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Current Eye Research Volume 39, 2014 - Issue 6
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Research Article

A Replication Competent HSV-1(McKrae) with a Mutation in the Amino-terminus of Glycoprotein K (gK) is Unable to Infect Mouse Trigeminal Ganglia after Cornea Infection

Ahmad A. SaiedDivision of Biotechnology and Molecular Medicine, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, LAUSA
,
V. N. ChouljenkoDivision of Biotechnology and Molecular Medicine, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, LAUSA
,
Ramesh SubramanianDivision of Biotechnology and Molecular Medicine, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, LAUSA
&
K.G. KousoulasDivision of Biotechnology and Molecular Medicine, Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University Baton Rouge, LAUSACorrespondence[email protected]
Pages 596-603 | Received 13 Aug 2013, Accepted 08 Oct 2013, Published online: 08 Jan 2014

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Shuyong Zhu & Abel Viejo-Borbolla. (2021) Pathogenesis and virulence of herpes simplex virus. Virulence 12:1, pages 2670-2702.
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Rafiq Nabi, Farhana Musarrat, Jose Cesar Menk P. Lima, Ingeborg M. Langohr, Vladimir N. Chouljenko & Konstantin G. Kousoulas. (2023) The Oncolytic herpes simplex virus type-1 (HSV-1) vaccine strain VC2 causes intratumor infiltration of functionally active T cells and inhibition of tumor metastasis and pro-tumor genes VEGF and PDL1 expression in the 4T1/Balb/c mouse model of stage four breast cancer. Frontiers in Molecular Biosciences 10.
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Madalina Preda, Loredana Sabina Cornelia Manolescu & Razvan Daniel Chivu. (2023) Advances in Alpha Herpes Viruses Vaccines for Human. Vaccines 11:6, pages 1094.
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Rafiq Nabi, Andrew C. Lewin, Therese M. Collantes, Vladimir N. Chouljenko & Konstantin G. Kousoulas. (2021) Intramuscular Vaccination With the HSV-1(VC2) Live-Attenuated Vaccine Strain Confers Protection Against Viral Ocular Immunopathogenesis Associated With γδT Cell Intracorneal Infiltration. Frontiers in Immunology 12.
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Nithya Jambunathan, Carolyn Clark, Farhana Musarrat, Vladimir Chouljenko, Jared Rudd & Konstantin Kousoulas. (2021) Two Sides to Every Story: Herpes Simplex Type-1 Viral Glycoproteins gB, gD, gH/gL, gK, and Cellular Receptors Function as Key Players in Membrane Fusion. Viruses 13:9, pages 1849.
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Farhana Musarrat, Vladimir Chouljenko & Konstantin G. Kousoulas. (2021) Cellular and Viral Determinants of Herpes Simplex Virus 1 Entry and Intracellular Transport toward the Nuclei of Infected Cells. Journal of Virology 95:7.
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Ifeanyi Kingsley Uche, Natalie Fowlkes, Luan Vu, Tatiane Watanabe, Mariano Carossino, Rafiq Nabi, Fabio del Piero, Jared S. Rudd, Konstantin G. Kousoulas & Paul J. F. Rider. (2021) Novel Oncolytic Herpes Simplex Virus 1 VC2 Promotes Long-Lasting, Systemic Anti-melanoma Tumor Immune Responses and Increased Survival in an Immunocompetent B16F10-Derived Mouse Melanoma Model. Journal of Virology 95:3.
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Christos Dogrammatzis, Hope Waisner & Maria Kalamvoki. (2020) “Non-Essential” Proteins of HSV-1 with Essential Roles In Vivo: A Comprehensive Review. Viruses 13:1, pages 17.
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Wuchao Zhang, Peng Gao, Xixi Gui, Lei Zhou, Xinna Ge, Xin Guo, John W. Wills, Jun Han & Hanchun Yang. (2020) Induction of Rod-Shaped Structures by Herpes Simplex Virus Glycoprotein I. Journal of Virology 94:17.
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Li Wang, Runbiao Wang, Chuyang Xu & Hongyan Zhou. (2020) Pathogenesis of Herpes Stromal Keratitis: Immune Inflammatory Response Mediated by Inflammatory Regulators. Frontiers in Immunology 11.
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Anwesha Banerjee, Smita Kulkarni & Anupam Mukherjee. (2020) Herpes Simplex Virus: The Hostile Guest That Takes Over Your Home. Frontiers in Microbiology 11.
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Shan K. Naidu, Rafiq Nabi, Nagarjuna R. Cheemarla, Brent A. Stanfield, Paul J. Rider, Nithya Jambunathan, Vladimir N. Chouljenko, Renee Carter, Fabio Del Piero, Ingeborg Langohr & Konstantin G. Kousoulas. (2020) Intramuscular vaccination of mice with the human herpes simplex virus type-1(HSV-1) VC2 vaccine, but not its parental strain HSV-1(F) confers full protection against lethal ocular HSV-1 (McKrae) pathogenesis. PLOS ONE 15:2, pages e0228252.
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Paul J. F. Rider, Ifeanyi K. Uche, Larissa Sweeny & Konstantin G. Kousoulas. (2019) Anti-viral Immunity in the Tumor Microenvironment: Implications for the Rational Design of Herpes Simplex Virus Type 1 Oncolytic Virotherapy. Current Clinical Microbiology Reports 6:4, pages 193-199.
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Paul J. F. Rider, Lyndon M. Coghill, Misagh Naderi, Jeremy M. Brown, Michal Brylinski & Konstantin G. Kousoulas. (2019) Identification and Visualization of Functionally Important Domains and Residues in Herpes Simplex Virus Glycoprotein K(gK) Using a Combination of Phylogenetics and Protein Modeling. Scientific Reports 9:1.
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David I. Bernstein, Rhonda D. Cardin, Derek A. Pullum, Fernando J. Bravo, Konstantin G. Kousoulas & David A. Dixon. (2019) Duration of protection from live attenuated vs. sub unit HSV-2 vaccines in the guinea pig model of genital herpes: Reassessing efficacy using endpoints from clinical trials. PLOS ONE 14:3, pages e0213401.
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Naveen K. Rajasagi & Barry T. Rouse. (2019) The Role of T Cells in Herpes Stromal Keratitis. Frontiers in Immunology 10.
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David I. Bernstein, Derek A. Pullum, Rhonda D. Cardin, Fernando J. Bravo, David A. Dixon & Konstantin G. Kousoulas. (2019) The HSV-1 live attenuated VC2 vaccine provides protection against HSV-2 genital infection in the guinea pig model of genital herpes. Vaccine 37:1, pages 61-68.
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Ujjaldeep Jaggi, Shaohui Wang, Kati Tormanen, Harry Matundan, Alexander V. Ljubimov & Homayon Ghiasi. (2018) Role of Herpes Simplex Virus Type 1 (HSV-1) Glycoprotein K (gK) Pathogenic CD8+ T Cells in Exacerbation of Eye Disease. Frontiers in Immunology 9.
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Jillian C. Carmichael, Hiroki Yokota, Rebecca C. Craven, Anthony Schmitt & John W. Wills. (2018) The HSV-1 mechanisms of cell-to-cell spread and fusion are critically dependent on host PTP1B. PLOS Pathogens 14:5, pages e1007054.
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Farhana Musarrat, Nithya Jambunathan, Paul J. F. Rider, V. N. Chouljenko & K. G. Kousoulas. (2018) The Amino Terminus of Herpes Simplex Virus 1 Glycoprotein K (gK) Is Required for gB Binding to Akt, Release of Intracellular Calcium, and Fusion of the Viral Envelope with Plasma Membranes. Journal of Virology 92:6.
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Paul J. F. Rider, Farhana Musarrat, Rafiq Nabi, Shan Naidu & Konstantin G. Kousoulas. (2018) First Impressions—the Potential of Altering Initial Host-Virus Interactions for Rational Design of Herpesvirus Vaccine Vectors. Current Clinical Microbiology Reports 5:1, pages 55-65.
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Paul J. F. Rider, Misagh Naderi, Scott Bergeron, Vladimir N. Chouljenko, Michal Brylinski & Konstantin G. Kousoulas. (2017) Cysteines and N-Glycosylation Sites Conserved among All Alphaherpesviruses Regulate Membrane Fusion in Herpes Simplex Virus 1 Infection. Journal of Virology 91:21.
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Kening Wang, Georgia D. Tomaras, Sinthujan Jegaskanda, M. Anthony Moody, Hua-Xin Liao, Kyle N. Goodman, Phillip W. Berman, Supachai Rerks-Ngarm, Punnee Pitisuttithum, Sorachai Nitayapan, Jaranit Kaewkungwal, Barton F. Haynes & Jeffrey I. Cohen. (2017) Monoclonal Antibodies, Derived from Humans Vaccinated with the RV144 HIV Vaccine Containing the HVEM Binding Domain of Herpes Simplex Virus (HSV) Glycoprotein D, Neutralize HSV Infection, Mediate Antibody-Dependent Cellular Cytotoxicity, and Protect Mice from Ocular Challenge with HSV-1. Journal of Virology 91:19.
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Brent A. Stanfield, Bapi Pahar, Vladimir N. Chouljenko, Ronald Veazey & Konstantin G. Kousoulas. (2017) Vaccination of rhesus macaques with the live-attenuated HSV-1 vaccine VC2 stimulates the proliferation of mucosal T cells and germinal center responses resulting in sustained production of highly neutralizing antibodies. Vaccine 35:4, pages 536-543.
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Nithya Jambunathan, Anu-Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko & Konstantin G. Kousoulas. (2016) Deletion of a Predicted β-Sheet Domain within the Amino Terminus of Herpes Simplex Virus Glycoprotein K Conserved among Alphaherpesviruses Prevents Virus Entry into Neuronal Axons. Journal of Virology 90:5, pages 2230-2239.
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Alex M Agelidis & Deepak Shukla. (2015) Cell entry mechanisms of HSV: what we have learned in recent years. Future Virology 10:10, pages 1145-1154.
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Brent Stanfield & Konstantin Gus Kousoulas. (2015) Herpes Simplex Vaccines: Prospects of Live-Attenuated HSV Vaccines to Combat Genital and Ocular Infections. Current Clinical Microbiology Reports 2:3, pages 125-136.
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Brent A. Stanfield, Jacque Stahl, Vladimir N. Chouljenko, Ramesh Subramanian, Anu-Susan Charles, Ahmad A. Saied, Jason D. Walker & Konstantin G. Kousoulas. (2014) A Single Intramuscular Vaccination of Mice with the HSV-1 VC2 Virus with Mutations in the Glycoprotein K and the Membrane Protein UL20 Confers Full Protection against Lethal Intravaginal Challenge with Virulent HSV-1 and HSV-2 Strains. PLoS ONE 9:10, pages e109890.
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