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Research Article

Application of Box–Behnken design in the preparation and optimization of fenofibrate-loaded self-microemulsifying drug delivery system (SMEDDS)

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Pages 31-40 | Received 08 Oct 2012, Accepted 29 Apr 2013, Published online: 08 Jul 2013

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Yoon Tae Goo, Sangkil Lee, Ji Yeh Choi, Min Song Kim, Gi Hyeong Sin, Sun Ho Hong, Chang Hyun Kim, Seh Hyon Song & Young Wook Choi. (2022) Enhanced oral absorption of insulin: hydrophobic ion pairing and a self-microemulsifying drug delivery system using a D-optimal mixture design. Drug Delivery 29:1, pages 2831-2845.
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Abid Mehmood Yousaf, Dong Wuk Kim, Dong Shik Kim, Jong Oh Kim, Yu Seok Youn, Kwan Hyung Cho, Chul Soon Yong & Han-Gon Choi. (2016) Influence of polyvinylpyrrolidone quantity on the solubility, crystallinity and oral bioavailability of fenofibrate in solvent-evaporated microspheres. Journal of Microencapsulation 33:4, pages 365-371.
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Nasr A. Emad, Yasmin Sultana, Mohd Aqil, Asmaa Saleh, Omkulthom Al kamaly & Fahd A Nasr. (2023) Omega-3 fatty acid-based self-microemulsifying drug delivery system (SMEDDS) of pioglitazone: Optimization, in vitro and in vivo studies. Saudi Journal of Biological Sciences 30:9, pages 103778.
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Darshan Petkar Ramachandra & Preethi Sudheer. (2023) Self-micro Emulsifying Drug Delivery via Intestinal Lymphatics: A Lucrative Approach to Drug Targeting. Pharmaceutical Nanotechnology 11:3, pages 238-264.
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Chien-Ming Hsieh, Ting-Lun Yang, Athika Darumas Putri & Chin-Tin Chen. (2023) Application of Design of Experiments in the Development of Self-Microemulsifying Drug Delivery Systems. Pharmaceuticals 16:2, pages 283.
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Maya Suresh Nair, Ravikumar Rajarathinam, Sivasubramanian Velmurugan, Kevin Joseph Sam & Loganathan Arumugam. (2022) Statistical Optimization and Downstream Processing of C‐Phycocyanin from Phormidium valderianum . Chemical Engineering & Technology 46:2, pages 279-289.
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Hany S. M. Ali, Sameh A. Ahmed, Abdulmalik A. Alqurshi, Ali M. Alalawi, Ahmed M. Shehata & Yaser M. Alahmadi. (2022) Boosting Tadalafil Bioavailability via Sono-Assisted Nano-Emulsion-Based Oral Jellies: Box–Behnken Optimization and Assessment. Pharmaceutics 14:12, pages 2592.
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Duygu Yilmaz Usta, Burcu Timur & Zeynep Safak Teksin. (2022) Formulation development, optimization by Box-Behnken design, characterization, in vitro, ex-vivo, and in vivo evaluation of bosentan-loaded self-nanoemulsifying drug delivery system: A novel alternative dosage form for pulmonary arterial hypertension treatment. European Journal of Pharmaceutical Sciences 174, pages 106159.
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Yan Zhang, Runan Zuo, Xinhao Song, Jiahao Gong, Junqi Wang, Mengjuan Lin, Fengzhu Yang, Xingxing Cheng, Xiuge Gao, Lin Peng, Hui Ji, Xia Chen, Shanxiang Jiang & Dawei Guo. (2022) Optimization of Maduramicin Ammonium-Loaded Nanostructured Lipid Carriers Using Box–Behnken Design for Enhanced Anticoccidial Effect against Eimeria tenella in Broiler Chickens. Pharmaceutics 14:7, pages 1330.
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Ahmed Alaa Kassem, Abeer Salama & Amira Mohamed Mohsen. (2022) Formulation and optimization of cationic nanoemulsions for enhanced ocular delivery of dorzolamide hydrochloride using Box-Behnken design: In vitro and in vivo assessments. Journal of Drug Delivery Science and Technology 68, pages 103047.
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Lucas Matheus Soares Pereira, Thaís Moré Milan & Delia Rita Tapia-Blácido. (2021) Using Response Surface Methodology (RSM) to optimize 2G bioethanol production: A review. Biomass and Bioenergy 151, pages 106166.
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Christina Karavasili, Ioannis I. Andreadis, Maria P. Tsantarliotou, Ioannis A. Taitzoglou, Paschalina Chatzopoulou, Dimitrios Katsantonis, Constantinos K. Zacharis, Catherine Markopoulou & Dimitrios G. Fatouros. (2020) Self-Nanoemulsifying Drug Delivery Systems (SNEDDS) Containing Rice Bran Oil for Enhanced Fenofibrate Oral Delivery: In Vitro Digestion, Ex Vivo Permeability, and In Vivo Bioavailability Studies. AAPS PharmSciTech 21:6.
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Olivia A. Attallah, Amro Shetta, Fatma Elshishiny & Wael Mamdouh. (2020) Essential oil loaded pectin/chitosan nanoparticles preparation and optimization via Box–Behnken design against MCF-7 breast cancer cell lines . RSC Advances 10:15, pages 8703-8708.
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Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Abdul Malik Alyousef, Mohammad Altamimi, Bader Alsulays & Faiyaz Shakeel. (2020) Flufenamic Acid-Loaded Self-Nanoemulsifying Drug Delivery System for Oral Delivery: From Formulation Statistical Optimization to Preclinical Anti-Inflammatory Assessment. Journal of Oleo Science 69:10, pages 1257-1271.
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Madhulika Pradhan, Arun K. Parihar, Deependra Singh & Manju Rawat Singh. 2020. Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents. Advances and Avenues in the Development of Novel Carriers for Bioactives and Biological Agents 555 594 .
Marwa Hasanein Asfour, Ahmed Alaa Kassem & Abeer Salama. (2019) Topical nanostructured lipid carriers/inorganic sunscreen combination for alleviation of all-trans retinoic acid-induced photosensitivity: Box-Behnken design optimization, in vitro and in vivo evaluation. European Journal of Pharmaceutical Sciences 134, pages 219-232.
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Jong Hyuck Park, Dong Shik Kim, Omer Mustapha, Abid Mehmood Yousaf, Jung Suk Kim, Dong Wuk Kim, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Soo-Jeong Lim, Jong Oh Kim & Han-Gon Choi. (2018) Comparison of a revaprazan-loaded solid dispersion, solid SNEDDS and inclusion compound: Physicochemical characterisation and pharmacokinetics. Colloids and Surfaces B: Biointerfaces 162, pages 420-426.
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Dong Shik Kim, Eun Su Yang, Chul Soon Yong, Yu Seok Youn, Kyung Taek Oh, Dong Xun Li, Jong Oh Kim, Sung Giu Jin & Han-Gon Choi. (2017) Effect of inorganic mesoporous carriers on 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol-loaded solid self-emulsifying drug delivery system: Physicochemical characterization and bioavailability in rats. Colloids and Surfaces B: Biointerfaces 160, pages 331-336.
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Raj Kumar Thapa, Han-Gon Choi, Jong Oh Kim & Chul Soon Yong. (2017) Analysis and optimization of drug solubility to improve pharmacokinetics. Journal of Pharmaceutical Investigation 47:2, pages 95-110.
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Omer Mustapha, Kyung Soo Kim, Shumaila Shafique, Dong Shik Kim, Sung Giu Jin, Youn Gee Seo, Yu Seok Youn, Kyung Taek Oh, Beom-Jin Lee, Young Joon Park, Chul Soon Yong, Jong Oh Kim & Han-Gon Choi. (2017) Development of novel cilostazol–loaded solid SNEDDS using a SPG membrane emulsification technique: Physicochemical characterization and in vivo evaluation. Colloids and Surfaces B: Biointerfaces 150, pages 216-222.
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Dong Shik Kim, Dong Wuk Kim, Kyeong Soo Kim, Jong Seo Choi, Youn Gee Seo, Yu Seok Youn, Kyung Taek Oh, Chul Soon Yong, Jong Oh Kim, Sung Giu Jin & Han-Gon Choi. (2016) Development of a novel l-sulpiride-loaded quaternary microcapsule: Effect of TPGS as an absorption enhancer on physicochemical characterization and oral bioavailability. Colloids and Surfaces B: Biointerfaces 147, pages 250-257.
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Dong Shik Kim, Jong Seo Choi, Dong Wuk Kim, Kyeong Soo Kim, Youn Gee Seo, Kwan Hyung Cho, Jong Oh Kim, Chul Soon Yong, Yu Seok Youn, Soo-Jeong Lim, Sung Giu Jin & Han-Gon Choi. (2016) Comparison of solvent⿿wetted and kneaded l -sulpiride⿿loaded solid dispersions: Powder characterization and in vivo evaluation. International Journal of Pharmaceutics 511:1, pages 351-358.
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Kyeong Soo Kim, Jeong Hyun Kim, Sung Giu Jin, Dong Wuk Kim, Dong Shik Kim, Jong Oh Kim, Chul Soon Yong, Kwan Hyung Cho, Dong Xun Li, Jong Soo Woo & Han-Gon Choi. (2016) Effect of magnesium carbonate on the solubility, dissolution and oral bioavailability of fenofibric acid powder as an alkalising solubilizer. Archives of Pharmacal Research 39:4, pages 531-538.
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Tuan Hiep Tran, Thiruganesh Ramasamy, Duy Hieu Truong, Han-Gon Choi, Chul Soon Yong & Jong Oh Kim. (2014) Preparation and Characterization of Fenofibrate-Loaded Nanostructured Lipid Carriers for Oral Bioavailability Enhancement. AAPS PharmSciTech 15:6, pages 1509-1515.
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