379
Views
43
CrossRef citations to date
0
Altmetric
Research Article

Prednisolone-loaded nanocapsules as ocular drug delivery system: development, in vitro drug release and eye toxicity

, , , , &
Pages 519-528 | Received 14 Jul 2013, Accepted 17 Dec 2013, Published online: 03 Apr 2014

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Rubia L. Pereira, Fernanda I. Leites, Karina Paese, Rafaela M. Sponchiado, Cecília B. Michalowski, Silvia S. Guterres & Elfrides E. S. Schapoval. (2016) Hydrogel containing adapalene- and dapsone-loaded lipid-core nanocapsules for cutaneous application: development, characterization, in vitro irritation and permeation studies. Drug Development and Industrial Pharmacy 42:12, pages 2001-2008.
Read now

Articles from other publishers (42)

Mahmoud Mostafa, Adel Al Fatease, Raid G. Alany & Hamdy Abdelkader. (2023) Recent Advances of Ocular Drug Delivery Systems: Prominence of Ocular Implants for Chronic Eye Diseases. Pharmaceutics 15:6, pages 1746.
Crossref
Federica De Gaetano, Consuelo Celesti, Giuseppe Paladini, Valentina Venuti, Maria Chiara Cristiano, Donatella Paolino, Daniela Iannazzo, Vincenza Strano, Anna M. Gueli, Silvana Tommasini, Cinzia Anna Ventura & Rosanna Stancanelli. (2023) Solid Lipid Nanoparticles Containing Morin: Preparation, Characterization, and Ex Vivo Permeation Studies. Pharmaceutics 15:6, pages 1605.
Crossref
Ye Yu, Xuesong Liu, Xinyi Ma, Gan Jiang, Qingxiang Song, Ruru Guo, Suli Wang, Xiaoling Gao & Liangjing Lu. (2023) Steroid-loaded reconstituted high-density lipoprotein nanocarrier: A new treatment for systemic lupus erythematosus. Journal of Biomaterials Applications 37:9, pages 1542-1554.
Crossref
Sora Yasri & Viroj Wiwanitkit. 2023. Advances in Novel Formulations for Drug Delivery. Advances in Novel Formulations for Drug Delivery 341 353 .
Arti Mehandole, Nikita Walke, Srushti Mahajan, Mayur Aalhate, Indrani Maji, Ujala Gupta, Neelesh Kumar Mehra & Pankaj Kumar Singh. (2023) Core–Shell Type Lipidic and Polymeric Nanocapsules: the Transformative Multifaceted Delivery Systems. AAPS PharmSciTech 24:1.
Crossref
Kimberly S. Butler, C. Jeffrey Brinker & Hon Sing Leong. (2022) Bridging the In Vitro to In Vivo gap: Using the Chick Embryo Model to Accelerate Nanoparticle Validation and Qualification for In Vivo studies . ACS Nano 16:12, pages 19626-19650.
Crossref
Mo’tasem M. Alsmadi, Nour M. AL-Daoud, Rana M. Obaidat & Niazy A. Abu-Farsakh. (2022) Enhancing Atorvastatin In Vivo Oral Bioavailability in the Presence of Inflammatory Bowel Disease and Irritable Bowel Syndrome Using Supercritical Fluid Technology Guided by wbPBPK Modeling in Rat and Human. AAPS PharmSciTech 23:5.
Crossref
Md Habban Akhter, Irfan Ahmad, Mohammad Y. Alshahrani, Alhanouf I. Al-Harbi, Habibullah Khalilullah, Obaid Afzal, Abdulmalik S. A. Altamimi, Shehla Nasar Mir Najib Ullah, Abhijeet Ojha & Shahid Karim. (2022) Drug Delivery Challenges and Current Progress in Nanocarrier-Based Ocular Therapeutic System. Gels 8:2, pages 82.
Crossref
Carolina Landau Albrecht, Laura Elena Sperling, Daikelly Iglesias Braghirolli & Patricia Pranke. (2021) Characterization, Cytotoxicity and Anti-Inflammatory Effect Evaluation of Nanocapsules Containing Nicotine. Bioengineering 8:11, pages 172.
Crossref
Salma N. Tammam, Sara El Safy, Shahenda Ramadan, Sita Arjune, Eva Krakor & Sanjay Mathur. (2021) Repurpose but also (nano)-reformulate! The potential role of nanomedicine in the battle against SARS-CoV2. Journal of Controlled Release 337, pages 258-284.
Crossref
Eberhard Grambow, Heiko Sorg, Christian G. G. Sorg & Daniel Strüder. (2021) Experimental Models to Study Skin Wound Healing with a Focus on Angiogenesis. Medical Sciences 9:3, pages 55.
Crossref
Antonysamy Dennyson Savariraj, Ahmed Salih, Fahad Alam, Mohamed Elsherif, Bader AlQattan, Ammar A. Khan, Ali K. Yetisen & Haider Butt. (2021) Ophthalmic Sensors and Drug Delivery. ACS Sensors 6:6, pages 2046-2076.
Crossref
Sherif A. Gaballa, Uday B. Kompella, Omar Elgarhy, Ali M. Alqahtani, Barbara Pierscionek, Raid G. Alany & Hamdy Abdelkader. (2020) Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives. Drug Delivery and Translational Research 11:3, pages 866-893.
Crossref
Pravin Pawar, Anita Duduskar & Swati Waydande. (2021) Design and Evaluation of Eudragit RS-100 Based Itraconazole Nanosuspension for Ophthalmic Application. Current Drug Research Reviews 13:1, pages 36-48.
Crossref
Narimane Lammari, Tanguy Demautis, Ouahida Louaer, Abdeslam Hassen Meniai, Herve Casabianca, Chawki Bensouici, Gilles Devouassoux, Hatem Fessi, Abderrazzak Bentaher & Abdelhamid Elaissari. (2021) Nanocapsules containing Saussurea lappa essential oil: Formulation, characterization, antidiabetic, anti-cholinesterase and anti-inflammatory potentials. International Journal of Pharmaceutics 593, pages 120138.
Crossref
Greet MerckxHanna TayMelissa Lo MonacoMarc van ZandvoortWard De SpiegelaereIvo LambrichtsAnnelies Bronckaers. (2020) Chorioallantoic Membrane Assay as Model for Angiogenesis in Tissue Engineering: Focus on Stem Cells. Tissue Engineering Part B: Reviews 26:6, pages 519-539.
Crossref
Ágnes Szegedi, Ivalina Trendafilova, Judith Mihály, Károly Lázár, Péter Németh, Georgi Momekov, Denitsa Momekova, Lyubomir Marinov, Irina Nikolova & Margarita Popova. (2020) New insight on prednisolone polymorphs in mesoporous silica/maghemite nanocomposites. Journal of Drug Delivery Science and Technology 60, pages 102092.
Crossref
Mahendra Singh, Shiv Bharadwaj, Kyung Eun Lee & Sang Gu Kang. (2020) Therapeutic nanoemulsions in ophthalmic drug administration: Concept in formulations and characterization techniques for ocular drug delivery. Journal of Controlled Release 328, pages 895-916.
Crossref
Christoph R. Buhr, Nadine Wiesmann, Rachel C. Tanner, Jürgen Brieger & Jonas Eckrich. (2020) The Chorioallantoic Membrane Assay in Nanotoxicological Research—An Alternative for In Vivo Experimentation. Nanomaterials 10:12, pages 2328.
Crossref
Roseline Mazet, Josias B. G. Yaméogo, Denis Wouessidjewe, Luc Choisnard & Annabelle Gèze. (2020) Recent Advances in the Design of Topical Ophthalmic Delivery Systems in the Treatment of Ocular Surface Inflammation and Their Biopharmaceutical Evaluation. Pharmaceutics 12:6, pages 570.
Crossref
Dan Yan, Qinke Yao, Fei Yu, Liangbo Chen, Siyi Zhang, Hao Sun, Jinyou Lin & Yao Fu. (2020) Surface modified electrospun poly(lactic acid) fibrous scaffold with cellulose nanofibrils and Ag nanoparticles for ocular cell proliferation and antimicrobial application. Materials Science and Engineering: C 111, pages 110767.
Crossref
V. N. Prozorovskii, O. M. Ipatova, E. G. Tikhonova, T. S. Zakharova, O. S. Druzhilovskaya, E. I. Korotkevich & T. I. Torkhovskaya. (2020) Prednisolone in Phospholipid Nanoparticles: Prolonged Circulation and Increased Antiinflammatory Effect. Biochemistry (Moscow), Supplement Series B: Biomedical Chemistry 14:1, pages 78-81.
Crossref
Milad Reda Qelliny, Usama Farghaly Aly, Omar Helmy Elgarhy & Khaled Aly Khaled. (2019) Budesonide-Loaded Eudragit S 100 Nanocapsules for the Treatment of Acetic Acid-Induced Colitis in Animal Model. AAPS PharmSciTech 20:6.
Crossref
V.N. Prozorovskii, O.M. Ipatova, E.G. Tikhonova, T.S. Zakharova, O.S. Druzhilovskaya, E.I. Korotkevich & T.I. Torkhovskaya. (2019) Prednisolone in phospholipid nanoparticles: prolonged circulation and increased antiinflammatory effect. Biomeditsinskaya Khimiya 65:3, pages 222-226.
Crossref
Grigorios P. Panotopoulos & Ziyad S. Haidar. (2019) Mathematical Modeling for Pharmaco-Kinetic and -Dynamic Predictions from Controlled Drug Release NanoSystems: A Comparative Parametric Study. Scientifica 2019, pages 1-5.
Crossref
Ana Julia F. Dalcin, Bruno S. Vizzotto, Guilherme V. Bochi, Naiara S. Guarda, Kátia Nascimento, Michele R. Sagrillo, Rafael N. Moresco, André P. Schuch, Aline F. Ourique & Patrícia Gomes. (2019) Nanoencapsulation of the flavonoid dihydromyricetin protects against the genotoxicity and cytotoxicity induced by cationic nanocapsules. Colloids and Surfaces B: Biointerfaces 173, pages 798-805.
Crossref
Pamela Krug, Marta Bartel, Paulina Głowala, Barbara Wysocka, Ilona Mojzych, Marta Kwiatkowska, Aleksandra Skiba, Agata Wójtowicz & Maciej Mazur. 2019. Materials for Biomedical Engineering. Materials for Biomedical Engineering 59 111 .
Bhavika B. Patel, Anup D. Sharma, Najiba Mammadova, Elizabeth J. Sandquist, Metin Uz, Surya K. Mallapragada & Donald S. Sakaguchi. 2019. Nanoengineered Biomaterials for Regenerative Medicine. Nanoengineered Biomaterials for Regenerative Medicine 215 264 .
Ziyad S. Haidar. (2018) Mathematical Modeling for Pharmacokinetic Predictions from Controlled Drug Release Nano Systems: A Comparative Parametric Study. Biomedical and Pharmacology Journal 11:4, pages 1801-1806.
Crossref
Mariana Pohlmann, Karina Paese, Luíza Abrahão Frank & Silvia Stanisçuaski Guterres. (2017) Production, characterization and application of nanotechnology-based vegetable multi-component theospheres in nonwovens: A women's intimate hygiene approach. Textile Research Journal 88:20, pages 2292-2302.
Crossref
Julieta C. Imperiale, Gabriela B. Acosta & Alejandro Sosnik. (2018) Polymer-based carriers for ophthalmic drug delivery. Journal of Controlled Release 285, pages 106-141.
Crossref
Seung Choi & Jaeyun Kim. (2018) Therapeutic Contact Lenses with Polymeric Vehicles for Ocular Drug Delivery: A Review. Materials 11:7, pages 1125.
Crossref
Paula Dos Santos Chaves, Luiza Abrahão Frank, Alejandro Germán Frank, Adriana Raffin Pohlmann, Sílvia Stanisçuaski Guterres & Ruy Carlos Ruver Beck. (2018) Mucoadhesive Properties of Eudragit®RS100, Eudragit®S100, and Poly(ε-caprolactone) Nanocapsules: Influence of the Vehicle and the Mucosal Surface. AAPS PharmSciTech 19:4, pages 1637-1646.
Crossref
Rajesh Katara, Sameer Sachdeva & Dipak K. Majumdar. (2017) Enhancement of ocular efficacy of aceclofenac using biodegradable PLGA nanoparticles: formulation and characterization. Drug Delivery and Translational Research 7:5, pages 632-641.
Crossref
R.C.R. Beck, P.S. Chaves, A. Goyanes, B. Vukosavljevic, A. Buanz, M. Windbergs, A.W. Basit & S. Gaisford. (2017) 3D printed tablets loaded with polymeric nanocapsules: An innovative approach to produce customized drug delivery systems. International Journal of Pharmaceutics 528:1-2, pages 268-279.
Crossref
Afra Torge, Stefanie Wagner, Paula S. Chaves, Edilene G. Oliveira, Silvia S. Guterres, Adriana R. Pohlmann, Alexander Titz, Marc Schneider & Ruy C.R. Beck. (2017) Ciprofloxacin-loaded lipid-core nanocapsules as mucus penetrating drug delivery system intended for the treatment of bacterial infections in cystic fibrosis. International Journal of Pharmaceutics 527:1-2, pages 92-102.
Crossref
Rui Liu, Shuangshuang Wang, Shiming Fang, Jialu Wang, Jingjing Chen, Xingguo Huang, Xin He & Changxiao Liu. (2016) Liquid Crystalline Nanoparticles as an Ophthalmic Delivery System for Tetrandrine: Development, Characterization, and In Vitro and In Vivo Evaluation. Nanoscale Research Letters 11:1.
Crossref
R.V. Contri, L.A. Fiel, N. Alnasif, A.R. Pohlmann, S.S. Guterres & M. Schäfer-Korting. (2016) Skin penetration and dermal tolerability of acrylic nanocapsules: Influence of the surface charge and a chitosan gel used as vehicle. International Journal of Pharmaceutics 507:1-2, pages 12-20.
Crossref
Om Prakash Sharma, Viral Patel & Tejal Mehta. (2016) Nanocrystal for ocular drug delivery: hope or hype. Drug Delivery and Translational Research.
Crossref
Diego Fontana de Andrade, Carine Zuglianello, Adriana Raffin Pohlmann, Silvia Stanisçuaski Guterres & Ruy Carlos Ruver Beck. (2015) Assessing the In Vitro Drug Release from Lipid-Core Nanocapsules: a New Strategy Combining Dialysis Sac and a Continuous-Flow System. AAPS PharmSciTech 16:6, pages 1409-1417.
Crossref
Betiana Felice, Molamma P Prabhakaran, Maedeh Zamani, Andrea P Rodríguez & Seeram Ramakrishna. (2015) Electrosprayed poly(vinyl alcohol) particles: preparation and evaluation of their drug release profile. Polymer International 64:12, pages 1722-1732.
Crossref
Renata V. Contri, Rosane M.D. Soares, Adriana R. Pohlmann & Silvia S. Guterres. (2014) Structural analysis of chitosan hydrogels containing polymeric nanocapsules. Materials Science and Engineering: C 42, pages 234-242.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.