, Aalt Bast & Jan Noordhoek. (1985) Inhibition of diazepam metabolism in microsomal-and perfused liver preparations of the rat by desmethyldiazepam, N-methyloxazepam and oxazepam. European Journal of Drug Metabolism and Pharmacokinetics 10:1, pages 15-20.
Crossref
Crossref
H. C. Grice. 1984. The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies. The Selection of Doses in Chronic Toxicity/Carcinogenicity Studies
3
49
.
S.V. Otton, T. Inaba & W. Kalow. (1983) Inhibition of sparteine oxidation in human liver by tricyclic antidepressants and other drugs. Life Sciences 32:7, pages 795-800.
Crossref
Crossref
Aalt Bast & Jan Noordhoek. (1982) Spectral interaction of orphenadrine and its metabolites with oxidized and reduced hepatic microsomal cytochrome P-450 in the rat. Biochemical Pharmacology 31:17, pages 2745-2753.
Crossref
Crossref
Erland J. Erlandsen & Lars F. Gram. (2009) Imipramine Kinetics in the Single Pass Rat Liver Perfusion Model. Acta Pharmacologica et Toxicologica 50:2, pages 137-147.
Crossref
Crossref
Marianne Bjerre, L. F. Gram, P. Kragh-S�rensen, C. Bruun Kristensen, O. Lindegaard Pedersen, M. M�ller & P. Thayssen. (1981) Dose-dependent kinetics of imipramine in elderly patients. Psychopharmacology 75:4, pages 354-357.
Crossref
Crossref
Aalt Bast & Jan Noordhoek. (1981) Product inhibition during the hepatic microsomal N-demethylation of aminopyrine in the rat. Biochemical Pharmacology 30:1, pages 19-24.
Crossref
Crossref
M. H. Bickel. 1980. Psychotropic Agents. Psychotropic Agents
551
572
.
Adriaan P. Van Den Berg, Jan Noordhoek & Elisabeth Koopman-Kool. (1979) The use of competitive inhibition of substrate-binding to cytochrome P450 in the determination of spectral dissociation constants for substrates with multiple types of binding, as illustrated with 1-butanol. Biochemical Pharmacology 28:1, pages 37-41.
Crossref
Crossref
D. R. Britton, Z. S. El-Wardany, C. P. Brown & J. R. Bianchine. 1978. Handbook of Psychopharmacology. Handbook of Psychopharmacology
299
344
.
Lars F. Gram, Per Buch Andreasen, Kerstin Fredricson Over� & Johannes Christiansen. (1976) Comparison of single dose kinetics of imipramine, nortriptyline and antipyrine in man. Psychopharmacology 50:1, pages 21-27.
Crossref
Crossref
David M. Soda & Gerhard Levy. (1975) Inhibition of Drug Metabolism by Hydroxylated Metabolites: Cross‐Inhibition and Specificity. Journal of Pharmaceutical Sciences 64:12, pages 1928-1931.
Crossref
Crossref
Willy Stäubli, Walpurga Schweizer, Joseph Suter & Robert Hess. (1974) Ultrastructural and biochemical study of the action of benzoctamine and maprotiline on the rat liver. Agents and Actions 4:5, pages 391-403.
Crossref
Crossref
Robert Grundin, Peter Moldéus, Sten Orrenius, Karl Olov Borg, Inger Skånberg & Christer von Bahr. (2009) The Possible Role of Cytochrome P‐450 in the Liver “First Pass Elimination” of a P‐Receptor Blocking Drug. Acta Pharmacologica et Toxicologica 35:3, pages 242-260.
Crossref
Crossref
Lars F. Gram, Johannes Christiansen & Kerstin Fredricson Overø. (2009) Pharmacokinetic Interaction between Neuroleptics and Tricyclic Antidepressants in the Rat. Acta Pharmacologica et Toxicologica 35:3, pages 223-232.
Crossref
Crossref
K. O. Borg, B. Eklund, I. Skånberg & M. Wallborg. (2009) Metabolism of Alprenolol in Liver Microsomes, Perfused Liver and Conscious Rat. Acta Pharmacologica et Toxicologica 35:3, pages 169-179.
Crossref
Crossref
STEN ORRENIUS & LARS ERNSTER. 1974. Molecular Mechanisms of Oxygen Activation. Molecular Mechanisms of Oxygen Activation
215
244
.
B. Jalling, L. O. Bor�us, N. K�llberg & S. Agurell. (1973) Disappearance from the newborn of circulating prenatally administered phenobarbital. European Journal of Clinical Pharmacology 6:4, pages 234-238.
Crossref
Crossref
Ingrid Hoffstrom & Saten Orrenius. (1973)
The interaction of various
N
-substituted amphetamines with cytochrome
P
-450 of rabbit liver microsomes
. FEBS Letters 31:2, pages 205-208.
Crossref
Crossref
Christer von Bahr, Eino Hietanen & Hans Glaumann. (1972) Oxidation and Glucuronidation of Certain Drugs in Various Subcellular Fractions of Rat Liver: Binding of Desmethylimipramine and Hexobarbital to Cytochrome P-450 and Oxidation and Glucuronidation of Desmethylimipramine, Aminopyrine, p-Nitrophenol and 1-Na. Acta Pharmacologica et Toxicologica 31:1-2, pages 107-120.
Crossref
Crossref
S. ORRENIUS, C. VON BAHR, S.V. JAKOBSSON & L. ERNSTER. 1972. Structure and Function of Oxidation?Reduction Enzymes. Structure and Function of Oxidation?Reduction Enzymes
309
320
.
Folke Sjöqvist, Balzar Alexanderson, Marie Åsberg, Leif Bertilsson, Olof Borgå, Bertil Hamberger & Dick Tuck. (2009) Pharmacokinetics and Biological Effects of Nortriptyline in Man. Acta Pharmacologica et Toxicologica 29, pages 255-280.
Crossref
Crossref