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Xenobiotica
the fate of foreign compounds in biological systems
Volume 9, 1979 - Issue 4
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Original Article

The metabolism of 3-amino-1-chloropropan-2-ol in relation to its antifertility activity in male rats

A. R. Jones Department of Biochemistry, University of Sydney, Sydney, NSW, 2006, Australia
,
P. M. Mashford Department of Biochemistry, University of Sydney, Sydney, NSW, 2006, Australia
&
C. Murcott Department of Pharmacology, University of Manchester, Manchester, M13 9PL, UK
Pages 253-261 | Received 02 Oct 1978, Published online: 30 Sep 2009

Citations (14)

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Read on this site (3)

A. R. JONES & T. G. COOPER. (1997) Metabolism of 36Cl-ornidazole after oral application to the male rat in relation to its antifertility activity. Xenobiotica 27:7, pages 711-721.
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M. S. Dobbie, K. E. Porter & A. R. Jones. (1988) Is the Nephrotoxicity of (R)-3-Chlorolactate in the Rat Caused by 3-Chloropyruvate?. Xenobiotica 18:12, pages 1389-1399.
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A. R. Jones & R. W. O'brien. (1980) Metabolism of three active analogues of the male antifertility agent α-chlorohydrin in the rat. Xenobiotica 10:5, pages 365-370.
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Articles from other publishers (11)

Falko Frenzel, Axel Oberemm, Albert Braeuning & Alfonso Lampen. (2018) Proteomic analysis of 2-monochloropropanediol (2-MCPD) and 2-MCPD dipalmitate toxicity in rat kidney and liver in a 28-days study. Food and Chemical Toxicology 121, pages 1-10.
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Falko Frenzel, Axel Oberemm, Alfonso Lampen & Albert Braeuning. (2018) Proteomic effects of repeated-dose oral exposure to 2-monochloropropanediol and its dipalmitate in rat testes. Food and Chemical Toxicology 116, pages 354-359.
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J. Skamarauskas, W. Carter, M. Fowler, A. Madjd, T. Lister, G. Mavroudis & D.E. Ray. (2007) The selective neurotoxicity produced by 3-chloropropanediol in the rat is not a result of energy deprivation. Toxicology 232:3, pages 268-276.
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R. El Ramy, M. Ould Elhkim, S. Lezmi & J.M. Poul. (2007) Evaluation of the genotoxic potential of 3-monochloropropane-1,2-diol (3-MCPD) and its metabolites, glycidol and β-chlorolactic acid, using the single cell gel/comet assay. Food and Chemical Toxicology 45:1, pages 41-48.
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Andrew Hutt & Bhavesh Patel. 2004. Chirality in Drug Design and Development. Chirality in Drug Design and Development.
Trevor G. Cooper. 2002. The Epididymis: From Molecules to Clinical Practice. The Epididymis: From Molecules to Clinical Practice 483 502 .
WILHELM BONE, ALAN R. JONES, CHRISTOPHE MORIN, EBERHARD NIESCHLAG & TREVOR G. COOPER. (2013) Susceptibility of Glycolytic Enzyme Activity and Motility of Spermatozoa From Rat, Mouse, and Human to Inhibition by Proven and Putative Chlorinated Antifertility Compounds In Vitro. Journal of Andrology 22:3, pages 464-470.
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Bone & Cooper. (2000) In vitro inhibition of rat cauda epididymal sperm glycolytic enzymes by ornidazole, alpha-chlorohydrin and 1-chloro-3-hydroxypropanone. International Journal of Andrology 23:5, pages 284-293.
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JONES & COOPER. (2001) A re‐appraisal of the post‐testicular action and toxicity of chlorinated antifertility compounds. International Journal of Andrology 22:3, pages 130-138.
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TREVOR G. COOPER, CHING‐HEI YEUNG, ROLF SKUPIN & GÜNTER HAUFE. (2013) Antifertility Potential of Ornidazole Analogues in Rats. Journal of Andrology 18:4, pages 431-438.
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K.E. Porter & A.R. Jones. (1982) The effect of the isomers of α-chlorohydrin and racemic β-chlorolactate on the rat kidney. Chemico-Biological Interactions 41:1, pages 95-104.
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