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Xenobiotica
the fate of foreign compounds in biological systems
Volume 17, 1987 - Issue 11
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Original Article

Absorption, distribution and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs

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Pages 1341-1349 | Received 12 Dec 1986, Published online: 30 Sep 2009

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Yoshiyuki Saito, Hiroshi Ohguro, Ikuyo Ohguro, Noriyuki Sato, Futoshi Ishikawa, Hitoshi Yamazaki, Tomomi Metoki, Tadashi Ito & Mitsuru Nakazawa. (2008) Misregulation of rhodopsin phosphorylation and dephosphorylation found in P23H rat retinal degeneration. Clinical Ophthalmology 2:4, pages 821-828.
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S. Terashita, T. Sawamoto, S. Deguchi, Y. Tokuma & T. Hata. (1995) Sex-dependent and independent renal excretion of nilvadipine metabolites in rat: evidence for a sex-dependent active secretion in kidney. Xenobiotica 25:1, pages 37-47.
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M. Pellegatti, P. Grossi, J. Ayrton, G. L. Evans & A. J. Harker. (1990) Absorption, distribution and excretion of lacidipine, a dihydropyridine calcium antagonist, in rat and dog. Xenobiotica 20:8, pages 765-777.
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S. Terashita, Y. Tokuma, M. Sekiguchi & H. Noguchi. (1989) Sex differences in the metabolism and excretion of nilvadipine, a new dihydropyridine calcium antagonist, in rats. Xenobiotica 19:11, pages 1221-1229.
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Y. Tokuma, M. Sekiguchi, T. Niwa & H. Noguchi. (1988) Pharmacokinetics of nilvadipine, a new dihydropyridine calcium antagonist, in mice, rats, rabbits and dogs. Xenobiotica 18:1, pages 21-28.
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S. Terashita, Y. Tokuma, T. Fujiwara, Y. Shiokawa, K. Okumura & H. Noguchi. (1987) Metabolism of nilvadipine, a new dihydropyridine calcium antagonist, in rats and dogs. Xenobiotica 17:12, pages 1415-1425.
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Articles from other publishers (27)

Hidekazu Tsuruga, Hiroshi Murata, Makoto Araie & Makoto Aihara. (2023) Neuroprotective effect of the calcium channel blocker nilvadipine on retinal ganglion cell death in a mouse ocular hypertension model. Heliyon 9:3, pages e13812.
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Toshiro SakaiKazuhiro SakoMasahiro Hayashi. (2011) Factors Affecting the Absorption of Nilvadipine from Disintegration-Controlled Matrix Tablet in Dogs. Biological and Pharmaceutical Bulletin 34:11, pages 1731-1736.
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Mitsuru Nakazawa. (2011) Effects of Calcium Ion, Calpains, and Calcium Channel Blockers on Retinitis Pigmentosa. Journal of Ophthalmology 2011, pages 1-7.
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A. Uemura & A. Mizota. (2018) Retinal Concentration and Protective Effect against Retinal Ischemia of Nilvadipine in Rats. European Journal of Ophthalmology 18:1, pages 87-93.
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Kimio Takeuchi, Mitsuru Nakazawa & Sayuri Mizukoshi. (2008) Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds) mouse. Experimental Eye Research 86:1, pages 60-69.
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Haruo Hanyu, Kentaro Hirao, Soichiro Shimizu, Toshihiko Iwamoto, Kiyoshi Koizumi & Kimihiko Abe. (2007) Favourable effects of nilvadipine on cognitive function and regional cerebral blood flow on SPECT in hypertensive patients with mild cognitive impairment. Nuclear Medicine Communications 28:4, pages 281-287.
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Yukito Shinohara, Hideo Tohgi, Shunsaku Hirai, Akiro Terashi, Yasuo Fukuuchi, Takenori Yamaguchi & Toshio Okudera. (2007) Effect of the Ca Antagonist Nilvadipine on Stroke Occurrence or Recurrence and Extension of Asymptomatic Cerebral Infarction in Hypertensive Patients with or without History of Stroke (PICA Study). Cerebrovascular Diseases 24:2-3, pages 202-209.
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Tsugihisa SasakiYuusuke NakataniKazuhisa Sugiyama. (2006) The Inhibitory Effect of Nilvadipine on Calcium Channels in Retinal Ganglion Cells in Goldfish. Journal of Ocular Pharmacology and Therapeutics 22:6, pages 455-459.
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Huadong Tang & Michael Mayersohn. (2006) A global examination of allometric scaling for predicting human drug clearance and the prediction of large vertical allometry**This work was presented at the American Association of Pharmaceutical Scientists Annual meeting, Salt Lake City, USA, Oct. 26, 2003.. Journal of Pharmaceutical Sciences 95:8, pages 1783-1799.
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Nobuyuki Tanaka, Keiji Imai, Kazuto Okimoto, Satoshi Ueda, Yuji Tokunaga, Rinta Ibuki, Kazutaka Higaki & Toshikiro Kimura. (2006) Development of novel sustained-release system, disintegration-controlled matrix tablet (DCMT) with solid dispersion granules of nilvadipine (II): In vivo evaluation. Journal of Controlled Release 112:1, pages 51-56.
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Huadong Tang & Michael Mayersohn. (2005) A NOVEL MODEL FOR PREDICTION OF HUMAN DRUG CLEARANCE BY ALLOMETRIC SCALING. Drug Metabolism and Disposition 33:9, pages 1297-1303.
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Toshiki Himeda, Shiori Kanbara, Chie Oki, Hiroyuki Kato & Tsutomu Araki. (2005) Effects of Chronic Administration with Nilvadipine Against Immunohistochemical Changes Related to Aging in the Mouse Hippocampus. Metabolic Brain Disease 20:2, pages 141-153.
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Shahab Bohlooli, Fariborz Keyhanfar & Massoud Mahmoudian. (2004) Pharmacokinetics of mebudipine, a new calcium antagonist, following single intravenous and oral administrations in rats. Biopharmaceutics & Drug Disposition 25:4, pages 187-191.
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Yoshiko Takano, Hiroshi Ohguro, Mari Dezawa, Hiroto Ishikawa, Hitoshi Yamazaki, Ikuyo Ohguro, Kazuhisa Mamiya, Tomomi Metoki, Futoshi Ishikawa & Mitsuru Nakazawa. (2004) Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochemical and Biophysical Research Communications 313:4, pages 1015-1022.
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Yuan H Zhao, Michael H Abraham, Joelle Le, Anne Hersey, Chris N Luscombe, Gordon Beck, Brad Sherborne & Ian Cooper. (2003) Evaluation of rat intestinal absorption data and correlation with human intestinal absorption. European Journal of Medicinal Chemistry 38:3, pages 233-243.
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Rumiko Kurosaki, Megumi Akasaka, Mari Michimata, Mitsunobu Matsubara, Yutaka Imai & Tsutomu Araki. (2003) Effects of Ca2+ antagonists on motor activity and the dopaminergic system in aged mice. Neurobiology of Aging 24:2, pages 315-319.
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M. Stefek, V. Faberova, S. Musil & I. Kakalik. (2001) Urinary excretion of the 1,4-dihydropyridine calcium antagonist VULM 993 and its metabolites in the rat. European Journal of Drug Metabolism and Pharmacokinetics 26:4, pages 221-226.
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Hitoshi Ishibashi, Yoshinaka Murai & Norio Akaike. (1998) Effect of nilvadipine on the voltage-dependent Ca2+ channels in rat hippocampal CA1 pyramidal neurons. Brain Research 813:1, pages 121-127.
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Shinya Uchida, Shizuo Yamada, Kenji Nagai, Yoshiharu Deguchi & Ryohei Kimura. (1997) Brain pharmacokinetics and in vivo receptor binding of 1,4-dihydropyridine calcium channel antagonists. Life Sciences 61:21, pages 2083-2090.
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Hitoshi Ishibashi, Jeong Seop Rhee & Norio Akaike. (1997) Effect of nilvadipine on high-voltage activated Ca2+ channels in rat CNS neurons. NeuroReport 8:4, pages 853-857.
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Yoji Tokuma & Hideyo Noguchi. (1995) Stereoselective pharmacokinetics of dihydropyridine calcium antagonists. Journal of Chromatography A 694:1, pages 181-193.
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Shoji Takakura, Keizo Sogabe, Hisashi Satoh, Jo Mori, Tomoichi Fujiwara, Zenzaburou Totsuka, Yoji Tokuma & Masanobu Kohsaka. (1992) Nilvadipine as a neuroprotective calcium entry blocker in a rat model of global cerebral ischemia. A comparative study with nicardipine hydrochloride. Neuroscience Letters 141:2, pages 199-202.
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Shoji Takakura, Yasuhisa Furuichi, Hisashi Satoh, Jo Mori & Masanobu Kohsaka. (1992) Effects of nilvadipine on neuronal function in the ischemic cat brain. Surgical Neurology 37:4, pages 255-260.
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Natsuki Nakayama, Katsumi Ikezono, Naoki Fujio, Hiroyuki Sasabe, Keisuke Kitaura, Shigeharu Tamada, Toshinobu Shirafuji & Youichi Yabuuchi. (2007) OPC‐13340, a New Potent and Long‐Acting Dihydropyridine Calcium Antagonist. Cardiovascular Drug Reviews 9:2, pages 147-157.
Crossref
Shoji Takakura, Teruo Susumu, Hisashi Satoh, Jo Mori, Akihiko Shiino & Jyoji Handa. (1991) Nilvadipine, a New Calcium Channel Blocker, Reduces Ischemic Brain Injury in Rats. Japanese Journal of Pharmacology 56:4, pages 547-550.
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T KuwakiH SatohT OnoF ShibayamaT YamashitaT Nishimura. (1989) Nilvadipine attenuates ischemic degradation of gerbil brain cytoskeletal proteins.. Stroke 20:1, pages 78-83.
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G. Baillet, A. Pourcelot, A. Weil, C. Prevost & P. Guichard. (1988) Radio high-performance liquid chromathographic determination of 14C-labelled LF 2-0254, A 1,4-dihydropyridine calcium antagonist, in rat and dog plasma using off-line liquid scintillation counting. Journal of Chromatography A 456, pages 183-190.
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