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British Journal of Neurosurgery Volume 25, 2011 - Issue 2
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Original Article

Outcomes from stimulation of the caudal zona incerta and pedunculopontine nucleus in patients with Parkinson's disease

Sadaquate KhanDepartment of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
,
Lucy MooneyDepartment of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
,
Puneet PlahaDepartment of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
,
Shazia JavedDepartment of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
,
Paul WhiteDepartment of Mathematics and Statistics, University of the West of England, Bristol, UK
,
Alan L. WhoneDepartment of Neurology, Institute of Neurosciences, Frenchay Hospital, Bristol, UK
&
Steven S. GillDepartment of Neurosurgery, Institute of Neurosciences, Frenchay Hospital, Bristol, UKCorrespondence[email protected]
 show all
Pages 273-280 | Received 30 Aug 2010, Accepted 29 Nov 2010, Published online: 23 Feb 2011

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Matthew J. Barrett, Leslie J. Cloud, Harsh Shah & Kathryn L. Holloway. (2020) Therapeutic approaches to cholinergic deficiency in Lewy body diseases. Expert Review of Neurotherapeutics 20:1, pages 41-53.
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Anna Castrioto & Elena Moro. (2013) New targets for deep brain stimulation treatment of Parkinson’s disease. Expert Review of Neurotherapeutics 13:12, pages 1319-1328.
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Sadaquate Khan, Shazia Javed, Lucy Mooney, Paul White, Puneet Plaha, Alan Whone & Steven S. Gill. (2012) Clinical outcomes from bilateral versus unilateral stimulation of the pedunculopontine nucleus with and without concomitant caudal zona incerta region stimulation in Parkinson's disease. British Journal of Neurosurgery 26:5, pages 722-725.
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Articles from other publishers (53)

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Nicole C. Miranda, Luiz M. Oliveira, Yasmin C. Aquino, Thiago S. Moreira & Ana C. Takakura. (2023) The Pedunculopontine Tegmental Nucleus is not Important for Breathing Impairments Observed in a Parkinson’s Disease Model. Neuroscience 512, pages 32-46.
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Jiayue Cai, Aiping Liu, Yuheng Wang, Sun Nee Tan, Taylor Chomiak, Jacqueline Burt, Richard Camicioli, Bin Hu, Martin J. McKeown & Fang Ba. (2022) Walking exercise alters pedunculopontine nucleus connectivity in Parkinson’s disease in a dose-dependent manner. Frontiers in Neuroscience 16.
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Kaijia Yu, Zhiwei Ren, Song Guo, Jianyu Li & Yongjie Li. (2020) Effects of pedunculopontine nucleus deep brain stimulation on gait disorders in Parkinson’s Disease: A meta-analysis of the literature. Clinical Neurology and Neurosurgery 198, pages 106108.
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Fabin Lin, Dihang Wu, Chenxin Lin, Huihui Cai, Lina Chen, Guofa Cai, Qinyong Ye & Guoen Cai. (2020) Pedunculopontine Nucleus Deep Brain Stimulation Improves Gait Disorder in Parkinson’s Disease: A Systematic Review and Meta-analysis. Neurochemical Research 45:4, pages 709-719.
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Krystyna Ossowska. (2019) Zona incerta as a therapeutic target in Parkinson’s disease. Journal of Neurology 267:3, pages 591-606.
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Nicole Elaine Chambers, Kathryn Lanza & Christopher Bishop. (2020) Pedunculopontine Nucleus Degeneration Contributes to Both Motor and Non-Motor Symptoms of Parkinson’s Disease. Frontiers in Pharmacology 10.
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PareshK Doshi & Deepak Das. (2020) Deep Brain Stimulation for Parkinson's Disease: Currents Status and Emerging Concepts. Neurology India 68:8, pages 179.
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Stephen Joza, Richard Camicioli & Fang Ba. (2019) Falls in Synucleinopathies. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 47:1, pages 30-43.
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Andreas Nowacki, Salvatore Galati, Janine Ai-Schlaeppi, Claudio Bassetti, Alain Kaelin & Claudio Pollo. (2019) Pedunculopontine nucleus: An integrative view with implications on Deep Brain Stimulation. Neurobiology of Disease 128, pages 75-85.
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Zhiqi Mao, Zhipei Ling, Longsheng Pan, Xin Xu, Zhiqiang Cui, Shuli Liang & Xinguang Yu. (2019) Comparison of Efficacy of Deep Brain Stimulation of Different Targets in Parkinson's Disease: A Network Meta-Analysis. Frontiers in Aging Neuroscience 11.
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Xiao-lin Chou, Xiyue Wang, Zheng-gang Zhang, Li Shen, Brian Zingg, Junxiang Huang, Wen Zhong, Lukas Mesik, Li I. Zhang & Huizhong Whit Tao. (2018) Inhibitory gain modulation of defense behaviors by zona incerta. Nature Communications 9:1.
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Stina Sundstedt, Erik Nordh, Jan Linder, Johanna Hedström, Caterina Finizia & Katarina Olofsson. (2016) Swallowing Quality of Life After Zona Incerta Deep Brain Stimulation. Annals of Otology, Rhinology & Laryngology 126:2, pages 110-116.
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Christopher R. Honey, Clement Hamani, Suneil K. Kalia, Tejas Sankar, Marina Picillo, Renato P. Munhoz, Alfonso Fasano & Michel Panisset. (2016) Deep Brain Stimulation Target Selection for Parkinson’s Disease. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 44:1, pages 3-8.
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Han Wang, Huiqin Gao, Tianyu Jiao & Zhongli Luo. (2016) A meta-analysis of the pedunculopontine nucleus deep-brain stimulation effects on Parkinson’s disease. NeuroReport 27:18, pages 1336-1344.
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Tiago A. MestreChristos SidiropoulosClement Hamani, Yu‐Yan Poon, Andres M. Lozano, Anthony E. Lang & Elena Moro. (2016) Long‐term double‐blinded unilateral pedunculopontine area stimulation in Parkinson's disease. Movement Disorders 31:10, pages 1570-1574.
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Tiago A. Mestre & Elena Moro. 2016. Parkinson's Disease. Parkinson's Disease 216 230 .
. 2016. Parkinson's Disease. Parkinson's Disease 175 230 .
N. Yousif, H. Bhatt, P. G. Bain, D. Nandi & B. M. Seemungal. (2016) The effect of pedunculopontine nucleus deep brain stimulation on postural sway and vestibular perception. European Journal of Neurology 23:3, pages 668-670.
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Laleh Golestanirad, Behzad Elahi, Simon J. Graham, Sunit Das & Lawrence L. Wald. (2015) Efficacy and Safety of Pedunculopontine Nuclei (PPN) Deep Brain Stimulation in the Treatment of Gait Disorders: A Meta-Analysis of Clinical Studies. Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques 43:1, pages 120-126.
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Philipp Mahlknecht, Patricia Limousin & Thomas Foltynie. (2015) Deep brain stimulation for movement disorders: update on recent discoveries and outlook on future developments. Journal of Neurology 262:11, pages 2583-2595.
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D Nosko, M U Ferraye, V Fraix, L Goetz, S Chabardès, P Pollak & B Debû. (2015) Low-frequency versus high-frequency stimulation of the pedunculopontine nucleus area in Parkinson's disease: a randomised controlled trial. Journal of Neurology, Neurosurgery & Psychiatry 86:6, pages 674-679.
Crossref
Alfonso Fasano, Camila C. Aquino, Joachim K. Krauss, Christopher R. Honey & Bastiaan R. Bloem. (2015) Axial disability and deep brain stimulation in patients with Parkinson disease. Nature Reviews Neurology 11:2, pages 98-110.
Crossref
Amy W. Amara & Harrison C. Walker. 2015. Disorders of Sleep and Circadian Rhythms in Parkinson's Disease. Disorders of Sleep and Circadian Rhythms in Parkinson's Disease 195 207 .
Hokuto Morita, Chris J. Hass, Elena Moro, Atchar Sudhyadhom, Rajeev Kumar & Michael S. Okun. (2014) Pedunculopontine Nucleus Stimulation: Where are We Now and What Needs to be Done to Move the Field Forward?. Frontiers in Neurology 5.
Crossref
Aparna Wagle Shukla & Michael Scott Okun. (2013) Surgical Treatment of Parkinson’s Disease: Patients, Targets, Devices, and Approaches. Neurotherapeutics 11:1, pages 47-59.
Crossref
Monika Pötter‐Nerger & Jens Volkmann. (2013) Deep brain stimulation for gait and postural symptoms in Parkinson's disease. Movement Disorders 28:11, pages 1609-1615.
Crossref
Neil M. Issar & Joseph S. Neimat. 2013. Handbook of Parkinson’s Disease. Handbook of Parkinson’s Disease 496 519 .
Tao Xie, Jacqueline Bernard & Peter Warnke. (2012) Post subthalamic area deep brain stimulation for tremors: a mini-review. Translational Neurodegeneration 1:1.
Crossref
Patric Blomstedt, Anders Fytagoridis, Mattias Åström, Jan Linder, Lars Forsgren & Marwan I. Hariz. (2012) Unilateral caudal zona incerta deep brain stimulation for Parkinsonian tremor. Parkinsonism & Related Disorders 18:10, pages 1062-1066.
Crossref
B.R. Aravamuthan & D.E. Angelaki. (2012) Vestibular responses in the macaque pedunculopontine nucleus and central mesencephalic reticular formation. Neuroscience 223, pages 183-199.
Crossref
Mahlon DeLong & Thomas Wichmann. (2012) Deep brain stimulation for movement and other neurologic disorders. Annals of the New York Academy of Sciences 1265:1, pages 1-8.
Crossref
Alfonso Fasano, Antonio Daniele & Alberto Albanese. (2012) Treatment of motor and non-motor features of Parkinson's disease with deep brain stimulation. The Lancet Neurology 11:5, pages 429-442.
Crossref
Iciar Aviles-Olmos, Thomas Foltynie, Jalesh Panicker, Dorothy Cowie, Patricia Limousin, Marwan Hariz, Clare J. Fowler & Ludvic Zrinzo. (2012) Uncertainty, misunderstanding and the pedunculopontine nucleus. Acta Neurochirurgica 154:5, pages 839-841.
Crossref
S. KhanS.S. GillL. MooneyP. WhiteA. WhoneD.J. BrooksN. Pavese. (2012) Combined pedunculopontine-subthalamic stimulation in Parkinson disease. Neurology 78:14, pages 1090-1095.
Crossref
JOHN C. ROTHWELL. (2011) THE MOTOR FUNCTIONS OF THE BASAL GANGLIA. Journal of Integrative Neuroscience 10:03, pages 303-315.
Crossref

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