429
Views
28
CrossRef citations to date
0
Altmetric
Original Article

A Possible Role of Acrolein in Diabetic Retinopathy: Involvement of a VEGF/TGFβ Signaling Pathway of the Retinal Pigment Epithelium in Hyperglycemia

, , , &
Pages 1045-1053 | Received 03 Jan 2012, Accepted 07 Jul 2012, Published online: 20 Aug 2012

Keep up to date with the latest research on this topic with citation updates for this article.

Read on this site (1)

Rashidul Haque, P. Michael Iuvone, Li He, Elizabeth H. Hur, Kimberly Su Chung Choi, Daniel Park, Annie N. Farrell, Ashley Ngo, Samantha Gokhale, Madiha Aseem & Bhavna Kumar. (2017) Prorenin receptor (PRR)-mediated NADPH oxidase (Nox) signaling regulates VEGF synthesis under hyperglycemic condition in ARPE-19 cells. Journal of Receptors and Signal Transduction 37:6, pages 560-568.
Read now

Articles from other publishers (27)

Jia-Yu Jhuo, Zhen-Jie Tong, Pei-Hsuan Ku, Hsiao-Wei Cheng & Hsiang-Tsui Wang. (2023) Acrolein induces mitochondrial dysfunction and insulin resistance in muscle and adipose tissues in vitro and in vivo.. Environmental Pollution 336, pages 122380.
Crossref
Suneel Gupta, Lynn M. Martin, Eric Zhang, Prashant R. Sinha, James Landreneau, Nishant R. Sinha, Nathan P. Hesemann & Rajiv R. Mohan. (2023) Toxicological effects of ocular acrolein exposure to eyelids in rabbits in vivo. Experimental Eye Research 234, pages 109575.
Crossref
Pawel Hikisz & Damian Jacenik. (2023) Diet as a Source of Acrolein: Molecular Basis of Aldehyde Biological Activity in Diabetes and Digestive System Diseases. International Journal of Molecular Sciences 24:7, pages 6579.
Crossref
Ming Wang, Kang-Jia Sheng, Jia-Cheng Fang, Hui Zhao, Si-Min Lu, Zi-Yi Liu & Bi-Tao Chen. (2022) Redox signaling in diabetic retinopathy and opportunity for therapeutic intervention through natural products. European Journal of Medicinal Chemistry 244, pages 114829.
Crossref
Zhen-Jie Tong, Chin-Wei Kuo, Po-Cheng Yen, Chih-Ching Lin, Ming-Tsun Tsai, Shing-Hwa Lu, Yi-Ping Chang, Wen-Sheng Liu, Han-Hsing Tsou, Hsiao-Wei Cheng & Hsiang-Tsui Wang. (2022) Acrolein plays a culprit role in the pathogenesis of diabetic nephropathy in vitro and in vivo . European Journal of Endocrinology 187:4, pages 579-592.
Crossref
Moaddey Alfarhan, Fang Liu, Shengshuai Shan, Prahalathan Pichavaram, Payaningal R. Somanath & S. Priya Narayanan. (2022) Pharmacological Inhibition of Spermine Oxidase Suppresses Excitotoxicity Induced Neuroinflammation in Mouse Retina. International Journal of Molecular Sciences 23:4, pages 2133.
Crossref
Ching-Chia Wang, Huang-Jen Chen, Ding-Cheng Chan, Chen-Yuan Chiu, Shing-Hwa Liu & Kuo-Cheng Lan. (2021) Low-Dose Acrolein, an Endogenous and Exogenous Toxic Molecule, Inhibits Glucose Transport via an Inhibition of Akt-Regulated GLUT4 Signaling in Skeletal Muscle Cells. International Journal of Molecular Sciences 22:13, pages 7228.
Crossref
Vincenza Bonfiglio, Chiara Bianca Maria Platania, Francesca Lazzara, Federica Conti, Corrado Pizzo, Michele Reibaldi, Andrea Russo, Matteo Fallico, Elina Ortisi, Francesco Pignatelli, Antonio Longo, Teresio Avitabile, Filippo Drago & Claudio Bucolo. (2020) TGF-β Serum Levels in Diabetic Retinopathy Patients and the Role of Anti-VEGF Therapy. International Journal of Molecular Sciences 21:24, pages 9558.
Crossref
Azza K. Amer, Nervana A. Khalaf, Safia H. Aboelmakarem, Mehry S. Elsobky, Mona R. Abdelrasoul, Amira A. Abdelazeem, Shahira R. Noweir, Safa Refaat, Leqaa A. Moemen, Soheir A. Mohammed, Mona A. Abdelhameed, Mohmoud M. Kenawy, Manal H. Abuelela, Marwa A. Fouly, Olfat A. Hassanin, Sherif M. Saadeldin Karawya & Zeinab M. Osman. (2020) Vascular endothelial growth factor +405G/C polymorphism as a predictor of diabetic retinopathy. Bulletin of the National Research Centre 44:1.
Crossref
Moaddey Alfarhan, Eissa Jafari & S. Priya Narayanan. (2020) Acrolein: A Potential Mediator of Oxidative Damage in Diabetic Retinopathy. Biomolecules 10:11, pages 1579.
Crossref
Miyuki Murata, Kousuke Noda & Susumu Ishida. (2020) Pathological Role of Unsaturated Aldehyde Acrolein in Diabetic Retinopathy. Frontiers in Immunology 11.
Crossref
Hsin-Yi Chen, Yi-Jung Ho, Hsiu-Chuan Chou, En-Chi Liao, Yi-Ting Tsai, Yu-Shan Wei, Li-Hsun Lin, Meng-Wei Lin, Yi-Shiuan Wang, Mei-Lan Ko & Hong-Lin Chan. (2020) The Role of Transforming Growth Factor-Beta in Retinal Ganglion Cells with Hyperglycemia and Oxidative Stress. International Journal of Molecular Sciences 21:18, pages 6482.
Crossref
Xingyuan Ma, Zhiwei Cui, Zhide Du & Hui Lin. (2020) Transforming growth factor‐β signaling, a potential mechanism associated with diabetes mellitus and pancreatic cancer?. Journal of Cellular Physiology 235:9, pages 5882-5892.
Crossref
Kifai Bein & George D. Leikauf. 2020. Environmental Toxicants. Environmental Toxicants 205 259 .
Xiaolin Fu & Bo Ou. (2019) miR‐152/LIN28B axis modulates high‐glucose‐induced angiogenesis in human retinal endothelial cells via VEGF signaling. Journal of Cellular Biochemistry 121:2, pages 954-962.
Crossref
Fang Liu, Alan B. Saul, Prahalathan Pichavaram, Zhimin Xu, Madhuri Rudraraju, Payaningal R. Somanath, Sylvia B. Smith, Ruth B. Caldwell & S. Priya Narayanan. (2020) Pharmacological Inhibition of Spermine Oxidase Reduces Neurodegeneration and Improves Retinal Function in Diabetic Mice. Journal of Clinical Medicine 9:2, pages 340.
Crossref
S. Priya Narayanan, Esraa Shosha & Chithra D Palani. (2019) Spermine oxidase: A promising therapeutic target for neurodegeneration in diabetic retinopathy. Pharmacological Research 147, pages 104299.
Crossref
Zhongwei Zhou, Huixiang Ju, Mingzhong Sun & Hongmei Chen. (2019) Serum Vascular Endothelial Growth Factor Levels Correlate with Severity of Retinopathy in Diabetic Patients: A Systematic Review and Meta-Analysis. Disease Markers 2019, pages 1-15.
Crossref
Rosemary E. McDowell, Peter Barabas, Josy Augustine, Olivier Chevallier, Philip McCarron, Mei Chen, J. Graham McGeown & Tim M. Curtis. (2018) Müller glial dysfunction during diabetic retinopathy in rats is reduced by the acrolein-scavenging drug, 2-hydrazino-4,6-dimethylpyrimidine. Diabetologia 61:12, pages 2654-2667.
Crossref
Takeshi Uemura, Tomokazu Takasaka, Kazuei Igarashi & Hiroshi Ikegaya. (2017) Spermine oxidase promotes bile canalicular lumen formation through acrolein production. Scientific Reports 7:1.
Crossref
Eun-Ah Ye, Li Liu & Jena J. Steinle. (2017) miR-15a/16 inhibits TGF-beta3/VEGF signaling and increases retinal endothelial cell barrier proteins. Vision Research 139, pages 23-29.
Crossref
Aliya G. Feroe, Roberta Attanasio & Franco Scinicariello. (2016) Acrolein metabolites, diabetes and insulin resistance. Environmental Research 148, pages 1-6.
Crossref
Shwu‐Jiuan Sheu, Yung‐Mei Chao, Ni‐Chun Liu & Julie Y.H. Chan. (2015) Differential effects of bevacizumab, ranibizumab and aflibercept on cell viability, phagocytosis and mitochondrial bioenergetics of retinal pigment epithelial cell. Acta Ophthalmologica 93:8.
Crossref
Akshata Moghe, Smita Ghare, Bryan Lamoreau, Mohammad Mohammad, Shirish Barve, Craig McClain & Swati Joshi-Barve. (2015) Molecular Mechanisms of Acrolein Toxicity: Relevance to Human Disease. Toxicological Sciences 143:2, pages 242-255.
Crossref
Xiao-Li Chen, Xue-Dong Zhang, Ying-Yuan Li, Xue-Mei Chen, De-Rong Tang & Rui-Jin Ran. (2013) Involvement of HMGB1 mediated signalling pathway in diabetic retinopathy: evidence from type 2 diabetic rats and ARPE-19 cells under diabetic condition. British Journal of Ophthalmology 97:12, pages 1598-1603.
Crossref
Ryan T. Hamilton, Arunabh Bhattacharya, Michael E. Walsh, Yun Shi, Rochelle Wei, Yiqiang Zhang, Karl A. Rodriguez, Rochelle Buffenstein, Asish R. Chaudhuri & Holly Van Remmen. (2013) Elevated Protein Carbonylation, and Misfolding in Sciatic Nerve from db/db and Sod1−/− Mice: Plausible Link between Oxidative Stress and Demyelination. PLoS ONE 8:6, pages e65725.
Crossref
Seung Eun Lee & Yong Seek Park. (2013) Role of Lipid Peroxidation-Derived α , β -Unsaturated Aldehydes in Vascular Dysfunction . Oxidative Medicine and Cellular Longevity 2013, pages 1-7.
Crossref

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.