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Experimental Lung Research Volume 39, 2013 - Issue 2
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Research Article

Serotonin inhibits apoptosis of pulmonary artery smooth muscle cells through 5-HT2A receptors involved in the pulmonary artery remodeling of pulmonary artery hypertension

Ya LiuDepartment of Cardiolovascular Medicine, the First Affiliated Hospital of Medical college of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province Xi'an, Shaanxi, P.R. China
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Hongyan TianDepartment of Cardiolovascular Medicine, the First Affiliated Hospital of Medical college of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province Xi'an, Shaanxi, P.R. China
,
Xiaoli YanDepartment of Cardiolovascular Medicine, the First Affiliated Hospital of Medical college of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province Xi'an, Shaanxi, P.R. ChinaCorrespondence[email protected]
[email protected]
,
Fenling FanDepartment of Cardiolovascular Medicine, the First Affiliated Hospital of Medical college of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province Xi'an, Shaanxi, P.R. China
,
Wenping WangDepartment of Cardiolovascular Medicine, the First Affiliated Hospital of Medical college of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province Xi'an, Shaanxi, P.R. China
&
Junli HanDepartment of Cardiolovascular Medicine, the First Affiliated Hospital of Medical college of Xi'an Jiaotong University; Institute of Cardiovascular Channelopathy, Key Laboratory of Environment and Genes Related to Diseases (Xi'an Jiaotong University), Ministry of Education; Key Laboratory of Molecular Cardiology, Shannxi Province Xi'an, Shaanxi, P.R. China
Pages 70-79 | Received 19 Aug 2012, Accepted 10 Dec 2012, Published online: 09 Jan 2013

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Jie Geng, Fen-ling Fan, Sai He, Ya Liu, Yan Meng, Hua Tian, Dan Zhang, Qiang Ma, Jun-bo Zhang & Hong-yan Tian. (2016) The effects of the 5-HT2A receptor antagonist sarpogrelate hydrochloride on chronic hypoxic pulmonary hypertension in rats. Experimental Lung Research 42:4, pages 190-198.
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Articles from other publishers (14)

Nattawan Tangmahakul, Siriwan Sakarin, Somporn Techangamsuwan, Anudep Rungsipipat & Sirilak Surachetpong. (2022) Investigation of Genes and Proteins Expression Associating Serotonin Signaling Pathway in Lung and Pulmonary Artery Tissues of Dogs with Pulmonary Hypertension Secondary to Degenerative Mitral Valve Disease: The Preliminary Study. Veterinary Sciences 9:10, pages 530.
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Luís Pedro Baptista de Barros Ribeiro Dourado, Mário Santos & Daniel Moreira-Gonçalves. (2022) Nets, pulmonary arterial hypertension, and thrombo-inflammation. Journal of Molecular Medicine 100:5, pages 713-722.
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Xue Wang, Heng Gao, Chao Deng, Miaomiao Liu & Yang Yan. (2021) The occurrence and risk factors of bradycardia after the Maze procedure in patients with atrial fibrillation and tricuspid regurgitation. Journal of Cardiothoracic Surgery 16:1.
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Hironori Tabuchi, Yoshihisa Kitamura, Soichiro Ushio, Shiho Kan, Yudai Wada, Yusuke Sumiyoshi, Yasuhisa Izushi, Ikuko Miyazaki, Masato Asanuma & Toshiaki Sendo. (2021) Influence of 5-HT2A receptor function on anxiety-like behavior induced by a combination treatment with doxorubicin and cyclophosphamide in rats. Psychopharmacology 238:12, pages 3607-3614.
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Haiying Zhao, Shunxin Chen, Kaizhao Hu, Zhifei Zhang, Xiaoru Yan, Huijie Gao, Wei Du & Huiling Zheng. (2021) 5-HTP decreases goat mammary epithelial cells apoptosis through MAPK/ERK/Bcl-3 pathway. Gene 769, pages 145240.
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Nicholas M. Barnes, Gerard P. Ahern, Carine Becamel, Joël Bockaert, Michael Camilleri, Severine Chaumont-Dubel, Sylvie Claeysen, Kathryn A. Cunningham, Kevin C. Fone, Michael Gershon, Giuseppe Di Giovanni, Nathalie M. Goodfellow, Adam L. Halberstadt, Rachel M. Hartley, Ghérici Hassaine, Katharine Herrick-Davis, Ruud Hovius, Enza Lacivita, Evelyn K. Lambe, Marcello Leopoldo, Finn Olav Levy, Sarah C. R. Lummis, Philippe Marin, Luc Maroteaux, Andrew C. McCreary, David L. Nelson, John F. Neumaier, Adrian Newman-Tancredi, Hugues Nury, Alexander Roberts, Bryan L. Roth, Anne Roumier, Gareth J. Sanger, Milt Teitler, Trevor Sharp, Carlos M. Villalón, Horst Vogel, Stephanie W. Watts & Daniel Hoyer. (2020) International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function. Pharmacological Reviews 73:1, pages 310-520.
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Fenling Fan, Hua Tian, Jie Geng, Jizhao Deng, Ya Liu, Chunyan Chen, Songlin Zhang, Yushun Zhang, Jie Li, Hongyan Tian, Anthony M. Dart & Yuliang Zou. (2019) Mechanism of Beraprost Effects on Pulmonary Hypertension: Contribution of Cross-Binding to PGE2 Receptor 4 and Modulation of O2 Sensitive Voltage-Gated K+ Channels. Frontiers in Pharmacology 9.
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Karina Bravo, Jaime Eugenín & Isabel Llona. 2017. The Plastic Brain. The Plastic Brain 193 216 .
Jian Hu, Qinzi Xu, Charles McTiernan, Yen-Chun Lai, David Osei-Hwedieh & Mark Gladwin. (2015) Novel Targets of Drug Treatment for Pulmonary Hypertension. American Journal of Cardiovascular Drugs 15:4, pages 225-234.
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Xinyuan Han, Chunyan Chen, Gong Cheng, Lei Liang, Xiaowei Yao, Guang Yang, Penghua You & Xiling Shou. (2015) Peroxisome proliferator-activated receptor ? attenuates serotonin-induced pulmonary artery smooth muscle cell proliferation and apoptosis inhibition involving ERK1/2 pathway. Microvascular Research 100, pages 17-24.
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Wiebke Janssen, Yves Schymura, Tatyana Novoyatleva, Baktybek Kojonazarov, Mario Boehm, Astrid Wietelmann, Himal Luitel, Kirsten Murmann, Damian Richard Krompiec, Aleksandra Tretyn, Soni Savai Pullamsetti, Norbert Weissmann, Werner Seeger, Hossein Ardeschir Ghofrani & Ralph Theo Schermuly. (2015) 5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure. BioMed Research International 2015, pages 1-8.
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Daniel Morales-Cano, Carmen Menendez, Enrique Moreno, Javier Moral-Sanz, Bianca Barreira, Pilar Galindo, Rachele Pandolfi, Rosario Jimenez, Laura Moreno, Angel Cogolludo, Juan Duarte & Francisco Perez-Vizcaino. (2014) The Flavonoid Quercetin Reverses Pulmonary Hypertension in Rats. PLoS ONE 9:12, pages e114492.
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Chunyan Chen, Xinyuan Han, Fenling Fan, Ya Liu, Tingzhong Wang, Juanjuan Wang, Peijing Hu, Aiqun Ma & Hongyan Tian. (2014) Serotonin drives the activation of pulmonary artery adventitial fibroblasts and TGF-?1/Smad3-mediated fibrotic responses through 5-HT2A receptors. Molecular and Cellular Biochemistry 397:1-2, pages 267-276.
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Alejandro D. Hofmann, Florian Friedmacher, Manuela Hunziker, Hiromizu Takahashi, Johannes W. Duess, Jan-Hendrik Gosemann & Prem Puri. (2014) Upregulation of serotonin-receptor-2a and serotonin transporter expression in the pulmonary vasculature of nitrofen-induced congenital diaphragmatic hernia. Journal of Pediatric Surgery 49:6, pages 871-875.
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