Advanced search
Publication Cover
Drug and Chemical Toxicology Volume 33, 2010 - Issue 1
Submit an article Journal homepage
258
Views
43
CrossRef citations to date
0
Altmetric
Research Article

General pharmacological properties, developmental toxicity, and analgesic activity of gambogic acid, a novel natural anticancer agent

Li ZhaoJiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, China
,
Chen ZhenJiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, China
,
Zhaoqiu WuLife Science Institute, University of Michigan, Ann Arbor, Michigan, USA
,
Rong HuJiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, China
,
Changlin ZhouSchool of Life Science & Technology,China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected] [email protected]
&
Qinglong GuoJiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing, ChinaCorrespondence[email protected] [email protected]
Pages 88-96 | Received 18 Mar 2009, Accepted 08 Jul 2009, Published online: 14 Dec 2009

Citations (43)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (1)

Pankaj Pandey, Kuldeep K. Roy & Robert J. Doerksen. (2020) Negative allosteric modulators of cannabinoid receptor 2: protein modeling, binding site identification and molecular dynamics simulations in the presence of an orthosteric agonist. Journal of Biomolecular Structure and Dynamics 38:1, pages 32-47.
Read now

Articles from other publishers (42)

Atukuri Dorababu & Manikantha Maraswami. (2023) Recent Advances (2015–2020) in Drug Discovery for Attenuation of Pulmonary Fibrosis and COPD. Molecules 28:9, pages 3674.
Crossref
Gary E. Arevalo, Michelle K. Frank, Katelin S. Decker, Maria A. Theodoraki & Emmanuel A. Theodorakis. (2023) Gambogic acid: Multi-gram scale isolation, stereochemical erosion toward epi-gambogic acid and biological profile. Frontiers in Natural Products 1.
Crossref
Mingzhu Li, Yuan Chen, Lijuan Wang, Chujie Lu, Peiying Chen, Yuanling Jin, Jiacong Li, Fei Gao, Zhuo Shang & Wei Lin. (2022) Investigations into the antibacterial effects and potential mechanism of gambogic acid and neogambogic acid. Frontiers in Microbiology 13.
Crossref
Elham Hatami, Prashanth K. B. Nagesh, Neeraj Chauhan, Meena Jaggi, Subhash C. Chauhan & Murali M. Yallapu. (2022) In Situ Nanoparticle Self-Assembly for Combination Delivery of Therapeutics to Non-Small Cell Lung Cancer . ACS Applied Bio Materials 5:3, pages 1104-1119.
Crossref
Li-Zhi Cheng, Dan-Ling Huang, Min Liao, Ke-Ming Li, Zhao-Qiu Wu & Yong-Xian Cheng. (2022) Structural Optimization and Improving Antitumor Potential of Moreollic Acid from Gamboge. Molecules 27:2, pages 482.
Crossref
Xu Gao, Jingya Dai, Guifang Li & Xinya Dai. (2021) Gambogic acid protects LPS-induced apoptosis and inflammation in a cell model of neonatal pneumonia through the regulation of TrkA/Akt signaling pathway. BMC Pharmacology and Toxicology 22:1.
Crossref
Huanjie Yang, Xin Chen, Kai Li, Hassan Cheaito, Qianqian Yang, Guojun Wu, Jinbao Liu & Q. Ping Dou. (2021) Repurposing old drugs as new inhibitors of the ubiquitin-proteasome pathway for cancer treatment. Seminars in Cancer Biology 68, pages 105-122.
Crossref
Yi Han, Yuan Gao, Xiaoqing Cao, Mohammad Mahdi Zangeneh, Shuku Liu & Jie Li. (2020) Ag NPs on chitosan-alginate coated magnetite for synthesis of indazolo[2,1-b]phthalazines and human lung protective effects against α-Guttiferin. International Journal of Biological Macromolecules 164, pages 2974-2986.
Crossref
Elham Hatami, Prashanth K.B. Nagesh, Meena Jaggi, Subhash C. Chauhan & Murali M. Yallapu. (2020) Gambogic acid potentiates gemcitabine induced anticancer activity in non-small cell lung cancer. European Journal of Pharmacology 888, pages 173486.
Crossref
Elham Hatami, Meena Jaggi, Subhash C. Chauhan & Murali M. Yallapu. (2020) Gambogic acid: A shining natural compound to nanomedicine for cancer therapeutics. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 1874:1, pages 188381.
Crossref
Oraphin Chantarasriwong, Tanis J. Dorwart, Theodore Habarth Morales, Stephanie F. Maggio, Aspen L. Settle, Andrew T. Milcarek, Mary L. Alpaugh, Maria A. Theodoraki & Emmanuel A. Theodorakis. (2019) Chiral resolution of a caged xanthone and evaluation across a broad spectrum of breast cancer subtypes. Bioorganic Chemistry 93, pages 103303.
Crossref
Xin Hua, Yue Jia, Qin Yang, Wanjiang Zhang, Zhimin Dong & Siguo Liu. (2019) Transcriptional Analysis of the Effects of Gambogic Acid and Neogambogic Acid on Methicillin-Resistant Staphylococcus aureus. Frontiers in Pharmacology 10.
Crossref
Martin L Stephens, Sevcan Gül Akgün-Ölmez, Sebastian Hoffmann, Rob de Vries, Burkhard Flick, Thomas Hartung, Manoj Lalu, Alexandra Maertens, Hilda Witters, Robert Wright & Katya Tsaioun. (2019) Adaptation of the Systematic Review Framework to the Assessment of Toxicological Test Methods: Challenges and Lessons Learned With the Zebrafish Embryotoxicity Test. Toxicological Sciences 171:1, pages 56-68.
Crossref
Oraphin Chantarasriwong, Andrew T. Milcarek, Theodore Habarth Morales, Aspen L. Settle, Celso O. RezendeJr.Jr., Bashayer D. Althufairi, Maria A. Theodoraki, Mary L. Alpaugh & Emmanuel A. Theodorakis. (2019) Synthesis, structure-activity relationship and in vitro pharmacodynamics of A-ring modified caged xanthones in a preclinical model of inflammatory breast cancer. European Journal of Medicinal Chemistry 168, pages 405-413.
Crossref
Min Ji Seo, Dong Min Lee, In Young Kim, Dongjoo Lee, Min-Koo Choi, Joo-Youn Lee, Seok Soon Park, Seong-Yun Jeong, Eun Kyung Choi & Kyeong Sook Choi. (2019) Gambogic acid triggers vacuolization-associated cell death in cancer cells via disruption of thiol proteostasis. Cell Death & Disease 10:3.
Crossref
Ziqi Feng, Zelin Wang, Yun Yang, Yuzhi Du, Sixin Cui, Yi Zhang, Yanan Tong, Zhen Song, Hao Zeng, Quanming Zou, Liusheng Peng & Hongwu Sun. (2018) Development of a safety and efficacy nanoemulsion delivery system encapsulated gambogic acid for acute myeloid leukemia in vitro and in vivo. European Journal of Pharmaceutical Sciences 125, pages 172-180.
Crossref
Shengpeng Wang, Yingqi Xu, Chenyang Li, Hongxun Tao, Anqi Wang, Chenyu Sun, Zhangfeng Zhong, Xu Wu, Peng Li & Yitao Wang. (2018) Gambogic acid sensitizes breast cancer cells to TRAIL-induced apoptosis by promoting the crosstalk of extrinsic and intrinsic apoptotic signalings. Food and Chemical Toxicology 119, pages 334-341.
Crossref
Kishore Banik, Choudhary Harsha, Devivasha Bordoloi, Bethsebie Lalduhsaki Sailo, Gautam Sethi, Hin Chong Leong, Frank Arfuso, Srishti Mishra, Lingzhi Wang, Alan P. Kumar & Ajaikumar B. Kunnumakkara. (2018) Therapeutic potential of gambogic acid, a caged xanthone, to target cancer. Cancer Letters 416, pages 75-86.
Crossref
Oraphin Chantarasriwong, Bashayer D. Althufairi, Nicholas J. Checchia & Emmanuel A. Theodorakis. 2018. 93 131 .
Xiang Li, Yue Wu, Yanyan Wang, Qidong You & Xiaojin Zhang. (2017) ‘Click Chemistry’ Synthesis of Novel Natural Product-Like Caged Xanthones Bearing a 1,2,3-Triazole Moiety with Improved Druglike Properties as Orally Active Antitumor Agents. Molecules 22:11, pages 1834.
Crossref
Hangjun Ke, Joanne M. Morrisey, Shiwei Qu, Oraphin Chantarasriwong, Michael W. Mather, Emmanuel A. Theodorakis & Akhil B. Vaidya. (2017) Caged Garcinia Xanthones, a Novel Chemical Scaffold with Potent Antimalarial Activity. Antimicrobial Agents and Chemotherapy 61:1.
Crossref
Xiaoli Xu, Yue Wu, Mingyang Hu, Xiang Li, Qichao Bao, Jinlei Bian, Qidong You & Xiaojin Zhang. (2016) Novel Natural Product-like Caged Xanthones Bearing a Carbamate Moiety Exhibit Antitumor Potency and Anti-Angiogenesis Activity In vivo. Scientific Reports 6:1.
Crossref
Dharambir Kashyap, Rajkumar Mondal, Hardeep Singh Tuli, Gaurav Kumar & Anil K. Sharma. (2016) Molecular targets of gambogic acid in cancer: recent trends and advancements. Tumor Biology 37:10, pages 12915-12925.
Crossref
Fatima Zohra Dahmani, Yan Xiao, Juan Zhang, Yao Yu, Jianping Zhou & Jing Yao. (2016) Retracted: Multifunctional Polymeric Nanosystems for Dual‐Targeted Combinatorial Chemo/Antiangiogenesis Therapy of Tumors. Advanced Healthcare Materials 5:12, pages 1447-1461.
Crossref
Yubei Qu, Guanghua Zhang, Yunxia Ji, Haibo Zhua, Changjun Lv & Wanglin Jiang. (2016) Protective role of gambogic acid in experimental pulmonary fibrosis in vitro and in vivo. Phytomedicine 23:4, pages 350-358.
Crossref
Yiqing Zhou, Weichao Li, Xixi Zhang, Haibing Zhang & Youli Xiao. (2016) Global profiling of cellular targets of gambogic acid by quantitative chemical proteomics. Chemical Communications 52:97, pages 14035-14038.
Crossref
Shengpeng Wang, Yu Yang, Yitao Wang & Meiwan Chen. (2015) Gambogic acid-loaded pH-sensitive mixed micelles for overcoming breast cancer resistance. International Journal of Pharmaceutics 495:2, pages 840-848.
Crossref
Akiko Kojima-Yuasa, Xuedan Huang & Isao Matsui-Yuasa. (2015) Synergistic Anticancer Activities of Natural Substances in Human Hepatocellular Carcinoma. Diseases 3:4, pages 260-281.
Crossref
Buyun Jia, Shanshan Li, Xuerui Hu, Guangyu Zhu & Weidong Chen. (2015) Recent Research on Bioactive Xanthones from Natural Medicine: Garcinia hanburyi. AAPS PharmSciTech 16:4, pages 742-758.
Crossref
Shengpeng Wang, Lu Wang, Meiwan Chen & Yitao Wang. (2015) Gambogic acid sensitizes resistant breast cancer cells to doxorubicin through inhibiting P-glycoprotein and suppressing survivin expression. Chemico-Biological Interactions 235, pages 76-84.
Crossref
Maria Eliza Castro MoreiraRosemary Gualberto Fonseca Alvareng PereiraMarcelo Jose Dias SilvaDanielle Ferreira DiasVanessa Silva GontijoAlexandre Giusti-PaivaMarcia Paranho VelosoAntônio Carlos DoriguettoTanus Jorge NagemMarcelo Henrique dos Santos. (2014) Analgesic and Anti-Inflammatory Activities of the 2,8-Dihydroxy-1,6-Dimethoxyxanthone from Haploclathra paniculata (Mart) Benth (Guttiferae) . Journal of Medicinal Food 17:6, pages 686-693.
Crossref
Goutam Brahmachari. 2013. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds. Chemistry and Pharmacology of Naturally Occurring Bioactive Compounds 393 416 .
Xiaojin Zhang, Xiang Li, Haopeng Sun, Xiaojian Wang, Li Zhao, Yuan Gao, Xiaorong Liu, Shenglie Zhang, Yanyan Wang, Yingrui Yang, Su Zeng, Qinglong Guo & Qidong You. (2012) Garcinia Xanthones as Orally Active Antitumor Agents. Journal of Medicinal Chemistry 56:1, pages 276-292.
Crossref
Kristyna M. Elbel, Gianni Guizzunti, Maria A. Theodoraki, Jing Xu, Ayse Batova, Marianna Dakanali & Emmanuel A. Theodorakis. (2013) A-ring oxygenation modulates the chemistry and bioactivity of caged Garcinia xanthones. Organic & Biomolecular Chemistry 11:20, pages 3341.
Crossref
Xiao‐Jin ZhangXiang LiYing‐Rui YangHao‐Peng SunYuan Gao, Lei ZhangJin‐Xin WangQing‐Long Guo & Qi‐Dong You. (2012) Studies on Chemical‐Structure Modification and StructureActivity Relationship of Gambogic Acid Derivatives at Carbon(34). Chemistry & Biodiversity 9:10, pages 2295-2308.
Crossref
Gianni Guizzunti, Ayse Batova, Oraphin Chantarasriwong, Marianna Dakanali & Emmanuel A. Theodorakis. (2012) Subcellular Localization and Activity of Gambogic Acid. ChemBioChem 13:8, pages 1191-1198.
Crossref
Xiang Li, Xiaojin Zhang, Haopeng Sun, Lei Zhang, Yuan Gao, Jinxin Wang, Qinglong Guo & Qidong You. (2012) Synthesis and Anti‐tumor Evaluation of Novel C‐37 Modified Derivatives of Gambogic Acid. Chinese Journal of Chemistry 30:5, pages 1083-1091.
Crossref
Shengpeng Wang, Xu Wu, Miao Tan, Jian Gong, Wen Tan, Baolin Bian, Meiwan Chen & Yitao Wang. (2012) Fighting fire with fire: Poisonous Chinese herbal medicine for cancer therapy. Journal of Ethnopharmacology 140:1, pages 33-45.
Crossref
Xiaojin Zhang, Xiang Li, Haopeng Sun, Zhengyu Jiang, Lei Tao, Yuan Gao, Qinglong Guo & Qidong You. (2012) Synthesis and evaluation of novel aza-caged Garcinia xanthones. Organic & Biomolecular Chemistry 10:16, pages 3288.
Crossref
Xiang Li, Xiaojin Zhang, Xiaojian Wang, Nianguang Li, Changjun Lin, Yuan Gao, Zhuoqin Yu, Qinglong Guo & Qidong You. (2011) Synthesis and Anti‐tumor Evaluation of B‐ring Modified Caged Xanthone Analogues of Gambogic Acid. Chinese Journal of Chemistry 30:1, pages 35-42.
Crossref
Lianru Zhang, Yuting Yi, Junjie Chen, Yifei Sun, Qiuju Guo, Zhonghui Zheng & Siyang Song. (2010) Gambogic acid inhibits Hsp90 and deregulates TNF-α/NF-κB in HeLa cells. Biochemical and Biophysical Research Communications 403:3-4, pages 282-287.
Crossref
Oraphin Chantarasriwong, Ayse Batova, Warinthorn Chavasiri & Emmanuel A. Theodorakis. (2010) Chemistry and Biology of the Caged Garcinia Xanthones . Chemistry – A European Journal 16:33, pages 9944-9962.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.