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Xenobiotica
the fate of foreign compounds in biological systems
Volume 21, 1991 - Issue 2
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Original Article

The disposition of [14C]-labelled benazepril HC1 in normal adult volunteers after single and repeated oral dose

F. Waldmeier Research and Development Department, Pharmaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland
,
G. Kaiser Research and Development Department, Pharmaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland
,
R. Ackermann Research and Development Department, Pharmaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland
,
J. W. Faigle Research and Development Department, Pharmaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland
,
J. Wagner Research and Development Department, Pharmaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland
,
A. Barner Medical Department, Pharmaceuticals Division, Ciba-Geigy Ltd, Basle, Switzerland
&
K. C. Lasseter Clinical Pharmacology Associates, Inc., Miami, Florida, USA
 show all
Pages 251-261 | Received 30 Oct 1989, Accepted 12 Jul 1990, Published online: 27 Aug 2009

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Vivencio Barrios & Carlos Escobar. (2010) Antihypertensive and organ-protective effects of benazepril. Expert Review of Cardiovascular Therapy 8:12, pages 1653-1671.
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Sarah J. Roffey, R. Scott Obach, Jenny I. Gedge & Dennis A. Smith. (2007) What is the Objective of the Mass Balance Study? A Retrospective Analysis of Data in Animal and Human Excretion Studies Employing Radiolabeled Drugs. Drug Metabolism Reviews 39:1, pages 17-43.
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Steven G Chrysant & George S Chrysant. (2003) Pharmacological profile and clinical use of moexipril. Expert Review of Cardiovascular Therapy 1:3, pages 345-352.
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F. Waldmeier, G. Flesch, P. Mu Ller, T. Winkler, H.- P. Kriemler, P. Buhlmayer & M. De Gasparo. (1997) Pharmacokinetics, disposition and biotransformation of [14C]-radiolabelled valsartan in healthy male volunteers after a single oral dose. Xenobiotica 27:1, pages 59-71.
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Edmund Hoppe, Nicola J. Hewitt, Hans-Peter Buchstaller, Hans-Michael Eggenweiler, Christian Sirrenberg, Astrid Zimmermann, Joachim März, Harry Schwartz, Christoph Saal, Michael Meyring & Stefan Hecht. (2014) A Novel Strategy for ADME Screening of Prodrugs: Combined Use of Serum and Hepatocytes to Integrate Bioactivation and Clearance, and Predict Exposure to Both Active and Prodrug to the Systemic Circulation. Journal of Pharmaceutical Sciences 103:5, pages 1504-1514.
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Xue-Ding Wang, Eli Chan, Xiao Chen, Xiao-Xing Liao, Cheng Tang, Zhi-Wei Zhou, Min Huang & Shu-Feng Zhou. (2007) Simultaneous and rapid quantitation of benazepril and benazeprilat in human plasma by high performance liquid chromatography with ultraviolet detection. Journal of Pharmaceutical and Biomedical Analysis 44:1, pages 224-230.
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Bernard Testa. (2004) Prodrug research: futile or fertile?. Biochemical Pharmacology 68:11, pages 2097-2106.
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David J. Burinsky & Scott L. Sides. (2004) Mass spectral fragmentation reactions of angiotensin-converting enzyme (ACE) inhibitors. Journal of the American Society for Mass Spectrometry 15:9, pages 1300-1314.
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Steven G. Chrysant & George S. Chrysant. (2004) Pharmacological and Clinical Profile of Moexipril: A Concise Review. The Journal of Clinical Pharmacology 44:8, pages 827-836.
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Yuan H. Zhao, Joelle Le, Michael H. Abraham, Anne Hersey, Peter J. Eddershaw, Chris N. Luscombe, Darko Boutina, Gordon Beck, Brad Sherborne, Ian Cooper & James A. Platts. (2001) Evaluation of human intestinal absorption data and subsequent derivation of a quantitative structure–activity relationship (QSAR) with the Abraham descriptors. Journal of Pharmaceutical Sciences 90:6, pages 749-784.
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Per Eystein Lønning, Jürgen Geisler, Dag Clement Johannessen, Hans-Peter Gschwind, Felix Waldmeier, Werner Schneider, Bruno Galli, Tammo Winkler, Wolfgang Blum, Hans-Peter Kriemler, William Russell Miller & Johann Werner Faigle. (2001) Pharmacokinetics and metabolism of formestane in breast cancer patients. The Journal of Steroid Biochemistry and Molecular Biology 77:1, pages 39-47.
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T Radhakrishna, D.Sreenivas Rao, K Vyas & G.Om Reddy. (2000) A validated method for the determination and purity evaluation of benazepril hydrochloride in bulk and in pharmaceutical dosage forms by liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis 22:4, pages 641-650.
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Danielle Colussi, Claire Caron & Jacques Godbillon. (1996) Benazepril and benazeprilat binding to albumin and serum proteins. European Journal of Pharmaceutical Sciences 4:3, pages 139-145.
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P. Dominiak & W. Raasch. 1996. ACE-Hemmer in Klinik und Praxis. ACE-Hemmer in Klinik und Praxis 57 105 .
Michael Stimpel, Rainer Bonn, Brigitte Koch & Kenneth Dickstein. (2007) Pharmacology and Clinical Use of the New ACE‐Inhibitor Moexipril. Cardiovascular Drug Reviews 13:3, pages 211-229.
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J.S. Kim, R.L. Oberle, Daniel A. Krummel, J.B. Dressman & D. Fleisher. (1994) Absorption of Ace Inhibitors from Small Intestine and Colon. Journal of Pharmaceutical Sciences 83:9, pages 1350-1356.
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D. J. Clarke & B. Burchell. 1994. Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity. Conjugation—Deconjugation Reactions in Drug Metabolism and Toxicity 3 43 .
Ch. Schweizer, G. Kaiser, W. Dieterle & J. Mann. (1993) Pharmacokinetics and pharmacodynamics of benazepril hydrochloride in patients with major proteinuria. European Journal of Clinical Pharmacology 44:5, pages 463-466.
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Janet R. Wade, David M. Hughes, Andrew W. Kelman, Catherine A. Howie & Peter A. Meredith. (1993) A Novel Statistical Approach for the Comparison of Analytical Methods to Measure Angiotensin Converting Enzyme Activity, Enalaprilat, and Benazeprilat. Journal of Pharmaceutical Sciences 82:5, pages 471-474.
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JR Wade, PA Meredith, DM Hughes & HL Elliott. (2012) The effect of saturation of ACE binding sites on the pharmacokinetics of enalaprilat in man.. British Journal of Clinical Pharmacology 33:2, pages 155-160.
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