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Current Eye Research Volume 39, 2014 - Issue 8
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Research Article

The Beneficial Effects of Doxycycline, An Inhibitor of Matrix Metalloproteinases, on Sulfur Mustard-Induced Ocular Pathologies Depend on the Injury Stage

Vered HorwitzDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsraelCorrespondence[email protected]
,
Shlomit DachirDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Maayan CohenDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Hila GutmanDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Liat CohenDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Eliezer FishbineDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Rachel BrandeisDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Joseph TuretzDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Adina AmirDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
,
Ariel GoreDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
&
Tamar KadarDepartment of Pharmacology, Israel Institute for Biological Research Ness ZionaIsrael
 show all
Pages 803-812 | Received 11 Aug 2013, Accepted 08 Dec 2013, Published online: 06 Feb 2014

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Ali Khamisabadi, Eisa Tahmasbpour, Mostafa Ghanei & Alireza Shahriary. (2020) Roles of matrix metalloproteinases (MMPs) in SM-induced pathologies. Toxin Reviews 39:1, pages 24-33.
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Yeliz Ekim, Selcuk Kara, Baran Gencer & Turan Karaca. (2019) Efficacy of Sunitinib, Sunitinib-Hesperetin, and Sunitinib-Doxycycline Combinations on Experimentally-Induced Corneal Neovascularization. Current Eye Research 44:6, pages 590-598.
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Leila Etemad, Mohammad Moshiri & Mahdi Balali-Mood. (2019) Advances in treatment of acute sulfur mustard poisoning – a critical review. Critical Reviews in Toxicology 49:3, pages 191-214.
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Vered Horwitz, Shlomit Dachir, Maayan Cohen, Hila Gutman, Liat Cohen, Eliezer Fishbine, Rachel Brandeis, Joseph Turetz, Adina Amir, Ariel Gore & Tamar Kadar. (2016) Re: The Beneficial Effects of Doxycycline, an Inhibitor of Matrix Metalloproteinases, on Sulfur Mustard-induced Ocular Pathologies Depend on the Injury Stage. Current Eye Research 41:1, pages 135-136.
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Abdullah Ilhan, Umit Yolcu & Fatih C. Gundogan. (2016) Re: The Beneficial Effects of Doxycycline, an Inhibitor of Matrix Metalloproteinases, on Sulfur Mustard-induced Ocular Pathologies Depend on the Injury Stage. Current Eye Research 41:1, pages 133-134.
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Articles from other publishers (36)

Vered Horwitz, Maayan Cohen, Ariel Gore, Rellie Gez, Hila Gutman, Tamar Kadar, Shlomit Dachir & Shai Kendler. (2023) Predicting clinical outcome of sulfur mustard induced ocular injury using machine learning model. Experimental Eye Research 236, pages 109671.
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Jia Liu, Yingni Xu, Yongrui Huang, Xiaomin Sun, Yuehai Peng, Wenjing Song, Jin Yuan & Li Ren. (2023) Collagen membrane loaded with doxycycline through hydroxypropyl chitosan microspheres for the early reconstruction of alkali-burned cornea. International Journal of Biological Macromolecules 244, pages 125188.
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Fanny Caffin, David Boccara & Christophe Piérard. (2023) The Use of Hydrogel Dressings in Sulfur Mustard-Induced Skin and Ocular Wound Management. Biomedicines 11:6, pages 1626.
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Mohammad Soleimani, Bita Momenaei, Alireza Baradaran-Rafii, Kasra Cheraqpour, Seungwon An, Mohammad Javad Ashraf, Farshad Abedi, Mohammad Ali Javadi & Ali R. Djalilian. (2023) Mustard Gas–Induced Ocular Surface Disorders: An Update on the Pathogenesis, Clinical Manifestations, and Management. Cornea 42:6, pages 776-786.
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Ja Young Oh, Yeoun Sook Chun & Kyoung Woo Kim. (2023) Dichotomous versus 5-scale grading system for the interpretation of the point-of-care immunoassay for tear matrix metalloproteinase-9 in dry eye. Scientific Reports 13:1.
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Bonnie He, Alfonso Iovieno & Sonia N. Yeung. (2022) Efficacy of oral doxycycline in the treatment of recurrent corneal erosion syndrome. Clinical & Experimental Ophthalmology 50:9, pages 1110-1112.
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Laurie B. Joseph, Marion K. Gordon, Peihong Zhou, Rita A. Hahn, Hamdi Lababidi, Claire R. Croutch, Patrick J. Sinko, Diane E. Heck, Debra L. Laskin & Jeffrey D. Laskin. (2022) Sulfur mustard corneal injury is associated with alterations in the epithelial basement membrane and stromal extracellular matrix. Experimental and Molecular Pathology 128, pages 104807.
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Neha Mishra & Rajesh Agarwal. (2022) Research models of sulfur mustard- and nitrogen mustard-induced ocular injuries and potential therapeutics. Experimental Eye Research 223, pages 109209.
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Ali Reza KhoshdelOmid Emami AleaghaAlireza ShahriaryHossein AghamollaeiFarshad Najjar Asiabani. (2022) Topical Effects of N -Acetyl Cysteine and Doxycycline on Inflammatory and Angiogenic Factors in the Rat Model of Alkali-Burned Cornea . Journal of Interferon & Cytokine Research 42:2, pages 82-89.
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Dinesh G. Goswami, Neha Mishra, Rama Kant, Chapla Agarwal, Claire R. Croutch, Robert W. Enzenauer, Mark J. Petrash, Neera Tewari-Singh & Rajesh Agarwal. (2021) Pathophysiology and inflammatory biomarkers of sulfur mustard-induced corneal injury in rabbits. PLOS ONE 16:10, pages e0258503.
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Allison Fuchs, Elizabeth A. Giuliano, Nishant R. Sinha & Rajiv R. Mohan. (2021) Ocular toxicity of mustard gas: A concise review. Toxicology Letters 343, pages 21-27.
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Agata Tsvetanova, Roger M. Powell, Kamen A. Tsvetanov, Kerry M. Smith & David J. Gould. (2021) Melting corneal ulcers (keratomalacia) in dogs: A 5‐year clinical and microbiological study (2014–2018). Veterinary Ophthalmology 24:3, pages 265-278.
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Ariel Gore, Tamar Kadar, Shlomit Dachir & Vered Horwitz. (2021) Therapeutic measures for sulfur mustard-induced ocular injury. Toxicology Letters 340, pages 58-66.
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Seung Pil Bang, Myeong Jin Son, Harim Kim, You Hyun Lee & Jong Hwa Jun. (2020) In vitro validation of the tear matrix metalloproteinase 9 in-situ immunoassay. Scientific Reports 10:1.
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Yoke-Chen Chang, Rita A. Hahn, Marion K. Gordon, Jeffrey D. Laskin & Donald R. Gerecke. (2020) A type IV collagenase inhibitor, N-hydroxy-3-phenyl-2-(4-phenylbenzenesulfonamido) propanamide (BiPS), suppresses skin injury induced by sulfur mustard. Toxicology and Applied Pharmacology 401, pages 115078.
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Jiahao Zhang, Shurong Wang, Yuxi He, Boyuan Yao & Yan Zhang. (2020) Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization. Chemical Biology & Drug Design 95:5, pages 485-492.
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Joshua P. Gray, Michael P. Shakarjian, Donald R. Gerecke & Robert P. Casillas. 2020. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 613 639 .
Berg Elina, Zadok David, Gore Ariel, Cohen Maayan, Gutman Hila, Gez Rellie, Horwitz Vered, Dachir Shlomit & Kadar Tamar. (2019) The cellular inflammatory response associated with sulfur mustard induced delayed limbal stem cell deficiency and evaluation of tacrolimus treatment. Advances in Toxicology and Toxic Effects 3:1, pages 023-030.
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Hassan Ghasemi, Roya Yaraee, Soghrat Faghihzadeh, Mohammad Ghassemi-Broumand, Mahmoud Mahmoudi, Mahmoud Babaei, Mostafa Naderi, Maliheh Safavi, Zeinab Ghazanfari, Maryam Rastin, Shahrzad Zamani, Nafiseh Tabasi, Elham Faghihzadeh, Reza Gharebaghi, Zuhair Mohammad Hassan, Ensie sadat Mirsharif & Tooba Ghazanfari. (2019) Tear and serum MMP-9 and serum TIMPs levels in the severe sulfur mustard eye injured exposed patients. International Immunopharmacology 77, pages 105812.
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Dinesh G. Goswami, Rama Kant, David A. Ammar, Dileep Kumar, Robert W. Enzenauer, J. Mark Petrash, Neera Tewari-Singh & Rajesh Agarwal. (2019) Acute corneal injury in rabbits following nitrogen mustard ocular exposure. Experimental and Molecular Pathology 110, pages 104275.
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Vered Horwitz, Inbar Cohen-Gihon, Inbal Egoz, Shlomit Dachir, Maayan Cohen, Liat Cohen, Hila Gutman, Rellie Gez, Tamar Kadar, Ariel Gore, Adi Beth-Din, Anat Zvi, Galia Zaide & Ofir Israeli. (2019) A comprehensive analysis of corneal mRNA levels during sulfur mustard induced ocular late pathology in the rabbit model using RNA sequencing. Experimental Eye Research 184, pages 201-212.
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Vered Horwitz, Shlomit Dachir, Maayan Cohen, Hila Gutman, Liat Cohen, Rellie Gez, Hillel Buch, Tamar Kadar & Ariel Gore. (2018) Differential expression of corneal and limbal cytokines and chemokines throughout the clinical course of sulfur mustard induced ocular injury in the rabbit model. Experimental Eye Research 177, pages 145-152.
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Dinesh G. Goswami, Rama Kant, Neera Tewari-Singh & Rajesh Agarwal. (2018) Efficacy of anti-inflammatory, antibiotic and pleiotropic agents in reversing nitrogen mustard-induced injury in ex vivo cultured rabbit cornea. Toxicology Letters 293, pages 127-132.
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Mingxue Sun, Yuyan Yang, Wenqi Meng, Qingqiang Xu, Fengwu Lin, Yongchun Chen, Jie Zhao & Kai Xiao. (2018) Advanced biotherapy for the treatment of sulfur mustard poisoning. Chemico-Biological Interactions 286, pages 111-118.
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Karel D. Capek, Derek M. Culnan, Kevin Merkley, Ted T. Huang & Stefan Trocme. 2018. Total Burn Care. Total Burn Care 435 444.e6 .
Neera Tewari-Singh, Dinesh G Goswami, Rama Kant, David A AmmarDileep Kumar, Robert W EnzenauerRobert P Casillas, Claire R Croutch, J Mark PetrashRajesh Agarwal. (2017) Histopathological and Molecular Changes in the Rabbit Cornea From Arsenical Vesicant Lewisite Exposure. Toxicological Sciences 160:2, pages 420-428.
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Kowsalya Vellingiri, Ligy Philip & Ki-Hyun Kim. (2017) Metal–organic frameworks as media for the catalytic degradation of chemical warfare agents. Coordination Chemistry Reviews 353, pages 159-179.
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Hui Fang, Quan-Li Li, Min Han, May Lei Mei & Chun Hung Chu. (2017) Anti-proteolytic property and bonding durability of mussel adhesive protein-modified dentin adhesive interface. Dental Materials 33:10, pages 1075-1083.
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Karam M. Hamweyah & Donald U. Stone. (2017) Evidence-Based Update on Ocular Chemical Injuries. Current Ophthalmology Reports 5:1, pages 49-57.
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Marion K. Gordon, Andrea DeSantis-Rodrigues, Rita Hahn, Peihong Zhou, Yokechen Chang, Kathy K. H. Svoboda & Donald R. Gerecke. (2016) The molecules in the corneal basement membrane zone affected by mustard exposure suggest potential therapies. Annals of the New York Academy of Sciences 1378:1, pages 158-165.
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Dinesh G. Goswami, Neera Tewari-Singh & Rajesh Agarwal. (2016) Corneal toxicity induced by vesicating agents and effective treatment options. Annals of the New York Academy of Sciences 1374:1, pages 193-201.
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Edgardo Rivera-Delgado, Emily Ward & Horst A. von Recum. (2016) Providing sustained transgene induction through affinity-based drug delivery. Journal of Biomedical Materials Research Part A 104:5, pages 1135-1142.
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Alina Bakunowicz-Łazarczyk & Beata Urban. (2016) Assessment of therapeutic options for reducing alkali burn-induced corneal neovascularization and inflammation. Advances in Medical Sciences 61:1, pages 101-112.
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Dinesh G. Goswami, Neera Tewari-Singh, Deepanshi Dhar, Dileep Kumar, Chapla Agarwal, David A. Ammar, Rama Kant, Robert W. Enzenauer, J. Mark Petrash & Rajesh Agarwal. (2016) Nitrogen Mustard-Induced Corneal Injury Involves DNA Damage and Pathways Related to Inflammation, Epithelial-Stromal Separation, and Neovascularization. Cornea 35:2, pages 257-266.
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Joshua P. Gray, Michael P. Shakarjian, Donald R. Gerecke & Robert P. Casillas. 2015. Handbook of Toxicology of Chemical Warfare Agents. Handbook of Toxicology of Chemical Warfare Agents 557 576 .
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