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Original Article

Distribution of Antigen Presenting Cells in the Human Cornea: Correlation of In Vivo Confocal Microscopy and Immunohistochemistry in Different Pathologic Entities

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Pages 1012-1018 | Received 15 Mar 2012, Accepted 17 May 2012, Published online: 05 Jun 2012

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Crossref
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Crossref
Godefroy Kaswin, Antoine Rousseau, Mohamed M'Garrech, Emmanuel Barreau, Nicolas Pogorzalek, Ivan De Monchy, Richard Legras & Marc Labetoulle. (2013) Optical aberrations in patients with recurrent herpes simplex keratitis and apparently normal vision. British Journal of Ophthalmology 97:9, pages 1113-1117.
Crossref
Jiaxu Hong, Zuguo Liu, Xinghuai Sun & Jianjiang Xu. (2013) Cyclosporine A Drug-Delivery System for High-risk Keratoplasty. Ophthalmology 120:9, pages e65-e66.
Crossref

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