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Research Article

N-acetylcysteine effectively mitigates cadmium-induced oxidative damage and cell death in Leydig cells in vitro

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Pages 74-80 | Received 14 Nov 2014, Accepted 08 Mar 2015, Published online: 17 Apr 2015

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Nima Rahmani Talatappeh, Najmeh Ranji & Asghar Beigi Harchegani. (2021) The effect of N-acetyl cysteine on oxidative stress and apoptosis in the liver tissue of rats exposed to cadmium. Archives of Environmental & Occupational Health 76:8, pages 518-525.
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Emmanuel Joseph Ikokide, Ademola Adetokunbo Oyagbemi & Matthew Olugbenga Oyeyemi. (2022) Impacts of cadmium on male fertility: Lessons learnt so far. Andrologia 54:9.
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Bentolhoda Alizadeh, Ali Salehzadeh, Najmeh Ranji & Amir Arasteh. (2021) Effects of N-Acetyl Cysteine on Genes Expression of c-myc, and Ask-1, Histopathological, Oxidative Stress, Inflammation, and Apoptosis in the Liver of Male Rats Exposed to Cadmium. Biological Trace Element Research 200:2, pages 661-668.
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Lingna Yi, Juan Dai, Yong Chen, Yeqing Tong, You Li, Guoqing Fu, Zengguang Teng, Jufeng Huang, Chao Quan, Zhibing Zhang, Ting Zhou, Ling Zhang & Yuqin Shi. (2021) Reproductive toxicity of cadmium in pubertal male rats induced by cell apoptosis. Toxicology and Industrial Health 37:8, pages 469-480.
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Clifford N. Abiaezute, Kenneth O. Anya, Edwin A. Uwagie-Ero & Chinaka O. Nwaehujor. (2021) Ameliorative effects of Garcinia hydroxybiflavanonol 1 (GB1) isolated from Garcinia kola seeds on cadmium chloride (CdCl2) induced reproductive toxicity in the testis of the male Wistar rats. Comparative Clinical Pathology 30:2, pages 229-240.
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Elizabeth Torres-Arce, Barbara Vizmanos, Nancy Babio, Fabiola Márquez-Sandoval & Albert Salas-Huetos. (2021) Dietary Antioxidants in the Treatment of Male Infertility: Counteracting Oxidative Stress. Biology 10:3, pages 241.
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Zahra Azarmehr, Najmeh Ranji, Zeinab Khazaei Koohpar & Hadi Habibollahi. (2021) The effect of N-Acetyl cysteine on the expression of Fxr (Nr1h4), LXRα (Nr1h3) and Sirt1 genes, oxidative stress, and apoptosis in the liver of rats exposed to different doses of cadmium. Molecular Biology Reports 48:3, pages 2533-2542.
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Aliasghar Ghafarizadeh, Mahdi Malmir, Samira Naderi Noreini & Tayebeh Faraji. (2020) Antioxidant effects of N‐acetylcysteine on the male reproductive system: A systematic review. Andrologia 53:1.
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Lijuan Xiong, Bin Zhou, Hong Liu & Lu Cai. 2021. Reviews of Environmental Contamination and Toxicology Volume 258. Reviews of Environmental Contamination and Toxicology Volume 258 151 193 .
Ehitare Ikekhuamen Ekhoye, Samson Eshikhokhale Olerimi & Santos Ehizokhale Ehebha. (2020) Comparison of the deleterious effects of yaji and cadmium chloride on testicular physiomorphological and oxidative stress status: The gonadoprotective effects of an omega-3 fatty acid. Clinical and Experimental Reproductive Medicine 47:3, pages 168-179.
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Qiqi Zhu, Xiaoheng Li & Ren-Shan Ge. (2020) Toxicological Effects of Cadmium on Mammalian Testis. Frontiers in Genetics 11.
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E. A. Uwagie-Ero & C. O. Nwaehujor. (2020) Effects of Garcinia hydroxybiflavanonol-1 (GB1) isolated from Garcinia kola Heckel (Guttiferae) seeds on reproductive toxicity induced with cadmium chloride (CdCl2) in male Wistar rats. Nigerian Journal of Environmental Sciences and Technology 4:1, pages 21-30.
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Magdalena Mezynska & Malgorzata M. Brzóska. (2017) Environmental exposure to cadmium—a risk for health of the general population in industrialized countries and preventive strategies. Environmental Science and Pollution Research 25:4, pages 3211-3232.
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Xiuyuan He, Jing Wu, Liyun Yuan, Feng Lin, Jine Yi, Jing Li, Hui Yuan, Jinling Shi, Tingting Yuan, Shufang Zhang, Yongheng Fan & Zhihang Zhao. (2017) Lead induces apoptosis in mouse TM3 Leydig cells through the Fas/FasL death receptor pathway. Environmental Toxicology and Pharmacology 56, pages 99-105.
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Joydeep Das, Yun-Jung Choi, Hyuk Song & Jin-Hoi Kim. (2016) Potential toxicity of engineered nanoparticles in mammalian germ cells and developing embryos: treatment strategies and anticipated applications of nanoparticles in gene delivery. Human Reproduction Update 22:5, pages 588-619.
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Adolf Sandbichler & Martina Höckner. (2016) Cadmium Protection Strategies—A Hidden Trade-Off?. International Journal of Molecular Sciences 17:1, pages 139.
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