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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 4
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Original Article

Some factors involved in the N-oxidation of 3-substituted pyridines by microsomal preparations in vitro

J. W. Gorrod Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK
&
L. A. Damani Department of Pharmacy, Chelsea College (University of London), Manresa Road, London, SW3 6LX, UK; Department of Pharmacy, University of Manchester, Manchester, M13 9PL
Pages 209-218 | Received 17 Nov 1978, Published online: 30 Sep 2009

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T. G. Altunas & J. W. Gorrod. (1996) Effect of various potential inhibitors, activators and inducers on the N-oxidation of isomeric aromatic diazines in vitro using rabbit liver microsomal preparations. Xenobiotica 26:1, pages 9-15.
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Raymond f. Novak, Karen l. Kaul & Sang Geon Kim. (1989) Induction of the Alcohol Inducible Form of Cytochrome P-450 By Nitrogen-Containing Heterocycles: Effects on Pyridine It-Oxide Production. Drug Metabolism Reviews 20:2-4, pages 781-792.
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T. J. Wilke, W. R. Jondorf & G. Powis. (1989) Oxidative metabolism of 14C-pyridine by human and rat tissue subcellular fractions. Xenobiotica 19:9, pages 1013-1022.
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J. W. Gorrord & L. H. Patterson. (1983) The metabolism of 4-substituted N-ethyl-N-methylanilines: III. Effect of various potential inhibitors, activators and inducers on α-C- and N-oxidation. Xenobiotica 13:9, pages 521-529.
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Peter Hlavica & John W. Gorrod. (1982) Biological Oxidation of Nitrogen in Organic Compounds and Disposition of N-Oxidized Product. Critical Reviews in Biochemistry 12:1, pages 39-101.
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L. A. Damani, P. A. Crooks, M. S. Shaker, J. Caldwell, J. D'souza & R. L. Smith. (1982) Species differences in the metabolic C- and N-oxidation, and N-methylation of [14C]pyridine in vivo. Xenobiotica 12:8, pages 527-534.
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B. J. Blaauboer & A. J. Paine. (1980) Reversed phase high-performance liquid chromatography of heterocyclic aromatic N-oxides: application to measurement of N-oxidation by microsomes and rat hepatocytes in primary culture. Xenobiotica 10:7-8, pages 655-660.
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L. A. Damani, J. Bryan, D. A. Cowan & J. W. Gorrod. (1980) The origin of 1-(3-pyridyl-N-oxide)ethanol as a metabolite of 3-acetylpyridine. Xenobiotica 10:7-8, pages 645-653.
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J. W. Gorrod & L. A. Damani. (1979) The effect of various potential inhibitors, activators and inducers on the N-oxidation of 3-substituted pyridines in vitro. Xenobiotica 9:4, pages 219-226.
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Articles from other publishers (15)

Gerald L. KennedyJr.Jr.. 2003. Patty's Toxicology. Patty's Toxicology 1 158 .
Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
Henry J. Trochimowicz, Gerald L. KennedyJr.Jr. & Neil D. Krivanek. 2003. Patty's Toxicology. Patty's Toxicology.
Gary P. Carlson. (1996) Comparison of the effects of pyridine and its metabolites on rat liver and kidney. Toxicology Letters 85:3, pages 173-178.
Crossref
T. Gul Altuntas & John W. Gorrod. (1995) Factors Involved in the N-Oxidation of Isomeric Aromatic Diazines by Microsomal Preparations. Drug Metabolism and Drug Interactions 12:2.
Crossref
P. A. Crooks. 1993. Nicotine and Related Alkaloids. Nicotine and Related Alkaloids 81 109 .
AZIZ EL-HRAIKI. 1990. Nitrogen and Phosphorus Solvents. Nitrogen and Phosphorus Solvents 225 231 .
L.A. Damani & A.A. Houdi. (1988) CYTOCHROME P-450 AND FAD-MONOOXYGENASE MEDIATED S- AND N-OXYGENATIONS. Drug Metabolism and Drug Interactions 6:3-4.
Crossref
K. El-Ghomari & J. W. Gorrod. (1987) Metabolic N-oxygenation of 2,4-diamino-6-substituted pyrimidines. European Journal of Drug Metabolism and Pharmacokinetics 12:4, pages 253-258.
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P. J. Watkins & J. W. Gorrod. (1987) Studies on thein vitro biological N-oxidation of trimethoprim. European Journal of Drug Metabolism and Pharmacokinetics 12:4, pages 245-251.
Crossref
A. Jori, D. Calamari, F. Cattabeni, A. Di Domenico, C.L. Galli, E. Galli & V. Silano. (1983) Ecotoxicological profile of pyridine. Ecotoxicology and Environmental Safety 7:3, pages 251-275.
Crossref
Gösta Hallström & Björn Lindeke. (1981) MetabolicN-oxidation of α-acetylenic amines—A gas chromatographic mass spectrometric investigation of the chemical decomposition ofN-(5-pyrrolidinopent-3-ynyl)succinimideN'-oxide using deuterium substitution. Biological Mass Spectrometry 8:10, pages 514-520.
Crossref
Lyaquatali A. Damani, Peter A. Crooks & David A. Cowan. (1981) Metabolism of metyrapone: 2—chromatographic and mass spectral properties of theN-oxides of metyrapone and metyrapol. Biological Mass Spectrometry 8:6, pages 270-277.
Crossref
J.W. Gorrod, J. Bryan, D.A. Cowan & L.A. Damani. 1980. Microsomes, Drug Oxidations and Chemical Carcinogenesis. Microsomes, Drug Oxidations and Chemical Carcinogenesis 961 964 .
J. W. Gorrod & L. A. Damani. (1980) The metabolic N-oxidation of 3-substituted pyridines in various animal species in vivo. European Journal of Drug Metabolism and Pharmacokinetics 5:1, pages 53-57.
Crossref

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