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Research Article

Beneficial effects of levosimendan on cerebral vasospasm induced by subarachnoid haemorrhage: An experimental study

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Pages 877-885 | Received 09 Dec 2009, Accepted 18 Mar 2010, Published online: 30 Apr 2010

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Dariusz Onichimowski, Krzysztof Nosek, Radosław Goraj, Rakesh Jalali, Aleksandra Wińska, Aleksandra Pawlos & Bułat Tuyakov. (2018) Use of levosimendan in the treatment of cerebral vascular vasospasm: a case study. Drug Design, Development and Therapy 12, pages 1777-1783.
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Bora Gürer. 2023. Handbook of Animal Models in Neurological Disorders. Handbook of Animal Models in Neurological Disorders 631 640 .
Abdurrahman Aycan, Ersoy Oksuz, Edip Gonullu, Tuncay Kume, Bekir Ergur, Mehmet Edip Akyol, Abdurrahim Tas & Fetullah Kuyumcu. (2022) A New Approach in the Treatment of Traumatic Brain Injury: The Effects of Levosimendan on Necrosis, Apoptosis, and Oxidative Stress. World Neurosurgery 168, pages e432-e441.
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Vincent Cottenceau, Bastien Poutier, Florent Gariel, Noemie Sauvage, Laurent Petit, Cedric Carrie & Matthieu Biais. (2019) May levosimendan be safe and effective in refractory vasospasm despite adequate treatment with repeated angiography and milrinone infusion after subarachnoid haemorrhage?. Anaesthesia Critical Care & Pain Medicine 38:6, pages 665-667.
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Ammar Al-Chalabi, Leo M. A. Heunks, Zoltán Papp & Piero Pollesello. (2019) Potential of the Cardiovascular Drug Levosimendan in the Management of Amyotrophic Lateral Sclerosis. Journal of Cardiovascular Pharmacology 74:5, pages 389-399.
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Emre BİLGİN, Kadir OKTAY, Semih Kıvanç OLGUNER, Gökhan ÇAVUŞ, Vedat AÇIK, Ali ARSLAN & Metin TUNA. (2019) Endothelin-1 levels in serum and cerebrospinal fluid after vasospasm following spontaneous subarachnoid haemorrhageSpontan subaraknoid kanamayı takiben gelişen vazospazm sonrası serum ve serebrospinal sıvıda endotelin-1 düzeyleri. Cukurova Medical Journal 44:2, pages 334-340.
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Dimitrios Farmakis, Julian Alvarez, Tuvia Ben Gal, Dulce Brito, Francesco Fedele, Candida Fonseca, Anthony C. Gordon, Israel Gotsman, Elena Grossini, Fabio Guarracino, Veli-Pekka Harjola, Yaron Hellman, Leo Heunks, Visnja Ivancan, Apostolos Karavidas, Matti Kivikko, Vladimir Lomivorotov, Dan Longrois, Josep Masip, Marco Metra, Andrea Morelli, Maria Nikolaou, Zoltán Papp, Alexander Parkhomenko, Gerhard Poelzl, Piero Pollesello, Hanne Berg Ravn, Steffen Rex, Hynek Riha, Sven-Erik Ricksten, Robert H.G. Schwinger, Bojan Vrtovec, M. Birhan Yilmaz, Marzenna Zielinska & John Parissis. (2016) Levosimendan beyond inotropy and acute heart failure: Evidence of pleiotropic effects on the heart and other organs: An expert panel position paper. International Journal of Cardiology 222, pages 303-312.
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Giolanda Varvarousi, Theodoros Xanthos, Pavlina Sarafidou, Ellisavet Katsioula, Marianthi Georgiadou, Maria Eforakopoulou & Hlias Pavlou. (2016) Role of levosimendan in the management of subarachnoid hemorrhage. The American Journal of Emergency Medicine 34:2, pages 298-306.
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Matti Kivikko, Mikko Kuoppamäki, Lauri Soinne, Stig Sundberg, Pasi Pohjanjousi, Juha Ellmen & Risto O. Roine. (2015) Oral Levosimendan Increases Cerebral Blood Flow Velocities in Patients with a History of Stroke or Transient Ischemic Attack: A Pilot Safety Study. Current Therapeutic Research 77, pages 46-51.
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Yuichiro Kikkawa, Ryota Kurogi & Tomio Sasaki. (2014) The Single and Double Blood Injection Rabbit Subarachnoid Hemorrhage Model. Translational Stroke Research 6:1, pages 88-97.
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John Papanikolaou, Vasiliki Tsolaki, Demosthenes Makris & Epaminondas Zakynthinos. (2014) Early levosimendan administration may improve outcome in patients with subarachnoid hemorrhage complicated by acute heart failure. International Journal of Cardiology 176:3, pages 1435-1437.
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Giolanda Varvarousi, Antonia Stefaniotou, Dimitrios Varvaroussis, Filippia Aroni & Theodoros Xanthos. (2014) The role of Levosimendan in cardiopulmonary resuscitation. European Journal of Pharmacology 740, pages 596-602.
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Poongundran Namachivayam, Joseph J. Smolich, Amy E. Shields, Sandra Rees, Lee Coleman, Steven B. Horton, Igor E. Konstantinov, Daniel J. Penny & Lara S. Shekerdemian. (2014) Impact of levosimendan on brain injury patterns in a lamb model of infant cardiopulmonary bypass. Pediatric Research 76:1, pages 64-71.
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Marc Hein, Norbert Zoremba, Chistian Bleilevens, Christian Bruells, Rolf Rossaint & Anna B Roehl. (2013) Levosimendan limits reperfusion injury in a rat middle cerebral artery occlusion (MCAO) model. BMC Neurology 13:1.
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Anna B Roehl, Norbert Zoremba, Markus Kipp, Johannes Schiefer, Andreas Goetzenich, Christian Bleilevens, Nikolaus Kuehn-Velten, Rene Tolba, Rolf Rossaint & Marc Hein. (2012) The effects of levosimendan on brain metabolism during initial recovery from global transient ischaemia/hypoxia. BMC Neurology 12:1.
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A. Küçük, M. Yucel, N. Erkasap, M. Tosun, T. Koken, M. Ozkurt & S. Erkasap. (2012) The effects of PDE5 inhibitory drugs on renal ischemia/reperfusion injury in rats. Molecular Biology Reports 39:10, pages 9775-9782.
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