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Current Eye Research Volume 36, 2011 - Issue 10
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Original Article

Effects of Y-39983, a Selective Rho-Associated Protein Kinase Inhibitor, on Blood Flow in Optic Nerve Head in Rabbits and Axonal Regeneration of Retinal Ganglion Cells in Rats

Hideki TokushigeResearch Laboratories, Senju Pharmaceutical Co. Ltd., Kobe, JapanCorrespondence[email protected]
,
Mitsunori WakiResearch Laboratories, Senju Pharmaceutical Co. Ltd., Kobe, Japan
,
Yoshiko TakayamaResearch Laboratories, Senju Pharmaceutical Co. Ltd., Kobe, Japan
&
Hidenobu TaniharaDepartment of Ophthalmology & Visual Science, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan
Pages 964-970 | Received 20 Dec 2010, Accepted 18 Jun 2011, Published online: 27 Sep 2011

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Ghadeer Al-Humimat, Ibtisam Marashdeh, Duaa Daradkeh & Karanjit Kooner. (2021) Investigational Rho Kinase Inhibitors for the Treatment of Glaucoma. Journal of Experimental Pharmacology 13, pages 197-212.
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Seniz Demiryürek, Seydi Okumus, İbrahim Bozgeyik, Serdar Oztuzcu, Erol Coskun, Emrah Mat, Ela Durucu, Mehmet G. Tatar, İbrahim Erbagci, Bülent Gürler & Abdullah T. Demiryürek. (2016) Investigation of the Rho-kinase Gene Polymorphism in Primary Open-angle Glaucoma. Ophthalmic Genetics 37:1, pages 9-13.
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Sean K Wang & Robert T Chang. (2014) An emerging treatment option for glaucoma: Rho kinase inhibitors. Clinical Ophthalmology 8, pages 883-890.
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Gibran Farook Butt, Abubakar Habib, Kareem Mahgoub, Agbolahan Sofela, Mark Tilley, Li Guo & M Francesca Cordeiro. (2012) Optic nerve regeneration. Expert Review of Ophthalmology 7:6, pages 533-554.
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Articles from other publishers (38)

Jun Wang, Hanke Wang & Yalong Dang. (2023) Rho-Kinase Inhibitors as Emerging Targets for Glaucoma Therapy. Ophthalmology and Therapy 12:6, pages 2943-2957.
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Najam A. Sharif. (2023) Recently Approved Drugs for Lowering and Controlling Intraocular Pressure to Reduce Vision Loss in Ocular Hypertensive and Glaucoma Patients. Pharmaceuticals 16:6, pages 791.
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Liang Yu, Kai Yang, Xiaoyan He, Min Li, Lin Gao & Yunhong Zha. (2023) Repositioning linifanib as a potent anti-necroptosis agent for sepsis. Cell Death Discovery 9:1.
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Nisha M Thomas & Prachi Nagrale. (2022) Rho Kinase Inhibitors as a Neuroprotective Pharmacological Intervention for the Treatment of Glaucoma. Cureus.
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Jignesh Jethva, Purvi Bhagat, Kamini Prajapati & Gunjan Tank. (2022) Safety, efficacy, and patient selection of ripasudil in patients with uncontrolled glaucoma with maximum conventional medical therapy. Indian Journal of Ophthalmology 70:6, pages 2020.
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Yong-Woo Kim, Eunoo Bak, Seoyoung Wy, Seung-Chan Lee, Yu-Jeong Kim, Young-Kook Kim, Ki-Ho Park & Jin-Wook Jeoung. (2021) Genetic Risk and Phenotype Correlation of Primary Open-Angle Glaucoma Based on Rho-Kinase Gene Polymorphisms. Journal of Clinical Medicine 10:9, pages 1953.
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C. Erb & K. Konieczka. (2021) Rho-Kinase-Hemmer als neue lokale Therapieoption beim primären OffenwinkelglaukomRho kinase inhibitors as new local therapy option in primary open angle glaucoma. Der Ophthalmologe 118:5, pages 449-460.
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Junhui Shen, Yuanqi Wang & Ke Yao. (2021) Protection of retinal ganglion cells in glaucoma: Current status and future. Experimental Eye Research 205, pages 108506.
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Kelly A. Leary, Kuan‐Ting Lin, Juan P. Steibel, Christine D. Harman & András M. Komáromy. (2019) Safety and efficacy of topically administered netarsudil (Rhopressa™) in normal and glaucomatous dogs with ADAMTS10 ‐open‐angle glaucoma ( ADAMTS10 ‐OAG) . Veterinary Ophthalmology 24:S1, pages 75-86.
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Takayuki KamiyaTsuneaki OmaeSeigo NakabayashiKengo TakahashiAkira TannerAkitoshi Yoshida. (2021) Effect of Rho Kinase Inhibitor Ripasudil (K-115) on Isolated Porcine Retinal Arterioles. Journal of Ocular Pharmacology and Therapeutics 37:2, pages 104-111.
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Lei Fang, Ziliang Shen, Shengming Xu, Yu Chen & Shuqiang Wang. (2020) Mining novel natural reactive oxygen species (ROS) inhibitors by targeting Rho Kinase for prevention of secondary spinal cord injury: An in-silico trial using traditional Chinese medicinal compounds. Journal of King Saud University - Science 32:5, pages 2540-2552.
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Carolien van Alphen, Jacqueline Cloos, Robin Beekhof, David G.J. Cucchi, Sander R. Piersma, Jaco C. Knol, Alex A. Henneman, Thang V. Pham, Johan van Meerloo, Gert J. Ossenkoppele, Henk M.W. Verheul, Jeroen J.W.M. Janssen & Connie R. Jimenez. (2020) Phosphotyrosine-based Phosphoproteomics for Target Identification and Drug Response Prediction in AML Cell Lines. Molecular & Cellular Proteomics 19:5, pages 884-899.
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Vasudha Abbhi & Poonam Piplani. (2020) Rho-kinase (ROCK) Inhibitors - A Neuroprotective Therapeutic Paradigm with a Focus on Ocular Utility. Current Medicinal Chemistry 27:14, pages 2222-2256.
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Nathan M. Kerr & Keith Barton. 2020. Current Concepts in Ophthalmology. Current Concepts in Ophthalmology 99 119 .
Nuno Moura-Coelho, Joana Tavares Ferreira, Carolina Pereira Bruxelas, Marco Dutra-Medeiros, João Paulo Cunha & Rita Pinto Proença. (2019) Rho kinase inhibitors—a review on the physiology and clinical use in Ophthalmology. Graefe's Archive for Clinical and Experimental Ophthalmology 257:6, pages 1101-1117.
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Diah Gemala Ibrahim, Ji‐Ae Ko, Wakana Iwata, Hideaki Okumichi & Yoshiaki Kiuchi. (2019) An in vitro study of scarring formation mediated by human Tenon fibroblasts: Effect of Y‐27632, a Rho kinase inhibitor. Cell Biochemistry and Function 37:2, pages 113-124.
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Yasushi Wada, Tomomi Higashide, Atsushi Nagata & Kazuhisa Sugiyama. (2018) Effects of ripasudil, a rho kinase inhibitor, on blood flow in the optic nerve head of normal rats. Graefe's Archive for Clinical and Experimental Ophthalmology 257:2, pages 303-311.
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Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, Brian S. Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A. Egan, Gail M. Freiberg, Sujatha M. Gopalakrishnan, Christopher M. Harris, Marie P. Honore, Karen L. Kage, Nicolas J. Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S. Moore, Bernhard K. Mueller, Reinhold Mueller, Marian T. Namovic, Kaushal Patel, Steve D. Pratt, C. Brent Putman, Kara L. Queeney, Kathy K. Sarris, Lisa M. Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl & Kimberly Yach. (2018) Identification of Selective Dual ROCK1 and ROCK2 Inhibitors Using Structure-Based Drug Design. Journal of Medicinal Chemistry 61:24, pages 11074-11100.
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Angelo P. Tanna & Mark Johnson. (2018) Rho Kinase Inhibitors as a Novel Treatment for Glaucoma and Ocular Hypertension. Ophthalmology 125:11, pages 1741-1756.
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Etsuo Chihara, Galina Dimitrova & Tomoyuki Chihara. (2018) Increase in the OCT angiographic peripapillary vessel density by ROCK inhibitor ripasudil instillation: a comparison with brimonidine. Graefe's Archive for Clinical and Experimental Ophthalmology 256:7, pages 1257-1264.
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Megumi Honjo & Hidenobu Tanihara. (2018) Impact of the clinical use of ROCK inhibitor on the pathogenesis and treatment of glaucoma. Japanese Journal of Ophthalmology 62:2, pages 109-126.
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Rand Shahin, Omar Shaheen, Faris El-Dahiyat, Maha Habash & Sana Saffour. (2017) Research advances in kinase enzymes and inhibitors for cardiovascular disease treatment. Future Science OA 3:4, pages FSO204.
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Ayumi MoriChiho YabutaYayoi KishimotoSeiko KozaiAkira OhtoriThomas R. ShearerMitsuyoshi Azuma. (2017) In Silico Ocular Pharmacokinetic Modeling: Delivery of Topical FK962 to Retina . Journal of Ocular Pharmacology and Therapeutics 33:7, pages 556-566.
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Ponugoti Vasantha Rao, Padmanabhan P. Pattabiraman & Casey Kopczynski. (2017) Role of the Rho GTPase/Rho kinase signaling pathway in pathogenesis and treatment of glaucoma: Bench to bedside research. Experimental Eye Research 158, pages 23-32.
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Peter X. Shaw, Alan Sang, Yan Wang, Daisy Ho, Christopher Douglas, Lara Dia & Jeffrey L. Goldberg. (2017) Topical administration of a Rock/Net inhibitor promotes retinal ganglion cell survival and axon regeneration after optic nerve injury. Experimental Eye Research 158, pages 33-42.
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Yoshio Kaneko, Masayuki Ohta, Tomoyuki Isobe, Yuto Nakamura & Ken Mizuno. (2017) Additive Intraocular Pressure-Lowering Effects of Ripasudil with Glaucoma Therapeutic Agents in Rabbits and Monkeys. Journal of Ophthalmology 2017, pages 1-8.
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Carol B. TorisMarsha A. McLaughlinDouglas P. DworakShan FanShane HavensGui-Lin ZhanNicholas HoranGanesh Prasanna. (2016) Effects of Rho Kinase Inhibitors on Intraocular Pressure and Aqueous Humor Dynamics in Nonhuman Primates and Rabbits. Journal of Ocular Pharmacology and Therapeutics 32:6, pages 355-364.
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Yangbo Feng, Philip V. LoGrasso, Olivier Defert & Rongshi Li. (2015) Rho Kinase (ROCK) Inhibitors and Their Therapeutic Potential. Journal of Medicinal Chemistry 59:6, pages 2269-2300.
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Rebecca K. Donegan & Raquel L. Lieberman. (2015) Discovery of Molecular Therapeutics for Glaucoma: Challenges, Successes, and Promising Directions. Journal of Medicinal Chemistry 59:3, pages 788-809.
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Jianglong Yu, Xinping Luan, Shiying Lan, Baofeng Yan & Aba Maier. (2015) Fasudil, a Rho-Associated Protein Kinase Inhibitor, Attenuates Traumatic Retinal Nerve Injury in Rabbits. Journal of Molecular Neuroscience 58:1, pages 74-82.
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Seigo Nakabayashi, Motofumi Kawai, Takafumi Yoshioka, Yong-Seok Song, Tomofumi Tani, Akitoshi Yoshida & Taiji Nagaoka. (2015) Effect of intravitreal Rho kinase inhibitor ripasudil (K-115) on feline retinal microcirculation. Experimental Eye Research 139, pages 132-135.
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Sarah Van de Velde, Lies De Groef, Ingeborg Stalmans, Lieve Moons & Inge Van Hove. (2015) Towards axonal regeneration and neuroprotection in glaucoma: Rho kinase inhibitors as promising therapeutics. Progress in Neurobiology 131, pages 105-119.
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Hidenobu Tanihara, Toshihiro Inoue, Tetsuya Yamamoto, Yasuaki Kuwayama, Haruki Abe, Hideki Suganami & Makoto Araie. (2014) Intra‐ocular pressure‐lowering effects of a Rho kinase inhibitor, ripasudil (K‐115), over 24 hours in primary open‐angle glaucoma and ocular hypertension: a randomized, open‐label, crossover study. Acta Ophthalmologica 93:4.
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Rong-Fang Wang, Jennifer E. Williamson, Casey Kopczynski & Janet B. Serle. (2015) Effect of 0.04% AR-13324, a ROCK, and Norepinephrine Transporter Inhibitor, on Aqueous Humor Dynamics in Normotensive Monkey Eyes. Journal of Glaucoma 24:1, pages 51-54.
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Carol A. Rasmussen & Paul L. Kaufman. (2014) Exciting directions in glaucoma. Canadian Journal of Ophthalmology 49:6, pages 534-543.
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Hiroe Sagawa, Hiroko Terasaki, Keiko Nakanishi, Yoshihito Tokita & Masami Watanabe. (2013) Regeneration of optic nerve fibers with unoprostone, a prostaglandin-related antiglaucoma drug, in adult cats. Japanese Journal of Ophthalmology 58:1, pages 100-109.
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Hiroaki Takahashi, Tetsuya Sugiyama, Hideki Tokushige, Takatoshi Maeno, Toru Nakazawa, Tsunehiko Ikeda & Makoto Araie. (2013) Comparison of CCD-equipped laser speckle flowgraphy with hydrogen gas clearance method in the measurement of optic nerve head microcirculation in rabbits. Experimental Eye Research 108, pages 10-15.
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Lianfu Deng. (2012) Y-39983 downregulates RhoA/Rho-associated kinase expression during its promotion of axonal regeneration. Oncology Reports.
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