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Xenobiotica
the fate of foreign compounds in biological systems
Volume 15, 1985 - Issue 12
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Research Article

Absorption, excretion and metabolism of tiquizium bromide in dogs, and relationship between pharmacological effect and plasma levels of unchanged drug

T. Nishikawa Research Laboratories Hokuriku Seiyaku Co., Ltd, Inokuchi Katsuyama-shi, Fukui, 911, Japan
,
O. Nagata Research Laboratories Hokuriku Seiyaku Co., Ltd, Inokuchi Katsuyama-shi, Fukui, 911, Japan
,
K. Tanbo Research Laboratories Hokuriku Seiyaku Co., Ltd, Inokuchi Katsuyama-shi, Fukui, 911, Japan
,
T. Yamada Research Laboratories Hokuriku Seiyaku Co., Ltd, Inokuchi Katsuyama-shi, Fukui, 911, Japan
,
Y. Takahara Research Laboratories Hokuriku Seiyaku Co., Ltd, Inokuchi Katsuyama-shi, Fukui, 911, Japan
,
H. Kato Research Laboratories Hokuriku Seiyaku Co., Ltd, Inokuchi Katsuyama-shi, Fukui, 911, Japan
&
Y. Yamamoto Faculty of Pharmaceutical Sciences, Kanazawa University, Takara-machi, Kanazawa, 920, Japan
 show all
Pages 1053-1060 | Received 30 Jan 1985, Published online: 22 Sep 2008

Citations (9)

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R. J. S. Hickman, B. J. Christie, R. W. Guy & T. J. White. (1992) Thioethers as urinary metabolites of thiophene and monobromothiophenes. Xenobiotica 22:8, pages 917-923.
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Articles from other publishers (8)

Derek R. Boyd, Narain D. Sharma, Paul J. Stevenson, Patrick Hoering, Christopher C. R. Allen & Patrick M. Dansette. (2022) Monooxygenase- and Dioxygenase-Catalyzed Oxidative Dearomatization of Thiophenes by Sulfoxidation, cis-Dihydroxylation and Epoxidation. International Journal of Molecular Sciences 23:2, pages 909.
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Christine Medower, Lian Wen & William W. Johnson. (2008) Cytochrome P450 Oxidation of the Thiophene-Containing Anticancer Drug 3-[(Quinolin-4-ylmethyl)-amino]-thiophene-2-carboxylic Acid (4-Trifluoromethoxy-phenyl)-amide to an Electrophilic Intermediate. Chemical Research in Toxicology 21:8, pages 1570-1577.
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Patrick M. Dansette, Gildas Bertho & Daniel Mansuy. (2005) First evidence that cytochrome P450 may catalyze both S-oxidation and epoxidation of thiophene derivatives. Biochemical and Biophysical Research Communications 338:1, pages 450-455.
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Alexander Treiber. (2002) Mechanism of the Aromatic Hydroxylation of Thiophene by Acid-Catalyzed Peracid Oxidation. The Journal of Organic Chemistry 67:21, pages 7261-7266.
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Pascale Pouzet, Irene Erdelmeier, Patrick M. Dansette & Daniel Mansuy. (1998) Synthesis of (4-chlorophenyl)-(1-oxo-1λ4-benzo[b]thien-2-yl)methanone and study of its reactivity towards sulfur- and oxygen-containing nucleophiles. Tetrahedron 54:49, pages 14811-14824.
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Jeffery B. Press. 1991. Chemistry of Heterocyclic Compounds. Chemistry of Heterocyclic Compounds 397 502 .
E. Neau, P.M. Dansette, V. Andronik & D. Mansuy. (1990) Hydroxylation of the thiophene ring by hepatic monooxygenases. Biochemical Pharmacology 39:6, pages 1101-1107.
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P.M. Dansette, C. Amar, C. Smith, C. Pons & D. Mansuy. (1990) Oxidative activation of the thiophene ring by hepatic enzymes. Biochemical Pharmacology 39:5, pages 911-918.
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