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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 11
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Original Article

A comparison of in vivo and in vitro metabolites of the H1-antagonist N, N-dimethyl-N'-2-pyridyl-N'-(2-thienylmethyl)- 1,2-ethanediamine (methapyrilene) in the rat

S. S. Singer NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Frederick, MD, 21701, USA
,
W. Lijinsky NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Frederick, MD, 21701, USA
,
L. E. Kratz NCI-Frederick Cancer Research Facility, BRI-Basic Research Program, Frederick, MD, 21701, USA
,
N. Castagnoli Jr Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94143, USA
&
J. E. Rose Department of Pharmaceutical Chemistry, University of California, San Francisco, San Francisco, CA, 94143, USA
Pages 1279-1291 | Received 29 Sep 1986, Published online: 30 Sep 2009

Citations (6)

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D. W. Kelly, C. L. Holder, W. A. Korfmacher, T. A. Getek, J. O. Lay, D. A. Casciano, J. G. Shaddock, H. M. Duhart & W. Slikker. (1992) Metabolism of methapyrilene by Fischer-344 rat and B6C3F1 mouse hepatocytes. Xenobiotica 22:12, pages 1367-1381.
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Articles from other publishers (5)

Emma E. Graham, Rachel J. Walsh, Charlotte M. Hirst, James L. Maggs, Scott Martin, Martin J. Wild, Ian D. Wilson, John R. Harding, J. Gerald Kenna, Raimund M. Peter, Dominic P. Williams & B. Kevin Park. (2008) Identification of the Thiophene Ring of Methapyrilene as a Novel Bioactivation-Dependent Hepatic Toxicophore. Journal of Pharmacology and Experimental Therapeutics 326:2, pages 657-671.
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Hisham K. Hamadeh, Brian L. Knight, Astrid C. Haugen, Stella Sieber, Rupesh P. Amin, Pierre R. Bushel, Raymond Stoll, Kerry Blanchard, Supriya Jayadev, Raymond W. Tennant, Michael L. Cunningham, Cynthia A. Afshari & Richard S. Paules. (2016) Methapyrilene Toxicity: Anchorage of Pathologic Observations to Gene Expression Alterations. Toxicologic Pathology 30:4, pages 470-482.
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Gurpreet S Ratra, Winston A Morgan, Jenny Mullervy, Christopher J Powell & Matthew C Wright. (1998) Methapyrilene hepatotoxicity is associated with oxidative stress, mitochondrial disfunction and is prevented by the Ca2+ channel blocker verapamil. Toxicology 130:2-3, pages 79-93.
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John W. Gorrod, Catherine M. C. Whittlesea & Siu Ping Lam. 1991. Biological Reactive Intermediates IV. Biological Reactive Intermediates IV 657 664 .
Jeffery B. Press. 1991. Chemistry of Heterocyclic Compounds. Chemistry of Heterocyclic Compounds 397 502 .

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