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Research Article

Regulation of Human Corneal Epithelial Mucins by Rebamipide

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Pages 133-141 | Received 05 Jan 2013, Accepted 27 Jul 2013, Published online: 27 Sep 2013

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Read on this site (6)

Candela Rodríguez-Pomar, Jesus Pintor, Basilio Colligris & Gonzalo Carracedo. (2017) Therapeutic inhibitors for the treatment of dry eye syndrome. Expert Opinion on Pharmacotherapy 18:17, pages 1855-1865.
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William H Ridder III & Apoorva Karsolia. (2015) New drugs for the treatment of dry eye disease. Clinical Optometry 7, pages 91-102.
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Tomoyuki Kashima, Hirotaka Itakura, Hideo Akiyama & Shoji Kishi. (2014) Rebamipide ophthalmic suspension for the treatment of dry eye syndrome: a critical appraisal. Clinical Ophthalmology 8, pages 1003-1010.
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Antonio Ballesteros-Sánchez, María Carmen Sánchez-González, Concepción De-Hita-Cantalejo, Estanislao Gutiérrez-Sánchez, Carlos Rocha-de-Lossada & José-María Sánchez-González. (2023) The Efficacy and Safety of Rebamipide Ophthalmic Suspension (OPC-12759) in Patients with Dry Eye Disease: A Systematic Review of Randomized Controlled Trials. Journal of Clinical Medicine 12:22, pages 7155.
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Pragnya R Donthineni, Mariya B Doctor, Swapna Shanbhag, Anahita Kate, Anat Galor, Ali R Djalilian, Swati Singh & Sayan Basu. (2023) Aqueous-deficient dry eye disease: Preferred practice pattern guidelines on clinical approach, diagnosis, and management. Indian Journal of Ophthalmology 71:4, pages 1332-1347.
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Kalpna Jain, Meenu Jaju & Dinesh Yadav. (2023) Efficacy and safety of topical 2% rebamipide ophthalmic suspension in dry eye disease at tertiary care centre. Indian Journal of Ophthalmology 71:4, pages 1598-1602.
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Keisuke Watanabe, Masataka Yoshida, Takashi Okumura, Takayuki Sassa, Akio Kihara & Akira Uchiyama. (2021) Improvement of Evaporative Dry Eye With Meibomian Gland Dysfunction in Model Mice by Treatment With Ophthalmic Solution Containing Mineral Oil. Translational Vision Science & Technology 10:4, pages 21.
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Gaia Favero, Enrico Moretti, Kristína Krajčíková, Vladimíra Tomečková & Rita Rezzani. (2021) Evidence of Polyphenols Efficacy against Dry Eye Disease. Antioxidants 10:2, pages 190.
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Aoi Komuro, Norihiko Yokoi, Hiroaki Kato, Yukiko Sonomura, Chie Sotozono & Shigeru Kinoshita. (2021) The Relationship between Subjective Symptoms and Quality of Life in Conjunctivochalasis Patients. Diagnostics 11:2, pages 179.
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Amy C. Madl, Gerald F. Fuller & David Myung. (2020) Modeling and Restoring the Tear Film. Current Ophthalmology Reports 8:4, pages 281-300.
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Prasanta Kumar Nanda, Bishnu Prasad Rath & Jayaram Meher. (2019) Topical Rebamipide Treatment for Dry Eye Syndrome in Thyroid Ophthalmopathy. Journal of Evidence Based Medicine and Healthcare 6:52, pages 3275-3279.
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Georgi As. Georgiev, Petar Eftimov & Norihiko Yokoi. (2019) Contribution of Mucins towards the Physical Properties of the Tear Film: A Modern Update. International Journal of Molecular Sciences 20:24, pages 6132.
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Xiaohong Wang, Adrian Gericke, Maximilian Ackermann, Shunfeng Wang, Meik Neufurth, Heinz C. Schröder, Norbert Pfeiffer & Werner E. G. Müller. (2019) Polyphosphate, the physiological metabolic fuel for corneal cells: a potential biomaterial for ocular surface repair. Biomaterials Science 7:12, pages 5506-5515.
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Kiumars Shamloo, Ashley Barbarino, Saleh Alfuraih & Ajay Sharma. (2019) Graft Versus Host Disease-Associated Dry Eye: Role of Ocular Surface Mucins and the Effect of Rebamipide, a Mucin Secretagogue. Investigative Opthalmology & Visual Science 60:14, pages 4511.
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Cem Simsek, Takashi Kojima, Shigeru Nakamura, Murat Dogru & Kazuo Tsubota. (2019) The Effects of Rebamipide 2% Ophthalmic Solution Application on Murine Subbasal Corneal Nerves After Environmental Dry Eye Stress. International Journal of Molecular Sciences 20:16, pages 4031.
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Maria Markoulli & Alex Hui. (2019) Emerging targets of inflammation and tear secretion in dry eye disease. Drug Discovery Today 24:8, pages 1427-1432.
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Cem SimsekMurat DogruMegumi ShinzawaSeika DenTakashi KojimaHiroyuki IsedaMai SuzukiYoshiyuki ShibasakiNaoshi YoshidaJun Shimazaki. (2019) The Efficacy of 2% Topical Rebamipide on Conjunctival Squamous Metaplasia and Goblet Cell Density in Dry Eye Disease. Journal of Ocular Pharmacology and Therapeutics 35:6, pages 350-358.
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Rongrong Fu, Yanhua Jiang, Jing Zhou & Jinsong Zhang. (2019) Rebamipide ophthalmic solution modulates the ratio of T�helper cell 17/regulatory T cells in dry eye disease mice. Molecular Medicine Reports.
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Mamoru Ogawa, Cem Simsek, Takashi Kojima, Taeko Nagata, Ayako Igarashi, Tetsuya Kawakita, Murat Dogru, Jun Shimazaki & Kazuo Tsubota. (2019) The Effect of Rebamipide Ophthalmic Solution on Cytokine and Mucin Secretion in Culture of Conjunctival Epithelial Cells From the Cu, Zn-Superoxide Dismutase-1 (SOD-1) Knock-Down Mouse. Eye & Contact Lens: Science & Clinical Practice 45:2, pages 93-98.
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Norihiko Yokoi & Georgi As Georgiev. (2019) Tear-film-oriented diagnosis for dry eye. Japanese Journal of Ophthalmology 63:2, pages 127-136.
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Yuichi Uchino. (2018) The Ocular Surface Glycocalyx and its Alteration in Dry Eye Disease: A Review. Investigative Opthalmology & Visual Science 59:14, pages DES157.
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Yuichi Hori. (2018) Secreted Mucins on the Ocular Surface. Investigative Opthalmology & Visual Science 59:14, pages DES151.
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Chika Shigeyasu, Masakazu Yamada, Yoko Akune & Masaki Fukui. (2018) The effect of rebamipide ophthalmic suspension on ocular surface mucins in soft contact lens wearers. Contact Lens and Anterior Eye 41:4, pages 357-361.
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Yuriko Yasuda-Onozawa, Osamu Handa, Yuji Naito, Chihiro Ushiroda, Yosuke Suyama, Yuki Toyokawa, Takaaki Murakami, Tomoyo Yasuda, Tomohiro Ueda, Atsushi Majima, Yuma Hotta, Toshifumi Doi, Makoto Tanaka, Yusuke Horii, Yasuki Higashimura, Katsura Mizushima, Mayuko Morita, Yukiko Uehara, Hideki Horie, Akifumi Fukui, Osamu Dohi, Tetsuya Okayama, Naohisa Yoshida, Kazuhiro Kamada, Kazuhiro Katada, Kazuhiko Uchiyama, Takeshi Ishikawa, Tomohisa Takagi, Hideyuki Konishi & Yoshito Itoh. (2017) Rebamipide upregulates mucin secretion of intestinal goblet cells via Akt phosphorylation. Molecular Medicine Reports 16:6, pages 8216-8222.
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Jun Shimazaki, Den Seika, Masamichi Saga, Kazumi Fukagawa, Miki Sakata, Miki Iwasaki & Takashi Okano. (2017) A Prospective, Randomized Trial of Two Mucin Secretogogues for the Treatment of Dry Eye Syndrome in Office Workers. Scientific Reports 7:1.
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Yuichi HoriTomofumi KageyamaAsuka SakamotoTomoaki ShibaMasatsugu NakamuraTakatoshi Maeno. (2017) Comparison of Short-Term Effects of Diquafosol and Rebamipide on Mucin 5AC Level on the Rabbit Ocular Surface. Journal of Ocular Pharmacology and Therapeutics 33:6, pages 493-497.
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Lyndon Jones, Laura E. Downie, Donald Korb, Jose M. Benitez-del-Castillo, Reza Dana, Sophie X. Deng, Pham N. Dong, Gerd Geerling, Richard Yudi Hida, Yang Liu, Kyoung Yul Seo, Joseph Tauber, Tais H. Wakamatsu, Jianjiang Xu, James S. Wolffsohn & Jennifer P. Craig. (2017) TFOS DEWS II Management and Therapy Report. The Ocular Surface 15:3, pages 575-628.
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Yuichi Uchino, Ashley M. Woodward & Pablo Argüeso. (2016) Differential effect of rebamipide on transmembrane mucin biosynthesis in stratified ocular surface epithelial cells. Experimental Eye Research 153, pages 1-7.
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Noriaki Nagai, Yoshimasa Ito, Norio Okamoto & Yoshikazu Shimomura. (2016) Size effect of rebamipide ophthalmic nanodispersions on its therapeutic efficacy for corneal wound healing. Experimental Eye Research 151, pages 47-53.
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William Stevenson, Sangeethabalasri Pugazhendhi & Mingwu Wang. (2016) Is the main lacrimal gland indispensable? Contributions of the corneal and conjunctival epithelia. Survey of Ophthalmology 61:5, pages 616-627.
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Kaori Ueda, Wataru Matsumiya, Keiko Otsuka, Yoshifumi Maeda, Takayuki Nagai & Makoto Nakamura. (2015) Effectiveness and relevant factors of 2 % rebamipide ophthalmic suspension treatment in dry eye. BMC Ophthalmology 15:1.
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Atsushi Arimoto, Kazuko Kitagawa, Norihiro Mita, Yoriko Takahashi, Eri Shibuya & Hiroshi Sasaki. (2014) Effect of Rebamipide Ophthalmic Suspension on Signs and Symptoms of Keratoconjunctivitis Sicca in Sjögren Syndrome Patients With or Without Punctal Occlusions. Cornea 33:8, pages 806-811.
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