Publication Cover
Xenobiotica
the fate of foreign compounds in biological systems
Volume 26, 1996 - Issue 11
71
Views
23
CrossRef citations to date
0
Altmetric
Original Article

Effects of roxithromycin, erythromycin and troleandomycin on their N-demethylation by rat and human cytochrome P450 enzymes

, , , &
Pages 1143-1153 | Published online: 27 Aug 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (5)

M. Miyazawa & K. Gyoubu. (2007) Roles of human CYP2A6 and rat CYP2B1 in the oxidation of (+)-fenchol by liver microsomes. Xenobiotica 37:9, pages 943-953.
Read now
X. G. Shi, J. P. Fawcett, X. Y. Chen & D. F. Zhong. (2005) Structural identification of bitespiramycin metabolites in rat: A single oral dose study. Xenobiotica 35:4, pages 343-358.
Read now
Slobodan Rendic. (2002) Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metabolism Reviews 34:1-2, pages 83-448.
Read now
E. TANAKA, C. NARISAWA, H. NAKAMURA, Y. SAWA, H. ETOH, K. TADANO, T. HORIE, H. OHKAWA & S. MISAWA. (1998) Changes in the enzymatic activities of beagle liver during maturation as assessed both in vitro and in vivo. Xenobiotica 28:8, pages 795-802.
Read now

Articles from other publishers (18)

Liyun Zhang, Xiaoqing Xu, Sara Badawy, Awais Ihsan, Zhenli Liu, Changqing Xie, Xu Wang & Yanfei Tao. (2020) A Review: Effects of Macrolides on CYP450 Enzymes. Current Drug Metabolism 21:12, pages 928-937.
Crossref
Jiri Patocka, Qinghua Wu, Eugenie Nepovimova & Kamil Kuca. (2020) Phenytoin – An anti-seizure drug: Overview of its chemistry, pharmacology and toxicology. Food and Chemical Toxicology 142, pages 111393.
Crossref
Sara Rodrigues, Sara C. Antunes, Alberto T. Correia & Bruno Nunes. (2018) Toxicity of erythromycin to Oncorhynchus mykiss at different biochemical levels: detoxification metabolism, energetic balance, and neurological impairment. Environmental Science and Pollution Research 26:1, pages 227-239.
Crossref
Yi Qin, Weizhe Xu, Lanjian Mo, Xiaorong Li, Beikang Ge, Jie Xiong, Lifang Gao, Pinxiang Xu & Ming Xue. (2017) Comparison of Pharmacokinetics and Tissue Distribution Kinetics of Roxithromycin and Expression of CYP 3A1 between Pregnant Mice and Foetuses. Basic & Clinical Pharmacology & Toxicology 120:2, pages 146-151.
Crossref
Avanthika Venkatachalam, Abhinav Parashar & Kelath Murali Manoj. (2016) Functioning of drug-metabolizing microsomal cytochrome P450s: In silico probing of proteins suggests that the distal heme ‘active site’ pocket plays a relatively ‘passive role’ in some enzyme-substrate interactions. In Silico Pharmacology 4:1.
Crossref
G. Csikó, G. Nagy, G. Mátis, Z. Neogrády, A. Kulcsár, Á. Jerzsele, K. Szekér & P. Gálfi. (2014) Effects of dietary sodium butyrate on hepatic biotransformation and pharmacokinetics of erythromycin in chickens. Journal of Veterinary Pharmacology and Therapeutics 37:4, pages 406-412.
Crossref
Jianchao Liu, Guanghua Lu, Jiannan Ding, Zhenghua Zhang & Yonghua Wang. (2014) Tissue distribution, bioconcentration, metabolism, and effects of erythromycin in crucian carp (Carassius auratus). Science of The Total Environment 490, pages 914-920.
Crossref
Jianchao Liu, Guanghua Lu, Yonghua Wang, Zhenhua Yan, Xiaofan Yang, Jiannan Ding & Ze Jiang. (2014) Bioconcentration, metabolism, and biomarker responses in freshwater fish Carassius auratus exposed to roxithromycin. Chemosphere 99, pages 102-108.
Crossref
Adaweyah El-Merhibi, Suong N.T. Ngo, Tamara A. Crittenden, Ceilidh L. Marchant, Ieva Stupans & Ross A. McKinnon. (2011) Cytochrome P450 CYP3A in marsupials: Cloning and characterisation of the second identified CYP3A subfamily member, isoform 3A78 from koala (Phascolarctos cinereus). Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology 154:4, pages 367-376.
Crossref
Adaweyah El-Merhibi, Suong N.T. Ngo, Ceilidh L. Marchant, Tamara A. Height, Ieva Stupans & Ross A. McKinnon. (2011) WITHDRAWN: Cytochrome P450 CYP3A in marsupials: Characterisation of the first identified CYP3A subfamily member, isoform 3A70 from Eastern grey kangaroo (Macropus giganteus). Gene.
Crossref
Kanokwan Jarukamjorn, Therese Thalhammer, Bernd Gollackner, Ernst Pittenauer & Walter Jäger. (1998) Metabolism of Roxithromycin in the Isolated Perfused Rat Liver. Journal of Pharmacy and Pharmacology 50:5, pages 515-519.
Crossref
Olavi Pelkonen, Miia Turpeinen, Jukka Hakkola, Paavo Honkakoski, Janne Hukkanen & Hannu Raunio. (2008) Inhibition and induction of human cytochrome P450 enzymes: current status. Archives of Toxicology 82:10, pages 667-715.
Crossref
Christine Biagini, Virginie Bender, Françoise Borde, Elodie Boissel, Marie-Claire Bonnet, Marie-Thérèse Masson, Doris Cassio & Stephan Chevalier. (2006) Cytochrome P450 expression-induction profile and chemically mediated alterations of the WIF-B9 cell line. Biology of the Cell 98:1, pages 23-32.
Crossref
Maxwell Afari Gyamfi, Tatsuo Tanaka & Yoko Aniya. (2004) Selective suppression of cytochrome P450 gene expression by the medicinal herb, Thonningia sanguinea in rat liver. Life Sciences 74:14, pages 1723-1737.
Crossref
J.L.C.M Dorne, K Walton & A.G Renwick. (2003) Human variability in CYP3A4 metabolism and CYP3A4-related uncertainty factors for risk assessment. Food and Chemical Toxicology 41:2, pages 201-224.
Crossref
Yoshiro Kohno. 2003. Macrolide Antibiotics. Macrolide Antibiotics 327 361 .
Hisakazu Ohtani, Chieko Taninaka, Erika Hanada, Hajime Kotaki, Hitoshi Sato, Yasufumi Sawada & Tatsuji Iga. (2000) Comparative Pharmacodynamic Analysis of Q-T Interval Prolongation Induced by the Macrolides Clarithromycin, Roxithromycin, and Azithromycin in Rats. Antimicrobial Agents and Chemotherapy 44:10, pages 2630-2637.
Crossref
Robert J. Riley & D. Howbrook. (1997) In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin. Journal of Pharmacological and Toxicological Methods 38:4, pages 189-193.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.