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Xenobiotica
the fate of foreign compounds in biological systems
Volume 25, 1995 - Issue 4
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Research Article

Metabolism of thioridazine by microsomal monooxygenases: relative roles of P450 and flavin-containing monooxygenase

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Pages 377-393 | Received 08 Oct 1994, Published online: 22 Sep 2008

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Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
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C. MONTESISSA. (1998) In vitro metabolism of clenbuterol and bromobuterol by pig liver microsomes. Xenobiotica 28:11, pages 1049-1060.
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Slobodan Rendic & Frederick J. Di Carlo. (1997) Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors. Drug Metabolism Reviews 29:1-2, pages 413-580.
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Nikhil Taxak, Vinod Parmar, Dhilon S. Patel, Anuja Kotasthane & Prasad V. Bharatam. (2011) S-Oxidation of Thiazolidinedione with Hydrogen Peroxide, Peroxynitrous Acid, and C4a-Hydroperoxyflavin: A Theoretical Study. The Journal of Physical Chemistry A 115:5, pages 891-898.
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Michael Murray. (2006) Role of CYP pharmacogenetics and drug-drug interactions in the efficacy and safety of atypical and other antipsychotic agents. Journal of Pharmacy and Pharmacology 58:7, pages 871-885.
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Sharon K. Krueger & David E. Williams. (2005) Mammalian flavin-containing monooxygenases: structure/function, genetic polymorphisms and role in drug metabolism. Pharmacology & Therapeutics 106:3, pages 357-387.
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Cristiane Masetto de Gaitani, Alexandre Souto Martinez & Pierina Sueli Bonato. (2004) Degradation and configurational changes of thioridazine 2-sulfoxide. Journal of Pharmaceutical and Biomedical Analysis 36:3, pages 601-607.
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Michael B. Fisher, Kwansik Yoon, Marcie L. Vaughn, Timothy J. Strelevitz & Robert S. Foti. (2002) Flavin-Containing Monooxygenase Activity in Hepatocytes and Microsomes: In Vitro Characterization and In Vivo Scaling of Benzydamine Clearance. Drug Metabolism and Disposition 30:10, pages 1087-1093.
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Randy L. Rose. (2002) Measurements of Flavin‐Containing Monooxygenase ( FMO ) Activities . Current Protocols in Toxicology 13:1.
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Steven G. Potkin, Per T. Thyrum, Gustavo Alva, Rimal Bera, Chiao Yeh & Lisa A. Arvanitis. (2002) The Safety and Pharmacokinetics of Quetiapine When Coadministered With Haloperidol, Risperidone, or Thioridazine. Journal of Clinical Psychopharmacology 22:2, pages 121-130.
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Wladyslawa A Daniel, Maciej Syrek, Anna Haduch & Jacek Wójcikowski. (2009) Pharmacokinetics and metabolism of thioridazine during co‐administration of tricyclic antidepressants. British Journal of Pharmacology 131:2, pages 287-295.
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W.A. Daniel, M. Syrek, A. Haduch & J. Wójcikowski. (1999) The influence of selective serotonin reuptake inhibitors (SSRIs) on the pharmacokinetics of thioridazine and its metabolites: in vivo and in vitro studies. Experimental and Toxicologic Pathology 51:4-5, pages 309-314.
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W.A. Daniel, M. Syrek & J. Wójcikowski. (1999) The influence of selective serotonin reuptake inhibitors on the plasma and brain pharmacokinetics of the simplest phenothiazine neuroleptic promazine in the rat. European Neuropsychopharmacology 9:4, pages 337-344.
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Ernest Hodgson, Nathan J. Cherrington, Richard M. Philpot & Randy L. Rose. 1999. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes. Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes 55 70 .
J.Greg Falls, Nathan J. Cherrington, Kieran M. Clements, Richard M. Philpot, Patricia E. Levi, Randy L. Rose & Ernest Hodgson. (1997) Molecular Cloning, Sequencing, and Expression inEscherichia coliof Mouse Flavin-Containing Monooxygenase 3 (FMO3): Comparison with the Human Isoform. Archives of Biochemistry and Biophysics 347:1, pages 9-18.
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Winston W. Shen. (1997) The metabolism of psychoactive drugs: A review of enzymatic biotransformation and inhibition. Biological Psychiatry 41:7, pages 814-826.
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Ge Lin, Ka-Wing Chu, Lyaquatali A. Damani & Edward M. Hawes. (1996) Identification of lactams as in vitro metabolites of piperidine-type phenothiazine antipsychotic drugs. Journal of Pharmaceutical and Biomedical Analysis 14:6, pages 727-738.
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E Hodgson & P E Levi. (1996) Pesticides: an important but underused model for the environmental health sciences.. Environmental Health Perspectives 104:suppl 1, pages 97-106.
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E. Hodgson, R.L. Rose, D.-Y. Ryu, G. Falls, B.L. Blake & P.E. Levi. (1995) Pesticide-metabolizing enzymes. Toxicology Letters 82-83, pages 73-81.
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J. Greg Falls, Bonnie L. Blake, Yan Cao, Patricia E. Levi & Ernest Hodgson. (2006) Gender differences in hepatic expression of flavin‐containing monooxygenase isoforms (FMO1, FMO3, and FMO5) in Mice. Journal of Biochemical Toxicology 10:3, pages 171-177.
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