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The American Journal of Drug and Alcohol Abuse
Encompassing All Addictive Disorders
Volume 41, 2015 - Issue 1
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Original Article

Varenicline, naltrexone, and their combination for heavy-drinking smokers: preliminary neuroimaging findings

Lara A. RayDepartments of Psychology, ;Psychiatry and Biobehavioral Sciences, Correspondence[email protected]
, PhD,
Kelly E. CourtneyDepartments of Psychology,
, MA,
Dara G. GhahremaniPsychiatry and Biobehavioral Sciences,
, PhD,
Karen MiottoPsychiatry and Biobehavioral Sciences,
, MD,
Arthur BrodyPsychiatry and Biobehavioral Sciences, ;Research, VA Greater Los Angeles Healthcare System, and
, MD &
Edythe D. LondonPsychiatry and Biobehavioral Sciences, ;Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA, USA
, PhD
Pages 35-44 | Received 02 Jan 2014, Accepted 20 May 2014, Published online: 20 Jun 2014

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An-Li Wang, Zhenhao Shi, Igor Elman & Daniel D. Langleben. (2020) Reduced cigarette smoking during injectable extended-release naltrexone treatment for opioid use disorder. The American Journal of Drug and Alcohol Abuse 46:4, pages 472-477.
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Michael Soyka & Christian A. Müller. (2017) Pharmacotherapy of alcoholism – an update on approved and off-label medications. Expert Opinion on Pharmacotherapy 18:12, pages 1187-1199.
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Articles from other publishers (23)

Xingbao Li, Kevin A. Caulfield, Karen. J. Hartwell, Scott Henderson, Kathleen T. Brady & Mark S. George. (2023) Reduced executive and reward connectivity is associated with smoking cessation response to repetitive transcranial magnetic stimulation: A double-blind, randomized, sham-controlled trial. Brain Imaging and Behavior.
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Steven J. Nieto, Craig K. Enders, Katie Witkiewitz, Stephanie S. O'Malley & Lara A. Ray. (2022) Combination treatment with varenicline and naltrexone reduces World Health Organization risk drinking levels. Alcoholism: Clinical and Experimental Research 46:12, pages 2258-2266.
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Pascal Valentin Fischler, Michael Soyka, Erich Seifritz & Jochen Mutschler. (2022) Off-label and investigational drugs in the treatment of alcohol use disorder: A critical review. Frontiers in Pharmacology 13.
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Lara A. RayReJoyce GreenCraig EndersAdam M. LeventhalErica N. GrodinGang LiAaron LimEmily HartwellAlex VenegasLindsay MeredithSteven J. NietoSteven ShoptawDiana HoKaren Miotto. (2021) Efficacy of Combining Varenicline and Naltrexone for Smoking Cessation and Drinking Reduction: A Randomized Clinical Trial. American Journal of Psychiatry 178:9, pages 818-828.
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Erica N. Grodin, Elizabeth M. Burnette, ReJoyce Green, Aaron C. Lim, Karen Miotto & Lara A. Ray. (2021) Combined varenicline and naltrexone attenuates alcohol cue-elicited activation in heavy drinking smokers. Drug and Alcohol Dependence 225, pages 108825.
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Ana Domi, Estelle Barbier, Louise Adermark & Esi Domi. (2021) Targeting the Opioid Receptors: A Promising Therapeutic Avenue for Treatment in “Heavy Drinking Smokers”. Alcohol and Alcoholism 56:2, pages 127-138.
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Awirut Oon-arom, Surinporn Likhitsathain & Manit Srisurapanont. (2019) Efficacy and acceptability of varenicline for alcoholism: A systematic review and meta-analysis of randomized-controlled trials. Drug and Alcohol Dependence 205, pages 107631.
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Aaron C. Lim, Dara G. Ghahremani, Erica N. Grodin, ReJoyce Green, Spencer Bujarski, Emily E. Hartwell, Kelly E. Courtney, Kent Hutchison, Karen Miotto & Lara A. Ray. (2019) Neuroimaging findings from an experimental pharmacology trial of naltrexone in heavy drinkers of East Asian descent. Drug and Alcohol Dependence 200, pages 181-190.
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Amanda Elton, Samantha Dove, Cory N. Spencer, Donita L. Robinson & Charlotte A. Boettiger. (2019) Naltrexone Acutely Enhances Connectivity Between the Ventromedial Prefrontal Cortex and a Left Frontoparietal Network. Alcoholism: Clinical and Experimental Research 43:5, pages 965-978.
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Andrew T. Fox, Delwyn Catley, Kimber P. Richter, Edward F. Ellerbeck, Morgan G. Brucks, Vlad B. Papa & Laura E. Martin. (2018) Functional brain activation changes associated with practice in delaying smoking among moderate to heavy smokers: study protocol and rationale of a randomized trial (COPE). Trials 19:1.
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Yanhui Liao, Maritza Johnson, Chang Qi, Qiuxia Wu, An Xie, Jianbin Liu, Mei Yang, Maifang Huang, Yan Zhang, Tieqiao Liu, Wei Hao & Jinsong Tang. (2018) Cue-Induced Brain Activation in Chronic Ketamine-Dependent Subjects, Cigarette Smokers, and Healthy Controls: A Task Functional Magnetic Resonance Imaging Study. Frontiers in Psychiatry 9.
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Xingbao Li, Gregory L. Sahlem, Bashar W. Badran, Lisa M. McTeague, Colleen A. Hanlon, Karen. J. Hartwell, Scott Henderson & Mark S. George. (2017) Transcranial magnetic stimulation of the dorsal lateral prefrontal cortex inhibits medial orbitofrontal activity in smokers. The American Journal on Addictions 26:8, pages 788-794.
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Haval Norman & Manoranjan S. D’Souza. (2017) Endogenous opioid system: a promising target for future smoking cessation medications. Psychopharmacology 234:9-10, pages 1371-1394.
Crossref
Janice C. Froehlich, Stephen M. Fischer, Emily R. Nicholson, Julian E. Dilley, Nicholas J. Filosa, Teal N. Smith & Logan C. Rademacher. (2017) A Combination of Naltrexone + Varenicline Retards the Expression of a Genetic Predisposition Toward High Alcohol Drinking. Alcoholism: Clinical and Experimental Research 41:3, pages 644-652.
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Richard J. Bodnar. (2017) Endogenous Opiates and Behavior: 2015. Peptides 88, pages 126-188.
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Kelly E Courtney, Dara G Ghahremani & Lara A Ray. (2016) The Effects of Pharmacological Opioid Blockade on Neural Measures of Drug Cue-Reactivity in Humans. Neuropsychopharmacology 41:12, pages 2872-2881.
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Elizabeth A. Cabrera, Corinde E. Wiers, Elsa Lindgren, Gregg Miller, Nora D. Volkow & Gene-Jack Wang. (2016) Neuroimaging the Effectiveness of Substance Use Disorder Treatments. Journal of Neuroimmune Pharmacology 11:3, pages 408-433.
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Joshua L. Gowin, Vatsalya Vatsalya, Jonathan G. Westman, Melanie L. Schwandt, Selena Bartlett, Markus Heilig, Reza Momenan & Vijay A. Ramchandani. (2016) The Effect of Varenicline on the Neural Processing of Fearful Faces and the Subjective Effects of Alcohol in Heavy Drinkers. Alcoholism: Clinical and Experimental Research 40:5, pages 979-987.
Crossref
Mira Fauth-Bühler & Falk Kiefer. (2016) Alcohol and the Human Brain: a Systematic Review of Recent Functional Neuroimaging and Imaging Genetics Findings. Current Addiction Reports 3:1, pages 109-124.
Crossref
Daniel J. O. Roche, Lara A. Ray, Megan M. Yardley & Andrea C. King. (2016) Current Insights into the Mechanisms and Development of Treatments for Heavy-Drinking Cigarette Smokers. Current Addiction Reports 3:1, pages 125-137.
Crossref
Vatsalya Vatsalya, Joshua L. Gowin, Melanie L. Schwandt, Reza Momenan, Marion A. Coe, Megan E. Cooke, Daniel W. Hommer, Selena Bartlett, Markus Heilig & Vijay A. Ramchandani. (2015) Effects of Varenicline on Neural Correlates of Alcohol Salience in Heavy Drinkers. International Journal of Neuropsychopharmacology 18:12, pages pyv068.
Crossref
Megan M. Yardley, Michael M. Mirbaba & Lara A. Ray. (2015) Pharmacological Options for Smoking Cessation in Heavy-Drinking Smokers. CNS Drugs 29:10, pages 833-845.
Crossref
Lara A Ray, Spencer Bujarski, Kelly E Courtney, Nathasha R Moallem, Katy Lunny, Daniel Roche, Adam M Leventhal, Steve Shoptaw, Keith Heinzerling, Edythe D London & Karen Miotto. (2015) The Effects of Naltrexone on Subjective Response to Methamphetamine in a Clinical Sample: a Double-Blind, Placebo-Controlled Laboratory Study. Neuropsychopharmacology 40:10, pages 2347-2356.
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