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Xenobiotica
the fate of foreign compounds in biological systems
Volume 22, 1992 - Issue 7
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Research Article

Role of metabolism and pharmacokinetic studies in the discovery of new drugs—present and future perspectives

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Pages 743-755 | Received 04 Jul 1991, Accepted 14 Feb 1992, Published online: 22 Sep 2008

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Siva Nageswara Rao Gajula, Nimisha Nadimpalli & Rajesh Sonti. (2021) Drug metabolic stability in early drug discovery to develop potential lead compounds. Drug Metabolism Reviews 53:3, pages 459-477.
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M. J. Humphrey. (1996) Application of Metabolism and Pharmacokinetic Studies to the Drug Discovery Process. Drug Metabolism Reviews 28:3, pages 473-489.
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Ala F. Nassar. 2010. Biotransformation and Metabolite Elucidation of Xenobiotics. Biotransformation and Metabolite Elucidation of Xenobiotics 163 216 .
Myung Joo KANG, Woo Heon SONG, Byung Ho SHIM, Seung Youn OH, Hyun Young LEE, Eun Young CHUNG, Yesung SOHN & Jaehwi LEE. (2010) Pharmacologically Active Metabolites of Currently Marketed Drugs: Potential Resources for New Drug Discovery and Development. YAKUGAKU ZASSHI 130:10, pages 1325-1337.
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Alaa-Eldin F. Nassar, Amin M. Kamel & Caroline Clarimont. (2004) Improving the decision-making process in the structural modification of drug candidates: enhancing metabolic stability. Drug Discovery Today 9:23, pages 1020-1028.
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Gary W. Caldwell, Zhengyin Yan, John A. Masucci, William Hageman, Gregory Leo & David M. Ritchie. (2012) Applied Pharmacokinetics in Drug Development. Pharmaceutical Development and Regulation 1:2, pages 117-132.
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Srinivasu Poondru, Ralph E. Parchment, Vivek Purohit, Patricia LoRusso, Jerome P. Horwitz, Stuart T. Hazeldine, Lisa Polin, Thomas Corbett & Bhaskara R. Jasti. (2002) Lack of in Vitro – in Vivo Correlation of a Novel Investigational Anticancer Agent, SH 30. Investigational New Drugs 20:1, pages 23-33.
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Thomas N. Thompson. (2001) Optimization of metabolic stability as a goal of modern drug design. Medicinal Research Reviews 21:5, pages 412-449.
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Jack L. Segal MD, Keith C. Hayes, Sherry R. Brunnemann, Jane T. C. Hsieh, Patrick J. Potter, Mayank S. Pathak, David S. Tierney & David Mason. (2013) Absorption Characteristics of Sustained‐Release 4‐Aminopyridine (Fampridine SR) in Patients with Chronic Spinal Cord Injury. The Journal of Clinical Pharmacology 40:4, pages 402-409.
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L. Williams, D. P. Hill, J. A. Davis & D. T. Lowenthal. (1996) The influence of food on the absorption and metabolism of drugs: an update. European Journal of Drug Metabolism and Pharmacokinetics 21:3, pages 201-211.
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S.J. Barnett. (1996) A literature review looking at contemporary developments in antimicrobial agents, with special reference to applications in the field of podiatry. The Foot 6:2, pages 51-57.
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Steven A. Wrighton, Barbara J. Ring & Mark Vandenbranden. (2016) The Use of In Vitro Metabolism Techniques in the Planning and Interpretation of Drug Safety Studies. Toxicologic Pathology 23:2, pages 199-208.
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Mitchell N. Cayen. (2016) Considerations in the Design of Toxicokinetic Programs. Toxicologic Pathology 23:2, pages 148-157.
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Anthony Y. H. Lu. 1995. Molecular Aspects of Oxidative Drug Metabolizing Enzymes. Molecular Aspects of Oxidative Drug Metabolizing Enzymes 503 513 .
Dennis A. Smith. (1994) Design of drugs through a consideration of drug metabolism and pharmacokinetics. European Journal of Drug Metabolism and Pharmacokinetics 19:3, pages 193-199.
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Alastair Monro. (1994) Drug toxicokinetics: scope and limitations that arise from species differences in pharmacodynamic and carcinogenic responses. Journal of Pharmacokinetics and Biopharmaceutics 22:1, pages 41-57.
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Manuel A. Navia & Debra A. Peattie. (1993) Structure-based drug design: applications in immunopharmacology and immunosuppression. Immunology Today 14:6, pages 296-302.
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Manuel A. Navia & Debra A. Peattie. (1993) Structure-based drug design: applications in immunopharmacology and immunosuppression. Trends in Pharmacological Sciences 14:5, pages 189-195.
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