Citations (37)
Keep up to date with the latest research on this topic with citation updates for this article.
Read on this site (5)
Tewes Tralau, Juliane Sowada & Andreas Luch. (2015) Insights on the human microbiome and its xenobiotic metabolism: what is known about its effects on human physiology?. Expert Opinion on Drug Metabolism & Toxicology 11:3, pages 411-425.
Read now
Read now
Bart Ploeger, Tjeert Mensinga, Adriënne Sips, Willem Seinen, Jan Meulenbelt & Joost DeJongh. (2001) THE PHARMACOKINETICS OF GLYCYRRHIZIC ACID EVALUATED BY PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING†. Drug Metabolism Reviews 33:2, pages 125-147.
Read now
Read now
Dennis V. Parke. (1997) A History of Drug Metabolism in the United Kingdom. Drug Metabolism Reviews 29:3, pages 801-851.
Read now
Read now
W. M. H. Heijbroek, D. F. Muggleton & D. V. Parke. (1984) Metabolism of the carbamate herbicide, asulam, in the rat. Xenobiotica 14:3, pages 235-247.
Read now
Read now
H. P. A. Illing. (1981) Techniques for microfloral and associated metabolic studies in relation to the absorption and enterohepatic circulation of drugs. Xenobiotica 11:12, pages 815-830.
Read now
Read now
Articles from other publishers (32)
Kanon Takahashi, Tetsuhiro Yoshino, Yasuhito Maki, Kan’ichiro Ishiuchi, Takao Namiki, Keiko Ogawa-Ochiai, Kiyoshi Minamizawa, Toshiaki Makino, Tomonori Nakamura, Masaru Mimura & Kenji Watanabe. (2019) Identification of glycyrrhizin metabolites in humans and of a potential biomarker of liquorice-induced pseudoaldosteronism: a multi-centre cross-sectional study. Archives of Toxicology 93:11, pages 3111-3119.
Crossref
Crossref
Jason M. Koontz, Blair C. R. Dancy, Cassandra L. Horton, Jonathan D. Stallings, Valerie T. DiVito & John A. Lewis. (2019) The Role of the Human Microbiome in Chemical Toxicity. International Journal of Toxicology 38:4, pages 251-264.
Crossref
Crossref
Justin L. Poklis, Maciej M. Gonek, Carl E. Wolf, Hamid I. Akbarali & William L. Dewey. (2019) Analysis of carbenoxolone by ultra‐high‐performance liquid chromatography tandem mass spectrometry in mouse brain and blood after systemic administration. Biomedical Chromatography 33:4.
Crossref
Crossref
Mark L. Schultz, Luis Tecedor, Elena Lysenko, Shyam Ramachandran, Colleen S. Stein & Beverly L. Davidson. (2018) Modulating membrane fluidity corrects Batten disease phenotypes in vitro and in vivo. Neurobiology of Disease 115, pages 182-193.
Crossref
Crossref
Chiharu Sadakane, Junko Watanabe, Miwako Fukutake, Hiroaki Nisimura, Kazuya Maemura, Yoshio Kase & Toru Kono. (2015) Pharmacokinetic Profiles of Active Components After Oral Administration of a Kampo Medicine, Shakuyakukanzoto, to Healthy Adult Japanese Volunteers. Journal of Pharmaceutical Sciences 104:11, pages 3952-3959.
Crossref
Crossref
Henry J. Haiser & Peter J. Turnbaugh. (2013) Developing a metagenomic view of xenobiotic metabolism. Pharmacological Research 69:1, pages 21-31.
Crossref
Crossref
. 2013. Principles and Practice of Phytotherapy. Principles and Practice of Phytotherapy
353
961
.
So Ha Ton, Chanchal Chandramouli & Khalid BAK. 2013. Natural Products. Natural Products
3803
3826
.
J W Bridges, J B Houston, M J Humphrey, W E Lindup, D V Parke, J S Shillingford & D G Upshall. (1976)
Gastrointestinal absorption of carbenoxolone in the rat determined
in vitro
and
in situ
: deviations from the pH-partition hypothesis
. Journal of Pharmacy and Pharmacology 28:2, pages 117-126.
Crossref
Crossref
Jing Jing, Weichao Ren, Xijing Chen, Yue Wang, Qiaoling Yu, Guangji Wang, Andrew K. Davey, Jiping Wang & Ning Jing. (2008) Glucuronide-sulfate Diconjugate as a Novel Metabolite of Glycyrrhetic Acid in Rat Bile. Drug Metabolism and Pharmacokinetics 23:3, pages 175-180.
Crossref
Crossref
R.A. Isbrucker & G.A. Burdock. (2006) Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regulatory Toxicology and Pharmacology 46:3, pages 167-192.
Crossref
Crossref
Herbert F. Person. 2004. Nutraceuticals. Nutraceuticals
285
300
.
Bart A. Ploeger, Jan Meulenbelt & Joost DeJongh. (2000) Physiologically Based Pharmacokinetic Modeling of Glycyrrhizic Acid, a Compound Subject to Presystemic Metabolism and Enterohepatic Cycling. Toxicology and Applied Pharmacology 162:3, pages 177-188.
Crossref
Crossref
P Wang, S.F.Y Li & H.K Lee. (1998) Determination of glycyrrhizic acid and 18-β-glycyrrhetinic acid in biological fluids by micellar electrokinetic chromatography. Journal of Chromatography A 811:1-2, pages 219-224.
Crossref
Crossref
Silvia Pindado, Owen I. Corriganh & Caitriona M. O'Driscoll. 1996.
1
43
.
Stephan Krähenbühl, Felix Hasler & Reto Krapf. (1994) Analysis and pharmacokinetics of glycyrrhizic acid and glycyrrhetinic acid in humans and experimental animals. Steroids 59:2, pages 121-126.
Crossref
Crossref
Felix Hasler, Reto Krapf, Rudolf Brenneisen, Daniel Bourquin & Stephan Krähenbühl. (1993) Determination of 18β-glycyrrhetinic acid in biological fluids from humans and rats by solid-phase extraction and high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 620:1, pages 73-82.
Crossref
Crossref
M.Abu Shamat. (1993) The role of the gastrointestinal microflora in the metabolism of drugs. International Journal of Pharmaceutics 97:1-3, pages 1-13.
Crossref
Crossref
F.C. Størmer, R. Reistad & J. Alexander. (1993) Glycyrrhizic acid in liquorice—Evaluation of health hazard. Food and Chemical Toxicology 31:4, pages 303-312.
Crossref
Crossref
Junichi Kawakami, Yoshikazu Yamamura, Tomofumi Santa, Hajime Kotaki, Katsuyoshi Uchino, Yasufumi Sawada & Tatsuji Iga. (1993) Kinetic Analysis of Glycyrrhetic Acid, an Active Metabolite of Glycyrrhizin, in Rats: Role of Enterohepatic Circulation. Journal of Pharmaceutical Sciences 82:3, pages 301-305.
Crossref
Crossref
Yoshikazu Yamamura, Junichi Kawakami, Tomofumi Santa, Hajime Kotaki, Katsuyoshi Uchino, Yasufumi Sawada & Tatsuji Iga. (1991) Selective high-performance liquid chromatographic method for the determination of glycyrrhizin and glycyrrhetic acid-3-O-glucuronide in biological fluids: application of ion-pair extraction and fluorescence labelling agent. Journal of Chromatography B: Biomedical Sciences and Applications 567:1, pages 151-160.
Crossref
Crossref
Teruaki Akao, Taiko Akao, Muneo Aoyama & Kyoichi Kobashi. (1991) Metabolism of glycyrrhetic acid by rat liver microsomes?III. Biochemical Pharmacology 42:1, pages 103-107.
Crossref
Crossref
Teruaki Akao, Muneo Aoyama, Taiko Akao, Masao Hattori, Yoshiro Imai, Tsuneo Namba, Yasuhiro Tezuka, Tohru Kikuchi & Kyoichi Kobashi. (1990) Metabolism of glycyrrhetic acid by rat liver microsomes?II. Biochemical Pharmacology 40:2, pages 291-296.
Crossref
Crossref
Taiko Akao, Teruaki Akao & Kyoichi Kobashi. (1990) Metabolism of glycyrrhetic acid by rat liver microsomes: glycyrrhetinate dehydrogenase. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism 1042:2, pages 241-246.
Crossref
Crossref
G.L. LARSEN. 1988. Role of the Gut Flora in Toxicity and Cancer. Role of the Gut Flora in Toxicity and Cancer
79
107
.
D. V. Parke. 1987. The Future of Predictive Safety Evaluation. The Future of Predictive Safety Evaluation
3
38
.
David M. Conning & A. B. G. LansdownI. R. Rowland & R. Walker. 1983. Toxic Hazards in Food. Toxic Hazards in Food
183
274
.
Dennis V. Parke. 1983. Animals in Scientific Research: An Effective Substitute for Man?. Animals in Scientific Research: An Effective Substitute for Man?
7
28
.
M.A. Pass & M.W. Goosem. (1982) Observation of metabolites of reduced lantadene a in bile canalicular membranes of rats with triterpene-induced cholestasis. Chemico-Biological Interactions 40:3, pages 375-378.
Crossref
Crossref
C. Ioannides, B. Sweatman, R. Richards & D.V. Parke. (1977) Drug metabolism in the ferret: Effects of age, sex and strain. General Pharmacology: The Vascular System 8:4, pages 243-249.
Crossref
Crossref
N. D. Yeomans & D. J. B. St. John. (1974) Effect of carbenoxolone sodium on aspirin-induced injury of the rat gastric mucosa. The American Journal of Digestive Diseases 19:3, pages 217-222.
Crossref
Crossref
Dennis V. Parke & W. Edward Lindup. (1973) QUANTITATIVE AND QUALITATIVE ASPECTS OF THE PLASMA PROTEIN BINDING OF CARBENOXOLONE, AN ULCER-HEALING DRUG. Annals of the New York Academy of Sciences 226:1 Drug-Protein, pages 200-213.
Crossref
Crossref