Advanced search
Publication Cover
Current Eye Research Volume 35, 2010 - Issue 11
Submit an article Journal homepage
846
Views
53
CrossRef citations to date
0
Altmetric
Mini Review

Mesenchymal Stem Cells and Potential Applications in Treating Ocular Disease

Aaron W JoeDepartment of Ophthalmology and Visual Science, University of British Columbia, Vancouver, BC, Canada
&
Kevin Gregory-EvansDepartment of Ophthalmology and Visual Science, University of British Columbia, Vancouver, BC, CanadaCorrespondence[email protected]
Pages 941-952 | Received 17 May 2010, Accepted 08 Aug 2010, Published online: 19 Oct 2010

Citations (53)

Keep up to date with the latest research on this topic with citation updates for this article.

Subscribe to citation updates

Read on this site (2)

Wei Xu, Xiao-Ting Wang, Guo-Xing Xu, Jian Guo & Li-Bin Huang. (2014) Stromal Cell-Derived Factor 1α-Stimulated Mesenchymal Stem Cells Confer Enhanced Protection Against Light-Induced Retinal Degeneration in Rats. Current Eye Research 39:1, pages 69-78.
Read now
Sergio Zaccaria Scalinci, Lucia Scorolli, Giulia Corradetti, Daniela Domanico, Enzo Maria Vingolo, Alessandro Meduri, Mario Bifani & Duilio Siravo. (2011) Potential role of intravitreal human placental stem cell implants in inhibiting progression of diabetic retinopathy in type 2 diabetes: neuroprotective growth factors in the vitreous. Clinical Ophthalmology 5, pages 691-696.
Read now

Articles from other publishers (51)

Yuan-Fang Zhu, Wen-Ya Qiu, Ye-Sheng Xu & Yu-Feng Yao. (2023) Clinical efficacy of a new surgical technique of oral mucosal epithelial transplantation for severe ocular surface disorders. BMC Ophthalmology 23:1.
Crossref
Scott D. Fitzpatrick, Mohammad Abu Jafar Mazumder, Lindsay E. Fitzpatrick, Ben Muirhead, Shelley R. Boyd, Talena Rambarran & Heather Sheardown. (2023) Synthesis of an optically transparent poly( N -isopropylacrylamide)-based thermally gelling material . Canadian Journal of Chemistry 101:2, pages 59-69.
Crossref
Inês E. Dias, Carlos A. Viegas, João F. Requicha, Maria J. Saavedra, Jorge M. Azevedo, Pedro P. Carvalho & Isabel R. Dias. (2022) Mesenchymal Stem Cell Studies in the Goat Model for Biomedical Research—A Review of the Scientific Literature. Biology 11:9, pages 1276.
Crossref
Lina Moallemi Rad, Alexey V. Yumashev, Bashdar Mahmud Hussen, Hazha Hadayat Jamad, Soudeh Ghafouri-Fard, Mohammad Taheri, Samaneh Rostami, Vahid Niazi & Mohammadreza Hajiesmaeili. (2022) Therapeutic Potential of Microvesicles in Cell Therapy and Regenerative Medicine of Ocular Diseases With an Especial Focus on Mesenchymal Stem Cells-Derived Microvesicles. Frontiers in Genetics 13.
Crossref
E. Zakirova, A. M. Aimaletdinov, A. G. Malanyeva, C. S. Rutland & A. A. Rizvanov. 2022. Handbook of Stem Cell Therapy. Handbook of Stem Cell Therapy 323 347 .
E. Zakirova, A. M. Aimaletdinov, A. G. Malanyeva, С. S. Rutland & A. A. Rizvanov. 2022. Handbook of Stem Cell Therapy. Handbook of Stem Cell Therapy 1 25 .
Luis A. Martinez Velazquez & Brian G. Ballios. (2021) The Next Generation of Molecular and Cellular Therapeutics for Inherited Retinal Disease. International Journal of Molecular Sciences 22:21, pages 11542.
Crossref
Subramaniam Mohana Devi, B Abishek Kumar, Iyer Mahalaxmi & Vellingiri Balachandar. (2021) Leber’s hereditary optic neuropathy: Current approaches and future perspectives on Mesenchymal stem cell-mediated rescue. Mitochondrion 60, pages 201-218.
Crossref
Anna Maria Roszkowska, Giovanni William Oliverio, Emanuela Aragona, Leandro Inferrera, Alice Antonella Severo, Federica Alessandrello, Rosaria Spinella, Elisa Imelde Postorino & Pasquale Aragona. (2021) Ophthalmologic Manifestations of Primary Sjögren’s Syndrome. Genes 12:3, pages 365.
Crossref
Yao-Tseng Wen, Yu-Chieh Ho, Yueh-Chang Lee, Dah-Ching Ding, Pei-Kang Liu & Rong-Kung Tsai. (2021) The Benefits and Hazards of Intravitreal Mesenchymal Stem Cell (MSC) Based-Therapies in the Experimental Ischemic Optic Neuropathy. International Journal of Molecular Sciences 22:4, pages 2117.
Crossref
Baraa Noueihed, José Carlos Rivera, Rabah Dabouz, Pénélope Abram, Samy Omri, Isabelle Lahaie & Sylvain Chemtob. (2021) Mesenchymal Stromal Cells Promote Retinal Vascular Repair by Modulating Sema3E and IL-17A in a Model of Ischemic Retinopathy. Frontiers in Cell and Developmental Biology 9.
Crossref
TongalpH Tezel & Adam Ruff. (2021) Retinal cell transplantation in retinitis pigmentosa. Taiwan Journal of Ophthalmology 11:4, pages 336.
Crossref
Carmen Gutierrez‐Millan, Clara Calvo Díaz, José M. Lanao & Clara I. Colino. (2020) Advances in Exosomes‐Based Drug Delivery Systems. Macromolecular Bioscience 21:1, pages 2000269.
Crossref
Libin Huang, Junmei You, Yao Yao & Maosong Xie. (2019) Interleukin-13 Gene Modification Enhances Grafted Mesenchymal Stem Cells Survival After Subretinal Transplantation. Cellular and Molecular Neurobiology 40:5, pages 725-735.
Crossref
Bo Yu, Xiao-Rong Li & Xiao-Min Zhang. (2020) Mesenchymal stem cell-derived extracellular vesicles as a new therapeutic strategy for ocular diseases. World Journal of Stem Cells 12:3, pages 178-187.
Crossref
Xin Liu, Jia'nan Xie, Longfei Yang, Ying Li, Yuxi He, Zaoxia Liu, Yan Zhang & Guanfang Su. (2020) Bone marrow mesenchymal stem cells enhance autophagy and help protect cells under hypoxic and retinal detachment conditions. Journal of Cellular and Molecular Medicine 24:6, pages 3346-3358.
Crossref
E. Yu Zakirova, A.N. Valeeva, A.M. Aimaletdinov, L.V. Nefedovskaya, R.F. Akhmetshin, C.S. Rutland & A.A. Rizvanov. (2019) Potential therapeutic application of mesenchymal stem cells in ophthalmology. Experimental Eye Research 189, pages 107863.
Crossref
Margarita Calonge, Inmaculada Pérez, Sara Galindo, Teresa Nieto-Miguel, Marina López-Paniagua, Itziar Fernández, Mercedes Alberca, Javier García-Sancho, Ana Sánchez & José M. Herreras. (2019) A proof-of-concept clinical trial using mesenchymal stem cells for the treatment of corneal epithelial stem cell deficiency. Translational Research 206, pages 18-40.
Crossref
Erdal Karaoz, Filiz Tepekoy, Irem Yilmaz, Cansu Subasi & Serdar Kabatas. (2019) Reduction of Inflammation and Enhancement of Motility after Pancreatic Islet Derived Stem Cell Transplantation Following Spinal Cord Injury. Journal of Korean Neurosurgical Society 62:2, pages 153-165.
Crossref
Juan Sendon-Lago, Samuel Seoane, Anxo Martinez-Ordoñez, Noemi Eiro, Jorge Saa, Francisco J. Vizoso, Francisco Gonzalez, Roman Perez-Fernandez & Maria A. Bermudez. (2019) Corneal regeneration by conditioned medium of human uterine cervical stem cells is mediated by TIMP-1 and TIMP-2. Experimental Eye Research 180, pages 110-121.
Crossref
Ricardo P. Casaroli-Marano, Núria Nieto-Nicolau & Raquel A. Martínez-García de la Torre. 2019. Cell-Based Therapy for Degenerative Retinal Disease. Cell-Based Therapy for Degenerative Retinal Disease 53 80 .
Helen P. Makarenkova & Robyn Meech. 2019. Mouse Cell Culture. Mouse Cell Culture 169 180 .
Carolina Assis P. Vilela, Lucas Eduardo B. Souza, Rubens C. Siqueira, Rodrigo T. Calado, Dimas T. Covas & Jayter S. Paula. (2018) Ex vivo evaluation of intravitreal mesenchymal stromal cell viability using bioluminescence imaging. Stem Cell Research & Therapy 9:1.
Crossref
Mingqi Zhang, Zhuoshi Wang, Yan Zhao, Lirong Zhang, Ling Xu, Liu Cao & Wei He. (2018) The Effect of Age on the Regenerative Potential of Human Eyelid Adipose-Derived Stem Cells. Stem Cells International 2018, pages 1-11.
Crossref
C. Randall Harrell, Bojana Simovic Markovic, Crissy Fellabaum, Aleksandar Arsenijevic, Valentin Djonov, Nebojsa Arsenijevic & Vladislav Volarevic. 2018. Cell Biology and Translational Medicine, Volume 2. Cell Biology and Translational Medicine, Volume 2 47 57 .
Antonio Villatoro, Viviana Fernández, Silvia Claros, Cristina Alcoholado, Manuel Cifuentes, Jesús Merayo-Lloves, José Andrades & José Becerra. (2017) Regenerative Therapies in Dry Eye Disease: From Growth Factors to Cell Therapy. International Journal of Molecular Sciences 18:11, pages 2264.
Crossref
Sara Galindo, José M. Herreras, Marina López-Paniagua, Esther Rey, Ana de la Mata, María Plata-Cordero, Margarita Calonge & Teresa Nieto-Miguel. (2017) Therapeutic Effect of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Experimental Corneal Failure Due to Limbal Stem Cell Niche Damage. Stem Cells 35:10, pages 2160-2174.
Crossref
Hossein Salehi, Noushin Amirpour, Shahnaz Razavi, Ebrahim Esfandiari & Reihaneh Zavar. (2017) Overview of retinal differentiation potential of mesenchymal stem cells: A promising approach for retinal cell therapy. Annals of Anatomy - Anatomischer Anzeiger 210, pages 52-63.
Crossref
Puay Yong Neo, Eugene Yong-Shun See, Siew Lok Toh & James Cho-Hong Goh. (2016) Temporal profiling of the growth and multi-lineage potentiality of adipose tissue-derived mesenchymal stem cells cell-sheets. Journal of Tissue Engineering and Regenerative Medicine 10:7, pages 564-579.
Crossref
Eun-Ah Ye, Sagar S Chawla, Michael Z Khan & Donald S Sakaguchi. (2016) Bone marrow-derived mesenchymal stem cells (MSCs) stimulate neurite outgrowth from differentiating adult hippocampal progenitor cells. Stem Cell Biology and Research 3:1, pages 3.
Crossref
Liyun Zhang, Vivien Jane Coulson-Thomas, Tarsis Gesteira Ferreira & Winston W. Y. Kao. (2015) Mesenchymal stem cells for treating ocular surface diseases. BMC Ophthalmology 15:S1.
Crossref
Hossein Nazari, Li Zhang, Danhong Zhu, Gerald J. Chader, Paulo Falabella, Francisco Stefanini, Teisha Rowland, Dennis O. Clegg, Amir H. Kashani, David R. Hinton & Mark S. Humayun. (2015) Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Progress in Retinal and Eye Research 48, pages 1-39.
Crossref
Joshua T. Morgan, Heung Sun Kwon, Joshua A. Wood, Dori L. Borjesson, Stanislav I. Tomarev, Christopher J. Murphy & Paul Russell. (2015) Thermally labile components of aqueous humor potently induce osteogenic potential in adipose-derived mesenchymal stem cells. Experimental Eye Research 135, pages 127-133.
Crossref
Peter Cimalla, Theresa Werner, Kai Winkler, Claudia Mueller, Sebastian Wicht, Maria Gaertner, Mirko Mehner, Julia Walther, Bernd Rellinghaus, Dierk Wittig, Mike O. Karl, Marius Ader, Richard H. W. Funk & Edmund Koch. (2015) Imaging of nanoparticle-labeled stem cells using magnetomotive optical coherence tomography, laser speckle reflectometry, and light microscopy. Journal of Biomedical Optics 20:3, pages 036018.
Crossref
Yuanfeng Jiang, Yan Zhang, Lingjun Zhang, Meiyan Wang, Xiaomin Zhang & Xiaorong Li. (2014) Therapeutic Effect of Bone Marrow Mesenchymal Stem Cells on Laser-Induced Retinal Injury in Mice. International Journal of Molecular Sciences 15:6, pages 9372-9385.
Crossref
Che Man Rohaina, Kong Yong Then, Angela Min Hwei Ng, Wan Haslina Wan Abdul Halim, Aida Zairani Mohd Zahidin, Aminuddin Saim & Ruszymah B.H. Idrus. (2014) Reconstruction of limbal stem cell deficient corneal surface with induced human bone marrow mesenchymal stem cells on amniotic membrane. Translational Research 163:3, pages 200-210.
Crossref
Emrullah Beyazyıldız, Ferda Alpaslan Pınarlı, Özlem Beyazyıldız, Emine Rümeysa Hekimoğlu, Uğur Acar, Muhammed Necati Demir, Aynur Albayrak, Figen Kaymaz, Güngör Sobacı & Tuncay Delibaşı. (2014) Efficacy of Topical Mesenchymal Stem Cell Therapy in the Treatment of Experimental Dry Eye Syndrome Model. Stem Cells International 2014, pages 1-9.
Crossref
Yichi Zhang, Yan Luo, Kaijing Li, Min Zhang, Bing Huang, Yuting Peng, Wenchong Wang, Weihua Li & Yizhi Liu. (2013) Pre-induced adult human peripheral blood mononuclear cells migrate widely into the degenerative retinas of rd1 mice. Cytotherapy 15:11, pages 1416-1425.
Crossref
Wei Xu, Xiaoting Wang, Guoxing Xu & Jian Guo. (2013) Basic Fibroblast Growth Factor Expression is Implicated in Mesenchymal Stem Cells Response to Light-Induced Retinal Injury. Cellular and Molecular Neurobiology 33:8, pages 1171-1179.
Crossref
John V. Forrester, Raymond J. Steptoe, Izabela P. Klaska, Cristina Martin-Granados, Harminder S. Dua, Mariapia A. Degli-Esposti & Matthew E. Wikstrom. (2013) Cell-based therapies for ocular inflammation. Progress in Retinal and Eye Research 35, pages 82-101.
Crossref
Aliakbar Haddad‐Mashadrizeh, Ahmad R. Bahrami, Maryam M. Matin, Mohammad A. Edalatmanesh, Alireza Zomorodipour, Mossa Gardaneh, Moein Farshchian & Madjid Momeni‐Moghaddam. (2013) Human adipose‐derived mesenchymal stem cells can survive and integrate into the adult rat eye following xenotransplantation. Xenotransplantation 20:3, pages 165-176.
Crossref
Joni H. Ylöstalo & Thomas J. Bartosh. 2006. Encyclopedia of Molecular Cell Biology and Molecular Medicine. Encyclopedia of Molecular Cell Biology and Molecular Medicine.
Ricardo P. Casaroli-Marano, Nuria Nieto-Nicolau & Eva M. Martínez-Conesa. (2013) Progenitor Cells for Ocular Surface Regenerative Therapy. Ophthalmic Research 49:3, pages 115-121.
Crossref
Abu Emran Bashar, Andrew Metcalfe, Anat Yanai, Christopher Laver, Urs O. Hafeli, Cheryl Y. Gregory-Evans, Orson L. Moritz, Joanne A. Matsubara & Kevin Gregory-Evans. (2013) Influence of Iron Oxide Nanoparticles on Innate and Genetically Modified Secretion Profiles of Mesenchymal Stem Cells. IEEE Transactions on Magnetics 49:1, pages 389-393.
Crossref
Kevin Gregory-Evans, Mark E. Pennesi & Richard G. Weleber. 2013. Retina. Retina 761 835 .
Anat Yanai, Urs O. Häfeli, Andrew L. Metcalfe, Peter Soema, Lois Addo, Cheryl Y. Gregory-Evans, Kelvin Po, Xianghong Shan, Orson L. Moritz & Kevin Gregory-Evans. (2012) Focused Magnetic Stem Cell Targeting to the Retina Using Superparamagnetic Iron Oxide Nanoparticles. Cell Transplantation 21:6, pages 1137-1148.
Crossref
Khrishen Cunnusamy, Rafael Ufret-Vincenty & Shusheng Wang. (2012) Next-generation therapeutic solutions for age-related macular degeneration. Pharmaceutical Patent Analyst 1:2, pages 193-206.
Crossref
Joëlle A. Baddour, Konstantinos Sousounis & Panagiotis A. Tsonis. (2012) Organ repair and regeneration: An overview. Birth Defects Research Part C: Embryo Today: Reviews 96:1, pages 1-29.
Crossref
. (2011) Current World Literature. Current Opinion in Rheumatology 23:6, pages 620-625.
Crossref
Hall F. Chew. (2011) Limbal stem cell disease: Treatment and advances in technology. Saudi Journal of Ophthalmology 25:3, pages 213-218.
Crossref
Margit Schulze & Edda Tobiasch. 2012. Tissue Engineering III: Cell - Surface Interactions for Tissue Culture. Tissue Engineering III: Cell - Surface Interactions for Tissue Culture 153 194 .

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Order Reprints Request Corporate Permissions

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

Request Academic Permissions

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.