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Original Article

Long-Term Topical Antiglaucoma Medications Cause Enhanced Tenon’s Capsule Fibroblast Proliferation and Abnormal TGF-β and MMP Expressions: Potential Effects on Glaucoma Filtering Surgery

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Pages 301-309 | Received 25 Jun 2010, Accepted 08 Dec 2010, Published online: 24 Feb 2011

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Susana Duch, Carlos A Arciniegas-Perasso, Stefania Piludu, Shirin Djavanmardi & Elena Milla. (2021) Risk Factors for Failure in Double-Plate Tube Surgery for Refractory Glaucoma: 25 Years Surgical Experience. Clinical Ophthalmology 15, pages 461-472.
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Jonathan Cheuk-hung Chan, Shing Chuen Chow & Jimmy Shiu-ming Lai. (2020) Effectiveness and Safety of Long Duration versus Short Duration Diode Laser Transscleral Cyclophotocoagulation. Clinical Ophthalmology 14, pages 197-204.
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Antoine Labbé, Eric Gabison, Françoise Brignole-Baudouin, Luisa Riancho, Suzanne Menashi & Christophe Baudouin. (2015) Increased Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Expression in the Conjunctival Epithelium Exposed to Antiglaucoma Treatments. Current Eye Research 40:1, pages 40-47.
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Articles from other publishers (21)

Joanna Piłat, Agata Przekora, Dominika Wróbel-Dudzińska, Paulina Kazimierczak, Tomasz Żarnowski & Ewa Kosior-Jarecka. (2023) Analysis of the impact of different schemes of preparation to trabeculectomy on the healing markers on the Tenon fibroblasts cultures. Scientific Reports 13:1.
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Dada Tanuj & Ramesh Priyanka. 2023. The Science of Glaucoma Management. The Science of Glaucoma Management 231 245 .
Luca Agnifili, Matteo Sacchi, Michele Figus, Chiara Posarelli, Rosario Alfio Umberto Lizzio, Paolo Nucci & Leonardo Mastropasqua. (2022) Preparing the ocular surface for glaucoma filtration surgery: an unmet clinical need. Acta Ophthalmologica 100:7, pages 740-751.
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Sampath Nikhalashree, Ronnie George, Balekudaru Shantha, Lingam Vijaya, Konerirajapuram Natarajan Sulochana & Karunakaran Coral. (2022) Anti-glaucoma medications lowered decorin and altered profibrotic proteins in human tenon's fibroblasts. Experimental Eye Research 224, pages 109199.
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Shuhao Fu, Zhaozeng Lu & Wen Ye. (2022) TGF-β1 Induces Interlukin-11 Expression and Pro-Fibrotic Effect by DNA Demethylation in Subconjunctival Fibroblasts. Evidence-Based Complementary and Alternative Medicine 2022, pages 1-10.
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Jordan M. Graff, Veeral S. Sheth, Robert T. Chang, Alicia R. Menezes, Giulio Barteselli & Varun K. Malhotra. (2022) Conjunctiva and Tenon's Capsule Handling in the Port Delivery System with Ranibizumab Implant Insertion Procedure: Surgical Pearls. Ophthalmic Surgery, Lasers and Imaging Retina 53:5, pages 266-273.
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Christophe Baudouin, Miriam Kolko, Stéphane Melik-Parsadaniantz & Elisabeth M. Messmer. (2021) Inflammation in Glaucoma: From the back to the front of the eye, and beyond. Progress in Retinal and Eye Research 83, pages 100916.
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Le-Tien Lin, Jiann-Torng Chen, Da-Wen Lu, Ming-Cheng Tai, Chang-Min Liang, Ching-Long Chen, Shu-I Pao, Chih-Kang Hsu & Yi-Hao Chen. (2020) Antifibrotic role of low-dose mitomycin-c-induced cellular senescence in trabeculectomy models. PLOS ONE 15:6, pages e0234706.
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Dirk Bauer, Maren Kasper, Karoline Walscheid, Jörg M. Koch, Philipp S. Müther, Bernd Kirchhof, Arnd Heiligenhaus & Carsten Heinz. (2018) Multiplex Cytokine Analysis of Aqueous Humor in Juvenile Idiopathic Arthritis-Associated Anterior Uveitis With or Without Secondary Glaucoma. Frontiers in Immunology 9.
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Agata Przekora, Tomasz Zarnowski & Grazyna Ginalska. (2017) A simple and effective protocol for fast isolation of human Tenon’s fibroblasts from a single trabeculectomy biopsy – a comparison of cell behaviour in different culture media. Cellular & Molecular Biology Letters 22:1.
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Tao Guan, Guiyang Zhao, Honghui Duan, Yang Liu & Feng Zhao. (2017) Activation of type 2 cannabinoid receptor (CB2R) by selective agonists regulates the deposition and remodelling of the extracellular matrix. Biomedicine & Pharmacotherapy 95, pages 1704-1709.
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Justus G. Garweg, Souska Zandi, Christin Gerhardt & Isabel B. Pfister. (2017) Isoforms of TGF-β in the aqueous humor of patients with pseudoexfoliation syndrome and a possible association with the long-term stability of the capsular bag after cataract surgery. Graefe's Archive for Clinical and Experimental Ophthalmology 255:9, pages 1763-1769.
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Yuan Wang, Jing Wang, Li-Juan Wei, Dong-Mei Zhu & Jin-Song Zhang. (2017) Biological function and mechanism of lncRNA-MEG3 in Tenon’s capsule fibroblasts proliferation: By MEG3-Nrf2 protein interaction. Biomedicine & Pharmacotherapy 87, pages 548-554.
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Jingli Peng, Hezheng Zhou, Guoping Kuang, Lilian Xie, Tao Tian & Ru Liu. (2017) The selective cysteinyl leukotriene receptor 1 (CysLT1R) antagonist montelukast regulates extracellular matrix remodeling. Biochemical and Biophysical Research Communications 484:3, pages 474-479.
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Alejandro Rodríguez-García, Luis Alonso González-González & J. Carlos Alvarez-Guzmán. (2015) Trans-scleral diode laser cyclophotocoagulation for refractory glaucoma after high-risk penetrating keratoplasty. International Ophthalmology 36:3, pages 373-383.
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Samin Hong, Sueng-Han Han, Chan Yun Kim, Kang Yoon Kim, Yoo Kyung Song & Gong Je Seong. (2015) Brimonidine reduces TGF-beta-induced extracellular matrix synthesis in human Tenon’s fibroblasts. BMC Ophthalmology 15:1.
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Guan Fook Ng, Ishak Siti Raihan, Yaakub Azhany, Che Hussin Che Maraina, K. Gurusamy Banumathi & Tajudin Liza-Sharmini. (2015) Conjunctival TGF-B Level in Primary Augmented Trabeculectomy. The Open Ophthalmology Journal 9:1, pages 136-144.
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Minna Helin-Toiviainen, Seppo Rönkkö, Tuomo Puustjärvi, Petri Rekonen, Minna Ollikainen & Hannu Uusitalo. (2015) Conjunctival matrix metalloproteinases and their inhibitors in glaucoma patients. Acta Ophthalmologica 93:2, pages 165-171.
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Kwou-Yeung Wu, Pei-Cheng Wu, Yu-Hung Lai & Show-Jen Hong. (2013) Novel usage of intraocular pressure-lowering drugs as wound-healing inhibitors after trabeculectomy with cell culture and animal models. The Kaohsiung Journal of Medical Sciences 29:7, pages 353-361.
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Elena De Falco, Gaia Scafetta, Chiara Napoletano, Rosa Puca, Enzo Maria Vingolo, Giuseppe Ragona, Olga Iorio & Giacomo Frati. (2012) A standardized laboratory and surgical method for in vitro culture isolation and expansion of primary human Tenon’s fibroblasts. Cell and Tissue Banking 14:2, pages 277-287.
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Elisabeth M. Messmer, Véronique M. Valet & Anselm Kampik. (2012) Differences in basement membrane zone components of normal conjunctiva, conjunctiva in glaucoma and normal skin. Acta Ophthalmologica 90:6.
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