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Promotion of Sleep by Suvorexant—A Novel Dual Orexin Receptor Antagonist

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Pages 52-61 | Received 01 Feb 2011, Accepted 24 Feb 2011, Published online: 08 Apr 2011

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Crossref
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Crossref
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Crossref
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Andrea Lawson, Roohie Parmar & Eileen P. Sloan. 2019. Perinatal Psychopharmacology. Perinatal Psychopharmacology 341 376 .
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Crossref
Shi-Bin Li, Natalie Nevárez, William J Giardino & Luis de Lecea. (2018) Optical probing of orexin/hypocretin receptor antagonists. Sleep 41:10.
Crossref
Qifeng Bai, Horacio Pérez-Sánchez, Zhuoyu Shi, Lanlan Li, Danfeng Shi, Huanxiang Liu & Xiaojun Yao. (2018) Computational studies on horseshoe shape pocket of human orexin receptor type 2 and boat conformation of suvorexant by molecular dynamics simulations. Chemical Biology & Drug Design 92:1, pages 1221-1231.
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Crossref
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W. Joseph Herring, Kathryn M. Connor, Ellen Snyder, Duane B. Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, Ruth M. Benca, Andrew D. Krystal, James K. Walsh, Christopher Lines, Thomas Roth & David Michelson. (2017) Suvorexant in Elderly Patients with Insomnia: Pooled Analyses of Data from Phase III Randomized Controlled Clinical Trials. The American Journal of Geriatric Psychiatry 25:7, pages 791-802.
Crossref
Eisuke Booka, Yasuhiro Tsubosa, Teruaki Matsumoto, Mari Takeuchi, Takashi Kitani, Masato Nagaoka, Atsushi Imai, Tomoyuki Kamijo, Yoshiyuki Iida, Ayako Shimada, Katsushi Takebayashi, Masahiro Niihara, Keita Mori, Tetsuro Onitsuka, Hiroya Takeuchi & Yuko Kitagawa. (2017) Postoperative delirium after pharyngolaryngectomy with esophagectomy: a role for ramelteon and suvorexant. Esophagus 14:3, pages 229-234.
Crossref
Stephanie Born, David V. Gauvin, Suman Mukherjee & Richard Briscoe. (2017) Preclinical assessment of the abuse potential of the orexin receptor antagonist, suvorexant. Regulatory Toxicology and Pharmacology 86, pages 181-192.
Crossref
W. Joseph Herring, Kathryn M. Connor, Ellen Snyder, Duane B. Snavely, Ying Zhang, Jill Hutzelmann, Deborah Matzura-Wolfe, Ruth M. Benca, Andrew D. Krystal, James K. Walsh, Christopher Lines, Thomas Roth & David Michelson. (2017) Clinical profile of suvorexant for the treatment of insomnia over 3 months in women and men: subgroup analysis of pooled phase-3 data. Psychopharmacology 234:11, pages 1703-1711.
Crossref
Songliang Wu, Yu Sun, Yi Hu, Hongmei Zhang, Lijuan Hou, Xing Liu, Yufeng Li, Haiying He, Zhi Luo, Yuan Chen, Yuhe Wang, Weihua Shi, Liang Shen, Changqing Cao, Wei Liang, Qing Xu, Qiang Lv, Jiong Lan, Jian Li & Shuhui Chen. (2017) Discovery of novel substituted octahydropyrrolo[3,4- c ]pyrroles as dual orexin receptor antagonists for insomnia treatment. Bioorganic & Medicinal Chemistry Letters 27:6, pages 1458-1462.
Crossref
Paul J. ColemanAnthony L. Gotter, W. Joseph Herring, Christopher J. Winrow & John J. Renger. (2017) The Discovery of Suvorexant, the First Orexin Receptor Drug for Insomnia. Annual Review of Pharmacology and Toxicology 57:1, pages 509-533.
Crossref
Manabu Ishikawa, Yuri Aono & Tadashi Saigusa. (2017) Role of orexin receptor subtypes in the inhibitory effects of orexin-A on potassium chloride-induced increases in intracellular calcium ion levels in neurons derived from dorsal root ganglion of carrageenan-treated rats. Journal of Oral Science 59:4, pages 557-564.
Crossref
Daniel J. Buysse & Shachi Tyagi. 2017. Principles and Practice of Sleep Medicine. Principles and Practice of Sleep Medicine 432 445.e7 .
Thomas S. Kilduff & Wallace B. Mendelson. 2017. Principles and Practice of Sleep Medicine. Principles and Practice of Sleep Medicine 424 431.e5 .
B.T. Shireman & M.A. Letavic. 2017. Comprehensive Medicinal Chemistry III. Comprehensive Medicinal Chemistry III 225 279 .
Paula K. Schweitzer & Stephen D. Feren. 2017. Clinical Handbook of Insomnia. Clinical Handbook of Insomnia 97 132 .
Max Hirshkowitz & Hanul Bhandari. 2017. Sleep Disorders Medicine. Sleep Disorders Medicine 103 118 .
Arie Struyk, Cynthia Gargano, Melissa Drexel, S. Aubrey Stoch, Vladimir Svetnik, Junshui Ma & David Mayleben. (2016) Pharmacodynamic effects of suvorexant and zolpidem on EEG during sleep in healthy subjects. European Neuropsychopharmacology 26:10, pages 1649-1656.
Crossref
Simon Authier, Marcus S. Delatte, Mary-Jeanne Kallman, Joanne Stevens & Carrie Markgraf. (2016) EEG in non-clinical drug safety assessments: Current and emerging considerations. Journal of Pharmacological and Toxicological Methods 81, pages 274-285.
Crossref
Hiroshi Tsuneki, Toshiyasu Sasaoka & Takeshi Sakurai. (2016) Sleep Control, GPCRs, and Glucose Metabolism. Trends in Endocrinology & Metabolism 27:9, pages 633-642.
Crossref
Kerri A. SchoedelHong SunEdward M. SellersJanice FaulknorNaama Levy-CoopermanXiaodong LiWilliam P. KennedyJang-Ho ChaNicole M. LewisWen LiuPhung BondiskeyJacqueline B. McCreaDeborah L. PanebiancoMatthew D. TroyerJohn A. Wagner. (2016) Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study. Journal of Clinical Psychopharmacology 36:4, pages 314-323.
Crossref
Kathryn M. Connor, Erin Mahoney, Saheeda Jackson, Jill Hutzelmann, Xin Zhao, Nan Jia, Ellen Snyder, Duane Snavely, David Michelson, Thomas Roth & W. Joseph Herring. (2016) A Phase II Dose-Ranging Study Evaluating the Efficacy and Safety of the Orexin Receptor Antagonist Filorexant (MK-6096) in Patients with Primary Insomnia. International Journal of Neuropsychopharmacology 19:8, pages pyw022.
Crossref
Anthony L. Gotter, Mark S. Forman, Charles M. Harrell, Joanne Stevens, Vladimir Svetnik, Ka Lai Yee, Xiaodong Li, Anthony J. Roecker, Steven V. Fox, Pamela L. Tannenbaum, Susan L. Garson, Inge De Lepeleire, Nicole Calder, Laura Rosen, Arie Struyk, Paul J. Coleman, W. Joseph Herring, John J. Renger & Christopher J. Winrow. (2016) Orexin 2 Receptor Antagonism is Sufficient to Promote NREM and REM Sleep from Mouse to Man. Scientific Reports 6:1.
Crossref
Anil Kumar, Priyanka Chanana & Supriti Choudhary. (2016) Emerging role of orexin antagonists in insomnia therapeutics: An update on SORAs and DORAs. Pharmacological Reports 68:2, pages 231-242.
Crossref
Pamela L. Tannenbaum, Spencer J. Tye, Joanne Stevens, Anthony L. Gotter, Steven V. Fox, Alan T. Savitz, Paul J. Coleman, Jason M. Uslaner, Scott D. Kuduk, Richard Hargreaves, Christopher J. Winrow & John J. Renger. (2016) Inhibition of Orexin Signaling Promotes Sleep Yet Preserves Salient Arousability in Monkeys. Sleep 39:3, pages 603-612.
Crossref
Gregory S Parks, Deepti R Warrier, Lars Dittrich, Michael D Schwartz, Jeremiah B Palmerston, Thomas C Neylan, Stephen R Morairty & Thomas S Kilduff. (2015) The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems. Neuropsychopharmacology 41:4, pages 1144-1155.
Crossref
Ellen Snyder, Junshui Ma, Vladimir Svetnik, Kathryn M. Connor, Christopher Lines, David Michelson & W. Joseph Herring. (2016) Effects of suvorexant on sleep architecture and power spectral profile in patients with insomnia: analysis of pooled phase 3 data. Sleep Medicine 19, pages 93-100.
Crossref
Jacqueline Vazquez-DeRose, Michael D. Schwartz, Alexander T. Nguyen, Deepti R. Warrier, Srishti Gulati, Thomas K. Mathew, Thomas C. Neylan & Thomas S. Kilduff. (2014) Hypocretin/orexin antagonism enhances sleep-related adenosine and GABA neurotransmission in rat basal forebrain. Brain Structure and Function 221:2, pages 923-940.
Crossref
Anthony J. Roecker, Christopher D. Cox & Paul J. Coleman. (2015) Orexin Receptor Antagonists: New Therapeutic Agents for the Treatment of Insomnia. Journal of Medicinal Chemistry 59:2, pages 504-530.
Crossref
Yoshitaka Tanaka, Ikuo Aoki, Takaaki Ishine, John J. Renger, Christopher J. Winrow & Satoru Hisada. (2016) Preclinical and clinical results of dual orexin receptor antagonist, suvorexant (BELSOMRA<sup>®</sup>), a novel therapeutic agent for insomnia. Folia Pharmacologica Japonica 148:1, pages 46-56.
Crossref
Debra J. Wallace, Ian Mangion & Paul Coleman. 2016. Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1. Comprehensive Accounts of Pharmaceutical Research and Development: From Discovery to Late-Stage Process Development Volume 1 1 36 .
W. Joseph Herring, Kathryn M. Connor, Neely Ivgy-May, Ellen Snyder, Ken Liu, Duane B. Snavely, Andrew D. Krystal, James K. Walsh, Ruth M. Benca, Russell Rosenberg, R. Bart Sangal, Kerry Budd, Jill Hutzelmann, Heather Leibensperger, Samar Froman, Christopher Lines, Thomas Roth & David Michelson. (2016) Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials. Biological Psychiatry 79:2, pages 136-148.
Crossref
Laura H. Jacobson, Sui Chen, Sanjida Mir & Daniel Hoyer. 2017. Behavioral Neuroscience of Orexin/Hypocretin. Behavioral Neuroscience of Orexin/Hypocretin 105 136 .
Michael D. Schwartz & Thomas S. Kilduff. (2015) The Neurobiology of Sleep and Wakefulness. Psychiatric Clinics of North America 38:4, pages 615-644.
Crossref
Dirk Behnke, Simona Cotesta, Samuel Hintermann, Markus Fendt, Christine E. Gee, Laura H. Jacobson, Grit Laue, Arndt Meyer, Trixie Wagner, Sangamesh Badiger, Vinod Chaudhari, Murali Chebrolu, Chetan Pandit, Daniel Hoyer & Claudia Betschart. (2015) Discovery of 1 H -pyrazolo[3,4- b ]pyridines as potent dual orexin receptor antagonists (DORAs). Bioorganic & Medicinal Chemistry Letters 25:23, pages 5555-5560.
Crossref
Nadia M. Ahmad. 2015. Innovative Drug Synthesis. Innovative Drug Synthesis 223 242 .
Annemiek Vermeeren, Hong Sun, Eric F.P.M. Vuurman, Stefan Jongen, Cees J. Van Leeuwen, Anita C.M. Van Oers, John Palcza, Xiadong Li, Tine Laethem, Ingeborg Heirman, An Bautmans, Matthew D. Troyer, Rebecca Wrishko & Jacqueline McCrea. (2015) On-the-Road Driving Performance the Morning after Bedtime Use of Suvorexant 20 and 40 mg: A Study in Non-Elderly Healthy Volunteers. Sleep 38:11, pages 1803-1813.
Crossref
Hong Sun, Ka Lai Yee, Sean Gill, Wen Liu, Xiaodong Li, Deborah Panebianco, Eric Mangin, Dennis Morrison, Jacqueline McCrea, John A Wagner & Matthew D Troyer. (2015) Psychomotor effects, pharmacokinetics and safety of the orexin receptor antagonist suvorexant administered in combination with alcohol in healthy subjects. Journal of Psychopharmacology 29:11, pages 1159-1169.
Crossref
Anthony J. Roecker, Swati P. Mercer, Jeffrey M. Bergman, Kevin F. Gilbert, Scott D. Kuduk, C. Meacham Harrell, Susan L. Garson, Steven V. Fox, Anthony L. Gotter, Pamela L. Tannenbaum, Thomayant Prueksaritanont, Tamara D. Cabalu, Donghui Cui, Wei Lemaire, Christopher J. Winrow, John J. Renger & Paul J. Coleman. (2015) Discovery of diazepane amide DORAs and 2-SORAs enabled by exploration of isosteric quinazoline replacements. Bioorganic & Medicinal Chemistry Letters 25:21, pages 4992-4999.
Crossref
Takashi Nagahara, Tsuyoshi Saitoh, Noriki Kutsumura, Yoko Irukayama-Tomobe, Yasuhiro Ogawa, Daisuke Kuroda, Hiroaki Gouda, Hidetoshi Kumagai, Hideaki Fujii, Masashi Yanagisawa & Hiroshi Nagase. (2015) Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. Journal of Medicinal Chemistry 58:20, pages 7931-7937.
Crossref
S.A. Breidinger, R.C. Simpson, E. Mangin & E.J. Woolf. (2015) Determination of suvorexant in human plasma using 96-well liquid–liquid extraction and HPLC with tandem mass spectrometric detection. Journal of Chromatography B 1002, pages 254-259.
Crossref
Naoto Uemura, Jacqueline McCrea, Hong Sun, Mardik Donikyan, Gary Zammit, Rong Liu, Bonnie Louridas, Sabrina Marsilio, Christopher Lines, Matthew D. Troyer & John Wagner. (2015) Effects of the orexin receptor antagonist suvorexant on respiration during sleep in healthy subjects. The Journal of Clinical Pharmacology 55:10, pages 1093-1100.
Crossref
Vijayakumar Mavanji, Claudio E. Perez-Leighton, Catherine M. Kotz, Charles J. Billington, Sairam Parthasarathy, Christopher M. Sinton & Jennifer A. Teske. (2015) Promotion of Wakefulness and Energy Expenditure by Orexin-A in the Ventrolateral Preoptic Area. Sleep 38:9, pages 1361-1370.
Crossref
Yu Yoshida, Yoshimitsu Naoe, Taro Terauchi, Fumihiro Ozaki, Takashi Doko, Ayumi Takemura, Toshiaki Tanaka, Keiichi Sorimachi, Carsten T. Beuckmann, Michiyuki Suzuki, Takashi Ueno, Shunsuke Ozaki & Masahiro Yonaga. (2015) Discovery of (1 R ,2 S )-2-{[(2,4-Dimethylpyrimidin-5-yl)oxy]methyl}-2-(3-fluorophenyl)- N -(5-fluoropyridin-2-yl)cyclopropanecarboxamide (E2006): A Potent and Efficacious Oral Orexin Receptor Antagonist . Journal of Medicinal Chemistry 58:11, pages 4648-4664.
Crossref
Scott D. Kuduk, Jason W. Skudlarek, Christina N. DiMarco, Joseph G. Bruno, Mark H. Pausch, Julie A. O’Brien, Tamara D. Cabalu, Joanne Stevens, Joseph Brunner, Pamela L. Tannenbaum, Susan L. Garson, Alan T. Savitz, Charles M. Harrell, Anthony L. Gotter, Christopher J. Winrow, John J. Renger & Paul J. Coleman. (2015) Identification of MK-8133: An orexin-2 selective receptor antagonist with favorable development properties. Bioorganic & Medicinal Chemistry Letters 25:12, pages 2488-2492.
Crossref
Daniele Viviani, Patrizia Haegler, Francois Jenck & Michel A. Steiner. (2014) Orexin neuropeptides contribute to the development and persistence of generalized avoidance behavior in the rat. Psychopharmacology 232:8, pages 1383-1393.
Crossref
Hong Sun, John Palcza, Russell Rosenberg, Meir Kryger, Tara Siringhaus, Janice Rowe, Christopher Lines, John A. Wagner & Matthew D. Troyer. (2015) Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respiratory Medicine 109:3, pages 416-426.
Crossref
Siamak Sorooshyari, Ramón Huerta & Luis de Lecea. (2015) A Framework for Quantitative Modeling of Neural Circuits Involved in Sleep-to-Wake Transition. Frontiers in Neurology 6.
Crossref
Abhishek Reddy, Sowmya C Puvvada, Satyanarayana Kommisetti, Rif S. El-Mallakh & Steven Lippmann. (2014) Suvorexant: something new for sleep?. Acta Neuropsychiatrica 27:1, pages 53-55.
Crossref
Izzat T. Raheem, Michael J. Breslin, Joseph Bruno, Tamara D. Cabalu, Andrew Cooke, Christopher D. Cox, Donghui Cui, Susan Garson, Anthony L. Gotter, Steven V. Fox, C. Meacham Harrell, Scott D. Kuduk, Wei Lemaire, Thomayant Prueksaritanont, John J. Renger, Craig Stump, Pamela L. Tannenbaum, Peter D. Williams, Christopher J. Winrow & Paul J. Coleman. (2015) Discovery of piperidine ethers as selective orexin receptor antagonists (SORAs) inspired by filorexant. Bioorganic & Medicinal Chemistry Letters 25:3, pages 444-450.
Crossref
Dennis J. Cada, Terri L. Levien & Danial E. Baker. (2015) Suvorexant. Hospital Pharmacy 50:1, pages 059-074.
Crossref
Dennis Cada, Terri Levien & Danial Baker. (2015) Suvorexant. Hospital Pharmacy 50:1, pages 059-071.
Crossref
Benjamin E. Blass. 2015. Basic Principles of Drug Discovery and Development. Basic Principles of Drug Discovery and Development 415 446 .
Jason M. Uslaner, John J. Renger, Paul J. Coleman & Chris J. Winrow. 2015. Orexin and Sleep. Orexin and Sleep 323 338 .
Vivien C. Abad & Christian Guilleminault. 2015. Sleep, Neuronal Plasticity and Brain Function. Sleep, Neuronal Plasticity and Brain Function 503 553 .
Quanhui Chen, Luis de Lecea, Zhian Hu & Dong Gao. (2015) The Hypocretin/Orexin System: An Increasingly Important Role in Neuropsychiatry. Medicinal Research Reviews 35:1, pages 152-197.
Crossref
Anthony L Gotter, Susan L Garson, Joanne Stevens, Regina L Munden, Steven V Fox, Pamela L Tannenbaum, Lihang Yao, Scott D Kuduk, Terrence McDonald, Jason M Uslaner, Spencer J Tye, Paul J Coleman, Christopher J Winrow & John J Renger. (2014) Differential sleep-promoting effects of dual orexin receptor antagonists and GABAAreceptor modulators. BMC Neuroscience 15:1.
Crossref
Yu Yoshida, Taro Terauchi, Yoshimitsu Naoe, Yuji Kazuta, Fumihiro Ozaki, Carsten T. Beuckmann, Makoto Nakagawa, Michiyuki Suzuki, Ikuo Kushida, Osamu Takenaka, Takashi Ueno & Masahiro Yonaga. (2014) Design, synthesis, and structure–activity relationships of a series of novel N-aryl-2-phenylcyclopropanecarboxamide that are potent and orally active orexin receptor antagonists. Bioorganic & Medicinal Chemistry 22:21, pages 6071-6088.
Crossref
Junshui Ma, Vladimir Svetnik, Ellen Snyder, Christopher Lines, Thomas Roth & W. Joseph Herring. (2014) Electroencephalographic Power Spectral Density Profile of the Orexin Receptor Antagonist Suvorexant in Patients with Primary Insomnia and Healthy Subjects. Sleep 37:10, pages 1609-1619.
Crossref
Lily P. H. Yang. (2014) Suvorexant: First Global Approval. Drugs 74:15, pages 1817-1822.
Crossref
Shaun Yon-Seng Khoo & Robyn Mary Brown. (2014) Orexin/Hypocretin Based Pharmacotherapies for the Treatment of Addiction: DORA or SORA?. CNS Drugs 28:8, pages 713-730.
Crossref
Pamela L. Tannenbaum, Joanne Stevens, Jacquelyn Binns, Alan T. Savitz, Susan L. Garson, Steven V. Fox, Paul Coleman, Scott D. Kuduk, Anthony L. Gotter, Michael Marino, Spencer J. Tye, Jason M. Uslaner, Christopher J. Winrow & John J. Renger. (2014) Orexin receptor antagonist-induced sleep does not impair the ability to wake in response to emotionally salient acoustic stimuli in dogs. Frontiers in Behavioral Neuroscience 8.
Crossref
Miles D. Thompson, Henri Xhaard, Takeshi Sakurai, Innocenzo Rainero & Jyrki P. Kukkonen. (2014) OX1 and OX2 orexin/hypocretin receptor pharmacogenetics. Frontiers in Neuroscience 8.
Crossref
Anthony J. Roecker, Swati P. Mercer, C. Meacham Harrell, Susan L. Garson, Steven V. Fox, Anthony L. Gotter, Thomayant Prueksaritanont, Tamara D. Cabalu, Donghui Cui, Wei Lemaire, Christopher J. Winrow, John J. Renger & Paul J. Coleman. (2014) Discovery of dual orexin receptor antagonists with rat sleep efficacy enabled by expansion of the acetonitrile-assisted/diphosgene-mediated 2,4-dichloropyrimidine synthesis. Bioorganic & Medicinal Chemistry Letters 24:9, pages 2079-2085.
Crossref
David Michelson, Ellen Snyder, Erin Paradis, Mary Chengan-Liu, Duane B Snavely, Jill Hutzelmann, James K Walsh, Andrew D Krystal, Ruth M Benca, Martin Cohn, Christopher Lines, Thomas Roth & W Joseph Herring. (2014) Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial. The Lancet Neurology 13:5, pages 461-471.
Crossref
William Vaughn McCallJulieta ScaloKaren Rascati. 2014. Advances in the Management of Primary and Secondary Insomnia. Advances in the Management of Primary and Secondary Insomnia 72 90 .
M. Dresler, V.I. Spoormaker, P. Beitinger, M. Czisch, M. Kimura, A. Steiger & F. Holsboer. (2014) Neuroscience-driven discovery and development of sleep therapeutics. Pharmacology & Therapeutics 141:3, pages 300-334.
Crossref
Anthony J. Roecker, Swati P. Mercer, John D. Schreier, Christopher D. Cox, Mark E. Fraley, Justin T. Steen, Wei Lemaire, Joseph G. Bruno, C. Meacham Harrell, Susan L. Garson, Anthony L. Gotter, Steven V. Fox, Joanne Stevens, Pamela L. Tannenbaum, Thomayant Prueksaritanont, Tamara D. Cabalu, Donghui Cui, Joyce Stellabott, George D. Hartman, Steven D. Young, Christopher J. Winrow, John J. Renger & Paul J. Coleman. (2014) Discovery of 5′′-Chloro- N -[(5,6-dimethoxypyridin-2-yl)methyl]-2,2′:5′,3′′-terpyridine-3′-carboxamide (MK-1064): A Selective Orexin 2 Receptor Antagonist (2-SORA) for the Treatment of Insomnia . ChemMedChem 9:2, pages 311-322.
Crossref
Jingcheng Li, Zhian Hu & Luis de Lecea. (2014) The hypocretins/orexins: integrators of multiple physiological functions. British Journal of Pharmacology 171:2, pages 332-350.
Crossref
C J Winrow & J J Renger. (2014) Discovery and development of orexin receptor antagonists as therapeutics for insomnia. British Journal of Pharmacology 171:2, pages 283-293.
Crossref
Artur Pałasz, Damien Lapray, Christelle Peyron, Ewa Rojczyk-Gołębiewska, Rafał Skowronek, Grzegorz Markowski, Beata Czajkowska, Marek Krzystanek & Ryszard Wiaderkiewicz. (2013) Dual orexin receptor antagonists – promising agents in the treatment of sleep disorders. The International Journal of Neuropsychopharmacology 17:01, pages 157-168.
Crossref
J.A. Teske, C.J. Billington & C.M. Kotz. (2014) Mechanisms underlying obesity resistance associated with high spontaneous physical activity. Neuroscience 256, pages 91-100.
Crossref
Anthony L Gotter, Christopher J Winrow, Joseph Brunner, Susan L Garson, Steven V Fox, Jacquelyn Binns, Charles M Harrell, Donghui Cui, Ka Lai Yee, Mark Stiteler, Joanne Stevens, Alan Savitz, Pamela L Tannenbaum, Spencer J Tye, Terrence McDonald, Leon Yao, Scott D Kuduk, Jason Uslaner, Paul J Coleman & John J Renger. (2013) The duration of sleep promoting efficacy by dual orexin receptor antagonists is dependent upon receptor occupancy threshold. BMC Neuroscience 14:1.
Crossref
Daniel Hoyer & Laura H. Jacobson. (2013) Orexin in sleep, addiction and more: Is the perfect insomnia drug at hand?. Neuropeptides 47:6, pages 477-488.
Crossref
Swati P. Mercer, Anthony J. Roecker, Susan Garson, Duane R. Reiss, C. Meacham Harrell, Kathy L. Murphy, Joseph G. Bruno, Rodney A. Bednar, Wei Lemaire, Donghui Cui, Tamara D. Cabalu, Cuyue Tang, Thomayant Prueksaritanont, George D. Hartman, Steven D. Young, Christopher J. Winrow, John J. Renger & Paul J. Coleman. (2013) Discovery of 2,5-diarylnicotinamides as selective orexin-2 receptor antagonists (2-SORAs). Bioorganic & Medicinal Chemistry Letters 23:24, pages 6620-6624.
Crossref
Steven V Fox, Anthony L Gotter, Spencer J Tye, Susan L Garson, Alan T Savitz, Jason M Uslaner, Joseph I Brunner, Pamela L Tannenbaum, Terrence P McDonald, Robert Hodgson, Lihang Yao, Mark R Bowlby, Scott D Kuduk, Paul J Coleman, Richard Hargreaves, Christopher J Winrow & John J Renger. (2013) Quantitative Electroencephalography Within Sleep/Wake States Differentiates GABAA Modulators Eszopiclone and Zolpidem From Dual Orexin Receptor Antagonists in Rats. Neuropsychopharmacology 38:12, pages 2401-2408.
Crossref
Changning Wang, Colin M. Wilson, Christian K. Moseley, Stephen M. Carlin, Shirley Hsu, Grae Arabasz, Frederick A. Schroeder, Christin Y. Sander & Jacob M. Hooker. (2013) Evaluation of potential PET imaging probes for the orexin 2 receptors. Nuclear Medicine and Biology 40:8, pages 1000-1005.
Crossref
I. G. Sil’kis. (2013) Possible Mechanisms for the Effects of Orexin on Hippocampal Functioning and Spatial Learning (analytical review). Neuroscience and Behavioral Physiology 43:9, pages 1049-1057.
Crossref
Claudia Betschart, Samuel Hintermann, Dirk Behnke, Simona Cotesta, Markus Fendt, Christine E. Gee, Laura H. Jacobson, Grit Laue, Silvio Ofner, Vinod Chaudhari, Sangamesh Badiger, Chetan Pandit, Juergen Wagner & Daniel Hoyer. (2013) Identification of a Novel Series of Orexin Receptor Antagonists with a Distinct Effect on Sleep Architecture for the Treatment of Insomnia. Journal of Medicinal Chemistry 56:19, pages 7590-7607.
Crossref
Manas K. Ghorai, Deo Prakash Tiwari & Aditya Bhattacharyya. 2015. Stereoselective Synthesis of Drugs and Natural Products. Stereoselective Synthesis of Drugs and Natural Products 1 38 .
Terry P. Lebold, Pascal Bonaventure & Brock T. Shireman. (2013) Selective orexin receptor antagonists. Bioorganic & Medicinal Chemistry Letters 23:17, pages 4761-4769.
Crossref
Norihito Oi, Michiyuki SuzukiTaro TerauchiMasaki TokunagaYosuke Nakatani, Noboru YamamotoToshimitsu FukumuraMing-Rong ZhangTetsuya Suhara & Makoto Higuchi. (2013) Synthesis and Evaluation of Novel Radioligands for Positron Emission Tomography Imaging of the Orexin-2 Receptor. Journal of Medicinal Chemistry 56:16, pages 6371-6385.
Crossref
Matthias Hoch, Petra Hoever, Rudolf Theodor & Jasper Dingemanse. (2013) Almorexant effects on CYP3A4 activity studied by its simultaneous and time-separated administration with simvastatin and atorvastatin. European Journal of Clinical Pharmacology 69:6, pages 1235-1245.
Crossref
Michel A. Steiner, John Gatfield, Catherine Brisbare-Roch, Hendrik Dietrich, Alexander Treiber, Francois Jenck & Christoph Boss. (2013) Discovery and Characterization of ACT-335827, an Orally Available, Brain Penetrant Orexin Receptor Type 1 Selective Antagonist. ChemMedChem 8:6, pages 898-903.
Crossref
Jason M. UslanerSpencer J. TyeDonnie M. EddinsXiaohai WangSteven V. FoxAlan T. SavitzJacquelyn BinnsChristopher E. CannonSusan L. GarsonLihang YaoRobert HodgsonJoanne StevensMark R. BowlbyPamela L. TannenbaumJoseph BrunnerTerrence P. McdonaldAnthony L. GotterScott D. KudukPaul J. ColemanChristopher J. WinrowJohn J. Renger. (2013) Orexin Receptor Antagonists Differ from Standard Sleep Drugs by Promoting Sleep at Doses That Do Not Disrupt Cognition. Science Translational Medicine 5:179.
Crossref
Michel A. Steiner, Carla Sciarretta, Catherine Brisbare-Roch, Daniel S. Strasser, Rolf Studer & Francois Jenck. (2013) Examining the role of endogenous orexins in hypothalamus–pituitary–adrenal axis endocrine function using transient dual orexin receptor antagonism in the rat. Psychoneuroendocrinology 38:4, pages 560-571.
Crossref
Sarah Wurts Black, Stephen R. Morairty, Simon P. Fisher, Tsui-Ming Chen, Deepti R. Warrier & Thomas S. Kilduff. (2013) Almorexant Promotes Sleep and Exacerbates Cataplexy in a Murine Model of Narcolepsy. Sleep 36:3, pages 325-336.
Crossref
Michel Alexander Steiner, Hugues Lecourt & François Jenck. (2013) The dual orexin receptor antagonist almorexant, alone and in combination with morphine, cocaine and amphetamine, on conditioned place preference and locomotor sensitization in the rat. International Journal of Neuropsychopharmacology 16:2, pages 417-432.
Crossref
Matthias Hoch, Petra Hoever, Federica Alessi, Rudolf Theodor & Jasper Dingemanse. (2012) Pharmacokinetic interactions of almorexant with midazolam and simvastatin, two CYP3A4 model substrates, in healthy male subjects. European Journal of Clinical Pharmacology 69:3, pages 523-532.
Crossref
Matthias Hoch, Justin L. Hay, Petra Hoever, Marieke L. de Kam, Erik T. te Beek, Joop M.A. van Gerven & Jasper Dingemanse. (2013) Dual orexin receptor antagonism by almorexant does not potentiate impairing effects of alcohol in humans. European Neuropsychopharmacology 23:2, pages 107-117.
Crossref
Claudio E. Perez‐Leighton, Kelsey Boland, Charles J. Billington & Catherine M. Kotz. (2013) High and low activity rats: Elevated intrinsic physical activity drives resistance to diet‐induced obesity in non‐bred rats. Obesity 21:2, pages 353-360.
Crossref
Jyrki P. Kukkonen. (2013) Physiology of the orexinergic/hypocretinergic system: a revisit in 2012. American Journal of Physiology-Cell Physiology 304:1, pages C2-C32.
Crossref
W. Joseph HerringEllen SnyderKerry BuddJill HutzelmannDuane SnavelyKenneth LiuChristopher LinesThomas RothDavid Michelson. (2012) Orexin receptor antagonism for treatment of insomnia. Neurology 79:23, pages 2265-2274.
Crossref
Géraldine M. Mang, Thomas Dürst, Hugo Bürki, Stefan Imobersteg, Dorothee Abramowski, Edi Schuepbach, Daniel Hoyer, Markus Fendt & Christine E. Gee. (2012) The Dual Orexin Receptor Antagonist Almorexant Induces Sleep and Decreases Orexin-Induced Locomotion by Blocking Orexin 2 Receptors. Sleep 35:12, pages 1625-1635.
Crossref
Christopher J. Winrow, Anthony L. Gotter, Paul J. Coleman, Richard Hargreaves & John J. Renger. 2012. Drug Discovery for Psychiatric Disorders. Drug Discovery for Psychiatric Disorders 416 442 .
Daniel Hoyer & Tamas Bartfai. (2012) Neuropeptides and Neuropeptide Receptors: Drug Targets, and Peptide and Non-Peptide Ligands: a Tribute to Prof. Dieter Seebach . Chemistry & Biodiversity 9:11, pages 2367-2387.
Crossref
Claudio E. Perez-Leighton, Kelsey BolandJennifer A. Teske, Charles BillingtonCatherine M. Kotz. (2012) Behavioral responses to orexin, orexin receptor gene expression, and spontaneous physical activity contribute to individual sensitivity to obesity. American Journal of Physiology-Endocrinology and Metabolism 303:7, pages E865-E874.
Crossref
Stephen R. Morairty, Florent G. Revel, Pari Malherbe, Jean-Luc Moreau, Daniel Valladao, Joseph G. Wettstein, Thomas S. Kilduff & Edilio Borroni. (2012) Dual Hypocretin Receptor Antagonism Is More Effective for Sleep Promotion than Antagonism of Either Receptor Alone. PLoS ONE 7:7, pages e39131.
Crossref
John A Christopher. (2012) Orexin receptor antagonists. Pharmaceutical Patent Analyst 1:3, pages 329-346.
Crossref
Anthony L. Gotter, Andrea L. Webber, Paul J. Coleman, John J. Renger & Christopher J. Winrow. (2012) International Union of Basic and Clinical Pharmacology. LXXXVI. Orexin Receptor Function, Nomenclature and Pharmacology. Pharmacological Reviews 64:3, pages 389-420.
Crossref
Rong Jiang, Xinyi Song, Purva Bali, Anthony Smith, Claudia Ruiz Bayona, Li Lin, Michael D. Cameron, Patricia H. McDonald, Paul J. Kenny & Theodore M. Kamenecka. (2012) Disubstituted piperidines as potent orexin (hypocretin) receptor antagonists. Bioorganic & Medicinal Chemistry Letters 22:12, pages 3890-3894.
Crossref
Tian-Rui Xu, Richard J. Ward, John D. Pediani & Graeme Milligan. (2012) Intramolecular Fluorescence Resonance Energy Transfer (FRET) Sensors of the Orexin OX1 and OX2 Receptors Identify Slow Kinetics of Agonist Activation. Journal of Biological Chemistry 287:18, pages 14937-14949.
Crossref
Paul J. Coleman, John D. Schreier, Christopher D. Cox, Michael J. Breslin, David B. Whitman, Michael J. Bogusky, Georgia B. McGaughey, Rodney A. Bednar, Wei Lemaire, Scott M. Doran, Steven V. Fox, Susan L. Garson, Anthony L. Gotter, C. Meacham Harrell, Duane R. Reiss, Tamara D. Cabalu, Donghui Cui, Thomayant Prueksaritanont, Joanne Stevens, Pamela L. Tannenbaum, Richard G. Ball, Joyce Stellabott, Steven D. Young, George D. Hartman, Christopher J. Winrow & John J. Renger. (2012) Discovery of [(2 R ,5 R )-5-{[(5-Fluoropyridin-2-yl)oxy]methyl}-2-methylpiperidin-1-yl][5-methyl-2-(pyrimidin-2-yl)phenyl]methanone (MK-6096): A Dual Orexin Receptor Antagonist with Potent Sleep-Promoting Properties . ChemMedChem 7:3, pages 415-424.
Crossref
Anne E. Panhelainen & Esa R. Korpi. (2012) Evidence for a role of inhibition of orexinergic neurons in the anxiolytic and sedative effects of diazepam: A c-Fos study. Pharmacology Biochemistry and Behavior 101:1, pages 115-124.
Crossref
Christopher J. Winrow, Anthony L. Gotter, Christopher D. Cox, Pamela L. Tannenbaum, Susan L. Garson, Scott M. Doran, Michael J. Breslin, John D. Schreier, Steven V. Fox, Charles M. Harrell, Joanne Stevens, Duane R. Reiss, Donghui Cui, Paul J. Coleman & John J. Renger. (2012) Pharmacological characterization of MK-6096 – A dual orexin receptor antagonist for insomnia. Neuropharmacology 62:2, pages 978-987.
Crossref

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