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Research Article

The modulatory effect of melatonin on genotoxicity of irinotecan in healthy human lymphocytes and cancer cells

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Pages 335-342 | Received 21 Jun 2012, Accepted 24 Sep 2012, Published online: 05 Nov 2012

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Read on this site (4)

Sangiliyandi Gurunathan, Muhammad Qasim, Min-Hee Kang & Jin-Hoi Kim. (2021) Role and Therapeutic Potential of Melatonin in Various Type of Cancers. OncoTargets and Therapy 14, pages 2019-2052.
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Jae-Ho Lee, Ki-Sang Eom, Dae-Kyu Song, Sung-Il Suh & Dae-Kwang Kim. (2016) In vitro and in vivo effects of melatonin on sister chromatid exchange in human blood lymphocytes exposed to hypoxia. Drug and Chemical Toxicology 39:2, pages 153-156.
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Tapan A. Patel & Mandava V. Rao. (2015) Ameliorative effect of certain antioxidants against mercury induced genotoxicity in peripheral blood lymphocytes. Drug and Chemical Toxicology 38:4, pages 408-414.
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Anshita R. Purohit & Mandava Venkatesh Rao. (2014) Mitigative role of melatonin and α-tocopherol against mercury-induced genotoxicity. Drug and Chemical Toxicology 37:2, pages 221-226.
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Articles from other publishers (19)

Chandra Lekha Putta, Kalyani Eswar & Aravind Kumar Rengan. (2023) Melatonin: Avenues in cancer therapy and its nanotechnological advancements. MedComm – Biomaterials and Applications 2:3.
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Mateusz Kciuk, Somdutt Mujwar, Beata Marciniak, Adrianna Gielecińska, Karol Bukowski, Mariusz Mojzych & Renata Kontek. (2023) Genotoxicity of Novel Pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine Sulfonamides in Normal and Cancer Cells In Vitro. International Journal of Molecular Sciences 24:4, pages 4053.
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Zi Ni Ngai, Kian Chung Chok, Khuen Yen Ng, Rhun Yian Koh & Soi Moi Chye. (2022) Potential role of melatonin in prevention and treatment of lung cancer. Hormone Molecular Biology and Clinical Investigation 43:4, pages 485-503.
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Niloufar Targhazeh, Karla J. Hutt, Amy L. Winship, Russel Reiter & Bahman Yousefi. (2022) Melatonin as an oncostatic agent: Review of the modulation of tumor microenvironment and overcoming multidrug resistance. Biochimie 202, pages 71-84.
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Natnicha Leelaviwat, Poemlarp Mekraksakit, Kristina M. Cross, Dylan M. Landis, Madison McLain, Laveena Sehgal & J. Drew Payne. (2022) Melatonin: Translation of Ongoing Studies Into Possible Therapeutic Applications Outside Sleep Disorders. Clinical Therapeutics 44:5, pages 783-812.
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Seyed Mostafa Mir, Azadeh Aliarab, Golnaz Goodarzi, Moein Shirzad, Seyyed Mehdi Jafari, Durdi Qujeq, Sadra Samavarchi Tehrani & Jahanbakhsh Asadi. (2021) Melatonin: A smart molecule in the DNA repair system . Cell Biochemistry and Function 40:1, pages 4-16.
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Zeynab Kohandel, Tahereh Farkhondeh, Michael Aschner & Saeed Samarghandian. (2021) Molecular targets for the management of gastrointestinal cancer using melatonin, a natural endogenous body hormone. Biomedicine & Pharmacotherapy 140, pages 111782.
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Carolina Alonso-González, Alicia González, Javier Menéndez-Menéndez, Carlos Martínez-Campa & Samuel Cos. (2020) Melatonin as a Radio-Sensitizer in Cancer. Biomedicines 8:8, pages 247.
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Mindaugas Kvietkauskas, Viktorija Zitkute, Bettina Leber, Kestutis Strupas, Philipp Stiegler & Peter Schemmer. (2020) The role of melatonin in colorectal cancer treatment: a comprehensive review. Therapeutic Advances in Medical Oncology 12, pages 175883592093171.
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Jablonska, Nowinska, Piotrowska, Partynska, Katnik, Pawelczyk, Glatzel-Plucinska, Podhorska-Okolow & Dziegiel. (2019) Prognostic Impact of Melatonin Receptors MT1 and MT2 in Non-Small Cell Lung Cancer (NSCLC). Cancers 11:7, pages 1001.
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Masoud Najafi, Eniseh Salehi, Bagher Farhood, Maryam Shabani Nashtaei, Nasser Hashemi Goradel, Neda Khanlarkhani, Zeinab Namjoo & Keywan Mortezaee. (2018) Adjuvant chemotherapy with melatonin for targeting human cancers: A review. Journal of Cellular Physiology 234:3, pages 2356-2372.
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Qin Wang, Zhijuan Sun, Liqing Du, Chang Xu, Yan Wang, Bing Yang, Ningning He, Jinhan Wang, Kaihua Ji, Yang Liu & Qiang Liu. (2018) Melatonin Sensitizes Human Colorectal Cancer Cells to γ-ray Ionizing Radiation In Vitro and In Vivo. International Journal of Molecular Sciences 19:12, pages 3974.
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Maryam Majidinia, Alireza Sadeghpour, Saeed Mehrzadi, Russel J. Reiter, Nasrin Khatami & Bahman Yousefi. (2017) Melatonin: A pleiotropic molecule that modulates DNA damage response and repair pathways. Journal of Pineal Research 63:1, pages e12416.
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Zhiqiang Ma, Yang Yang, Chongxi Fan, Jing Han, Dongjin Wang, Shouyin Di, Wei Hu, Dong Liu, Xiaofei Li, Russel J. Reiter & Xiaolong Yan. (2016) Melatonin as a potential anticarcinogen for non-small-cell lung cancer. Oncotarget 7:29, pages 46768-46784.
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Chongxi Fan, Yunhu Pan, Yang Yang, Shouyin Di, Shuai Jiang, Zhiqiang Ma, Tian Li, Zhipei Zhang, Weimiao Li, Xiaofei Li, Russel J. Reiter & Xiaolong Yan. (2015) Retracted: HDAC 1 inhibition by melatonin leads to suppression of lung adenocarcinoma cells via induction of oxidative stress and activation of apoptotic pathways . Journal of Pineal Research 59:3, pages 321-333.
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Zhenlong Xin, Shuai Jiang, Peng Jiang, Xiaolong Yan, Chongxi Fan, Shouyin Di, Guiling Wu, Yang Yang, Russel J. Reiter & Gang Ji. (2015) Melatonin as a treatment for gastrointestinal cancer: a review. Journal of Pineal Research 58:4, pages 375-387.
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Carolina Alonso-González, Alicia González, Carlos Martínez-Campa, José Gómez-Arozamena & Samuel Cos. (2015) Melatonin sensitizes human breast cancer cells to ionizing radiation by downregulating proteins involved in double-strand DNA break repair. Journal of Pineal Research 58:2, pages 189-197.
Crossref
Renata Kontek, Marta Jakubczak & Ksenia Matlawska-Wasowska. (2014) The antioxidants, vitamin A and E but not vitamin C and melatonin enhance the proapoptotic effects of irinotecan in cancer cells in vitro. Toxicology in Vitro 28:2, pages 282-291.
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Li Hui Zhao, De Ming Han & Xiu Ping Sun. (2013) Study on Cancer Serum Components by Fourier Transform Infrared Spectroscopy. Advanced Materials Research 781-784, pages 832-835.
Crossref

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