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Original Article

Evaluation of Pain in Intravitreal Bevacizumab Injections

, MD, , MD, , MD & , MD
Pages 813-817 | Received 01 Feb 2012, Accepted 27 Mar 2012, Published online: 05 Jun 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (8)

Cina Karimaghaei, Amir Ali, Nida Safdar, Anika Tanwani, Mary Schmitz-Brown, Touka Banaee, Jaafar El-Annan & Praveena K Gupta. (2023) The Injection Practice Patterns of Retina Specialists in Managing Exudative Age-Related Macular Degeneration: A Retrospective Study. Clinical Ophthalmology 17, pages 375-383.
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Priya R Chandrasekaran, Aamir A Aziz, Hannah Khan & Arshad M Khanani. (2023) Cooling Anesthesia for Intravitreal Injections – A Review. Clinical Ophthalmology 17, pages 197-207.
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Amir Sternfeld, Michal Schaap-Fogler, Assaf Dotan, Bashir Alaa, Elinor Megiddo, Rita Ehrlich & Eitan Livny. (2021) Effect of Penetration Angle and Velocity During Intravitreal Injection on Pain. Seminars in Ophthalmology 36:5-6, pages 437-443.
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Michelle Blyth, William Innes, Nyma Mohsin-Shaikh & James Talks. (2020) A Comparison of Conventional Intravitreal Injection Method vs InVitria Intravitreal Injection Method. Clinical Ophthalmology 14, pages 2507-2513.
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Elif Ertan, Rahmi Duman & Reşat Duman. (2020) Comparison of pain during intravitreal dexamethasone, ranibizumab and aflibercept injection. Clinical and Experimental Optometry 103:5, pages 630-633.
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Ori Segal, Yael Segal-Trivitz, Arie Y Nemet, Noa Geffen, Ronit Nesher & Michael Mimouni. (2016) Survey of intravitreal injection techniques among retina specialists in Israel. Clinical Ophthalmology 10, pages 1111-1116.
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Jessica Boyle, Meri Vukicevic, Konstandina Koklanis & Catherine Itsiopoulos. (2015) Experiences of patients undergoing anti-VEGF treatment for neovascular age-related macular degeneration: A systematic review. Psychology, Health & Medicine 20:3, pages 296-310.
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Maria Rosa Sanabria, Javier A. Montero, María Victoria Losada, Marta Fernández-Muñoz, Alicia Galindo, Itziar Fernández, Rosa M. Coco & Ana Sampedro. (2013) Ocular Pain After Intravitreal Injection. Current Eye Research 38:2, pages 278-282.
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Articles from other publishers (31)

Ran Moshkovsky, Nili Golan, Einat Aviel Gadot, Asaf Bar, Asaf Achiron, Naomi Fischer & Oriel Spierer. (2023) Pain control and subconjunctival haemorrhage after intravitreal injection using cooled anaesthetic eyedrops and antiseptics: A prospective, double‐blind, randomized controlled trial. Acta Ophthalmologica.
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Chen Shtayer, A Lily Okrent Smolar, Mohamad Elmalak, Lena Abayev, Andrzej Grzybowski & Elad Moisseiev. (2023) Post-Intravitreal injection pain reduction using topical NSAIDS: A comparative study. European Journal of Ophthalmology.
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Christina Yiallouridou, Jennifer H Acton, Sanjiv Banerjee, Heather Waterman & Ashley Wood. (2023) Pain related to intravitreal injections for age-related macular degeneration: a qualitative study of the perspectives of patients and practitioners. BMJ Open 13:8, pages e069625.
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Xiubin MaQianqian LiangShuyue XueQi RenQing DuZhichun ZhangXinying LiXin LiuYan GaoJun Li. (2023) EFFECT OF ANESTHESIA DURATION ON INTRAVITREAL INJECTION PAIN. Retina 43:8, pages 1386-1392.
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Deon Shaughnessy, Sarah Powell & Louise O’Toole. (2022) The value of handholding during intravitreal injections. Irish Journal of Medical Science (1971 -) 192:1, pages 441-445.
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Lauren M. Wasser, Eduardo Roditi, Adina R. Weiss, Yishay Weill, Meni Koslowsky, David Zadok, Joel Hanhart & Itay Magal. (2022) Anxiety and pain perception using a speculum-free eyelid retraction technique for intravitreal injection. Graefe's Archive for Clinical and Experimental Ophthalmology 260:6, pages 2023-2028.
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Mark Krauthammer, Etty Trabelsi & Elad Moisseiev. (2021) Intravitreal air bubbles following intravitreal injections: a comprehensive analysis. Graefe's Archive for Clinical and Experimental Ophthalmology 259:12, pages 3697-3702.
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Refika Hande Karakahya. (2021) Anterior Chamber Paracentesis Offers a Less Painful Experience During Intravitreal Anti-vascular Endothelial Growth Factor Administration: An Intraindividual Study. Cureus.
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Matthew S. Wieder, Moshe Szlechter, Noam Fischman, Steven Inker, Irene Rusu & Joyce N. Mbekeani. (2021) Impact of Anxiety Levels and Sleep Patterns on Perceived Pain During Intravitreal Bevacizumab Injections. Ophthalmic Surgery, Lasers and Imaging Retina 52:9, pages 498-504.
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Saeed T Alshahrani, Uriel Rubin, Vasudha Gupta, Tom Gonder & Sanjay Sharma. (2021) Reflux, Intraocular Pressure Variation and Pain Following Intravitreal Ranibizumab Injections Using 30-Gauge or 32-Gauge Needles for Patients With Retinal Pathologies: A Randomized Clinical Trial. Cureus.
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Seung-Ki Lee, Woong Hee Kim, Sung Jin Kim & Jong Seok Park. (2020) Ocular Pain According to Needle Diameter during Intravitreal Injection. Journal of the Korean Ophthalmological Society 61:9, pages 1042-1047.
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Tal YahalomiIdan HechtOded LagsteinAchia NemetLiron Pe'erFady HadadAri Keren-Yaar, Rabea KassemZvia Burgansky-EliashAsaf BarAsaf Achiron. (2020) REDUCTION OF POSTINTRAVITREAL INJECTION PAIN USING ICE. Retina 40:7, pages 1434-1438.
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A. Martel, S. Nahon-Esteve, K. Martini, F. Almairac & S. Baillif. (2020) Feelings, preoperative anxiety, and need for information in patients undergoing intravitreal injections. Graefe's Archive for Clinical and Experimental Ophthalmology 258:7, pages 1395-1403.
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Kun Hae Kim, Soo Hyun Lim & Jae Hui Kim. (2020) Hemodynamic Change after Intravitreal Anti-vascular Endothelial Growth Factor Injection. Journal of Retina 5:1, pages 23-28.
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Joseph Raevis, Eric M. Shrier & Seenu M. Hariprasad. (2020) Intravitreal Injections: Minimizing the Risk and Maximizing Comfort. Ophthalmic Surgery, Lasers and Imaging Retina 51:1, pages 5-8.
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Itamar LoewensteinMichaella Goldstein, Joseph MoisseievElad Moisseiev. (2019) ACCURACY AND PRECISION OF INTRAVITREAL INJECTIONS OF ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS IN REAL LIFE. Retina 39:7, pages 1385-1391.
Crossref
Beata Miller, Yinon Shapira, Victor Flores, Michael Mimouni, Niveen Shibli, Eytan Z Blumenthal & Shiri Zayit-Soudry. (2019) Reducing Perceived Pain Intensity during Intravitreal Injections by Patient Handholding. Ophthalmology Retina 3:5, pages 451-453.
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Saeed Karimi, Seyed Aliasghar Mosavi, Khosrow Jadidi, Homayoun Nikkhah & Bahareh Kheiri. (2018) Which quadrant is less painful for intravitreal injection? A prospective study. Eye 33:2, pages 304-312.
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Burak Bilgin & Şemsettin Bilak. (2019) Assessment of patient pain experience during intravitreal ranibizumab and aflibercept injection. Middle East African Journal of Ophthalmology 26:2, pages 55.
Crossref
J. Alexander Torres, Nathan A. Fischer, Leonard K. Seibold, Mina B. Pantcheva, Malik Y. Kahook & Jeffrey R. SooHoo. (2018) A Survey of Patient Perceptions and Preferences for Glaucoma Treatment with Intravitreal Injections. Ophthalmology Glaucoma 1:1, pages 61-65.
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Sibel Doguizi, Mehmet A. Sekeroglu, Merve Inanc, Mustafa A. Anayol & Pelin Yilmazbas. (2017) Evaluation of pain during intravitreal aflibercept injections. European Journal of Ophthalmology 28:1, pages 63-67.
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Seong Hwan ShinSung Pyo ParkYong-Kyu Kim. (2018) Factors Associated with Pain Following Intravitreal Injections. Korean Journal of Ophthalmology 32:3, pages 196.
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Oded Lagstein, Noa Ben-Artzi, Asaf Achiron, Achia NemetMaroun KhreishElisha Bartov & Zvia Burgansky-Eliash. (2017) TOPICAL APRACLONIDINE REDUCES PAIN AFTER INTRAVITREAL INJECTIONS. Retina 37:8, pages 1575-1580.
Crossref
Hugo Senra, Konstantinos Balaskas, Neda Mahmoodi & Tariq Aslam. (2017) Experience of Anti-VEGF Treatment and Clinical Levels of Depression and Anxiety in Patients With Wet Age-Related Macular Degeneration. American Journal of Ophthalmology 177, pages 213-224.
Crossref
Hugo Senra, Zaria Ali, Konstantinos Balaskas & Tariq Aslam. (2016) Psychological impact of anti-VEGF treatments for wet macular degeneration—a review. Graefe's Archive for Clinical and Experimental Ophthalmology 254:10, pages 1873-1880.
Crossref
Paulina Haas, Christiane Falkner-Radler, Barbara Wimpissinger, Magdalena Malina & Susanne Binder. (2016) Needle size in intravitreal injections - pain evaluation of a randomized clinical trial. Acta Ophthalmologica 94:2, pages 198-202.
Crossref
Kyeong Do JeongJung Hoon KimJae Suk KimJe Hyung Hwang. (2016) Relationship between Pain and Injection Site during Intravitreal Injection. Journal of the Korean Ophthalmological Society 57:6, pages 930.
Crossref
E Moisseiev, D Loberman, E Zunz, A Kesler, A Loewenstein & J Mandelblum. (2015) Pupil dilation using drops vs gel: a comparative study. Eye 29:6, pages 815-819.
Crossref
Nathalie Massamba, Maud Elluard, Wassila Agoune, Vincent Guyader, April Ingram, Bernard Pasquier & Juliette Knoeri. (2014) Assessment of ocular pain following ranibizumab intravitreal injection. Acta Ophthalmologica 93:3.
Crossref
Mete GülerBurak BilginMusa ÇapkınAli ŞimşekŞemsettin Bilak. (2015) Assessment of Patient Pain Experience during Intravitreal 27-Gauge Bevacizumab and 30-Gauge Ranibizumab Injection. Korean Journal of Ophthalmology 29:3, pages 190.
Crossref
E Moisseiev, M Regenbogen, T Rabinovitch, A Barak, A Loewenstein & M Goldstein. (2014) Evaluation of pain during intravitreal Ozurdex injections vs intravitreal bevacizumab injections. Eye 28:8, pages 980-985.
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