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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 12
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Research Article

Microsomal N- and C-oxidation of 4-substituted N-benzylanilines

J. W. Gorrod Department of Pharmacy, Chelsea College, University of London, Manresa Road, London, SW3 6LX, UK
&
N. J. Gooderham Department of Pharmacy, Chelsea College, University of London, Manresa Road, London, SW3 6LX, UK
Pages 1021-1031 | Received 15 Dec 1983, Published online: 22 Sep 2008

Citations (15)

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Read on this site (5)

J. W. Gorrod & M. Ulgen. (1994) Metabolic N-Oxidation of Diarylimines: A New Metabolic Reaction of Potential Toxicological Significance. Drug Metabolism Reviews 26:1-2, pages 241-252.
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M. Ulgen, J. W. Gorrod & D. Barlow. (1994) Structure-activity relationships in the formation of amides from substituted N-benzylanilines. Xenobiotica 24:8, pages 735-748.
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S. Boeren, B. Tyrakowska, J. Vervoort, E. de Hoffman, K. Teunis, A. Van Veldhuizen & I. M. C. M. Rietjens. (1992) Rat liver microsomal metabolism of 2-halogenated 4-methylanilines. Xenobiotica 22:12, pages 1403-1423.
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J. W. Gorrod & N. J. Gooderham. (1987) The metabolism of N-benzyl-4-substituted anilines: factors influencing in vitro C- and N-oxidation. Xenobiotica 17:2, pages 165-177.
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J. W. Gorrod & D. Manson. (1986) The metabolism of aromatic amines. Xenobiotica 16:10-11, pages 933-955.
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Articles from other publishers (10)

Mert Ulgen & John W Gorrod. (1996) The Failure of Substrate pKa to Influence the Microsomal Formation of Amides from N -Benzylamines: the Microsomal Metabolism of N -Benzyl Pyrrolidine, N -Benzyl Carbazole and N -Acetyl- N -benzyl-4-methylaniline . Journal of Pharmacy and Pharmacology 48:12, pages 1320-1326.
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Chian-Ming Low M Ulgen & J W Gorrod. (1994) The Recognition of a Diarylimine as a Metabonate Produced During Incubation of N -Benzyl-4-chloroaniline with Hepatic Microsomal Preparations . Journal of Pharmacy and Pharmacology 46:7, pages 585-590.
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M Ulgen & J W Gorrod. (1992) Microsomal formation of N -benzyl-4-hydroxymethylaniline from N -benzyl-4-methylaniline . Journal of Pharmacy and Pharmacology 44:10, pages 865-866.
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Zvi RappoportPeter Hlavica & Michael Lehnerer. 2010. Patai's Chemistry of Functional Groups. Patai's Chemistry of Functional Groups.
M. Ülgen & J. W. Gorrod. (2000) Studies on thein vitro hepatic microsomal formation of amides during the metabolism of certain secondary and tertiary benzylic amines. European Journal of Drug Metabolism and Pharmacokinetics 25:2, pages 145-150.
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Ilkay Küçükgüzel, Mert Ülgen & John W Gorrod. (1999) In vitro hepatic microsomal metabolism of N-benzyl-N-methylaniline. Il Farmaco 54:5, pages 331-337.
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I. Küçükgüzel, M. Ülgen & J. W. Gorrod. (1997) In vitro microsomal metabolism of nuclear chloro substituted secondary amines and imines. European Journal of Drug Metabolism and Pharmacokinetics 22:4, pages 351-358.
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Mert Ulgen, Ufuk Ozer, Ilkay Kucukguzel & John W. Gorrod. (1997) MICROSOMAL METABOLISM OF N-BENZYL-N-ETHYLANILINE AND N-BENZYL-N-ETHYL-p-TOLUIDINE. Drug Metabolism and Drug Interactions 14:2.
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Mert Ulgen, Feyza Yilmaz, Seda Unsalan & John W. Gorrod. (1995) Chemical and Metabolic Studies on N-Benzyl-tert-Butylamine and its Potential Metabolites. Drug Metabolism and Drug Interactions 12:2.
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M. Ulgen, M. Kajbaf, J. H. Lamb, M. Jahanshahi, J. W. Gorrod & S. Naylor. (1994) Characterization of N-benzylcarbazole and its metabolites from microsomal mixtures by tandem mass spectrometry. European Journal of Drug Metabolism and Pharmacokinetics 19:4, pages 343-348.
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