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Research Article

Anti-VEGF Therapy (Bevacizumab) for Sulfur Mustard-Induced Corneal Neovascularization Associated with Delayed Limbal Stem Cell Deficiency in Rabbits

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Pages 439-450 | Received 19 Jun 2013, Accepted 24 Sep 2013, Published online: 11 Nov 2013

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Raziyeh Mahmoudzadeh, Saeed Heidari-Keshel, Mohammad Mehrpour, Fahimeh Asadi Amoli, Leila Aghajanpour & Alireza Lashay. (2021) Comparison of Topical Pigment Epithelium-Derived Factor (PEDF) with Topical Bevacizumab for Accelerating the Regression of Corneal Neovascularization in an Experimental Model of Rabbit Corneal Angiogenesis. Ocular Immunology and Inflammation 29:7-8, pages 1471-1477.
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Melad Sabzevare, Farshad Yazdani, Ali Karami, Mohaddese Haddadi, Hossein Aghamollaei & Alireza Shahriary. (2021) The effect of N-acetyl cysteine and doxycycline on TNF-α-Rel-a inflammatory pathway and downstream angiogenesis factors in the cornea of rats injured by 2-chloroethyl-ethyl sulfide. Immunopharmacology and Immunotoxicology 43:4, pages 452-460.
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Leila Etemad, Mohammad Moshiri & Mahdi Balali-Mood. (2019) Advances in treatment of acute sulfur mustard poisoning – a critical review. Critical Reviews in Toxicology 49:3, pages 191-214.
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Articles from other publishers (30)

Vered Horwitz, Maayan Cohen, Ariel Gore, Rellie Gez, Hila Gutman, Tamar Kadar, Shlomit Dachir & Shai Kendler. (2023) Predicting clinical outcome of sulfur mustard induced ocular injury using machine learning model. Experimental Eye Research 236, pages 109671.
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Majid Moshirfar, Maliha Masud, Devon Hori Harvey, Carter Payne, Elayna Bruce, Yasmyne C. Ronquillo & Philip C. Hoopes. (2023) The Multifold Etiologies of Limbal Stem Cell Deficiency: A Comprehensive Review on the Etiologies and Additional Treatment Options for Limbal Stem Cell Deficiency. Journal of Clinical Medicine 12:13, pages 4418.
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Mohammad Soleimani, Bita Momenaei, Alireza Baradaran-Rafii, Kasra Cheraqpour, Seungwon An, Mohammad Javad Ashraf, Farshad Abedi, Mohammad Ali Javadi & Ali R. Djalilian. (2023) Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management. Cornea 42:6, pages 776-786.
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Okoyeocha OM. Ebenezar, Andrew Roney, Dinesh G. Goswami, J. Mark Petrash, Dodd Sledge, András M. Komáromy, Karen T. Liby & Neera Tewari-Singh. (2023) Ocular injury progression and cornea histopathology from chloropicrin vapor exposure: Relevant clinical biomarkers in mice. Experimental Eye Research 230, pages 109440.
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Ariel Gore, Tamar Kadar, Maayan Cohen, Hila Gutman, Rellie Gez, Shlomit Dachir & Vered Horwitz. (2023) The use of aflibercept (VEGF trap) in mitigating sulfur mustard-induced corneal neovascularization in a rabbit model. Toxicology Reports 10, pages 206-215.
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Assylbek Zhylkibayev, Ritesh Srivastava, Poojya Anantharam, Claire Crotch, Mohammad Athar & Marina Gorbatyuk. (2023) Retinal injury mouse model and pathophysiological assessment of the effect of arsenical vesicants. Experimental Eye Research 226, pages 109354.
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Faisal Masood, Jin-Hong Chang, Anosh Akbar, Amy Song, Wen-Yang Hu, Dimitri Azar & Mark Rosenblatt. (2022) Therapeutic Strategies for Restoring Perturbed Corneal Epithelial Homeostasis in Limbal Stem Cell Deficiency: Current Trends and Future Directions. Cells 11:20, pages 3247.
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Laurie B. Joseph, Marion K. Gordon, Peihong Zhou, Rita A. Hahn, Hamdi Lababidi, Claire R. Croutch, Patrick J. Sinko, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2022) Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Experimental and Molecular Pathology 128, pages 104807.
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Neha Mishra & Rajesh Agarwal. (2022) Research models of sulfur mustard- and nitrogen mustard-induced ocular injuries and potential therapeutics. Experimental Eye Research 223, pages 109209.
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Dinesh G. Goswami, Neha Mishra, Rama Kant, Chapla Agarwal, Claire R. Croutch, Robert W. Enzenauer, Mark J. Petrash, Neera Tewari-Singh & Rajesh Agarwal. (2021) Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits. PLOS ONE 16:10, pages e0258503.
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Allison Fuchs, Elizabeth A. Giuliano, Nishant R. Sinha & Rajiv R. Mohan. (2021) Ocular toxicity of mustard gas: A concise review. Toxicology Letters 343, pages 21-27.
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Ariel Gore, Tamar Kadar, Shlomit Dachir & Vered Horwitz. (2021) Therapeutic measures for sulfur mustard-induced ocular injury. Toxicology Letters 340, pages 58-66.
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Houmam Araj, Santa J. Tumminia & David T. Yeung. (2020) Ocular Surface – Merging Challenges and Opportunities. Translational Vision Science & Technology 9:12, pages 3.
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Matthew D. McGraw, So‐Young Kim, Carl W. White & Livia A. Veress. (2020) Acute cytotoxicity and increased vascular endothelial growth factor after in vitro nitrogen mustard vapor exposure . Annals of the New York Academy of Sciences 1479:1, pages 223-233.
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Berg Elina, Zadok David, Gore Ariel, Cohen Maayan, Gutman Hila, Gez Rellie, Horwitz Vered, Dachir Shlomit & Kadar Tamar. (2019) The cellular inflammatory response associated with sulfur mustard induced delayed limbal stem cell deficiency and evaluation of tacrolimus treatment. Advances in Toxicology and Toxic Effects 3:1, pages 023-030.
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Dinesh G. Goswami, Rama Kant, David A. Ammar, Dileep Kumar, Robert W. Enzenauer, J. Mark Petrash, Neera Tewari-Singh & Rajesh Agarwal. (2019) Acute corneal injury in rabbits following nitrogen mustard ocular exposure. Experimental and Molecular Pathology 110, pages 104275.
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Vered Horwitz, Inbar Cohen-Gihon, Inbal Egoz, Shlomit Dachir, Maayan Cohen, Liat Cohen, Hila Gutman, Rellie Gez, Tamar Kadar, Ariel Gore, Adi Beth-Din, Anat Zvi, Galia Zaide & Ofir Israeli. (2019) A comprehensive analysis of corneal mRNA levels during sulfur mustard induced ocular late pathology in the rabbit model using RNA sequencing. Experimental Eye Research 184, pages 201-212.
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Maya Eiger-Moscovich, Eitan Livny, Ruti Sella, Orly Gal-Or, Yael Nisgav, Tami Livnat & Irit Bahar. (2019) Comparison of Subconjunctival Aflibercept and Betamethasone for the Treatment of Formed Corneal Neovascularization in a Rabbit Model. Ophthalmic Research 62:2, pages 116-122.
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Vered Horwitz, Shlomit Dachir, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Hillel Buch, Tamar Kadar & Ariel Gore. (2018) Differential expression of corneal and limbal cytokines and chemokines throughout the clinical course of sulfur mustard induced ocular injury in the rabbit model. Experimental Eye Research 177, pages 145-152.
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Danial Roshandel, Medi Eslani, Alireza Baradaran-Rafii, Albert Y. Cheung, Khaliq Kurji, Sayena Jabbehdari, Alejandra Maiz, Setareh Jalali, Ali R. Djalilian & Edward J. Holland. (2018) Current and emerging therapies for corneal neovascularization. The Ocular Surface 16:4, pages 398-414.
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Dinesh G. Goswami, Rama Kant, Neera Tewari-Singh & Rajesh Agarwal. (2018) Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicology Letters 293, pages 127-132.
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Dinesh Giri Goswami, Rajesh Agarwal & Neera Tewari-Singh. (2018) Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite. Toxicology Letters 293, pages 112-119.
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Ariel Gore, Vered Horwitz, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Tamar Kadar & Shlomit Dachir. (2018) Successful single treatment with ziv-aflibercept for existing corneal neovascularization following ocular chemical insult in the rabbit model. Experimental Eye Research 171, pages 183-191.
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Steven A. Giannos, Edward R. Kraft, Zhen-Yang Zhao, Kevin H. Merkley & Jiyang Cai. (2018) Photokinetic Drug Delivery: Near infrared (NIR) Induced Permeation Enhancement of Bevacizumab, Ranibizumab and Aflibercept through Human Sclera. Pharmaceutical Research 35:6.
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Neera Tewari-Singh, Dinesh G Goswami, Rama Kant, David A AmmarDileep Kumar, Robert W EnzenauerRobert P Casillas, Claire R Croutch, J Mark PetrashRajesh Agarwal. (2017) Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicological Sciences 160:2, pages 420-428.
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Yunes Panahi, Seyyed Mahdi Rajaee & Amirhossein Sahebkar. (2017) Ocular Effects of Sulfur Mustard and Therapeutic Approaches. Journal of Cellular Biochemistry 118:11, pages 3549-3560.
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Yan Wu, Chunyan Xue, Yan Lu & Zhenping Huang. (2017) The inhibitory effect of different concentrations of KH902 eye drops on corneal neovascularization induced by alkali burn. Indian Journal of Ophthalmology 65:11, pages 1127.
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Dinesh G. Goswami, Neera Tewari-Singh & Rajesh Agarwal. (2016) Corneal toxicity induced by vesicating agents and effective treatment options. Annals of the New York Academy of Sciences 1374:1, pages 193-201.
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Dinesh G. Goswami, Neera Tewari-Singh, Deepanshi Dhar, Dileep Kumar, Chapla Agarwal, David A. Ammar, Rama Kant, Robert W. Enzenauer, J. Mark Petrash & Rajesh Agarwal. (2016) Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea 35:2, pages 257-266.
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K.M. Gronkiewicz, E.A. Giuliano, K. Kuroki, F. Bunyak, A. Sharma, L.B.C. Teixeira, C.W. Hamm & R.R. Mohan. (2016) Development of a novel in vivo corneal fibrosis model in the dog. Experimental Eye Research 143, pages 75-88.
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