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HELLP syndrome: Understanding and management of a pregnancy-specific disease

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Pages 331-337 | Published online: 08 May 2013

Keep up to date with the latest research on this topic with citation updates for this article.

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Arthur J. Vaught, Evan Braunstein, Shruti Chaturvedi, Karin Blakemore & Robert A. Brodsky. (2022) A review of the alternative pathway of complement and its relation to HELLP syndrome: is it time to consider HELLP syndrome a disease of the alternative pathway. The Journal of Maternal-Fetal & Neonatal Medicine 35:7, pages 1392-1400.
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Ranit Hizkiyahu, Anat Rabinovich, Jecko Thachil, Eyal Sheiner, Gad Shaked, Gilbert Sebbag, Eli Maymon & Offer Erez. (2019) Modified ISTH pregnancy-specific DIC score in parturients with liver rupture: population-based case series. The Journal of Maternal-Fetal & Neonatal Medicine 32:15, pages 2517-2523.
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Articles from other publishers (40)

Fabio R Garrote, Miguel E Perez-Viloria, Charles Caltagirone & Carolina De La Cuesta. (2023) The Conservative Management of an Uncommon Case of Postpartum HELLP (Hemolysis, Elevated Liver Enzymes, and Low Platelet Count) Syndrome Complicated by Liver Hematoma Causing Gastric Outlet Obstruction: A Case Report. Cureus.
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Julia Rimboeck, Michael Gruber, Marco Weigl, Pia Huber, Dirk Lunz & Walter Petermichl. (2023) Obesity Correlates with Chronic Inflammation of the Innate Immune System in Preeclampsia and HELLP Syndrome during Pregnancy. Biomedicines 11:10, pages 2851.
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Qiujin Sun, Yifan Lu, Junhui Zhong, Xianchun Yang, Lu Zhong, Wenwen Zhang, Yanhua Weng, Zhengwen Xu, Yanhong Zhai & Zheng Cao. (2023) A Retrospective Case-Control Study on the Diagnostic Values of Hemostatic Markers in Hypertensive Disorder of Pregnancy. Laboratory Medicine 54:4, pages 392-399.
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Nidhi Chawla, Hinal Shah, Kathleen Huynh, Alex Braun, Hanna Wollocko & Nilank C. Shah. (2023) The Role of Platelet-Activating Factor and Magnesium in Obstetrics and Gynecology: Is There Crosstalk between Pre-Eclampsia, Clinical Hypertension, and HELLP Syndrome?. Biomedicines 11:5, pages 1343.
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A F Leeuwerik, L N van Merendonk, M A de Boer, A J Wilhelm, A Kolkman & P M Bet. (2023) A new approach to drug intravenous compatibility research: the case of obstetric parenteral drugs. European Journal of Hospital Pharmacy, pages ejhpharm-2022-003577.
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Ayane Nishio, Ryo Kamidani, Hideshi Okada, Keiko Suzuki, Kodai Suzuki, Takahito Miyake, Haruka Okamoto, Tomoaki Doi, Akio Suzuki, Shozo Yoshida & Shinji Ogura. (2023) Serum syndecan-1 concentration in hemolysis, elevated liver enzymes, and low platelets syndrome: A case report. Frontiers in Medicine 10.
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Ilona Hromadnikova, Katerina Kotlabova & Ladislav Krofta. (2023) First-Trimester Screening for HELLP Syndrome—Prediction Model Based on MicroRNA Biomarkers and Maternal Clinical Characteristics. International Journal of Molecular Sciences 24:6, pages 5177.
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Sonali Gupta, Lohana Petras, Muhammad Umer Tufail, Juan Diego Rodriguez Salazar & Belinda Jim. (2023) Hypertension in Pregnancy: What We Now Know. Current Opinion in Nephrology & Hypertension 32:2, pages 153-164.
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Philippe Ichai, Hanane Bouchghoul, Astrid Laurent-Bellue, Sophie-Caroline Sacleux, Marc Boudon, Daniel Cherqui, Pauline Tortajada, Marius Braun, Elise Lemaitre, Gabriella Pittau, Marie-Amélie Ordan, Sharon Levi, Daniel Azoulay, Herve Fernandez, Catherine Guettier, Didier Samuel & Faouzi Saliba. (2022) Urgent Liver Transplantation for Acute Liver Failure in Pregnant Women: The Optimum Timing for Delivery. Transplantation 107:1, pages 172-180.
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Reza Salari, Daniel R. Ludwig & Vincent M. Mellnick. 2023. Emergency Imaging of At-Risk Patients. Emergency Imaging of At-Risk Patients 100 113 .
David Zhao, Karissa Arthur, Iman Moeini-Naghani & Michelle Johansen. 2023. Contemporary Topics in Cardio-Obstetrics. Contemporary Topics in Cardio-Obstetrics 197 217 .
Zahra Asadikalameh, Reza Maddah, Mohsen Maleknia, Zohre S. Nassaj, Neda Seyed Ali, Sepideh Azizi & Fatemeh Dastyar. (2022) Bioinformatics analysis of microarray data to identify hub genes, as diagnostic biomarker of HELLP syndrome: System biology approach . Journal of Obstetrics and Gynaecology Research 48:10, pages 2493-2504.
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Afia Akhter, Fatima Saleem, Mian Muhammad Jehanzeb, Bushra Mubarak, Kainat Waheed, Iqra Munir, Marya Saadullah & Masooma Anwar. (2022) Leukocytosis and thrombocytopenia in pre-partum, post-partum cases and non-pregnant women. Pakistan BioMedical Journal, pages 160-164.
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Diana Borre Naranjo, Laura Saavedra Valencia, Alejandra Vergara Schotborgh, Oscar Lavalle López, Miguel Ángel Aguilar Schotborgh & Rodrigo Daza Arnedo. (2022) Plasmaféresis en síndrome Hellp: reporte de un caso y revisión de la literatura. Revista Ciencias Biomédicas 11:1, pages 92-99.
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Annsa C. Huang, Joshua GrabJennifer A. FlemmingJennifer L. DodgeRoxanna A. IraniMonika Sarkar. (2022) Pregnancies With Cirrhosis Are Rising and Associated With Adverse Maternal and Perinatal Outcomes. American Journal of Gastroenterology 117:3, pages 445-452.
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Jacqueline E. Birkness‐Gartman & Kiyoko Oshima. (2021) Liver pathology in pregnancy. Pathology International 72:1, pages 1-13.
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Connie W. Wang, Joshua Grab, Michele M. Tana, Roxanna A. Irani & Monika Sarkar. (2021) Outcomes of pregnancy in autoimmune hepatitis: A population‐based study. Hepatology 75:1, pages 5-12.
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Hong Wang, Guimei Shen, Mengsi Liu, Linjuan Mao & Hui Mao. (2021) Expression and clinical significance of lncRNA TCL6 in serum of patients with preeclampsia. Experimental and Therapeutic Medicine 23:1.
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Taner Cam, Gamze Nur Cimilli Senocak, Nurinnisa Ozturk & Emsal Pınar Topdagi Yilmaz. (2021) May human epididymis 4 protein play a role in the etiopathogenesis of hemolysis, elevated liver enzymes and low platelets ( HELLP) syndrome? . Journal of Obstetrics and Gynaecology Research 47:7, pages 2324-2328.
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Nirmal K Mohakud, Hari Yerru, Monalisha Rajguru & Sushree S Naik. (2020) An Assumed Vertical Transmission of SARS-CoV-2 During Pregnancy: A Case Report and Review of Literature. Cureus.
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Monika Sarkar, Joshua Grab, Jennifer L. Dodge, Erica P. Gunderson, Jessica Rubin, Roxanna A. Irani, Marcelle Cedars & Norah Terrault. (2020) Non-alcoholic fatty liver disease in pregnancy is associated with adverse maternal and perinatal outcomes. Journal of Hepatology 73:3, pages 516-522.
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Marco Pappaccogli, Aleksander PrejbiszSimina CiuricăRosa Maria BrunoAnna Aniszczuk-HybiakIrene BracalenteTine De BackerFrédéric DebièvePhilippe DelmotteSilvia Di MonacoFaiçal JarrayaDaniel GordinPrzemysław KosińskiAbraham A. Kroon, Angela H.E.M. MaasDenise MarconPietro MinuzEnrique Montagud-MarrahiAgnès PasquetEsteban PochFranco RabbiaGeorge S. StergiouIlkka TikkanenLaurent Toubiana, Wouter VinckEwa Warchoł-CelińskaPatricia Van der Niepen, Peter de Leeuw, Andrzej JanuszewiczAlexandre Persu. (2020) Pregnancy-Related Complications in Patients With Fibromuscular Dysplasia. Hypertension 76:2, pages 545-553.
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Violeta Stojanovska & Ana Claudia Zenclussen. (2020) Innate and Adaptive Immune Responses in HELLP Syndrome. Frontiers in Immunology 11.
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Melissa A. Merideth, Laura A. Harney, Nina Vyas, Averyl Bachi, Ann Garrity Carr, D. Ashley Hill, Louis P. Dehner, Kris Ann P. Schultz, Douglas R. Stewart & Pamela Stratton. (2020) Gynecologic and reproductive health in patients with pathogenic germline variants in DICER1. Gynecologic Oncology 156:3, pages 647-653.
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Courtney C. Moreno, Pardeep K. Mittal & Frank H. Miller. (2020) Nonfetal Imaging During Pregnancy. Radiologic Clinics of North America 58:2, pages 363-380.
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Yoshihiko Araki & Mitsuaki Yanagida. 2020. 1 30 .
Zena KocherValerie Hobbs. (2019) Integrating Acupuncture for Preeclampsia with Severe Features and HELLP Syndrome in a High-Risk Antepartum Care Setting. Medical Acupuncture 31:6, pages 407-415.
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Yao-Lung Chang, An-Shine Chao, Shuenn-Dyh Chang, Tzu-Hao Wang & Po-Jen Cheng. (2019) The outcomes of transient elevation of maternal liver enzymes preceding laser treatment for twin-twin transfusion syndrome. Biomedical Journal 42:6, pages 417-421.
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Andrei V. Murashko, Margarita G. Sonich, Yana Y. Sulina, Sergei A. Timofeev & Anatoliy I. Ischenko. (2019) Surgical prophylaxis of bleeding during an the operative delivery in a patient with HELLP syndrome. Case Reports in Perinatal Medicine 8:2.
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E. V. Timokhina, A. N. Strizhakov, V. S. Belousova, A. G. Aslanov, I. M. Bogomazova, N. V. Afanasyeva, Ju. A. Samoylova, S. M. Ibragimova & A. M. Kechina. (2019) HELLP-syndrome as a life-threatening condition: current clinical considerations. Obstetrics, Gynecology and Reproduction 13:1, pages 35-42.
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Jordan Myers, Gary Wu, Robert E. Shapiro & Manuel C. Vallejo. (2019) Preeclampsia Induced Liver Dysfunction Complicated by Disseminated Intravascular Coagulopathy and Placental Abruption: A Case Report and Review of the Literature. Case Reports in Anesthesiology 2019, pages 1-5.
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Rihito NAGATA, Masahiko KOMAGOME, Tetsuya MITSUI, Riki NINOMIYA, Akira MAKI & Yoshifumi BECK. (2019) A Case of Hepatic Rupture Associated with a Right-sided Round Ligament Related to Partial Hellp Syndrome右側肝円索を伴うpartial HELLP症候群による肝破裂の1例. Nihon Rinsho Geka Gakkai Zasshi (Journal of Japan Surgical Association) 80:5, pages 957-963.
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Kyriaki C. Marti. 2018. Dental Management of the Pregnant Patient. Dental Management of the Pregnant Patient 125 128 .
Hollie M. Reeves & Hong Hong. 2018. Clinical Principles of Transfusion Medicine. Clinical Principles of Transfusion Medicine 119 133 .
Ariel Benson & Ran Oren. 2018. Zakim and Boyer's Hepatology. Zakim and Boyer's Hepatology 817 836.e5 .
Vasiliki Katsi, Georgios Georgountzos, Manolis S. Kallistratos, Ioannis Zerdes, Thomas Makris, Athanasios J. Manolis, Petros Nihoyannopoulos & Dimitris Tousoulis. (2017) The Role of Statins in Prevention of Preeclampsia: A Promise for the Future?. Frontiers in Pharmacology 8.
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Geoff K Frampton, Jeremy Jones, Micah Rose & Liz Payne. (2016) Placental growth factor (alone or in combination with soluble fms-like tyrosine kinase 1) as an aid to the assessment of women with suspected pre-eclampsia: systematic review and economic analysis. Health Technology Assessment 20:87, pages 1-160.
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Filomena Morisco, Raffaele Bruno, Elisabetta Bugianesi, Patrizia Burra, Vincenza Calvaruso, Alice Cannoni, Nicola Caporaso, Gian Paolo Caviglia, Alessia Ciancio, Silvia Fargion, Alessandro Federico, Annarosa Floreani, Giovanni Battista Gaeta, Maria Guarino, Pietro Invernizzi, Anna Licata, Carmela Loguercio, Giuseppe Mazzella, Felice Petraglia, Massimo Primignani, Kryssia Rodriguez-Castro, Antonina Smedile, Luca Valenti, Ester Vanni, Silvia Vannuccini, Chiara Voltolini & Erica Villa. (2016) AISF position paper on liver disease and pregnancy. Digestive and Liver Disease 48:2, pages 120-137.
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Luci Maria Dusse, Patrícia Nessralla Alpoim, Juliano Teixeira Silva, Danyelle Romana Alves Rios, Augusto Henriques Brandão & Antônio Carlos Vieira Cabral. (2015) Revisiting HELLP syndrome. Clinica Chimica Acta 451, pages 117-120.
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Kathryn E. Fitzpatrick, Kim Hinshaw, Jennifer J. Kurinczuk & Marian Knight. (2014) Risk Factors, Management, and Outcomes of Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome and Elevated Liver Enzymes, Low Platelets Syndrome. Obstetrics & Gynecology 123:3, pages 618-627.
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