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Original Article

Characterization of Human Meibum Lipid using Raman Spectroscopy

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Pages 824-835 | Received 06 Mar 2009, Accepted 15 Jun 2009, Published online: 06 Nov 2009

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (3)

Shiwani R. Raju, Chendur K. Palaniappan, Howard A. Ketelson, James W. Davis & Thomas J. Millar. (2013) Interfacial Dilatational Viscoelasticity of Human Meibomian Lipid Films. Current Eye Research 38:8, pages 817-824.
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Zara Ashraf, Uzma Pasha, Victoria Greenstone, Janeeta Akbar, Edwin Apenbrinck, Gary N Foulks & Douglas Borchman. (2011) Quantification of Human Sebum on Skin and Human Meibum on the Eye Lid Margin Using Sebutape®, Spectroscopy and Chemical Analysis. Current Eye Research 36:6, pages 553-562.
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Douglas Borchman, Gary N. Foulks & Marta C. Yappert. (2010) Confirmation of Changes in Human Meibum Lipid Infrared Spectra with Age Using Principal Component Analysis. Current Eye Research 35:9, pages 778-786.
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Articles from other publishers (37)

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Shiro Amano, Jun Shimazaki, Norihiko Yokoi, Yuichi Hori, Reiko Arita, Hiroto Obata, Motoko Kawashima, Shizuka Koh, Takashi Suzuki, Tomo Suzuki, Masahiko Yamaguchi, Masakazu Yamada, Takashi Itokawa, Hiroko Iwashita, Tomohiko Usui, Miki Uchino, Fumika Oya, Yukinobu Okajima, Minako Kaido, Koji Kakisu, Yuichi Kaji, Hiroaki Kato, Eiki Goto, Aoi Komuro, Yuri Sakane, Chika Shigeyasu, Sayaka Sumazaki, Seika Den, Yukiko Nagahara, Yasuhito Hayashi, Masatoshi Hirayama, Masaki Fukui, Shima Fukuoka, Yuka Hosotani, Naoyuki Morishige, Yasuto Sato, Akiko Yagami, Atsushi Shiraishi, Kazutaka Kamiya, Mika Noda & Takeshi Soma. (2023) Meibomian Gland Dysfunction Clinical Practice Guidelines. Japanese Journal of Ophthalmology 67:4, pages 448-539.
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Anthony Ewurum, Akhila Ankem, Georgi Georgiev & Douglas Borchman. (2021) A spectroscopic study of the composition and conformation of cholesteryl and wax esters purified from meibum. Chemistry and Physics of Lipids 238, pages 105088.
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Douglas Borchman. (2021) Lipid conformational order and the etiology of cataract and dry eye. Journal of Lipid Research 62, pages 100039.
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Lin-Wei Shang, Dan-Ying Ma, Juan-Juan Fu, Yan-Fei Lu, Yuan Zhao, Xin-Yu Xu & Jian-Hua Yin. (2020) Fluorescence imaging and Raman spectroscopy applied for the accurate diagnosis of breast cancer with deep learning algorithms. Biomedical Optics Express 11:7, pages 3673.
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Olga Guselnikova, Yevgeniya Kalachyova, Karolina Hrobonova, Marina Trusova, Jiri Barek, Pavel Postnikov, Vaclav Svorcik & Oleksiy Lyutakov. (2018) SERS platform for detection of lipids and disease markers prepared using modification of plasmonic-active gold gratings by lipophilic moieties. Sensors and Actuators B: Chemical 265, pages 182-192.
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Akinori Taketani, Bibin B. Andriana, Hiroko Matsuyoshi & Hidetoshi Sato. (2017) Raman endoscopy for monitoring the anticancer drug treatment of colorectal tumors in live mice. The Analyst 142:19, pages 3680-3688.
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Alba Alfonso-García, Jerry Paugh, Marjan Farid, Sumit Garg, James Jester & Eric Potma. (2017) A machine learning framework to analyze hyperspectral stimulated Raman scattering microscopy images of expressed human meibum. Journal of Raman Spectroscopy 48:6, pages 803-812.
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Sixian You, Haohua Tu, Youbo Zhao, Yuan Liu, Eric J. Chaney, Marina Marjanovic & Stephen A. Boppart. (2016) Raman Spectroscopic Analysis Reveals Abnormal Fatty Acid Composition in Tumor Micro- and Macroenvironments in Human Breast and Rat Mammary Cancer. Scientific Reports 6:1.
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Samiyyah M. Sledge, Hussain Khimji, Douglas Borchman, Alexandria L. Oliver, Heidi Michael, Emily K. Dennis, Dylan Gerlach, Rahul Bhola & Elsa Stephen. (2016) Evaporation and Hydrocarbon Chain Conformation of Surface Lipid Films. The Ocular Surface 14:4, pages 447-459.
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Jesse S. Pelletier, Kevin P. Stewart, Kara Capriotti & Joseph A. Capriotti. (2015) Rosacea Blepharoconjunctivitis Treated with a Novel Preparation of Dilute Povidone Iodine and Dimethylsulfoxide: a Case Report and Review of the Literature. Ophthalmology and Therapy 4:2, pages 143-150.
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Slavyana Ivanova, Vesselin Tonchev, Norihiko Yokoi, Marta Yappert, Douglas Borchman & Georgi Georgiev. (2015) Surface Properties of Squalene/Meibum Films and NMR Confirmation of Squalene in Tears. International Journal of Molecular Sciences 16:9, pages 21813-21831.
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S. Fermon, I. Hindi Zaga & D. Alvarez Melloni. (2015) Intraductal meibomian gland probing for the treatment of blepharitis. Archivos de la Sociedad Española de Oftalmología (English Edition) 90:2, pages 76-80.
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S. Fermon, I. Hindi Zaga & D. Alvarez Melloni. (2015) Sondaje intraductal de las glándulas de Meibomio para el tratamiento de blefaritis posterior severa. Archivos de la Sociedad Española de Oftalmología 90:2, pages 76-80.
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Mika Ishigaki & Hidetoshi Sato. The discrimination of fish egg quality and viability by using Raman spectroscopy. The discrimination of fish egg quality and viability by using Raman spectroscopy.
Akinori Taketani, Mika Ishigaki, Bibin Bintan Andriana & Hidetoshi Sato. Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice. Raman endoscopy for real time monitoring of anticancer drug treatment in colorectal tumors of live model mice.
Mika Ishigaki, Akinori Taketani & Hidetoshi Sato. (2014) Discrimination of fish egg quality and viability by Raman spectroscopy. Anal. Methods 6:23, pages 9206-9211.
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Jeffrey L. Suhalim, Geraint J. Parfitt, Yilu Xie, Cintia S. De Paiva, Stephen C. Pflugfelder, Tejas N. Shah, Eric O. Potma, Donald J. Brown & James V. Jester. (2014) Effect of Desiccating Stress on Mouse Meibomian Gland Function. The Ocular Surface 12:1, pages 59-68.
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Petra S. Larmo, Riikka L. Järvinen, Baoru Yang & Heikki P. Kallio. 2014. Handbook of Nutrition, Diet and the Eye. Handbook of Nutrition, Diet and the Eye 473 480 .
Igor A. Butovich. (2013) Tear film lipids. Experimental Eye Research 117, pages 4-27.
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Douglas Borchman, Marta C. Yappert, Sarah E. Milliner, Ryan J. Smith & Rahul Bhola. (2013) Confirmation of the Presence of Squalene in Human Eyelid Lipid by Heteronuclear Single Quantum Correlation Spectroscopy. Lipids 48:12, pages 1269-1277.
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Poonam Mudgil, Douglas Borchman, Marta C. Yappert, Diana Duran, Gregory W. Cox, Ryan J. Smith, Rahul Bhola, Gary R. Dennis & John S. Whitehall. (2013) Lipid order, saturation and surface property relationships: A study of human meibum saturation. Experimental Eye Research 116, pages 79-85.
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P. Ewen King-Smith, Melissa D. Bailey & Richard J. Braun. (2013) Four Characteristics and a Model of an Effective Tear Film Lipid Layer (TFLL). The Ocular Surface 11:4, pages 236-245.
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Douglas Borchman, Marta C. Yappert, Sarah E. Milliner, Diana Duran, Gregory W. Cox, Ryan J. Smith & Rahul Bhola. (2013) 13C and 1H NMR ester region resonance assignments and the composition of human infant and child meibum. Experimental Eye Research 112, pages 151-159.
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Gary N. Foulks, Douglas Borchman, Marta Yappert & Shelley Kakar. (2013) Topical Azithromycin and Oral Doxycycline Therapy of Meibomian Gland Dysfunction. Cornea 32:1, pages 44-53.
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Akinori Taketani, Retno Hariyani, Mika Ishigaki, Bibin B. Andriana & Hidetoshi Sato. (2013) Raman endoscopy for the in situ investigation of advancing colorectal tumors in live model mice. The Analyst 138:14, pages 4183.
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Sravya Vishnubhatla, Douglas Borchman & Gary N. Foulks. (2012) Contact lenses and the rate of evaporation measured in vitro; the influence of wear, squalene and wax. Contact Lens and Anterior Eye 35:6, pages 277-281.
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Andrew D. Pucker & Jason J. Nichols. (2012) Analysis of Meibum and Tear Lipids. The Ocular Surface 10:4, pages 230-250.
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Samad Faheem, Sung-Hye Kim, Jonathan Nguyen, Shantanu Neravetla, Matthew Ball, Gary N. Foulks, Marta C. Yappert & Douglas Borchman. (2012) Wax-tear and meibum protein, wax–β-carotene interactions in vitro using infrared spectroscopy. Experimental Eye Research 100, pages 32-39.
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Andrew D. Pucker & Jason J. Nichols. (2012) A Method of Imaging Lipids on Silicone Hydrogel Contact Lenses. Optometry and Vision Science 89:5, pages E777-E787.
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Petra S. Larmo, Baoru Yang, Riikka L. Järvinen, Niko L. Setälä, Matti H. Viitanen & Heikki P. Kallio. 2012. Emerging Trends in Dietary Components for Preventing and Combating Disease. Emerging Trends in Dietary Components for Preventing and Combating Disease 533 543 .
Riikka L Järvinen, Petra S Larmo, Niko L Setälä, Baoru Yang, Janne RK Engblom, Matti H Viitanen & Heikki P Kallio. (2011) Effects of Oral Sea Buckthorn Oil on Tear Film Fatty Acids in Individuals With Dry Eye. Cornea 30:9, pages 1013-1019.
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Igor A. Butovich. (2011) Lipidomics of human Meibomian gland secretions: Chemistry, biophysics, and physiological role of Meibomian lipids. Progress in Lipid Research 50:3, pages 278-301.
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Chia-Yu Lin, Jeffrey L. Suhalim, Chyong Ly Nien, Miloš D. Miljković, Max Diem, James V. Jester & Eric. O. Potma. (2011) Picosecond spectral coherent anti-Stokes Raman scattering imaging with principal component analysis of meibomian glands. Journal of Biomedical Optics 16:2, pages 021104.
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Pu Chen, Aiguo Shen, Xiaodong Zhou & Jiming Hu. (2011) Bio-Raman spectroscopy: a potential clinical analytical method assisting in disease diagnosis. Analytical Methods 3:6, pages 1257.
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Gary N. Foulks & Douglas Borchman. (2010) Meibomian Gland Dysfunction: The Past, Present, and Future. Eye & Contact Lens: Science & Clinical Practice 36:5, pages 249-253.
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Douglas Borchman, Marta C. Yappert & Gary N. Foulks. (2010) Changes in human meibum lipid with meibomian gland dysfunction using principal component analysis. Experimental Eye Research 91:2, pages 246-256.
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