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Research Article

Reproductive toxicity of di(2-ethylhexyl) phthalate in selenium-supplemented and selenium-deficient rats

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Pages 379-389 | Received 13 Sep 2010, Accepted 09 Dec 2010, Published online: 30 Jun 2011

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Gizem Ozkemahli, Aylin Balci Ozyurt, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal & Belma Kocer-Gumusel. (2022) The effects of prenatal and lactational bisphenol A and/or di(2-ethylhexyl) phthalate exposure on female reproductive system. Toxicology Mechanisms and Methods 32:8, pages 597-605.
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Aylin Balcı, Gizem Özkemahlı, Pınar Erkekoglu, Dilara Zeybek, Nilgün Yersal & Belma Kocer-Gumusel. (2022) Effects of prenatal and lactational bisphenol a and/or di(2-ethylhexyl) phthalate exposure on male reproductive system. International Journal of Environmental Health Research 32:4, pages 902-915.
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Ayşe Derya Buluş, Ali Aşci, Pinar Erkekoglu, Aylin Balci, Nesibe Andiran & Belma Koçer-Gümüşel. (2016) The evaluation of possible role of endocrine disruptors in central and peripheral precocious puberty. Toxicology Mechanisms and Methods 26:7, pages 493-500.
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Pınar Erkekoglu & Belma Kocer-Gumusel. (2014) Genotoxicity of phthalates. Toxicology Mechanisms and Methods 24:9, pages 616-626.
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Vanessa R. Kay, Michael S. Bloom & Warren G. Foster. (2014) Reproductive and developmental effects of phthalate diesters in males. Critical Reviews in Toxicology 44:6, pages 467-498.
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Pınar Erkekoglu, Belma Kocer Giray, Murat Kızilgün, Walid Rachidi, Isabelle Hininger-Favier, Anne-Marie Roussel, Alain Favier & Filiz Hincal. (2012) Di(2-ethylhexyl)phthalate-induced renal oxidative stress in rats and protective effect of selenium. Toxicology Mechanisms and Methods 22:6, pages 415-423.
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Dina R. S. Gad El-Karim, Mohamed A. Lebda, Badriyah S. Alotaibi, Attalla F. El-kott, Heba I. Ghamry & Mustafa Shukry. (2023) Lutein Modulates Oxidative Stress, Inflammatory and Apoptotic Biomarkers Related to Di-(2-Ethylhexyl) Phthalate (DEHP) Hepato-Nephrotoxicity in Male Rats: Role of Nuclear Factor Kappa B. Toxics 11:9, pages 742.
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Pınar Erkekoglu, Aylin ÖzyurtBalcıBalcı, Anıl Yirün & Deniz ÇakırArcaArca. (2021) Testicular dysgenesis syndrome and phthalate exposure: A review of literature. Arhiv za farmaciju 71:6, pages 508-543.
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Aylin Balci, Gizem Ozkemahli, Pinar Erkekoglu, Naciye Dilara Zeybek, Nilgun Yersal & Belma Kocer-Gumusel. (2020) Histopathologic, apoptotic and autophagic, effects of prenatal bisphenol A and/or di(2-ethylhexyl) phthalate exposure on prepubertal rat testis. Environmental Science and Pollution Research 27:16, pages 20104-20116.
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Chong Liu, Peng Duan, Ying-Jun Chen, Yan-Ling Deng, Qiong Luo, Yu Miao, Shu-Heng Cui, Er-Nan Liu, Qi Wang, Liang Wang, Wen-Qing Lu, Jorge E. Chavarro, Yi-Kai Zhou & Yi-Xin Wang. (2019) Mediation of the relationship between phthalate exposure and semen quality by oxidative stress among 1034 reproductive-aged Chinese men. Environmental Research 179, pages 108778.
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Dong Gil Lee, Kyung-Min Kim, Hyun-Shik Lee, Yong Chul Bae, Jae-Won Huh, Sang-Rae Lee & Dong-Seok Lee. (2019) Peroxiredoxin 5 prevents diethylhexyl phthalate-induced neuronal cell death by inhibiting mitochondrial fission in mouse hippocampal HT-22 cells. NeuroToxicology 74, pages 242-251.
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Jingsi Chen, Xiaofeng Zhou, Han Zhang, Yueming Liu, Chen Cao, Ruihua Dong, Yaqun Yuan, Min Wang, Yuanan Lu, Min Wu, Shuguang Li & Bo Chen. (2019) Association between urinary concentration of phthalate metabolites and impaired renal function in Shanghai adults. Environmental Pollution 245, pages 149-162.
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Duygu Aydemir, Gözde Karabulut, Gülsu Şimşek, Muslum Gok, Nurhayat Barlas & Nuriye Nuray Ulusu. (2018) Impact of the Di(2-Ethylhexyl) Phthalate Administration on Trace Element and Mineral Levels in Relation of Kidney and Liver Damage in Rats. Biological Trace Element Research 186:2, pages 474-488.
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Yi-Xin Wang, Bin Zhou, Ying-Jun Chen, Chong Liu, Li-Li Huang, Jia-Qiang Liao, Xi-Jiang Hu, Wen-Qing Lu, Qiang Zeng & An Pan. (2018) Thyroid function, phthalate exposure and semen quality: Exploring associations and mediation effects in reproductive-aged men. Environment International 116, pages 278-285.
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Erdem Durmaz, Pinar Erkekoglu, Ali Asci, Sema Akçurin, İffet Bircan & Belma Kocer-Gumusel. (2018) Urinary phthalate metabolite concentrations in girls with premature thelarche. Environmental Toxicology and Pharmacology 59, pages 172-181.
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Malha Oudir, Henni Chader, Bachir Bouzid, Kheira Bendisari, Batoul Latreche, Sofiane Boudalia & Mokrane Iguer-ouada. (2018) Male rat exposure to low dose of di(2-ethylhexyl) phthalate during pre-pubertal, pubertal and post-pubertal periods: Impact on sperm count, gonad histology and testosterone secretion. Reproductive Toxicology 75, pages 33-39.
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Yiyan Wang, Fenfen Chen, Leping Ye, Barry Zirkin & Haolin Chen. (2017) Steroidogenesis in Leydig cells: effects of aging and environmental factors. Reproduction 154:4, pages R111-R122.
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Hui Liu, Caiping Ren, Weidong Liu, Xingjun Jiang, Lei Wang, Bin Zhu, Wei Jia, Jianxing Lin, Jun Tan & Xiuying Liu. (2017) Embryotoxicity estimation of commonly used compounds with embryonic stem cell test. Molecular Medicine Reports.
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Jan Ludvig Lyche. 2017. Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology 829 856 .
Hai-Tao Gao, Run Xu, Wei-Xin Cao, Xu Zhou, Ye-Hui-Mei Yan, Lingeng Lu, Qian Xu & Yang Shen. (2016) Food Emulsifier Glycerin Monostearate Increases Internal Exposure Levels of Six Priority Controlled Phthalate Esters and Exacerbates Their Male Reproductive Toxicities in Rats. PLOS ONE 11:8, pages e0161253.
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MF Abd-Ellah, HAA Aly, HAM Mokhlis & AH Abdel-Aziz. (2015) Quercetin attenuates di-(2-ethylhexyl) phthalate-induced testicular toxicity in adult rats. Human & Experimental Toxicology 35:3, pages 232-243.
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Jonatan Axelsson, Lars Rylander, Anna Rignell-Hydbom, Bo A.G. Jönsson, Christian H. Lindh & Aleksander Giwercman. (2015) Phthalate exposure and reproductive parameters in young men from the general Swedish population. Environment International 85, pages 54-60.
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Michael J. Glade, Kyl Smith & Michael M. Meguid. (2015) A glance at…nutritional antioxidants and testosterone secretion. Nutrition 31:10, pages 1295-1298.
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Yi-Xin Wang, Ling You, Qiang Zeng, Yang Sun, Yue-Hui Huang, Cheng Wang, Peng Wang, Wen-Cheng Cao, Pan Yang, Yu-Feng Li & Wen-Qing Lu. (2015) Phthalate exposure and human semen quality: Results from an infertility clinic in China. Environmental Research 142, pages 1-9.
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Pinar Erkekoglu, Josiane Arnaud, Walid Rachidi, Belma Kocer-Gumusel, Alain Favier & Filiz Hincal. (2015) The effects of di(2-ethylhexyl) phthalate and/or selenium on trace element levels in different organs of rats. Journal of Trace Elements in Medicine and Biology 29, pages 296-302.
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Mona A.M. Helal. (2014) Celery oil modulates DEHP-induced reproductive toxicity in male rats. Reproductive Biology 14:3, pages 182-189.
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Pınar Erkekoglu, Naciye D. Zeybek, Belma K. Giray, Walid Rachidi, Murat Kızılgün, Isabelle Hininger-Favier, Alain Favier, Esin Asan & Filiz Hincal. (2014) The effects of di(2-ethylhexyl)phthalate on rat liver in relation to selenium status. International Journal of Experimental Pathology 95:1, pages 64-77.
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Pınar Erkekoglu, Belma Giray, Walid Rachidi, Isabelle Hininger-Favier, Anne-Marie Roussel, Alain Favier & Filiz Hincal. (2014) Effects of di(2-ethylhexyl)phthalate on testicular oxidant/antioxidant status in selenium-deficient and selenium-supplemented rats. Environmental Toxicology 29:1, pages 98-107.
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Xi-Feng Zhang, Teng Zhang, Liu Wang, Hong-Ying Zhang, Yong-De Chen, Xun-Si Qin, Yan-Min Feng, Yan-Ni Feng, Wei Shen & Lan Li. (2013) Effects of diethylhexyl phthalate (DEHP) given neonatally on spermatogenesis of mice. Molecular Biology Reports 40:11, pages 6509-6517.
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Zhi-Dan Wen, Da-Wen Gao, Zhe Li & Nan-Qi Ren. (2013) Effects of humic acid on phthalate adsorption to vermiculite. Chemical Engineering Journal 223, pages 298-303.
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Guangtao Yang, Xue Zhou, Jing Wang, Wenjuan Zhang, Hongyan Zheng, Wenhong Lu & Jing Yuan. (2012) MEHP-induced oxidative DNA damage and apoptosis in HepG2 cells correlates with p53-mediated mitochondria-dependent signaling pathway. Food and Chemical Toxicology 50:7, pages 2424-2431.
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Pinar Erkekoglu, N. Dilara Zeybek, Belma Giray, Esin Asan & Filiz Hincal. (2011) The Effects of Di(2-Ethylhexyl)Phthalate Exposure and Selenium Nutrition on Sertoli Cell Vimentin Structure and Germ-Cell Apoptosis in Rat Testis. Archives of Environmental Contamination and Toxicology 62:3, pages 539-547.
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P. Erkekoğlu, W. Rachidi, O.G. Yüzügüllü, B. Giray, M. Öztürk, A. Favier & F. Hıncal. (2011) Induction of ROS, p53, p21 in DEHP- and MEHP-exposed LNCaP cells-protection by selenium compounds. Food and Chemical Toxicology 49:7, pages 1565-1571.
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